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Strain Name:
C57BL/6J-MtgxR3411Btlr/Mmmh
Stock Number:
040629-MU
Citation ID:
RRID:MMRRC_040629-MU
Other Names:
R3411 (G1), C57BL/6J-MtgxR3411Btlr
Major Collection:

Strain Information

Htr1b
Name: 5-hydroxytryptamine (serotonin) receptor 1B
Synonyms: 5-HT1B receptor, 5HT1B receptor, 5-HT1B receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15551
HGNC: HGNC:5287
Homologene: 669
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: MAST205, Mtssk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17776
Homologene: 7428
Aff1
Name: AF4/FMR2 family, member 1
Synonyms: Af4, Rob, 9630032B01Rik, Mllt2h
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17355
HGNC: HGNC:7135
Homologene: 4340
Wdr7
Name: WD repeat domain 7
Synonyms: TGF-beta resistance associated gene, TRAG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 104082
VEGA: 18
Homologene: 11408
Klhl7
Name: kelch-like 7
Synonyms: 2700038B03Rik, SBBI26, Klhl6, D5Ertd363e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52323
Homologene: 10317
Arid4a
Name: AT-rich interaction domain 4A
Synonyms: A630067N03Rik, Rbbp1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238247
HGNC: HGNC:9885
Homologene: 11303
Usp53
Name: ubiquitin specific peptidase 53
Synonyms: Sp6, Phxr3, mbo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99526
Homologene: 34521
Snw1
Name: SNW domain containing 1
Synonyms: SKIP, NCoA-62, SNW1, 2310008B08Rik, Skiip
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66354
VEGA: 12
Homologene: 56557
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, QBRICK, crf11, eyes2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Smu1
Name: smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
Synonyms: 2600001O03Rik, SMU-1, 2610203K23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74255
Homologene: 10079
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, l7Rn3, ELM2, Odz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Hjurp
Name: Holliday junction recognition protein
Synonyms: C330011F01Rik, A730008H23Rik, 6430706D22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381280
Homologene: 10184
Sptb
Name: spectrin beta, erythrocytic
Synonyms: Spnb-1, spectrin R, D330027P03Rik, LOC383567, brain erythroid spectrin (235E), Spnb1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20741
Homologene: 295
Adgra3
Name: adhesion G protein-coupled receptor A3
Synonyms: 3830613O22Rik, Tem5-like, Gpr125
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70693
Homologene: 19235
Apc
Name: APC, WNT signaling pathway regulator
Synonyms: Min, CC1, adenomatosis polyposis coli
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11789
HGNC: HGNC:583
Homologene: 30950
Rpn2
Name: ribophorin II
Synonyms: Rpn-2, 1300012C06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20014
Homologene: 2214
Atp5po
Name: ATP synthase peripheral stalk subunit OSCP
Synonyms: D12Wsu28e, Atp5o
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 28080
HGNC: HGNC:850
Homologene: 1283
Mcm6
Name: minichromosome maintenance complex component 6
Synonyms: Mcmd6, D1Wsu22e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17219
HGNC: HGNC:6949
Homologene: 4322
Hacd3
Name: 3-hydroxyacyl-CoA dehydratase 3
Synonyms: B-ind1, Hspc121, Ptplad1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57874
VEGA: 9
Homologene: 9494
Ccdc88a
Name: coiled coil domain containing 88A
Synonyms: C330012F17Rik, D130005J21Rik, C130096N06Rik, GIV, HkRP1, Girdin, A430106J12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108686
Homologene: 41180
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Rhbdf2
Name: rhomboid 5 homolog 2
Synonyms: 4732465I17Rik, Rhbdl6, iRhom2, cub, Uncv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217344
Homologene: 11612
Gm6802
Name: predicted gene 6802
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, E030034C22Rik, B230373P09Rik, Dnahc1, G1-415-19, ferf1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Slc16a4
Name: solute carrier family 16 (monocarboxylic acid transporters), member 4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229699
Homologene: 74529
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Egfem1
Name: EGF-like and EMI domain containing 1
Synonyms: 6130401L20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75740
Homologene: 135950
Kcp
Name: kielin/chordin-like protein
Synonyms: LOC333088, KCP, Crim2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 333088
Homologene: 87817
Pdzd8
Name: PDZ domain containing 8
Synonyms: A630041P07Rik, Pdzk8
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107368
VEGA: 19
Homologene: 14879
Hcrtr2
Name: hypocretin (orexin) receptor 2
Synonyms: OX2r, mOX2bR, mOX2aR, mOXR2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 387285
HGNC: HGNC:4849
Homologene: 1168
Apcs
Name: amyloid P component, serum
Synonyms: Sap
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20219
HGNC: HGNC:584
Homologene: 123932
Adamts16
Name: ADAM metallopeptidase with thrombospondin type 1 motif 16
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271127
Homologene: 15146
Ripk4
Name: receptor-interacting serine-threonine kinase 4
Synonyms: PKK, DIk, RIP4, ANKK2, Ankrd3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72388
HGNC: HGNC:496
Homologene: 10772
Ccdc150
Name: coiled-coil domain containing 150
Synonyms: 4930511H11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78016
Homologene: 15814
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: KA2, GluRgamma2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: Gpat2, A530057A03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215456
Homologene: 19037
Serpina3n
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3N
Synonyms: Spi2-2, Spi2.2, Spi2/eb.4, antitrypsin, alpha-1 antiproteinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20716
HGNC: HGNC:16
Homologene: 111129
Or5b101
Name: olfactory receptor family 5 subfamily B member 101
Synonyms: GA_x6K02T2RE5P-3357666-3356743, MOR202-6, Olfr1453
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258695
HGNC: HGNC:8324
Homologene: 120159
Klra17
Name: killer cell lectin-like receptor, subfamily A, member 17
Synonyms: Ly49q1, Ly-49Q, Ly49Q
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170733
Or5p69
Name: olfactory receptor family 5 subfamily P member 69
Synonyms: GA_x6K02T2PBJ9-10697517-10698461, MOR204-10, Olfr494
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258732
Homologene: 133602
Aox4
Name: aldehyde oxidase 4
Synonyms: AOH2, 2310003G12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71872
Homologene: 70273
Fam120b
Name: family with sequence similarity 120, member B
Synonyms: CCPG, 4932442K08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67544
VEGA: 17
Homologene: 13033
Sypl2
Name: synaptophysin like 2
Synonyms: Mg29
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17306
Homologene: 7421
Bank1
Name: B cell scaffold protein with ankyrin repeats 1
Synonyms: A530094C12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242248
Homologene: 9926
Or10g1
Name: olfactory receptor family 10 subfamily G member 1
Synonyms: GA_x6K02T2RJGY-583652-584608, MOR223-6, Olfr1510, MOR29A
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258423
HGNC: HGNC:8170
Homologene: 87788
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100009609
Nlrp4c
Name: NLR family, pyrin domain containing 4C
Synonyms: Nalp-alpha, Rnh2, Nalp4c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83564
Homologene: 75315
Or8k3
Name: olfactory receptor family 8 subfamily K member 3
Synonyms: GA_x6K02T2Q125-47703682-47702723, MOR188-3, Olfr1047
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259014
Homologene: 133664
Adam4
Name: a disintegrin and metallopeptidase domain 4
Synonyms: tMDCV
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11498
Homologene: 86950
Pcdhb6
Name: protocadherin beta 6
Synonyms: Pcdhb5B, PcdhbF
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93877
HGNC: HGNC:8690
Homologene: 62177
Armcx4
Name: armadillo repeat containing, X-linked 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 100503043
Homologene: 131587
Adgra1
Name: adhesion G protein-coupled receptor A1
Synonyms: 2900059M17Rik, D7Ertd680e, Gpr123
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52389
Homologene: 18582
Mfsd9
Name: major facilitator superfamily domain containing 9
Synonyms: 4931419K03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211798
Homologene: 13100
Psmc3
Name: proteasome (prosome, macropain) 26S subunit, ATPase 3
Synonyms: Tat binding protein 1, TBP-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19182
HGNC: HGNC:9549
Homologene: 2097
AI429214
Name: expressed sequence AI429214
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 621080
Homologene: 82747
Styxl1
Name: serine/threonine/tyrosine interacting-like 1
Synonyms: 1700011C14Rik, Dusp24
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76571
Homologene: 9378
Tal2
Name: T cell acute lymphocytic leukemia 2
Synonyms: bHLHa19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21350
Homologene: 3954
D830014E11Rik
Name: RIKEN cDNA D830014E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320751
VEGA: 5
Six4
Name: sine oculis-related homeobox 4
Synonyms: AREC3, TrexBF
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20474
Homologene: 69089
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 40,786,225 bp
  • A to G, chromosome 1 at 54,356,773 bp
  • T to C, chromosome 1 at 58,239,106 bp
  • A to G, chromosome 1 at 75,316,626 bp
  • GT to GTT, chromosome 1 at 88,266,524 bp
  • T to C, chromosome 1 at 128,351,585 bp
  • T to C, chromosome 1 at 172,894,563 bp
  • C to A, chromosome 2 at 32,302,942 bp
  • A to C, chromosome 2 at 76,942,405 bp
  • T to C, chromosome 2 at 86,228,642 bp
  • A to C, chromosome 2 at 91,055,918 bp
  • G to A, chromosome 2 at 127,428,291 bp
  • C to A, chromosome 2 at 157,290,652 bp
  • C to T, chromosome 3 at 29,583,021 bp
  • G to A, chromosome 3 at 107,300,872 bp
  • C to T, chromosome 3 at 108,216,729 bp
  • T to C, chromosome 3 at 122,949,858 bp
  • G to A, chromosome 3 at 136,247,773 bp
  • T to C, chromosome 4 at 40,752,008 bp
  • A to G, chromosome 4 at 53,785,843 bp
  • T to C, chromosome 4 at 82,963,179 bp
  • C to G, chromosome 4 at 116,310,910 bp
  • G to T, chromosome 5 at 24,138,321 bp
  • A to G, chromosome 5 at 50,001,930 bp
  • T to A, chromosome 5 at 103,754,706 bp
  • A to T, chromosome 5 at 105,826,706 bp
  • T to C, chromosome 5 at 135,765,764 bp
  • T to C, chromosome 6 at 29,482,846 bp
  • T to A, chromosome 6 at 129,874,846 bp
  • A to G, chromosome 7 at 6,092,570 bp
  • T to C, chromosome 7 at 25,062,972 bp
  • T to C, chromosome 7 at 84,946,688 bp
  • T to C, chromosome 7 at 96,852,530 bp
  • A to T, chromosome 7 at 108,368,344 bp
  • A to G, chromosome 7 at 121,122,043 bp
  • T to C, chromosome 7 at 139,847,703 bp
  • C to T, chromosome 8 at 36,993,917 bp
  • A to G, chromosome 9 at 64,991,094 bp
  • A to G, chromosome 9 at 76,233,008 bp
  • A to C, chromosome 9 at 81,632,041 bp
  • T to A, chromosome 11 at 29,486,006 bp
  • A to G, chromosome 11 at 116,604,365 bp
  • C to A, chromosome 12 at 19,490,620 bp
  • T to C, chromosome 12 at 71,061,525 bp
  • A to G, chromosome 12 at 73,112,883 bp
  • T to G, chromosome 12 at 76,610,815 bp
  • A to T, chromosome 12 at 81,419,822 bp
  • A to T, chromosome 12 at 87,464,724 bp
  • A to G, chromosome 12 at 104,411,277 bp
  • T to C, chromosome 13 at 70,753,226 bp
  • A to T, chromosome 14 at 31,269,817 bp
  • T to A, chromosome 14 at 52,410,361 bp
  • G to T, chromosome 16 at 34,212,272 bp
  • C to T, chromosome 16 at 91,928,906 bp
  • T to C, chromosome 16 at 97,743,957 bp
  • T to A, chromosome 17 at 15,431,635 bp
  • T to C, chromosome 17 at 25,744,517 bp
  • C to A, chromosome 18 at 34,269,259 bp
  • A to G, chromosome 18 at 37,335,892 bp
  • T to C, chromosome 18 at 63,740,017 bp
  • G to C, chromosome 19 at 13,028,047 bp
  • A to G, chromosome 19 at 59,345,413 bp
  • C to A, chromosome X at 134,691,025 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3411 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040629-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.