Strain Name:
C57BL/6J-MtgxR3413Btlr/Mmmh
Stock Number:
040631-MU
Citation ID:
RRID:MMRRC_040631-MU
Other Names:
R3413 (G1), C57BL/6J-MtgxR3413Btlr
Major Collection:

Gene Information

Ubn2
Name: ubinuclein 2
Synonyms: 6030408G03Rik, 2900060J04Rik, D130059P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320538
Homologene: 45564
Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
Hs6st2
Name: heparan sulfate 6-O-sulfotransferase 2
Synonyms: 6OST2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 50786
Homologene: 9277
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: 1110013E22Rik, 2010005I16Rik, ZMYND8, RACK7, 3632413B07Rik, Prkcbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Axin1
Name: axin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12005
HGNC: HGNC:903
Homologene: 2614
Ddx42
Name: DEAD box helicase 42
Synonyms: B430002H05Rik, 1810047H21Rik, SF3b125, DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72047
Homologene: 49137
Ap2a2
Name: adaptor-related protein complex 2, alpha 2 subunit
Synonyms: alpha-C adaptin, alpha-adaptin C, L25, Adtab, 2410074K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11772
HGNC: HGNC:562
Homologene: 5335
Hip1
Name: huntingtin interacting protein 1
Synonyms: 2610109B09Rik, A930014B11Rik, E130315I21Rik, HIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Rtf1
Name: RTF1, Paf1/RNA polymerase II complex component
Synonyms: 6530416A09Rik, 2900005O08Rik, Gtl7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76246
Homologene: 133868
Map1s
Name: microtubule-associated protein 1S
Synonyms: VCY2IP1, 6430517J16Rik, Bpy2ip1, Map8, Mtap1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270058
Homologene: 10047
H2-T23
Name: histocompatibility 2, T region locus 23
Synonyms: H-2T23, T18c(37), T18c, 37c, 37b, T23d, T23b, Qed-1, Qa1, Qa-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15040
HGNC: HGNC:4962
Homologene: 134018
Clvs2
Name: clavesin 2
Synonyms: A330019N05Rik, Rlbp1l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215890
Homologene: 27894
Sez6l
Name: seizure related 6 homolog like
Synonyms: Acig1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56747
Homologene: 10895
Syk
Name: spleen tyrosine kinase
Synonyms: Sykb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20963
Homologene: 2390
Zfyve28
Name: zinc finger, FYVE domain containing 28
Synonyms: 9630058O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231125
Homologene: 15119
Col13a1
Name: collagen, type XIII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12817
HGNC: HGNC:2190
Homologene: 22421
Rusc2
Name: RUN and SH3 domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100213
Homologene: 18967
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Gckr
Name: glucokinase regulatory protein
Synonyms: GKRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231103
HGNC: HGNC:4196
Homologene: 1139
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246177
Homologene: 27996
Plcz1
Name: phospholipase C, zeta 1
Synonyms: 1700041H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114875
Homologene: 23815
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Got1l1
Name: glutamic-oxaloacetic transaminase 1-like 1
Synonyms: 1700083M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76615
Homologene: 65045
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 435975
Homologene: 104832
Golgb1
Name: golgi autoantigen, golgin subfamily b, macrogolgin 1
Synonyms: Giantin, C130074L01Rik, F730017E11Rik, 6330407A06Rik, Gm6840
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Nup210
Name: nucleoporin 210
Synonyms: gp210, gp190, Pom210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54563
Homologene: 41286
Olfr114
Name: olfactory receptor 114
Synonyms: MOR218-10, GA_x6K02T2PSCP-2049802-2048870
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258284
Homologene: 133642
Ppef2
Name: protein phosphatase, EF hand calcium-binding domain 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19023
HGNC: HGNC:9244
Homologene: 55959
Olfr638
Name: olfactory receptor 638
Synonyms: GA_x6K02T2PBJ9-6737723-6738670, MOR5-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259124
Homologene: 133592
St6galnac1
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Synonyms: ST6GalNAc I, Siat7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20445
Homologene: 7937
Tusc1
Name: tumor suppressor candidate 1
Synonyms: 2200001D17Rik, TSG-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69136
Homologene: 84597
Abhd13
Name: abhydrolase domain containing 13
Synonyms: 1110065L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 68904
Homologene: 6716
Ufsp2
Name: UFM1-specific peptidase 2
Synonyms: 1810047C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 192169
Homologene: 10151
Fcna
Name: ficolin A
Synonyms: ficolin A, Fcn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14133
Homologene: 117949
Cdca7
Name: cell division cycle associated 7
Synonyms: JPO1, 2310021G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66953
Homologene: 49970
Tbc1d8b
Name: TBC1 domain family, member 8B
Synonyms: 4921505D17Rik, 9030605E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 245638
Homologene: 41196
Slc1a7
Name: solute carrier family 1 (glutamate transporter), member 7
Synonyms: EAAT5, A930031E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242607
Homologene: 21327
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: Nl1, NEPLP gamma, NEPLP beta, NEPLP alpha, SEP, Mell1, Nep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27390
Homologene: 22778
Top1mt
Name: DNA topoisomerase 1, mitochondrial
Synonyms: 2900052H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72960
Homologene: 43082
Zfp92
Name: zinc finger protein 92
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 22754
Homologene: 69050
Spag8
Name: sperm associated antigen 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433700
Homologene: 8250
Coq10a
Name: coenzyme Q10A
Synonyms: LOC210582
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 210582
VEGA: 10
Homologene: 27027
Rab18
Name: RAB18, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 19330
VEGA: 18
Homologene: 40765
Tmed9
Name: transmembrane p24 trafficking protein 9
Synonyms: 2400003B06Rik, p24alpha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67511
VEGA: 13
Homologene: 68707
Ccnb3
Name: cyclin B3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 209091
Homologene: 13199
Dnaaf6b
Name: dynein axonemal assembly factor 6B
Synonyms: E230019M04Rik, Pih1h3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 331537
Homologene: 16553
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 14,274,209 bp
  • G to A, chromosome 1 at 66,639,305 bp
  • G to C, chromosome 2 at 25,627,493 bp
  • G to A, chromosome 2 at 72,485,287 bp
  • G to A, chromosome 2 at 119,705,426 bp
  • A to T, chromosome 2 at 165,815,451 bp
  • T to G, chromosome 4 at 43,415,935 bp
  • T to A, chromosome 4 at 43,651,606 bp
  • C to A, chromosome 4 at 93,334,936 bp
  • A to G, chromosome 4 at 108,010,994 bp
  • T to A, chromosome 4 at 154,889,586 bp
  • T to A, chromosome 5 at 31,300,867 bp
  • C to T, chromosome 5 at 34,199,684 bp
  • T to G, chromosome 5 at 92,228,722 bp
  • A to G, chromosome 5 at 112,475,361 bp
  • T to C, chromosome 5 at 135,422,172 bp
  • A to G, chromosome 6 at 38,498,739 bp
  • C to T, chromosome 6 at 48,480,697 bp
  • G to T, chromosome 6 at 91,025,242 bp
  • C to T, chromosome 6 at 140,002,081 bp
  • A to G, chromosome 7 at 42,926,982 bp
  • A to G, chromosome 7 at 104,003,832 bp
  • T to A, chromosome 7 at 141,598,776 bp
  • T to C, chromosome 8 at 9,987,387 bp
  • A to G, chromosome 8 at 27,199,836 bp
  • T to C, chromosome 8 at 45,996,690 bp
  • A to G, chromosome 8 at 70,912,519 bp
  • T to A, chromosome 10 at 33,622,971 bp
  • T to C, chromosome 10 at 61,920,080 bp
  • A to G, chromosome 10 at 128,365,129 bp
  • G to T, chromosome 11 at 6,517,870 bp
  • C to G, chromosome 11 at 59,067,930 bp
  • A to G, chromosome 11 at 106,247,810 bp
  • A to G, chromosome 11 at 116,765,856 bp
  • A to G, chromosome 13 at 52,631,739 bp
  • A to G, chromosome 13 at 55,595,574 bp
  • T to C, chromosome 15 at 75,657,176 bp
  • A to G, chromosome 16 at 36,887,347 bp
  • A to G, chromosome 16 at 49,138,732 bp
  • A to G, chromosome 17 at 26,188,038 bp
  • A to G, chromosome 17 at 36,031,925 bp
  • A to G, chromosome 17 at 37,589,696 bp
  • T to A, chromosome 18 at 6,765,342 bp
  • T to A, chromosome X at 7,007,801 bp
  • C to T, chromosome X at 51,681,455 bp
  • C to T, chromosome X at 73,420,294 bp
  • C to T, chromosome X at 139,713,391 bp
  • T to A, chromosome X at 140,106,021 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3413 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040631-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.