Strain Name:
C57BL/6J-MtgxR3441Btlr/Mmmh
Stock Number:
040659-MU
Citation ID:
RRID:MMRRC_040659-MU
Other Names:
R3441 (G1), C57BL/6J-MtgxR3441Btlr
Major Collection:

Gene Information

Epha4
Name: Eph receptor A4
Synonyms: Sek, Sek1, Tyro1, Hek8, Cek8, 2900005C20Rik, rb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13838
HGNC: HGNC:3388
Homologene: 20933
Htr3b
Name: 5-hydroxytryptamine (serotonin) receptor 3B
Synonyms: 5-HT3 receptor subunit B, 5-HT3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 57014
VEGA: 9
HGNC: HGNC:5298
Homologene: 38131
Rab21
Name: RAB21, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216344
VEGA: 10
Homologene: 8991
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, ELM2, l7Rn3, Odz4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23966
Homologene: 8034
Glb1l2
Name: galactosidase, beta 1-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244757
Homologene: 71790
Tmem98
Name: transmembrane protein 98
Synonyms: 6530411B15Rik, Rwhs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103743
Homologene: 9185
Rag2
Name: recombination activating gene 2
Synonyms: Rag-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19374
HGNC: HGNC:9832
Homologene: 7507
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Mx1
Name: MX dynamin-like GTPase 1
Synonyms: myxovirus (influenza) resistance 1 polypeptide, Mx-1, Mx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17857
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, POMFIL1, 4732483H20Rik, unc53H3, steerin 3, 9630020C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 260315
Homologene: 56688
Btnl6
Name: butyrophilin-like 6
Synonyms: NG13, Gm6519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 624681
Homologene: 106849
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Kif1a
Name: kinesin family member 1A
Synonyms: Kns1, ATSV, N-3 kinesin, LOC381283, C630002N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Adamts3
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3
Synonyms: 6330442E02Rik, 1100001H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330119
HGNC: HGNC:219
Homologene: 8596
4932425I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Cyba
Name: cytochrome b-245, alpha polypeptide
Synonyms: b558, cytochrome beta-558, p22 phox
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13057
HGNC: HGNC:2577
Homologene: 80
Plxnc1
Name: plexin C1
Synonyms: vespr, 2510048K12Rik, CD232
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Mrc2
Name: mannose receptor, C type 2
Synonyms: novel lectin, Endo180, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17534
Homologene: 4408
Vmn1r181
Name: vomeronasal 1 receptor 181
Synonyms: V1rd20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404289
Homologene: 104166
Cdh15
Name: cadherin 15
Synonyms: Cdh14, Mcad, M cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Asz1
Name: ankyrin repeat, SAM and basic leucine zipper domain containing 1
Synonyms: ORF3, 4933400N19Rik, Gasz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74068
HGNC: HGNC:1350
Homologene: 11374
Tchh
Name: trichohyalin
Synonyms: Thh, AHF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99681
Homologene: 136273
Tfpi2
Name: tissue factor pathway inhibitor 2
Synonyms: PP5/TFPI-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21789
Homologene: 38194
Psg27
Name: pregnancy-specific glycoprotein 27
Synonyms: cea15, EG545925
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545925
Homologene: 110989
Hyal6
Name: hyaluronoglucosaminidase 6
Synonyms: 4932701A20Rik, Hyal-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74409
HGNC: HGNC:5324
Homologene: 78028
Adam3
Name: a disintegrin and metallopeptidase domain 3 (cyritestin)
Synonyms: Taz83, tMDC, Cyrn1, ADAM3, Taz83
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Clrn3
Name: clarin 3
Synonyms: Tmem12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 212070
Homologene: 17544
Teddm1b
Name: transmembrane epididymal protein 1B
Synonyms: Gm5531
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 433365
Homologene: 131186
Olfr420
Name: olfactory receptor 420
Synonyms: GA_x6K02T2P20D-20995211-20994246, MOR105-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258302
Homologene: 17185
Olfr1112
Name: olfactory receptor 1112
Synonyms: GA_x6K02T2Q125-48676316-48677272, MOR264-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258655
Homologene: 64901
Cav3
Name: caveolin 3
Synonyms: M-caveolin, Cav-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12391
HGNC: HGNC:1529
Homologene: 7255
Krtap24-1
Name: keratin associated protein 24-1
Synonyms: LOC239932, Gm312
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239932
VEGA: 16
Homologene: 88056
Ap5b1
Name: adaptor-related protein complex 5, beta 1 subunit
Synonyms: Gm962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381201
VEGA: 19
Homologene: 16299
Gtf3c6
Name: general transcription factor IIIC, polypeptide 6, alpha
Synonyms: 2410016F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67371
VEGA: 10
Homologene: 12121
Scgb2b24
Name: secretoglobin, family 2B, member 24
Synonyms: C2b, Scgb2b3, Abpz, Abpbg24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233090
Homologene: 83171
1700013H16Rik
Name: RIKEN cDNA 1700013H16 gene
Synonyms: Xlr6, Slx2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 75514
Homologene: 133239
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 77,426,696 bp
  • C to T, chromosome 1 at 93,036,853 bp
  • A to G, chromosome 1 at 153,875,261 bp
  • A to T, chromosome 1 at 174,159,180 bp
  • A to G, chromosome 2 at 82,986,727 bp
  • A to G, chromosome 2 at 87,191,818 bp
  • T to A, chromosome 2 at 101,630,300 bp
  • A to T, chromosome 3 at 19,974,957 bp
  • A to T, chromosome 3 at 93,445,107 bp
  • A to G, chromosome 5 at 89,698,193 bp
  • A to T, chromosome 6 at 3,965,504 bp
  • A to C, chromosome 6 at 18,108,406 bp
  • C to T, chromosome 6 at 24,734,593 bp
  • G to A, chromosome 6 at 112,472,441 bp
  • T to A, chromosome 7 at 18,567,060 bp
  • A to G, chromosome 7 at 23,984,883 bp
  • G to A, chromosome 7 at 30,720,225 bp
  • G to T, chromosome 7 at 33,738,600 bp
  • A to T, chromosome 7 at 96,553,516 bp
  • A to C, chromosome 7 at 135,514,125 bp
  • T to C, chromosome 8 at 24,680,743 bp
  • C to T, chromosome 8 at 122,425,064 bp
  • G to A, chromosome 8 at 122,862,024 bp
  • C to T, chromosome 9 at 26,780,742 bp
  • T to C, chromosome 9 at 48,945,515 bp
  • T to A, chromosome 10 at 40,251,173 bp
  • G to A, chromosome 10 at 94,871,010 bp
  • A to G, chromosome 10 at 109,704,928 bp
  • CCCGCCGCCGCCGCCGCC to CCCGCCGCCGCCGCC, chromosome 10 at 115,315,309 bp
  • A to G, chromosome 11 at 80,814,299 bp
  • A to T, chromosome 11 at 105,347,716 bp
  • T to C, chromosome 16 at 38,333,806 bp
  • T to C, chromosome 16 at 88,611,825 bp
  • T to A, chromosome 16 at 97,456,231 bp
  • T to C, chromosome 17 at 34,508,318 bp
  • A to G, chromosome 19 at 5,569,983 bp
  • A to G, chromosome X at 53,743,343 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3441 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040659-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.