Strain Name:
C57BL/6J-MtgxR3689Btlr/Mmmh
Stock Number:
040684-MU
Citation ID:
RRID:MMRRC_040684-MU
Other Names:
R3689 (G1), C57BL/6J-MtgxR3689Btlr
Major Collection:

Gene Information

Dcx
Name: doublecortin
Synonyms: lissencephaly, X-linked (doublecortin), Dbct
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 13193
HGNC: HGNC:2714
Homologene: 7683
Ppp1r1b
Name: protein phosphatase 1, regulatory inhibitor subunit 1B
Synonyms: Darpp32, DARPP-32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19049
HGNC: HGNC:9287
Homologene: 12972
Blm
Name: Bloom syndrome, RecQ like helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12144
HGNC: HGNC:1058
Homologene: 47902
Mtss1
Name: MTSS I-BAR domain containing 1
Synonyms: D130001D01Rik, 2310003N14Rik, MIM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 211401
VEGA: 15
Homologene: 8841
Nms
Name: neuromedin S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 433292
Homologene: 67775
Bclaf1
Name: BCL2-associated transcription factor 1
Synonyms: 2700025J07Rik, 5730534O06Rik, 2610102K23Rik, 2810454G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72567
Homologene: 8832
Cog3
Name: component of oligomeric golgi complex 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 338337
VEGA: 14
Homologene: 5854
Myo9b
Name: myosin IXb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Atg16l1
Name: autophagy related 16-like 1 (S. cerevisiae)
Synonyms: APG16L, WDR30, 1500009K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77040
Homologene: 41786
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76501
Homologene: 8584
Chchd10
Name: coiled-coil-helix-coiled-coil-helix domain containing 10
Synonyms: 1620401E04Rik, Ndg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103172
VEGA: 10
Homologene: 27885
Txn1
Name: thioredoxin 1
Synonyms: Trx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22166
Homologene: 128202
Zap70
Name: zeta-chain (TCR) associated protein kinase
Synonyms: TZK, ZAP-70, Srk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22637
Homologene: 839
Napb
Name: N-ethylmaleimide sensitive fusion protein attachment protein beta
Synonyms: I47, Brp14, E161, SNARE, b-SNAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17957
Homologene: 5332
Nsun2
Name: NOL1/NOP2/Sun domain family member 2
Synonyms: Misu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 28114
Homologene: 9817
Grpel1
Name: GrpE-like 1, mitochondrial
Synonyms: mt-GrpE#1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17713
Homologene: 6992
Zfp169
Name: zinc finger protein 169
Synonyms: 4930429A13Rik, 1700025J14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67911
Homologene: 2572
Sec31a
Name: Sec31 homolog A (S. cerevisiae)
Synonyms: Sec31l1, 1810024J13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69162
Homologene: 42056
N4bp1
Name: NEDD4 binding protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 80750
Homologene: 23703
Mideas
Name: mitotic deacetylase associated SANT domain protein
Synonyms: 9430029N19Rik, C130039O16Rik, Elmsan1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238317
Homologene: 19330
Bpifb1
Name: BPI fold containing family B, member 1
Synonyms: LPlunc1, U46068, von Ebner minor salivary protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228801
Homologene: 50047
Pak6
Name: p21 (RAC1) activated kinase 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214230
Homologene: 23200
Fgd2
Name: FYVE, RhoGEF and PH domain containing 2
Synonyms: tcs2, tcs-2, Tcd2, Tcd-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 26382
HGNC: HGNC:3664
Homologene: 8438
Ttn
Name: titin
Synonyms: L56, 2310074I15Rik, 2310036G12Rik, 1100001C23Rik, connectin, shru, D830007G01Rik, mdm, D330041I19Rik, 2310057K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Wdr93
Name: WD repeat domain 93
Synonyms: EG626359
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 626359
Homologene: 56878
Taf5
Name: TATA-box binding protein associated factor 5
Synonyms: 6330528C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226182
VEGA: 19
Homologene: 5064
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: Epcs21, GlcT-1, Ugcgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22234
Homologene: 37763
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Ulk3
Name: unc-51-like kinase 3
Synonyms: 1200015E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71742
VEGA: 9
Homologene: 68482
Zc3h12c
Name: zinc finger CCCH type containing 12C
Synonyms: C230027N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244871
VEGA: 9
Homologene: 35462
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Slc13a4
Name: solute carrier family 13 (sodium/sulfate symporters), member 4
Synonyms: SUT1, 9630060C05Rik, SUT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243755
Homologene: 69125
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: 2410066K11Rik, line 158, Thm1, aln
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73668
Homologene: 57006
Mrpl44
Name: mitochondrial ribosomal protein L44
Synonyms: 5730593H20Rik, 1810030E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69163
Homologene: 11293
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382090
Homologene: 8930
Olfr1221
Name: olfactory receptor 1221
Synonyms: GA_x6K02T2Q125-50591144-50590209, MOR233-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258904
Homologene: 73987
Srsf9
Name: serine and arginine-rich splicing factor 9
Synonyms: SRp30c, Sfrs9, 2610029M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108014
Homologene: 20819
1300017J02Rik
Name: RIKEN cDNA 1300017J02 gene
Synonyms: mICA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71775
Homologene: 826
Tnk1
Name: tyrosine kinase, non-receptor, 1
Synonyms: Tnk1a, Kos1, Tnk1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 83813
Homologene: 2966
Pcdhb12
Name: protocadherin beta 12
Synonyms: Pcdhb5F, PcdhbL, Pcdh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93883
Homologene: 87126
Fam129a
Name: family with sequence similarity 129, member A
Synonyms: Niban
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 63913
Homologene: 62170
G930045G22Rik
Name: RIKEN cDNA G930045G22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Stt3a
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
Synonyms: Itm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16430
HGNC: HGNC:6172
Homologene: 40617
Pde11a
Name: phosphodiesterase 11A
Synonyms: A630086N24Rik, 6330414F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241489
HGNC: HGNC:8773
Homologene: 56763
Spatc1
Name: spermatogenesis and centriole associated 1
Synonyms: 1700084J23Rik, speriolin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74281
VEGA: 15
Homologene: 129861
Piwil4
Name: piwi-like RNA-mediated gene silencing 4
Synonyms: Miwi2, 9230101H05Rik, MIWI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330890
Homologene: 45122
Fbln7
Name: fibulin 7
Synonyms: 1600015H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70370
Homologene: 11489
Erich2
Name: glutamate rich 2
Synonyms: 4933404M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66748
Homologene: 75226
Wfikkn1
Name: WAP, FS, Ig, KU, and NTR-containing protein 1
Synonyms: Gasp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 215001
Homologene: 14244
Nexmif
Name: neurite extension and migration factor
Synonyms: Xpn, C77370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 245555
Homologene: 19589
1700057G04Rik
Name: RIKEN cDNA 1700057G04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78459
Homologene: 134508
Fam53c
Name: family with sequence similarity 53, member C
Synonyms: 2810012G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66306
VEGA: 18
HGNC: HGNC:1336
Homologene: 9586
Gm10923
Name: predicted gene 10923
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 100502582
Cdc42ep1
Name: CDC42 effector protein (Rho GTPase binding) 1
Synonyms: MSE55, Borg5, 1810058K22Rik, CEP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 104445
VEGA: 15
Homologene: 5128
Taf7l
Name: TATA-box binding protein associated factor 7 like
Synonyms: 4933438I11Rik, Taf2q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 74469
Homologene: 83311
Map3k15
Name: mitogen-activated protein kinase kinase kinase 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 270672
Homologene: 50401
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,781,412 bp
  • T to C, chromosome 1 at 38,946,994 bp
  • T to A, chromosome 1 at 79,779,649 bp
  • T to C, chromosome 1 at 87,785,904 bp
  • A to G, chromosome 1 at 151,703,696 bp
  • T to A, chromosome 2 at 66,224,144 bp
  • T to C, chromosome 2 at 70,540,753 bp
  • T to A, chromosome 2 at 76,291,166 bp
  • C to G, chromosome 2 at 76,799,244 bp
  • T to A, chromosome 2 at 89,112,042 bp
  • G to A, chromosome 2 at 101,886,331 bp
  • C to T, chromosome 2 at 118,693,440 bp
  • T to C, chromosome 2 at 128,880,437 bp
  • T to C, chromosome 2 at 148,703,057 bp
  • A to G, chromosome 2 at 154,209,899 bp
  • T to C, chromosome 4 at 57,950,846 bp
  • T to C, chromosome 4 at 59,211,883 bp
  • G to A, chromosome 5 at 36,469,425 bp
  • T to A, chromosome 5 at 100,382,907 bp
  • A to G, chromosome 5 at 115,327,328 bp
  • T to C, chromosome 6 at 35,268,910 bp
  • A to T, chromosome 6 at 50,846,555 bp
  • A to G, chromosome 7 at 79,771,585 bp
  • G to C, chromosome 7 at 80,513,079 bp
  • T to C, chromosome 7 at 120,016,565 bp
  • G to A, chromosome 8 at 71,334,337 bp
  • C to T, chromosome 8 at 86,860,556 bp
  • T to C, chromosome 9 at 14,725,963 bp
  • T to C, chromosome 9 at 36,759,322 bp
  • C to T, chromosome 9 at 52,115,956 bp
  • T to C, chromosome 9 at 57,593,794 bp
  • G to A, chromosome 9 at 87,225,694 bp
  • A to C, chromosome 9 at 92,352,620 bp
  • C to T, chromosome 9 at 103,277,614 bp
  • C to T, chromosome 10 at 20,325,397 bp
  • T to C, chromosome 10 at 75,936,001 bp
  • C to A, chromosome 11 at 69,855,599 bp
  • TCCCCCCCCCCCCCCC to TCCCCCCCCCCCCCCCCCCCCCCCCC, chromosome 11 at 98,355,297 bp
  • C to T, chromosome 12 at 84,156,471 bp
  • A to G, chromosome 13 at 48,506,901 bp
  • A to T, chromosome 13 at 68,630,969 bp
  • A to G, chromosome 13 at 69,612,337 bp
  • A to T, chromosome 13 at 81,481,838 bp
  • T to C, chromosome 14 at 75,754,438 bp
  • A to G, chromosome 15 at 58,953,536 bp
  • A to T, chromosome 15 at 76,268,295 bp
  • T to C, chromosome 15 at 78,847,429 bp
  • T to A, chromosome 15 at 85,117,263 bp
  • A to G, chromosome 17 at 25,878,718 bp
  • A to G, chromosome 17 at 29,378,950 bp
  • A to G, chromosome 18 at 34,770,833 bp
  • C to T, chromosome 18 at 37,436,074 bp
  • A to G, chromosome 19 at 47,078,785 bp
  • A to T, chromosome X at 104,087,607 bp
  • A to T, chromosome X at 134,464,325 bp
  • T to C, chromosome X at 143,877,244 bp
  • T to A, chromosome X at 160,122,572 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3689 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040684-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.