Strain Name:
C57BL/6J-MtgxR3690Btlr/Mmmh
Stock Number:
040685-MU
Citation ID:
RRID:MMRRC_040685-MU
Other Names:
R3690 (G1), C57BL/6J-MtgxR3690Btlr
Major Collection:

Gene Information

Pald1
Name: phosphatase domain containing, paladin 1
Synonyms: X99384, paladin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27355
VEGA: 10
Homologene: 8453
Dcx
Name: doublecortin
Synonyms: Dbct, lissencephaly, X-linked (doublecortin)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 13193
HGNC: HGNC:2714
Homologene: 7683
Bclaf1
Name: BCL2-associated transcription factor 1
Synonyms: 2610102K23Rik, 5730534O06Rik, 2810454G14Rik, 2700025J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72567
Homologene: 8832
Dusp16
Name: dual specificity phosphatase 16
Synonyms: MKP-7, D6Ertd213e, 3830417M17Rik, MKP7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70686
Homologene: 15604
Foxj3
Name: forkhead box J3
Synonyms: C330039G02Rik, Fhd6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230700
Homologene: 35243
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: A130086L21Rik, 5830462N02Rik, E6-AP ubiquitin protein ligase, Hpve6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22215
Homologene: 7988
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: Zfp291, D530014O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Afdn
Name: afadin, adherens junction formation factor
Synonyms: AF6, Afadin, 5033403D15Rik, Mllt4, I-afadin, S-afadin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17356
HGNC: HGNC:7137
Homologene: 21202
Inppl1
Name: inositol polyphosphate phosphatase-like 1
Synonyms: SHIP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16332
HGNC: HGNC:6080
Homologene: 1204
Cap1
Name: CAP, adenylate cyclase-associated protein 1 (yeast)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12331
Homologene: 74572
Ddias
Name: DNA damage-induced apoptosis suppressor
Synonyms: 4632434I11Rik, noxin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74041
Homologene: 51655
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76501
Homologene: 8584
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Gigyf2
Name: GRB10 interacting GYF protein 2
Synonyms: 2610016F01Rik, A830080H02Rik, Tnrc15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227331
Homologene: 41048
Zap70
Name: zeta-chain (TCR) associated protein kinase
Synonyms: Srk, TZK, ZAP-70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22637
Homologene: 839
Egfr
Name: epidermal growth factor receptor
Synonyms: 9030024J15Rik, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Wa5, Errb1, Erbb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Nup50
Name: nucleoporin 50
Synonyms: 1700030K07Rik, Npap60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18141
VEGA: 15
HGNC: HGNC:8065
Homologene: 5190
Lmbrd1
Name: LMBR1 domain containing 1
Synonyms: 0910001K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68421
Homologene: 10156
Nav1
Name: neuron navigator 1
Synonyms: 9930003A20Rik, unc53H1, steerin-1, POMFIL3, C230080M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215690
Homologene: 10719
Smcr8
Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Synonyms: 2310076G09Rik, D030073L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237782
Homologene: 16989
Ric3
Name: RIC3 acetylcholine receptor chaperone
Synonyms: E130307J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320360
Homologene: 49772
Ttn
Name: titin
Synonyms: D830007G01Rik, connectin, 1100001C23Rik, 2310036G12Rik, mdm, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Avl9
Name: AVL9 cell migration associated
Synonyms: 5830411G16Rik, D730049P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78937
Homologene: 62425
Cul9
Name: cullin 9
Synonyms: Parc, 1810035I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78309
Homologene: 56696
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Vmn2r116
Name: vomeronasal 2, receptor 116
Synonyms: EG619697, V2Rp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 619697
Homologene: 86604
Mrpl44
Name: mitochondrial ribosomal protein L44
Synonyms: 1810030E18Rik, 5730593H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69163
Homologene: 11293
Tram2
Name: translocating chain-associating membrane protein 2
Synonyms: C330003D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 170829
Homologene: 8183
Vmn2r59
Name: vomeronasal 2, receptor 59
Synonyms: EG628444
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628444
Homologene: 129683
Folr1
Name: folate receptor 1 (adult)
Synonyms: Folbp-1, Folbp1, FBP1, folate-binding protein 1, folate receptor [a]
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14275
HGNC: HGNC:3791
Homologene: 7322
Abcb5
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: FetA, 4930417M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320571
Homologene: 99882
Fpr-rs6
Name: formyl peptide receptor, related sequence 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 321020
Homologene: 104303
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: LOR/SDH, Lorsdh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 30956
Homologene: 4212
Fam171a1
Name: family with sequence similarity 171, member A1
Synonyms: 9630050M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269233
Homologene: 19521
Dnase2b
Name: deoxyribonuclease II beta
Synonyms: Dlad, DnaseIIb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56629
Homologene: 1052
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Pde11a
Name: phosphodiesterase 11A
Synonyms: 6330414F14Rik, A630086N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241489
HGNC: HGNC:8773
Homologene: 56763
Olfr666
Name: olfactory receptor 666
Synonyms: MOR34-1, GA_x6K02T2PBJ9-7522449-7521493
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259100
Homologene: 64956
Spatc1
Name: spermatogenesis and centriole associated 1
Synonyms: 1700084J23Rik, speriolin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74281
VEGA: 15
Homologene: 129861
Olfr11
Name: olfactory receptor 11
Synonyms: MOR256-11, GA_x6K02T2QHY8-11597382-11598323
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218066
HGNC: HGNC:8241
Homologene: 40838
Tex47
Name: testis expressed 47
Synonyms: 4921511H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70920
Homologene: 41723
Nexmif
Name: neurite extension and migration factor
Synonyms: Xpn, C77370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 245555
Homologene: 19589
Olfr294
Name: olfactory receptor 294
Synonyms: GA_x6K02T2NHDJ-9504525-9505532, MOR219-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257904
Heatr4
Name: HEAT repeat containing 4
Synonyms: Gm17673
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 101055670
Homologene: 45728
Cln6
Name: ceroid-lipofuscinosis, neuronal 6
Synonyms: D9Bwg1455e, 1810065L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76524
HGNC: HGNC:2077
Homologene: 9898
Olfr675
Name: olfactory receptor 675
Synonyms: GA_x6K02T2PBJ9-7653782-7652841, MOR32-9P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258147
Homologene: 133595
Olfr612
Name: olfactory receptor 612
Synonyms: GA_x6K02T2PBJ9-6251685-6250741, EG545985, MOR15-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545985
Homologene: 79675
Klk1b24
Name: kallikrein 1-related peptidase b24
Synonyms: mGk-24, Klk24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16617
HGNC: HGNC:6364
Homologene: 68141
Zfp579
Name: zinc finger protein 579
Synonyms: 1110003A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68490
Homologene: 17629
Fxyd5
Name: FXYD domain-containing ion transport regulator 5
Synonyms: Oit2, EF-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18301
HGNC: HGNC:4029
Homologene: 7458
Gm10923
Name: predicted gene 10923
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 100502582
Cdc42ep1
Name: CDC42 effector protein (Rho GTPase binding) 1
Synonyms: MSE55, Borg5, CEP1, 1810058K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 104445
VEGA: 15
Homologene: 5128
Taf7l
Name: TATA-box binding protein associated factor 7 like
Synonyms: 4933438I11Rik, Taf2q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 74469
Homologene: 83311
Map3k15
Name: mitogen-activated protein kinase kinase kinase 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 270672
Homologene: 50401
Btbd19
Name: BTB (POZ) domain containing 19
Synonyms: 9530048O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 78611
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 21,005,600 bp
  • T to A, chromosome 1 at 24,762,293 bp
  • T to C, chromosome 1 at 36,781,412 bp
  • T to A, chromosome 1 at 79,779,649 bp
  • T to C, chromosome 1 at 87,421,516 bp
  • T to A, chromosome 1 at 135,467,644 bp
  • T to C, chromosome 2 at 3,226,356 bp
  • T to C, chromosome 2 at 52,137,385 bp
  • T to A, chromosome 2 at 76,291,166 bp
  • C to G, chromosome 2 at 76,799,244 bp
  • G to A, chromosome 2 at 101,886,331 bp
  • A to T, chromosome 3 at 146,593,571 bp
  • T to C, chromosome 4 at 43,368,055 bp
  • A to T, chromosome 4 at 117,120,592 bp
  • T to C, chromosome 4 at 119,616,642 bp
  • A to G, chromosome 4 at 122,864,626 bp
  • A to G, chromosome 5 at 7,304,777 bp
  • T to A, chromosome 6 at 23,091,329 bp
  • C to T, chromosome 6 at 56,736,827 bp
  • C to T, chromosome 6 at 134,761,119 bp
  • T to C, chromosome 7 at 4,994,720 bp
  • G to T, chromosome 7 at 31,036,439 bp
  • A to G, chromosome 7 at 42,011,946 bp
  • A to T, chromosome 7 at 44,191,819 bp
  • A to G, chromosome 7 at 59,276,799 bp
  • G to A, chromosome 7 at 86,616,478 bp
  • G to A, chromosome 7 at 92,860,158 bp
  • A to G, chromosome 7 at 101,832,068 bp
  • T to C, chromosome 7 at 101,858,538 bp
  • T to C, chromosome 7 at 103,539,067 bp
  • T to C, chromosome 7 at 104,893,517 bp
  • A to G, chromosome 7 at 105,024,695 bp
  • A to G, chromosome 7 at 109,038,610 bp
  • C to T, chromosome 9 at 55,883,921 bp
  • T to C, chromosome 9 at 62,846,970 bp
  • C to T, chromosome 10 at 20,325,397 bp
  • A to T, chromosome 10 at 61,355,808 bp
  • A to G, chromosome 10 at 76,482,679 bp
  • T to C, chromosome 11 at 16,871,881 bp
  • T to G, chromosome 11 at 60,707,002 bp
  • A to G, chromosome 11 at 60,778,028 bp
  • T to C, chromosome 12 at 83,954,720 bp
  • T to A, chromosome 12 at 118,872,933 bp
  • A to G, chromosome 13 at 21,639,338 bp
  • A to T, chromosome 15 at 76,268,295 bp
  • T to C, chromosome 15 at 78,847,429 bp
  • C to T, chromosome 15 at 84,939,793 bp
  • T to A, chromosome 15 at 85,117,263 bp
  • A to G, chromosome 17 at 13,888,409 bp
  • T to C, chromosome 17 at 20,182,875 bp
  • T to A, chromosome 17 at 23,384,824 bp
  • T to C, chromosome 17 at 46,504,031 bp
  • A to T, chromosome X at 104,087,607 bp
  • A to T, chromosome X at 134,464,325 bp
  • T to C, chromosome X at 143,877,244 bp
  • T to A, chromosome X at 160,122,572 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3690 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040685-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.