Strain Name:
C57BL/6J-MtgxR3706Btlr/Mmmh
Stock Number:
040699-MU
Citation ID:
RRID:MMRRC_040699-MU
Other Names:
R3706 (G1), C57BL/6J-MtgxR3706Btlr
Major Collection:

Gene Information

Cd4
Name: CD4 antigen
Synonyms: L3T4, Ly-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12504
HGNC: HGNC:1678
Homologene: 513
Card11
Name: caspase recruitment domain family, member 11
Synonyms: BIMP3, 2410011D02Rik, CARMA1, 0610008L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108723
Homologene: 13024
Zfx
Name: zinc finger protein X-linked
Synonyms: Zfx5, Zfx6, Zfx5,6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 22764
Homologene: 2561
Crct1
Name: cysteine-rich C-terminal 1
Synonyms: Nice-1, 2300002G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74175
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Elovl5
Name: ELOVL family member 5, elongation of long chain fatty acids (yeast)
Synonyms: 1110059L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68801
Homologene: 41449
Helz
Name: helicase with zinc finger domain
Synonyms: 3110078M01Rik, 9630002H22Rik, 9430093I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78455
Homologene: 8918
Atxn2
Name: ataxin 2
Synonyms: ATX2, Sca2, 9630045M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20239
Homologene: 2234
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, 2810004D21Rik, 4632404O06Rik, Ndrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83946
Homologene: 41209
Immt
Name: inner membrane protein, mitochondrial
Synonyms: D830041H16Rik, Micos60, P87/89, P89, P87, HMP, 1700082C19Rik, mitofilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 76614
HGNC: HGNC:6047
Homologene: 38234
Sucla2
Name: succinate-Coenzyme A ligase, ADP-forming, beta subunit
Synonyms: 4930547K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20916
Homologene: 2856
Fgfr2
Name: fibroblast growth factor receptor 2
Synonyms: Fgfr-2, Fgfr7, KGFRTr, Bek, Fgfr-7, svs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14183
HGNC: HGNC:3689
Homologene: 22566
Phox2b
Name: paired-like homeobox 2b
Synonyms: GENA 269, Pmx2b, NBPhox, Phox2b, Px2b, Dilp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18935
HGNC: HGNC:9143
Homologene: 68371
Glb1l2
Name: galactosidase, beta 1-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244757
Homologene: 71790
Ddx24
Name: DEAD box helicase 24
Synonyms: 2510027P10Rik, 1700055J08Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27225
VEGA: 12
Homologene: 10702
Mctp2
Name: multiple C2 domains, transmembrane 2
Synonyms: LOC244049
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244049
Homologene: 69254
Pde4b
Name: phosphodiesterase 4B, cAMP specific
Synonyms: Dpde4, dunce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18578
HGNC: HGNC:8781
Homologene: 1953
Mthfd2l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
Synonyms: C630010D07Rik, 1110019K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665563
Homologene: 28295
Cenpl
Name: centromere protein L
Synonyms: 2610300B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70454
Homologene: 19618
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Lama2
Name: laminin, alpha 2
Synonyms: mer, merosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Zim1
Name: zinc finger, imprinted 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22776
Homologene: 129793
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: 2410089E03Rik, Hug, b2b012Clo, Jbts17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73692
Homologene: 11315
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319555
Homologene: 72261
Cfap69
Name: cilia and flagella associated protein 69
Synonyms: A330021E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 207686
Homologene: 11718
Plce1
Name: phospholipase C, epsilon 1
Synonyms: PLCepsilon, 4933403A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74055
Homologene: 9478
Mettl2
Name: methyltransferase like 2
Synonyms: 2810438F06Rik, D11Ertd768e, C130031G21Rik, PSENIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52686
Homologene: 10174
Tns4
Name: tensin 4
Synonyms: 9930017A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217169
Homologene: 13147
Pappa2
Name: pappalysin 2
Synonyms: pregnancy-associated plasma protein-E, Pappe, placenta-specific 3, pregnancy-associated plasma preproprotein-A2, PLAC3, PAPP-A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23850
Homologene: 10661
Dmc1
Name: DNA meiotic recombinase 1
Synonyms: Dmc1h, sgdp, Mei11, Dmc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13404
VEGA: 15
HGNC: HGNC:2927
Homologene: 5135
Olfr1494
Name: olfactory receptor 1494
Synonyms: GA_x6K02T2RE5P-4082427-4083374, MOR266-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258992
Homologene: 64855
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: 5830419M17Rik, gp115, EMILIN-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100952
Homologene: 5117
Ampd1
Name: adenosine monophosphate deaminase 1
Synonyms: Ampd-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229665
HGNC: HGNC:468
Homologene: 20
AC149051.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Kif21b
Name: kinesin family member 21B
Synonyms: N-5 kinesin, 2610511N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16565
Homologene: 56868
Fpgs
Name: folylpolyglutamyl synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14287
HGNC: HGNC:3824
Homologene: 6997
Hspa4l
Name: heat shock protein 4 like
Synonyms: APG-1, 94kDa, Osp94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18415
Homologene: 22610
Pigc
Name: phosphatidylinositol glycan anchor biosynthesis, class C
Synonyms: 3110030E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67292
HGNC: HGNC:8960
Homologene: 7109
Fam178b
Name: family with sequence similarity 178, member B
Synonyms: 1700024G10Rik, LOC381337
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381337
Homologene: 87288
Gpsm2
Name: G-protein signalling modulator 2 (AGS3-like, C. elegans)
Synonyms: LGN, 6230410J09Rik, Pins
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76123
Homologene: 56584
Olfr1445
Name: olfactory receptor 1445
Synonyms: MOR202-7, GA_x6K02T2RE5P-3213352-3214296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258694
Homologene: 133606
Donson
Name: downstream neighbor of SON
Synonyms: 1110025J21Rik, Donson, ORF60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 60364
HGNC: HGNC:2993
Homologene: 32350
Atp8b2
Name: ATPase, class I, type 8B, member 2
Synonyms: Id
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54667
Homologene: 23226
Anxa10
Name: annexin A10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26359
HGNC: HGNC:534
Homologene: 21409
Rab11b
Name: RAB11B, member RAS oncogene family
Synonyms: A730055L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19326
HGNC: HGNC:9761
Homologene: 68691
Lelp1
Name: late cornified envelope-like proline-rich 1
Synonyms: 1700012F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69332
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,608,448 bp
  • A to G, chromosome 1 at 136,159,410 bp
  • A to T, chromosome 1 at 158,834,918 bp
  • G to A, chromosome 1 at 161,078,415 bp
  • T to A, chromosome 1 at 161,971,094 bp
  • A to T, chromosome 2 at 32,687,996 bp
  • A to T, chromosome 3 at 40,781,693 bp
  • A to T, chromosome 3 at 89,945,152 bp
  • A to C, chromosome 3 at 92,135,407 bp
  • C to A, chromosome 3 at 93,014,707 bp
  • A to G, chromosome 3 at 103,088,311 bp
  • A to G, chromosome 3 at 108,697,646 bp
  • A to T, chromosome 4 at 102,597,445 bp
  • G to T, chromosome 5 at 5,613,843 bp
  • T to C, chromosome 5 at 21,995,589 bp
  • A to G, chromosome 5 at 30,917,822 bp
  • T to C, chromosome 5 at 67,096,529 bp
  • A to G, chromosome 5 at 91,000,630 bp
  • T to C, chromosome 5 at 121,785,868 bp
  • G to A, chromosome 5 at 140,887,135 bp
  • T to C, chromosome 6 at 71,862,362 bp
  • T to C, chromosome 6 at 124,879,388 bp
  • T to C, chromosome 7 at 6,677,291 bp
  • A to G, chromosome 7 at 72,214,111 bp
  • T to C, chromosome 7 at 130,198,431 bp
  • T to A, chromosome 8 at 62,064,287 bp
  • T to C, chromosome 8 at 63,928,145 bp
  • A to G, chromosome 8 at 72,667,116 bp
  • A to G, chromosome 9 at 26,771,020 bp
  • C to A, chromosome 9 at 77,979,837 bp
  • T to C, chromosome 9 at 82,900,743 bp
  • T to C, chromosome 10 at 27,138,996 bp
  • A to G, chromosome 11 at 99,075,101 bp
  • T to A, chromosome 11 at 105,139,726 bp
  • T to G, chromosome 11 at 107,661,080 bp
  • A to T, chromosome 12 at 103,417,416 bp
  • A to G, chromosome 14 at 73,591,052 bp
  • A to T, chromosome 14 at 103,156,414 bp
  • T to C, chromosome 15 at 8,259,816 bp
  • G to C, chromosome 15 at 79,562,581 bp
  • A to G, chromosome 16 at 91,686,161 bp
  • G to C, chromosome 17 at 33,747,766 bp
  • C to T, chromosome 19 at 12,883,896 bp
  • T to A, chromosome 19 at 13,749,112 bp
  • G to A, chromosome 19 at 38,749,277 bp
  • A to G, chromosome X at 94,098,807 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3706 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040699-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.