Strain Name:
C57BL/6J-MtgxR3708Btlr/Mmmh
Stock Number:
040701-MU
Citation ID:
RRID:MMRRC_040701-MU
Other Names:
R3708 (G1), C57BL/6J-MtgxR3708Btlr
Major Collection:

Gene Information

Ednrb
Name: endothelin receptor type B
Synonyms: Sox10m1, ETb, ETR-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13618
VEGA: 14
HGNC: HGNC:3180
Homologene: 89
Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: A230020K14Rik, N-CoR, 5730405M06Rik, Rxrip13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Pi4k2a
Name: phosphatidylinositol 4-kinase type 2 alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 84095
VEGA: 19
Homologene: 101681
Ptch1
Name: patched 1
Synonyms: Ptc, A230106A15Rik, Patched 1, Ptc1, wig
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Card11
Name: caspase recruitment domain family, member 11
Synonyms: 2410011D02Rik, BIMP3, 0610008L17Rik, CARMA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108723
Homologene: 13024
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Dnchc1, Dnec1, MAP1C, dynein heavy chain, retrograde transport, Swl, Loa, 9930018I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Abcc5
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Synonyms: Abcc5b, Mrp5, 2900011L11Rik, Abcc5a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 27416
HGNC: HGNC:56
Homologene: 21164
Macrod2
Name: mono-ADP ribosylhydrolase 2
Synonyms: 2900006F19Rik, 1110033L15Rik, 2610107G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72899
Homologene: 85987
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, Mtap2, repro4, G1-397-34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Dnahc8, Hst6.7b, P1-Loop
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Celf2
Name: CUGBP, Elav-like family member 2
Synonyms: Cugbp2, Napor-2, B230345P09Rik, ETR-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14007
HGNC: HGNC:2550
Homologene: 4783
Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
Synonyms: TEC, Nor1, MINOR, NOR-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18124
HGNC: HGNC:7982
Homologene: 5074
Amfr
Name: autocrine motility factor receptor
Synonyms: gp78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23802
HGNC: HGNC:463
Homologene: 888
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E16Rik, Myospryn, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Slc9c1
Name: solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Synonyms: LOC208169, Slc9a10, spermNHE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208169
Homologene: 19505
Olfr888
Name: olfactory receptor 888
Synonyms: MOR162-4, GA_x6K02T2PVTD-31787920-31788864
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258416
Homologene: 84577
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: 2010204N08Rik, Si-s, sucrase-isomaltase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69983
Homologene: 37424
Ppfia4
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Synonyms: LOC100042382, Liprin-alpha4, Gm3812, 1110008G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68507
HGNC: HGNC:9248
Homologene: 66200
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Obox7
Name: oocyte specific homeobox 7
Synonyms: Gm4745
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 194588
Homologene: 44937
Cyp2d10
Name: cytochrome P450, family 2, subfamily d, polypeptide 10
Synonyms: Cyp2d, P450-2D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13101
VEGA: 15
Homologene: 86099
Pappa2
Name: pappalysin 2
Synonyms: pregnancy-associated plasma preproprotein-A2, placenta-specific 3, pregnancy-associated plasma protein-E, PAPP-A2, PLAC3, Pappe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23850
Homologene: 10661
Polg2
Name: polymerase (DNA directed), gamma 2, accessory subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 50776
HGNC: HGNC:9180
Homologene: 5221
Gpr39
Name: G protein-coupled receptor 39
Synonyms: 4933415E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71111
HGNC: HGNC:4496
Homologene: 20380
Pnmal1
Name: PNMA-like 1
Synonyms: 0710005I19Rik, 4930488B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71691
Homologene: 10073
Rims3
Name: regulating synaptic membrane exocytosis 3
Synonyms: Rim3, Nim3, A730060M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242662
Homologene: 8837
Pcdhb19
Name: protocadherin beta 19
Synonyms: Pcdhb11, PcdhbS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93890
HGNC: HGNC:8683
Homologene: 128411
Serpinb9
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9
Synonyms: ovalbumin, PI-9, Spi6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20723
HGNC: HGNC:8955
Homologene: 37888
Olfr135
Name: olfactory receptor 135
Synonyms: GA_x6K02T2PSCP-2656648-2657586, MOR256-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258329
Homologene: 110603
Vps36
Name: vacuolar protein sorting 36
Synonyms: Eap45, 1700010A24Rik, 2810408E15Rik, 2210415M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70160
Homologene: 9374
Olfr1016
Name: olfactory receptor 1016
Synonyms: GA_x6K02T2Q125-47278889-47277960, MOR213-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257915
Homologene: 83133
Hspa4l
Name: heat shock protein 4 like
Synonyms: 94kDa, APG-1, Osp94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18415
Homologene: 22610
1700123L14Rik
Name: RIKEN cDNA 1700123L14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78482
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: Kv12.1, C130090D05Rik, ELK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 211468
Homologene: 14332
Pigc
Name: phosphatidylinositol glycan anchor biosynthesis, class C
Synonyms: 3110030E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67292
HGNC: HGNC:8960
Homologene: 7109
Atxn7l3
Name: ataxin 7-like 3
Synonyms: E030022H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217218
Homologene: 35401
Slc6a17
Name: solute carrier family 6 (neurotransmitter transporter), member 17
Synonyms: NTT4, D130012J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229706
Homologene: 27775
Gpsm2
Name: G-protein signalling modulator 2 (AGS3-like, C. elegans)
Synonyms: Pins, LGN, 6230410J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76123
Homologene: 56584
Olfr584
Name: olfactory receptor 584
Synonyms: MOR30-2, GA_x6K02T2PBJ9-5796876-5797820
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259056
Cyp3a41a
Name: cytochrome P450, family 3, subfamily a, polypeptide 41A
Synonyms: Cyp3a41, steroid inducible
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 53973
HGNC: HGNC:2638
Homologene: 133568
Bcs1l
Name: BCS1-like (yeast)
Synonyms: 9130022O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66821
HGNC: HGNC:1020
Homologene: 3193
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330581
Homologene: 115466
Atp8b2
Name: ATPase, class I, type 8B, member 2
Synonyms: Id
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54667
Homologene: 23226
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69324
Homologene: 78000
Ferd3l
Name: Fer3 like bHLH transcription factor
Synonyms: Mnato3, fer3, Nato3, bHLHa31, N-twist
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 114712
VEGA: 12
Homologene: 14136
Smad9
Name: SMAD family member 9
Synonyms: SMAD8A, SMAD8B, MADH6, Madh9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 55994
HGNC: HGNC:6774
Homologene: 21198
Lelp1
Name: late cornified envelope-like proline-rich 1
Synonyms: 1700012F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69332
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 66,416,555 bp
  • A to G, chromosome 1 at 74,590,105 bp
  • C to T, chromosome 1 at 125,872,612 bp
  • T to C, chromosome 1 at 134,309,660 bp
  • A to T, chromosome 1 at 158,834,918 bp
  • T to A, chromosome 1 at 161,971,094 bp
  • C to A, chromosome 2 at 6,624,678 bp
  • T to A, chromosome 2 at 85,799,998 bp
  • C to A, chromosome 2 at 141,810,629 bp
  • A to T, chromosome 3 at 40,781,693 bp
  • A to T, chromosome 3 at 54,786,181 bp
  • A to G, chromosome 3 at 72,943,523 bp
  • A to G, chromosome 3 at 86,285,024 bp
  • A to T, chromosome 3 at 89,945,152 bp
  • A to C, chromosome 3 at 92,135,407 bp
  • C to T, chromosome 3 at 107,493,085 bp
  • A to G, chromosome 3 at 108,697,646 bp
  • A to T, chromosome 4 at 48,056,699 bp
  • A to G, chromosome 4 at 120,883,155 bp
  • G to A, chromosome 5 at 140,887,135 bp
  • A to G, chromosome 5 at 145,717,923 bp
  • G to A, chromosome 6 at 96,165,952 bp
  • C to A, chromosome 7 at 14,664,197 bp
  • T to A, chromosome 7 at 16,960,225 bp
  • T to C, chromosome 7 at 85,411,821 bp
  • T to G, chromosome 7 at 103,086,294 bp
  • G to T, chromosome 8 at 22,192,883 bp
  • T to C, chromosome 8 at 93,983,320 bp
  • T to C, chromosome 9 at 38,109,444 bp
  • T to C, chromosome 11 at 62,344,687 bp
  • G to A, chromosome 11 at 102,291,879 bp
  • A to T, chromosome 11 at 106,777,261 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • T to C, chromosome 12 at 33,928,749 bp
  • T to C, chromosome 12 at 110,643,129 bp
  • A to T, chromosome 13 at 33,008,019 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • A to T, chromosome 13 at 93,095,366 bp
  • T to A, chromosome 14 at 79,062,696 bp
  • A to G, chromosome 14 at 103,817,080 bp
  • A to G, chromosome 15 at 82,403,016 bp
  • G to T, chromosome 16 at 20,372,180 bp
  • T to C, chromosome 16 at 45,580,066 bp
  • A to T, chromosome 17 at 30,739,657 bp
  • A to G, chromosome 17 at 38,208,283 bp
  • T to C, chromosome 17 at 52,961,784 bp
  • T to A, chromosome 18 at 37,497,389 bp
  • C to T, chromosome 19 at 42,090,931 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3708 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040701-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.