Strain Name:
C57BL/6J-MtgxR3708Btlr/Mmmh
Stock Number:
040701-MU
Citation ID:
RRID:MMRRC_040701-MU
Other Names:
R3708 (G1), C57BL/6J-MtgxR3708Btlr
Major Collection:

Strain Information

Ednrb
Name: endothelin receptor type B
Synonyms: ETb, Sox10m1, ETR-b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13618
VEGA: 14
HGNC: HGNC:3180
Homologene: 89
Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: Rxrip13, 5730405M06Rik, N-CoR, A230020K14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Pi4k2a
Name: phosphatidylinositol 4-kinase type 2 alpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 84095
VEGA: 19
Homologene: 101681
Ptch1
Name: patched 1
Synonyms: Patched 1, A230106A15Rik, Ptc, wig, Ptc1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Card11
Name: caspase recruitment domain family, member 11
Synonyms: BIMP3, 2410011D02Rik, CARMA1, 0610008L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108723
Homologene: 13024
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, Swl, Dnec1, Loa, dynein heavy chain, retrograde transport, 9930018I23Rik, Dnchc1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Abcc5
Name: ATP-binding cassette, sub-family C member 5
Synonyms: Abcc5a, 2900011L11Rik, Abcc5b, Mrp5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27416
HGNC: HGNC:56
Homologene: 21164
Macrod2
Name: mono-ADP ribosylhydrolase 2
Synonyms: 2610107G07Rik, 1110033L15Rik, 2900006F19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72899
Homologene: 85987
Map2
Name: microtubule-associated protein 2
Synonyms: Mtap2, G1-397-34, repro4, MAP-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Celf2
Name: CUGBP, Elav-like family member 2
Synonyms: B230345P09Rik, Napor-2, Cugbp2, ETR-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14007
HGNC: HGNC:2550
Homologene: 4783
Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
Synonyms: TEC, MINOR, Nor1, NOR-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18124
HGNC: HGNC:7982
Homologene: 5074
Amfr
Name: autocrine motility factor receptor
Synonyms: gp78
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23802
HGNC: HGNC:463
Homologene: 888
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E21Rik, 2310076E16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Slc9c1
Name: solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Synonyms: Slc9a10, spermNHE, LOC208169
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208169
Homologene: 19505
Or8b101
Name: olfactory receptor family 8 subfamily B member 101
Synonyms: MOR162-4, Olfr888, GA_x6K02T2PVTD-31787920-31788864
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258416
Homologene: 84577
Sis
Name: sucrase isomaltase
Synonyms: Si-s, 2010204N08Rik, sucrase-isomaltase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69983
Homologene: 37424
Ppfia4
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Synonyms: LOC100042382, Liprin-alpha4, Gm3812, 1110008G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68507
HGNC: HGNC:9248
Homologene: 66200
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 1300010F03Rik, 4932416F07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Obox7
Name: oocyte specific homeobox 7
Synonyms: Gm4745
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 194588
Homologene: 44937
Cyp2d10
Name: cytochrome P450, family 2, subfamily d, polypeptide 10
Synonyms: P450-2D, Cyp2d
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13101
VEGA: 15
Homologene: 86099
Pappa2
Name: pappalysin 2
Synonyms: pregnancy-associated plasma protein-E, Pappe, PAPP-A2, pregnancy-associated plasma preproprotein-A2, placenta-specific 3, PLAC3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23850
Homologene: 10661
Polg2
Name: polymerase (DNA directed), gamma 2, accessory subunit
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50776
HGNC: HGNC:9180
Homologene: 5221
Gpr39
Name: G protein-coupled receptor 39
Synonyms: 4933415E13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71111
HGNC: HGNC:4496
Homologene: 20380
Pnma8a
Name: PNMA family member 8A
Synonyms: 4930488B01Rik, Pnmal1, 0710005I19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71691
Homologene: 10073
Rims3
Name: regulating synaptic membrane exocytosis 3
Synonyms: Rim3, Nim3, A730060M23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242662
Homologene: 8837
Pcdhb19
Name: protocadherin beta 19
Synonyms: PcdhbS, Pcdhb11
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93890
Homologene: 128411
Serpinb9
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9
Synonyms: Spi6, ovalbumin, PI-9
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20723
HGNC: HGNC:8955
Homologene: 37888
Or2n1c
Name: olfactory receptor family 2 subfamily N member 1C
Synonyms: GA_x6K02T2PSCP-2656648-2657586, MOR256-48, Olfr135
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258329
Homologene: 110603
Vps36
Name: vacuolar protein sorting 36
Synonyms: Eap45, 2210415M20Rik, 1700010A24Rik, 2810408E15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70160
Homologene: 9374
Or9g20
Name: olfactory receptor family 9 subfamily G member 20
Synonyms: MOR213-9, Olfr1016, GA_x6K02T2Q125-47278889-47277960
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257915
Homologene: 83133
Hspa4l
Name: heat shock protein 4 like
Synonyms: APG-1, Osp94, 94kDa
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18415
Homologene: 22610
Nup50l
Name: nucleoporin 50 like
Synonyms: 1700123L14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78482
HGNC: HGNC:8065
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: C130090D05Rik, ELK1, Kv12.1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 211468
Homologene: 14332
Pigc
Name: phosphatidylinositol glycan anchor biosynthesis, class C
Synonyms: 3110030E07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67292
HGNC: HGNC:8960
Homologene: 7109
Atxn7l3
Name: ataxin 7-like 3
Synonyms: E030022H21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217218
Homologene: 35401
Slc6a17
Name: solute carrier family 6 (neurotransmitter transporter), member 17
Synonyms: NTT4, D130012J15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229706
Homologene: 27775
Gpsm2
Name: G-protein signalling modulator 2 (AGS3-like, C. elegans)
Synonyms: LGN, 6230410J09Rik, Pins
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76123
Homologene: 56584
Or52r1c
Name: olfactory receptor family 52 subfamily R member 1C
Synonyms: Olfr584, GA_x6K02T2PBJ9-5796876-5797820, MOR30-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259056
Cyp3a41a
Name: cytochrome P450, family 3, subfamily a, polypeptide 41A
Synonyms: steroid inducible, Cyp3a41
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53973
HGNC: HGNC:2638
Homologene: 133568
Bcs1l
Name: BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
Synonyms: 9130022O19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66821
HGNC: HGNC:1020
Homologene: 3193
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Atp8b2
Name: ATPase, class I, type 8B, member 2
Synonyms: Id
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54667
Homologene: 23226
Ferd3l
Name: Fer3 like bHLH transcription factor
Synonyms: Nato3, bHLHa31, fer3, N-twist, Mnato3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 114712
VEGA: 12
Homologene: 14136
Smad9
Name: SMAD family member 9
Synonyms: SMAD8B, SMAD8A, MADH6, Madh9
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 55994
HGNC: HGNC:6774
Homologene: 21198
Lelp1
Name: late cornified envelope-like proline-rich 1
Synonyms: 1700012F11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69332
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 66,416,555 bp
  • A to G, chromosome 1 at 74,590,105 bp
  • C to T, chromosome 1 at 125,872,612 bp
  • T to C, chromosome 1 at 134,309,660 bp
  • A to T, chromosome 1 at 158,834,918 bp
  • T to A, chromosome 1 at 161,971,094 bp
  • C to A, chromosome 2 at 6,624,678 bp
  • T to A, chromosome 2 at 85,799,998 bp
  • C to A, chromosome 2 at 141,810,629 bp
  • A to T, chromosome 3 at 40,781,693 bp
  • A to T, chromosome 3 at 54,786,181 bp
  • A to G, chromosome 3 at 72,943,523 bp
  • A to G, chromosome 3 at 86,285,024 bp
  • A to T, chromosome 3 at 89,945,152 bp
  • A to C, chromosome 3 at 92,135,407 bp
  • C to T, chromosome 3 at 107,493,085 bp
  • A to G, chromosome 3 at 108,697,646 bp
  • A to T, chromosome 4 at 48,056,699 bp
  • A to G, chromosome 4 at 120,883,155 bp
  • G to A, chromosome 5 at 140,887,135 bp
  • A to G, chromosome 5 at 145,717,923 bp
  • G to A, chromosome 6 at 96,165,952 bp
  • C to A, chromosome 7 at 14,664,197 bp
  • T to A, chromosome 7 at 16,960,225 bp
  • T to C, chromosome 7 at 85,411,821 bp
  • T to G, chromosome 7 at 103,086,294 bp
  • G to T, chromosome 8 at 22,192,883 bp
  • T to C, chromosome 8 at 93,983,320 bp
  • T to C, chromosome 9 at 38,109,444 bp
  • T to C, chromosome 11 at 62,344,687 bp
  • G to A, chromosome 11 at 102,291,879 bp
  • A to T, chromosome 11 at 106,777,261 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • T to C, chromosome 12 at 33,928,749 bp
  • T to C, chromosome 12 at 110,643,129 bp
  • A to T, chromosome 13 at 33,008,019 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • A to T, chromosome 13 at 93,095,366 bp
  • T to A, chromosome 14 at 79,062,696 bp
  • A to G, chromosome 14 at 103,817,080 bp
  • A to G, chromosome 15 at 82,403,016 bp
  • G to T, chromosome 16 at 20,372,180 bp
  • T to C, chromosome 16 at 45,580,066 bp
  • A to T, chromosome 17 at 30,739,657 bp
  • A to G, chromosome 17 at 38,208,283 bp
  • T to C, chromosome 17 at 52,961,784 bp
  • T to A, chromosome 18 at 37,497,389 bp
  • C to T, chromosome 19 at 42,090,931 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3708 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040701-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.