Strain Name:
C57BL/6J-MtgxR3709Btlr/Mmmh
Stock Number:
040702-MU
Citation ID:
RRID:MMRRC_040702-MU
Other Names:
R3709 (G1), C57BL/6J-MtgxR3709Btlr
Major Collection:

Gene Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: Fltn, D0Jmb2, myosin IIA, NMHC II-A, E030044M24Rik, Myhn1, Myhn-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Dhrs3
Name: dehydrogenase/reductase (SDR family) member 3
Synonyms: retSDR1, Rsdr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20148
Homologene: 20994
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Cnot7
Name: CCR4-NOT transcription complex, subunit 7
Synonyms: Caf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18983
Homologene: 49011
Nacc1
Name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Synonyms: 4930511N13Rik, Btbd14b, Nac1, 2010001H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66830
VEGA: 8
Homologene: 12042
Idh3a
Name: isocitrate dehydrogenase 3 (NAD+) alpha
Synonyms: 1500012E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67834
VEGA: 9
HGNC: HGNC:5384
Homologene: 4037
Armc8
Name: armadillo repeat containing 8
Synonyms: HSPC056, 1200015K23Rik, Gid5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74125
Homologene: 9121
Ptpn21
Name: protein tyrosine phosphatase, non-receptor type 21
Synonyms: PTPD1, PTPRL10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 24000
VEGA: 12
HGNC: HGNC:9651
Homologene: 5110
Ctdp1
Name: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Synonyms: 4930563P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67655
HGNC: HGNC:2498
Homologene: 31254
Cenpf
Name: centromere protein F
Synonyms: Lek1, mitosin, 6530404A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Ipo8
Name: importin 8
Synonyms: 6230418K12Rik, C130009K11Rik, Om1, Ranbp8, OM-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Zfp472
Name: zinc finger protein 472
Synonyms: Krim-1, Krim-1B, Krim-1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224691
Homologene: 77422
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, 4632407J06Rik, B130055D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71722
Homologene: 87637
Il15ra
Name: interleukin 15 receptor, alpha chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16169
HGNC: HGNC:5978
Homologene: 1650
Rbms2
Name: RNA binding motif, single stranded interacting protein 2
Synonyms: 2610315E04Rik, Scr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56516
VEGA: 10
HGNC: HGNC:9909
Homologene: 37706
Gfral
Name: GDNF family receptor alpha like
Synonyms: GRAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 404194
Homologene: 45748
Map2
Name: microtubule-associated protein 2
Synonyms: G1-397-34, repro4, Mtap2, MAP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Copb2
Name: coatomer protein complex, subunit beta 2 (beta prime)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 50797
HGNC: HGNC:2232
Homologene: 3499
Lsm14a
Name: LSM14A mRNA processing body assembly factor
Synonyms: Tral, 2700023B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67070
Homologene: 40537
Osbpl10
Name: oxysterol binding protein-like 10
Synonyms: C820004B04Rik, 4933433D06Rik, OPR-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74486
Homologene: 69240
Naa35
Name: N(alpha)-acetyltransferase 35, NatC auxiliary subunit
Synonyms: A330021G12Rik, A330027C19Rik, C030004C14Rik, Mak10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78689
Homologene: 5781
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, E530005C20Rik, 2210407G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Atp2b4
Name: ATPase, Ca++ transporting, plasma membrane 4
Synonyms: PMCA4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381290
HGNC: HGNC:817
Homologene: 48034
Ttn
Name: titin
Synonyms: L56, 2310074I15Rik, 2310036G12Rik, 1100001C23Rik, connectin, shru, D830007G01Rik, mdm, D330041I19Rik, 2310057K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cdc42bpa
Name: CDC42 binding protein kinase alpha
Synonyms: A930014J19Rik, DMPK-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226751
HGNC: HGNC:1737
Homologene: 55765
Rab44
Name: RAB44, member RAS oncogene family
Synonyms: 9830134C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 442827
Homologene: 53300
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
B4galt3
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Synonyms: ESTM26, beta4GalT-III, R74981, 9530061M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 57370
HGNC: HGNC:926
Homologene: 48241
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: mdig, Megf7, 6430526J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
Ttyh2
Name: tweety family member 2
Synonyms: 1110001A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 117160
Homologene: 41882
Mlxip
Name: MLX interacting protein
Synonyms: bHLHe36, Mir, Mondoa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208104
Homologene: 22851
Mctp1
Name: multiple C2 domains, transmembrane 1
Synonyms: 2810465F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78771
Homologene: 75211
Thumpd3
Name: THUMP domain containing 3
Synonyms: Gtrosa26as
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14911
Homologene: 7351
Tsks
Name: testis-specific serine kinase substrate
Synonyms: clone 4, Tsks, Stk22s1, Tssks1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22116
Homologene: 7984
Slc6a15
Name: solute carrier family 6 (neurotransmitter transporter), member 15
Synonyms: v7-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103098
VEGA: 10
Homologene: 18163
Abcc2
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Synonyms: multidrug resistance protein 2, Cmoat, Mrp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Mael
Name: maelstrom spermatogenic transposon silencer
Synonyms: 4933405K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98558
Homologene: 13143
Zfp267
Name: zinc finger protein 267
Synonyms: D3Ertd254e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241944
Homologene: 117700
Fhod3
Name: formin homology 2 domain containing 3
Synonyms: A930009H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225288
VEGA: 18
Homologene: 45323
Olfr479
Name: olfactory receptor 479
Synonyms: GA_x6K02T2PBJ9-10384085-10385068, MOR267-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257891
Homologene: 79346
Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Synonyms: multiple drug resistant 1a, mdr-3, MDR3, P-gp, Evi32, Pgy3, Pgp, Mdr1a, P-glycoprotein, Pgy-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Gm10322
Name: predicted gene 10322
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Cyp2c69
Name: cytochrome P450, family 2, subfamily c, polypeptide 69
Synonyms: AI098658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100043108
VEGA: 19
Homologene: 74936
Ccdc92b
Name: coiled-coil domain containing 92B
Synonyms: E130309D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432582
Homologene: 134144
Sh3bp2
Name: SH3-domain binding protein 2
Synonyms: 3BP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 24055
Homologene: 2276
C4bp
Name: complement component 4 binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12269
Cldn19
Name: claudin 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242653
HGNC: HGNC:2040
Homologene: 17528
Aida
Name: axin interactor, dorsalization associated
Synonyms: 2610208M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108909
Homologene: 11268
9930111J21Rik2
Name: RIKEN cDNA 9930111J21 gene 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245240
Trib1
Name: tribbles pseudokinase 1
Synonyms: Trb1, A530090O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 211770
Homologene: 75216
4933413J09Rik
Name: RIKEN cDNA 4933413J09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71106
Was
Name: Wiskott-Aldrich syndrome
Synonyms: Wasp, U42471
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 22376
Homologene: 30970
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 66,415,856 bp
  • G to A, chromosome 1 at 130,648,016 bp
  • A to G, chromosome 1 at 133,730,625 bp
  • T to C, chromosome 1 at 166,238,566 bp
  • C to A, chromosome 1 at 171,274,043 bp
  • A to G, chromosome 1 at 180,065,063 bp
  • C to A, chromosome 1 at 183,304,675 bp
  • A to G, chromosome 1 at 189,648,812 bp
  • G to T, chromosome 2 at 11,730,647 bp
  • C to T, chromosome 2 at 40,697,442 bp
  • G to T, chromosome 2 at 76,747,241 bp
  • A to C, chromosome 2 at 91,490,466 bp
  • T to A, chromosome 3 at 36,159,576 bp
  • T to C, chromosome 4 at 119,256,897 bp
  • T to C, chromosome 4 at 144,893,711 bp
  • A to G, chromosome 5 at 8,738,738 bp
  • T to C, chromosome 5 at 34,551,658 bp
  • T to C, chromosome 5 at 123,447,474 bp
  • A to G, chromosome 6 at 113,055,691 bp
  • A to T, chromosome 6 at 148,806,344 bp
  • A to G, chromosome 7 at 25,286,981 bp
  • T to A, chromosome 7 at 34,353,779 bp
  • G to T, chromosome 7 at 44,951,885 bp
  • G to A, chromosome 7 at 80,717,087 bp
  • A to G, chromosome 7 at 108,055,797 bp
  • T to G, chromosome 8 at 40,507,660 bp
  • T to A, chromosome 8 at 84,677,199 bp
  • T to A, chromosome 9 at 27,052,349 bp
  • T to C, chromosome 9 at 54,586,526 bp
  • G to A, chromosome 9 at 76,193,443 bp
  • T to C, chromosome 9 at 98,587,419 bp
  • A to G, chromosome 9 at 99,520,497 bp
  • C to A, chromosome 9 at 115,207,587 bp
  • CAAA to CA, chromosome 10 at 51,615,680 bp
  • C to A, chromosome 10 at 59,616,119 bp
  • A to G, chromosome 10 at 103,393,414 bp
  • C to T, chromosome 10 at 128,143,443 bp
  • T to G, chromosome 11 at 49,019,653 bp
  • C to A, chromosome 11 at 74,638,107 bp
  • T to G, chromosome 11 at 114,719,132 bp
  • G to T, chromosome 12 at 98,688,541 bp
  • T to A, chromosome 13 at 59,618,032 bp
  • T to C, chromosome 13 at 76,824,880 bp
  • C to T, chromosome 14 at 26,396,146 bp
  • A to G, chromosome 15 at 59,654,361 bp
  • T to C, chromosome 15 at 64,725,535 bp
  • T to C, chromosome 15 at 77,773,347 bp
  • C to T, chromosome 16 at 34,392,030 bp
  • C to T, chromosome 17 at 29,139,869 bp
  • T to A, chromosome 17 at 32,977,711 bp
  • T to A, chromosome 18 at 25,090,758 bp
  • G to A, chromosome 18 at 80,450,213 bp
  • A to G, chromosome 19 at 39,851,223 bp
  • G to T, chromosome 19 at 43,798,446 bp
  • G to T, chromosome X at 8,086,688 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3709 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040702-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.