Strain Name:
C57BL/6J-MtgxR3717Btlr/Mmmh
Stock Number:
040709-MU
Citation ID:
RRID:MMRRC_040709-MU
Other Names:
R3717 (G1), C57BL/6J-MtgxR3717Btlr
Major Collection:

Gene Information

Lamb1
Name: laminin B1
Synonyms: C80098, Lamb1-1, C81607, Lamb-1, D130003D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Ptx3
Name: pentraxin related gene
Synonyms: pentraxin 3, TSG-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19288
HGNC: HGNC:9692
Homologene: 7500
Ano6
Name: anoctamin 6
Synonyms: 2900059G15Rik, F730003B03Rik, Tmem16f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 2810413I22Rik, 2410152H17Rik, 6030449K19Rik, 2900036C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66315
Homologene: 10778
Rbbp4
Name: retinoblastoma binding protein 4, chromatin remodeling factor
Synonyms: RBAP48, CAF-1 p48 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19646
HGNC: HGNC:9887
Homologene: 21153
Mtrex
Name: Mtr4 exosome RNA helicase
Synonyms: 2610528A15Rik, Skiv2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72198
VEGA: 13
Homologene: 6257
Zfp90
Name: zinc finger protein 90
Synonyms: NK10, 6430515L01Rik, Nk10 expressed protein, Zfp64, Zfp83, KRAB17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22751
Homologene: 86800
Vdac1
Name: voltage-dependent anion channel 1
Synonyms: Vdac5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22333
Homologene: 107244
Dnajc10
Name: DnaJ heat shock protein family (Hsp40) member C10
Synonyms: 1200006L06Rik, JPDI, D2Ertd706e, ERdj5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66861
Homologene: 10358
Fgfr2
Name: fibroblast growth factor receptor 2
Synonyms: KGFRTr, Bek, Fgfr-2, Fgfr7, svs, Fgfr-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14183
HGNC: HGNC:3689
Homologene: 22566
Hoxd10
Name: homeobox D10
Synonyms: Hox-4.5, Hox-5.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15430
HGNC: HGNC:5133
Homologene: 1619
Htt
Name: huntingtin
Synonyms: IT15, huntingtin, htt, C430023I11Rik, Hdh, HD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Vps51
Name: VPS51 GARP complex subunit
Synonyms: 1110014N23Rik, 3110057M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68505
HGNC: HGNC:1172
Homologene: 34675
Ubac1
Name: ubiquitin associated domain containing 1
Synonyms: Ubadc1, 1110033G07Rik, Kpc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98766
Homologene: 9409
Nav1
Name: neuron navigator 1
Synonyms: steerin-1, POMFIL3, 9930003A20Rik, C230080M11Rik, unc53H1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215690
Homologene: 10719
Ttn
Name: titin
Synonyms: D830007G01Rik, L56, 1100001C23Rik, mdm, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, shru, connectin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E16Rik, 2310076E21Rik, Myospryn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Txnip
Name: thioredoxin interacting protein
Synonyms: Hyplip1, mVDUP1, THIF, VDUP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56338
Homologene: 38186
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: MINK, Map4k6, Ysk2, Misshapen/NIKs-related kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 50932
Homologene: 56762
Slc16a10
Name: solute carrier family 16 (monocarboxylic acid transporters), member 10
Synonyms: PRO0813, Mct10, TAT1, 2610103N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72472
VEGA: 10
Homologene: 75089
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Nxpe5
Name: neurexophilin and PC-esterase domain family, member 5
Synonyms: BC055004, Fam55 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381680
Homologene: 134143
Fetub
Name: fetuin beta
Synonyms: D17980, 2310011O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 59083
VEGA: 16
HGNC: HGNC:3658
Homologene: 8660
Skint10
Name: selection and upkeep of intraepithelial T cells 10
Synonyms: A030001H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230613
Homologene: 136292
Bbs10
Name: Bardet-Biedl syndrome 10 (human)
Synonyms: 1300007O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71769
VEGA: 10
Homologene: 49781
Rfx4
Name: regulatory factor X, 4 (influences HLA class II expression)
Synonyms: 4933412G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71137
HGNC: HGNC:9985
Homologene: 31119
Bpifb6
Name: BPI fold containing family B, member 6
Synonyms: Bpil3, LOC228796
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228796
Homologene: 18375
Kbtbd3
Name: kelch repeat and BTB (POZ) domain containing 3
Synonyms: Bklhd3, 2200003A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69149
Homologene: 12300
Spata18
Name: spermatogenesis associated 18
Synonyms: 1700067I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 73472
Homologene: 17057
Abhd10
Name: abhydrolase domain containing 10
Synonyms: D230019K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 213012
Homologene: 10173
St8sia6
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
Synonyms: Siat8f, ST8Sia VI, 1700007J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241230
Homologene: 17112
Olfr826
Name: olfactory receptor 826
Synonyms: MOR210-2, GA_x6K02T2PULF-11851623-11850682
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258671
Homologene: 121503
Sult2a8
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
Synonyms: 2810007J24Rik, mL-STL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76971
Sh3tc2
Name: SH3 domain and tetratricopeptide repeats 2
Synonyms: D430044G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225608
VEGA: 18
Homologene: 11596
Cmtr2
Name: cap methyltransferase 2
Synonyms: Ftsjd1, C730036L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234728
Homologene: 10144
Olfr1495
Name: olfactory receptor 1495
Synonyms: MOR266-9, GA_x6K02T2RE5P-4101369-4102328
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258341
Homologene: 73965
Alas2
Name: aminolevulinic acid synthase 2, erythroid
Synonyms: Alas-2, ALAS-E, ALAS, ALASE, erythroid-specific ALAS, 5-aminolevulinate synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 11656
HGNC: HGNC:397
Homologene: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 135,450,630 bp
  • T to C, chromosome 2 at 13,656,934 bp
  • C to T, chromosome 2 at 26,014,941 bp
  • T to C, chromosome 2 at 52,277,470 bp
  • C to T, chromosome 2 at 74,694,130 bp
  • G to A, chromosome 2 at 76,745,214 bp
  • T to C, chromosome 2 at 76,944,710 bp
  • A to G, chromosome 2 at 80,324,745 bp
  • A to G, chromosome 2 at 153,908,141 bp
  • G to T, chromosome 3 at 66,224,955 bp
  • C to G, chromosome 3 at 96,559,447 bp
  • A to T, chromosome 4 at 112,746,739 bp
  • T to A, chromosome 4 at 129,328,632 bp
  • G to A, chromosome 5 at 34,811,522 bp
  • A to T, chromosome 5 at 73,666,850 bp
  • T to C, chromosome 5 at 138,251,624 bp
  • C to T, chromosome 7 at 14,427,772 bp
  • G to A, chromosome 7 at 130,182,757 bp
  • A to G, chromosome 8 at 106,424,050 bp
  • T to C, chromosome 8 at 110,221,754 bp
  • A to T, chromosome 9 at 4,330,598 bp
  • G to C, chromosome 10 at 40,056,624 bp
  • A to G, chromosome 10 at 84,880,224 bp
  • A to G, chromosome 10 at 111,301,134 bp
  • T to A, chromosome 10 at 130,180,500 bp
  • A to G, chromosome 11 at 52,376,646 bp
  • C to T, chromosome 11 at 59,082,661 bp
  • T to A, chromosome 11 at 70,607,761 bp
  • A to G, chromosome 12 at 31,298,984 bp
  • A to T, chromosome 13 at 93,092,487 bp
  • A to G, chromosome 13 at 112,895,595 bp
  • A to G, chromosome 15 at 95,913,379 bp
  • T to A, chromosome 16 at 22,935,693 bp
  • C to T, chromosome 16 at 45,731,774 bp
  • T to A, chromosome 16 at 56,179,057 bp
  • T to C, chromosome 18 at 61,990,343 bp
  • G to A, chromosome 19 at 6,077,168 bp
  • A to G, chromosome 19 at 13,769,064 bp
  • T to C, chromosome X at 150,560,730 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3717 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040709-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.