Strain Name:
C57BL/6J-MtgxR3724Btlr/Mmmh
Stock Number:
040715-MU
Citation ID:
RRID:MMRRC_040715-MU
Other Names:
R3724 (G1), C57BL/6J-MtgxR3724Btlr
Major Collection:

Gene Information

Epha4
Name: Eph receptor A4
Synonyms: Sek, Sek1, Tyro1, Hek8, Cek8, 2900005C20Rik, rb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13838
HGNC: HGNC:3388
Homologene: 20933
Ccne2
Name: cyclin E2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12448
HGNC: HGNC:1590
Homologene: 7660
Etv5
Name: ets variant 5
Synonyms: 8430401F14Rik, erm, 1110005E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 104156
HGNC: HGNC:3494
Homologene: 3276
Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 1810041E18Rik, 5830410F13Rik, 2310047O13Rik, Fam188a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66960
Homologene: 11478
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: Daple, 0610010D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Tlk2
Name: tousled-like kinase 2 (Arabidopsis)
Synonyms: protein kinase U-alpha, PKUalpha, 4933403M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 24086
Homologene: 4993
Api5
Name: apoptosis inhibitor 5
Synonyms: AAC-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11800
HGNC: HGNC:594
Homologene: 4809
Iars
Name: isoleucine-tRNA synthetase
Synonyms: E430001P04Rik, 2510016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105148
HGNC: HGNC:5330
Homologene: 5325
Tex2
Name: testis expressed gene 2
Synonyms: Taz4, Def-5, 4930568E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21763
Homologene: 32414
Ctdp1
Name: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Synonyms: 4930563P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67655
HGNC: HGNC:2498
Homologene: 31254
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, Drad-1, E130320P19Rik, E030015M03Rik, b2b1200.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20563
Homologene: 3516
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: 5730469D23Rik, Ube1l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231380
Homologene: 10080
Srsf4
Name: serine and arginine-rich splicing factor 4
Synonyms: MNCb-2616, 5730499P16Rik, SRp75, Sfrs4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 57317
Homologene: 25624
Tpm1
Name: tropomyosin 1, alpha
Synonyms: Tpm-1, alpha-TM, TM2, Tm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22003
Homologene: 128637
Pros1
Name: protein S (alpha)
Synonyms: protein S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19128
HGNC: HGNC:9456
Homologene: 264
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Ten-m3, 2610100B16Rik, Odz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23965
Homologene: 22673
Marchf7
Name: membrane associated ring-CH-type finger 7
Synonyms: Axot, Gtrgeo17, March7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57438
Homologene: 10753
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: MOZ, Zfp220, 9930021N24Rik, Myst3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244349
Homologene: 4924
Atl1
Name: atlastin GTPase 1
Synonyms: AD-FSP, SPG3, FSP1, Spg3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73991
VEGA: 12
Homologene: 9302
Abhd8
Name: abhydrolase domain containing 8
Synonyms: 0910001L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 64296
Homologene: 11188
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Mdnah5, b2b1154Clo, b2b1134Clo, b2b1537Clo, b2b1565Clo, Dnahc5, b2b3491Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545370
Homologene: 23741
Plekhh2
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213556
VEGA: 17
Homologene: 35317
Sh3rf1
Name: SH3 domain containing ring finger 1
Synonyms: Posh, 2200003J05Rik, Sh3md2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 59009
Homologene: 10988
Cfap53
Name: cilia and flagella associated protein 53
Synonyms: 4933415I03Rik, Ccdc11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 74453
Homologene: 27056
Usp40
Name: ubiquitin specific peptidase 40
Synonyms: B230215L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227334
Homologene: 32400
Mbd6
Name: methyl-CpG binding domain protein 6
Synonyms: D10Wsu93e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110962
Homologene: 14171
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, alpha(1B), Cav2.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Prkce
Name: protein kinase C, epsilon
Synonyms: PKC[e], Pkce, 5830406C15Rik, PKCepsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18754
HGNC: HGNC:9401
Homologene: 48343
Zfp747
Name: zinc finger protein 747
Synonyms: 6430604K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269997
Homologene: 118005
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 333315
Homologene: 35388
Kctd16
Name: potassium channel tetramerisation domain containing 16
Synonyms: 4930434H12Rik, LOC383347, 2900055J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 73001
VEGA: 18
Homologene: 44779
Gtdc1
Name: glycosyltransferase-like domain containing 1
Synonyms: E330008O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227835
Homologene: 32590
Ccna1
Name: cyclin A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12427
HGNC: HGNC:1577
Homologene: 31203
6430548M08Rik
Name: RIKEN cDNA 6430548M08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234797
Homologene: 8825
Mefv
Name: Mediterranean fever
Synonyms: marenostrin, pyrin, FMF, TRIM20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 54483
VEGA: 16
HGNC: HGNC:6998
Homologene: 32441
Zfp422
Name: zinc finger protein 422
Synonyms: Krox25, 2900028O21Rik, KOX15, Krox-26, Krox26, Krox-25-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67255
Homologene: 5067
Olfr1187-ps1
Name: olfactory receptor 1187, pseudogene 1
Synonyms: GA_x6K02T2Q125-50027818-50027495
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404484
VEGA: 2
Itih4
Name: inter alpha-trypsin inhibitor, heavy chain 4
Synonyms: Itih-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16427
HGNC: HGNC:6169
Homologene: 1670
Vmn2r20
Name: vomeronasal 2, receptor 20
Synonyms: EG667180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 667180
Homologene: 84037
Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Synonyms: P450scc, D9Ertd411e, Cyp11a, cholesterol side chain cleavage, Scc, cscc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13070
HGNC: HGNC:2590
Homologene: 37347
Klhl29
Name: kelch-like 29
Synonyms: A230106N14Rik, Kbtbd9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 208439
VEGA: 12
Homologene: 66272
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp-epsilon, Nalp4e, 4930406H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 446099
Homologene: 75315
Stambp
Name: STAM binding protein
Synonyms: 5330424L14Rik, 5730422L11Rik, Amsh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70527
Homologene: 4719
Prpf38b
Name: PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
Synonyms: 1110021E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66921
Homologene: 9986
Foxf2
Name: forkhead box F2
Synonyms: FREAC2, Fkh20, LUN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14238
HGNC: HGNC:3810
Homologene: 1115
Trim3
Name: tripartite motif-containing 3
Synonyms: BERP1, HAC1, Rnf22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 55992
Homologene: 21290
Enkd1
Name: enkurin domain containing 1
Synonyms: E130303B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102124
Homologene: 12957
Galm
Name: galactose mutarotase
Synonyms: aldose 1-epimerase, A530057M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 319625
Homologene: 71795
C2cd6
Name: C2 calcium dependent domain containing 6
Synonyms: 1700052H20Rik, 4930408G06Rik, Als2cr11, Als2cr11b, Gm33589, C2cd6b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 102636554
Homologene: 134310
Ifna5
Name: interferon alpha 5
Synonyms: Ifa5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15968
HGNC: HGNC:5425
Homologene: 68536
Zfand2b
Name: zinc finger, AN1 type domain 2B
Synonyms: 1110060O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68818
Homologene: 32671
4932443L11Rik
Name: RIKEN cDNA 4932443L11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78899
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 59,066,235 bp
  • A to G, chromosome 1 at 75,169,855 bp
  • A to G, chromosome 1 at 77,426,543 bp
  • C to T, chromosome 1 at 87,978,297 bp
  • T to A, chromosome 1 at 150,689,518 bp
  • T to A, chromosome 2 at 12,355,354 bp
  • A to G, chromosome 2 at 24,762,757 bp
  • T to C, chromosome 2 at 44,756,307 bp
  • T to C, chromosome 2 at 60,229,745 bp
  • T to G, chromosome 2 at 88,540,286 bp
  • C to T, chromosome 2 at 94,425,613 bp
  • T to C, chromosome 3 at 55,050,932 bp
  • T to C, chromosome 3 at 108,904,340 bp
  • T to C, chromosome 4 at 11,203,039 bp
  • A to G, chromosome 4 at 88,835,934 bp
  • C to T, chromosome 4 at 131,900,102 bp
  • T to C, chromosome 5 at 48,256,883 bp
  • T to C, chromosome 5 at 86,135,047 bp
  • C to T, chromosome 6 at 83,557,466 bp
  • C to T, chromosome 6 at 116,626,379 bp
  • T to A, chromosome 6 at 123,385,747 bp
  • A to T, chromosome 7 at 23,321,377 bp
  • A to G, chromosome 7 at 105,611,189 bp
  • A to T, chromosome 7 at 127,374,590 bp
  • A to G, chromosome 8 at 4,178,080 bp
  • A to T, chromosome 8 at 22,862,788 bp
  • A to G, chromosome 8 at 48,277,746 bp
  • T to C, chromosome 8 at 61,372,722 bp
  • G to A, chromosome 8 at 71,461,492 bp
  • A to G, chromosome 8 at 80,615,271 bp
  • A to T, chromosome 8 at 105,703,925 bp
  • G to T, chromosome 8 at 120,149,360 bp
  • A to T, chromosome 9 at 58,019,322 bp
  • G to A, chromosome 9 at 67,031,945 bp
  • C to T, chromosome 10 at 127,283,891 bp
  • A to G, chromosome 11 at 105,247,564 bp
  • G to A, chromosome 11 at 106,529,330 bp
  • C to T, chromosome 12 at 5,090,603 bp
  • A to G, chromosome 12 at 69,959,380 bp
  • G to A, chromosome 12 at 100,930,524 bp
  • A to G, chromosome 13 at 31,630,530 bp
  • A to G, chromosome 13 at 49,687,384 bp
  • G to A, chromosome 14 at 30,892,584 bp
  • T to C, chromosome 15 at 28,270,420 bp
  • A to G, chromosome 16 at 3,708,194 bp
  • T to C, chromosome 16 at 22,435,912 bp
  • T to C, chromosome 16 at 62,900,329 bp
  • A to G, chromosome 17 at 80,183,280 bp
  • A to G, chromosome 17 at 84,559,588 bp
  • A to T, chromosome 17 at 86,168,623 bp
  • A to G, chromosome 18 at 40,258,859 bp
  • A to G, chromosome 18 at 74,359,569 bp
  • C to T, chromosome 18 at 80,459,267 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3724 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040715-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.