Strain Name:
C57BL/6J-MtgxR3743Btlr/Mmmh
Stock Number:
040729-MU
Citation ID:
RRID:MMRRC_040729-MU
Other Names:
R3743 (G1), C57BL/6J-MtgxR3743Btlr
Major Collection:

Strain Information

Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: Daple, 0610010D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Fbxw8
Name: F-box and WD-40 domain protein 8
Synonyms: FBXO29, Fbx29, FBW8, FBW6, 4930438M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231672
Homologene: 17731
Exoc5
Name: exocyst complex component 5
Synonyms: PRO1912, SEC10, Sec10l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105504
Homologene: 38195
Dhx40
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 40
Synonyms: ARG147, DDX40, 2410016C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67487
Homologene: 57000
Rfx2
Name: regulatory factor X, 2 (influences HLA class II expression)
Synonyms: 5430432H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19725
VEGA: 17
HGNC: HGNC:9983
Homologene: 30980
Ppil4
Name: peptidylprolyl isomerase (cyclophilin)-like 4
Synonyms: PPIase, 3732410E19Rik, 3830425H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67418
Homologene: 12126
Il20
Name: interleukin 20
Synonyms: Zcyto10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 58181
HGNC: HGNC:6002
Homologene: 10286
Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Synonyms: Hif1b, ESTM42, D3Ertd557e, bHLHe2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11863
HGNC: HGNC:700
Homologene: 1261
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Spats2
Name: spermatogenesis associated, serine-rich 2
Synonyms: 2700012F11Rik, p59scr, 59kDa, Scr59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72572
VEGA: 15
Homologene: 11314
Morc2a
Name: microrchidia 2A
Synonyms: 8430403M08Rik, Zcwcc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74522
Homologene: 8966
Trpv1
Name: transient receptor potential cation channel, subfamily V, member 1
Synonyms: capsaicin receptor, VR-1, OTRPC1, Vr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 193034
Homologene: 12920
Irf8
Name: interferon regulatory factor 8
Synonyms: IRF-8, ICSBP, Myls, Icsbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 15900
HGNC: HGNC:5358
Homologene: 1629
Ccr7
Name: chemokine (C-C motif) receptor 7
Synonyms: EBI1, Ebi1h, CD197, Cmkbr7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12775
HGNC: HGNC:1608
Homologene: 1387
Atmin
Name: ATM interactor
Synonyms: Asciz, gpg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234776
Homologene: 35321
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75777
Homologene: 44907
Cdh12
Name: cadherin 12
Synonyms: Br-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 215654
HGNC: HGNC:1751
Homologene: 37873
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382090
Homologene: 8930
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242050
Homologene: 18712
Map3k6
Name: mitogen-activated protein kinase kinase kinase 6
Synonyms: Ask2, MEKK6, MAPKKK6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 53608
HGNC: HGNC:6858
Homologene: 3435
Ninl
Name: ninein-like
Synonyms: LOC381388, LOC381387, 4930519N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78177
Homologene: 57024
Adamts10
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10
Synonyms: ZnMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224697
Homologene: 81940
Or2b11
Name: olfactory receptor family 2 subfamily B member 11
Synonyms: GA_x6K02SYYHDF-1415-2371, MOR256-45P, Olfr222
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 257962
Homologene: 71979
Pkp3
Name: plakophilin 3
Synonyms: 2310056L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56460
HGNC: HGNC:9025
Homologene: 5200
Pcdhb2
Name: protocadherin beta 2
Synonyms: PcdhbB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93873
HGNC: HGNC:8687
Homologene: 69266
Or2n1
Name: olfactory receptor family 2 subfamily N member 1
Synonyms: MOR256-5, GA_x6K02T2PSCP-2623613-2624551, Olfr134
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258829
Homologene: 110603
Lrrn4
Name: leucine rich repeat neuronal 4
Synonyms: B430119L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320974
Homologene: 17632
Cylc2
Name: cylicin, basic protein of sperm head cytoskeleton 2
Synonyms: 4930488P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74914
HGNC: HGNC:2583
Homologene: 136270
Zc3h6
Name: zinc finger CCCH type containing 6
Synonyms: 4631426G04Rik, 4833425H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78751
Homologene: 35328
Stpg1
Name: sperm tail PG rich repeat containing 1
Synonyms: 4930403G18Rik, 4930555I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 78806
Homologene: 12705
Cr2
Name: complement receptor 2
Synonyms: CD21, CD35, Cr-1, Cr-2, Cr1, C3DR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Fgf14
Name: fibroblast growth factor 14
Synonyms: Fhf4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14169
HGNC: HGNC:3671
Homologene: 3037
Cyp4a31
Name: cytochrome P450, family 4, subfamily a, polypeptide 31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 666168
Homologene: 128044
1700030K09Rik
Name: RIKEN cDNA 1700030K09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72254
Homologene: 12975
Or4f61
Name: olfactory receptor family 4 subfamily F member 61
Synonyms: GA_x6K02T2Q125-73139026-73138088, MOR245-2, Olfr1314
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258442
Homologene: 121538
Dlgap1
Name: DLG associated protein 1
Synonyms: SAPAP1, DAP-1 beta, D17Bwg0511e, GKAP/SAPAP, Sapap1, 4933422O14Rik, Gkap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224997
HGNC: HGNC:2905
Homologene: 31258
1700013G24Rik
Name: RIKEN cDNA 1700013G24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69380
Homologene: 124477
Atg3
Name: autophagy related 3
Synonyms: PC3-96, APG3, 2610016C12Rik, Apg3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67841
Homologene: 6836
Mtmr6
Name: myotubularin related protein 6
Synonyms: 4022440C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219135
VEGA: 14
HGNC: HGNC:7453
Homologene: 55842
Tmprss11e
Name: transmembrane protease, serine 11e
Synonyms: DESC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243084
Homologene: 8543
Slc7a10
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
Synonyms: Asc-1, D7Bwg0847e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53896
Homologene: 56767
Hoxd9
Name: homeobox D9
Synonyms: Hox-5.2, Hox-4.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15438
HGNC: HGNC:5140
Homologene: 8409
Csf1r
Name: colony stimulating factor 1 receptor
Synonyms: CSF-1R, M-CSFR, CD115, Fim-2, Fms, Csfmr, Fim2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12978
HGNC: HGNC:2433
Homologene: 3817
Gm20715
Name: predicted gene 20715
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 130,910,809 bp
  • A to G, chromosome 1 at 195,149,966 bp
  • T to A, chromosome 2 at 74,698,366 bp
  • A to G, chromosome 2 at 112,092,620 bp
  • A to G, chromosome 2 at 128,997,792 bp
  • A to G, chromosome 2 at 132,869,866 bp
  • A to G, chromosome 2 at 150,950,248 bp
  • T to C, chromosome 3 at 59,326,125 bp
  • T to C, chromosome 3 at 95,474,705 bp
  • T to C, chromosome 4 at 51,228,097 bp
  • A to C, chromosome 4 at 115,566,519 bp
  • C to T, chromosome 4 at 133,245,073 bp
  • T to A, chromosome 4 at 135,514,886 bp
  • A to G, chromosome 4 at 137,455,037 bp
  • G to A, chromosome 5 at 86,709,456 bp
  • A to G, chromosome 5 at 118,113,639 bp
  • G to T, chromosome 7 at 6,424,871 bp
  • C to T, chromosome 7 at 35,198,900 bp
  • A to G, chromosome 7 at 141,089,953 bp
  • A to G, chromosome 8 at 72,445,169 bp
  • T to C, chromosome 8 at 116,956,573 bp
  • C to T, chromosome 8 at 120,753,571 bp
  • A to T, chromosome 9 at 87,217,177 bp
  • T to A, chromosome 10 at 7,821,171 bp
  • G to A, chromosome 10 at 77,996,345 bp
  • A to G, chromosome 11 at 3,683,700 bp
  • T to C, chromosome 11 at 59,571,509 bp
  • G to A, chromosome 11 at 69,364,050 bp
  • A to T, chromosome 11 at 73,254,302 bp
  • A to T, chromosome 11 at 86,771,159 bp
  • G to T, chromosome 11 at 99,145,207 bp
  • G to A, chromosome 11 at 116,003,670 bp
  • G to A, chromosome 12 at 100,948,584 bp
  • T to C, chromosome 14 at 49,014,349 bp
  • A to T, chromosome 14 at 49,033,407 bp
  • T to C, chromosome 14 at 60,300,298 bp
  • C to A, chromosome 14 at 124,676,620 bp
  • CT to CTTGGATT, chromosome 15 at 10,537,562 bp
  • G to A, chromosome 15 at 10,537,566 bp
  • T to A, chromosome 15 at 21,537,659 bp
  • T to C, chromosome 15 at 99,210,914 bp
  • A to G, chromosome 16 at 45,178,228 bp
  • A to G, chromosome 17 at 33,528,712 bp
  • T to G, chromosome 17 at 38,175,902 bp
  • A to G, chromosome 17 at 56,803,751 bp
  • G to A, chromosome 17 at 70,718,226 bp
  • A to G, chromosome 18 at 37,296,417 bp
  • T to C, chromosome 18 at 61,114,774 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3743 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040729-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.