Strain Name:
C57BL/6J-MtgxR3750Btlr/Mmmh
Stock Number:
040735-MU
Citation ID:
RRID:MMRRC_040735-MU
Other Names:
R3750 (G1), C57BL/6J-MtgxR3750Btlr
Major Collection:

Gene Information

Nefh
Name: neurofilament, heavy polypeptide
Synonyms: NF-H, NF200, NEFH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380684
HGNC: HGNC:7737
Homologene: 40755
Polr3e
Name: polymerase (RNA) III (DNA directed) polypeptide E
Synonyms: RPC5, Sin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26939
Homologene: 14052
Upf1
Name: UPF1 regulator of nonsense transcripts homolog (yeast)
Synonyms: PNORF-1, B430202H16Rik, Rent1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 19704
HGNC: HGNC:9962
Homologene: 2185
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231326
Homologene: 71711
Slk
Name: STE20-like kinase
Synonyms: 9A2, mSLK, Etk4, SLK, Stk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20874
Homologene: 22515
Kcnc4
Name: potassium voltage gated channel, Shaw-related subfamily, member 4
Synonyms: Kv3.4, Kcr2-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99738
HGNC: HGNC:6236
Homologene: 68427
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Usp1
Name: ubiquitin specific peptidase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230484
Homologene: 2528
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Skil
Name: SKI-like
Synonyms: SnoN, Skir, sno-dE3, SnoN2, 9130011J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20482
Homologene: 3948
Ago1
Name: argonaute RISC catalytic subunit 1
Synonyms: argonaute 1, Eif2c1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 236511
HGNC: HGNC:3262
Homologene: 81826
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227446
Homologene: 10834
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
Rtca
Name: RNA 3'-terminal phosphate cyclase
Synonyms: 2310009A18Rik, Rtcd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66368
Homologene: 2766
Adam12
Name: a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Synonyms: Mltna, ADAM12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11489
HGNC: HGNC:190
Homologene: 74862
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Zswim4
Name: zinc finger SWIM-type containing 4
Synonyms: E130119J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212168
Homologene: 18183
Primpol
Name: primase and polymerase (DNA-directed)
Synonyms: Ccdc111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 408022
Homologene: 14065
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pdzph1
Name: PDZ and pleckstrin homology domains 1
Synonyms: 2610034M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69239
Homologene: 130756
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, A230052E19Rik, Scn2a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110876
Homologene: 75001
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
4930458L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Plce1
Name: phospholipase C, epsilon 1
Synonyms: 4933403A21Rik, PLCepsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74055
Homologene: 9478
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: EG235580, 1110001D15Rik, Dvwa, Vwa6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68553
Homologene: 130754
Hsd17b3
Name: hydroxysteroid (17-beta) dehydrogenase 3
Synonyms: 17(beta)HSD type 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15487
VEGA: 13
HGNC: HGNC:5212
Homologene: 20089
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: D15Wsu122e, 5730435J12Rik, p96, D630005B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
Adam26b
Name: a disintegrin and metallopeptidase domain 26B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382007
Homologene: 128363
Tcp11l1
Name: t-complex 11 like 1
Synonyms: C130096D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320554
Homologene: 41260
Spon1
Name: spondin 1, (f-spondin) extracellular matrix protein
Synonyms: D330035F22Rik, FSP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233744
Homologene: 4453
Gpd1l
Name: glycerol-3-phosphate dehydrogenase 1-like
Synonyms: 2210409H23Rik, D9Ertd660e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 333433
Homologene: 56097
Tas2r136
Name: taste receptor, type 2, member 136
Synonyms: mt2r52, Tas2r36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353165
Homologene: 136304
5930403N24Rik
Name: RIKEN cDNA 5930403N24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100040846
Cyp4v3
Name: cytochrome P450, family 4, subfamily v, polypeptide 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102294
Homologene: 133054
Pramel18
Name: PRAME like 18
Synonyms: Gm12800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381535
Foxd1
Name: forkhead box D1
Synonyms: BF-2, Hfh10, FREAC4, Hfhbf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15229
HGNC: HGNC:3802
Homologene: 3290
Bckdk
Name: branched chain ketoacid dehydrogenase kinase
Synonyms: BCKD-kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12041
Homologene: 37642
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 105,753,577 bp
  • T to G, chromosome 2 at 65,713,771 bp
  • G to A, chromosome 2 at 76,754,006 bp
  • A to G, chromosome 2 at 104,698,542 bp
  • T to A, chromosome 2 at 118,615,455 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • G to A, chromosome 3 at 5,243,165 bp
  • A to G, chromosome 3 at 31,116,834 bp
  • T to G, chromosome 3 at 86,375,953 bp
  • A to G, chromosome 3 at 107,448,190 bp
  • A to T, chromosome 3 at 116,493,001 bp
  • C to T, chromosome 4 at 98,934,120 bp
  • T to A, chromosome 4 at 101,909,876 bp
  • A to G, chromosome 4 at 126,461,044 bp
  • G to T, chromosome 4 at 148,024,187 bp
  • C to A, chromosome 5 at 76,888,654 bp
  • A to T, chromosome 6 at 132,777,237 bp
  • T to C, chromosome 7 at 113,766,384 bp
  • T to A, chromosome 7 at 114,016,791 bp
  • T to C, chromosome 7 at 120,933,671 bp
  • C to A, chromosome 7 at 127,905,418 bp
  • T to C, chromosome 7 at 134,172,865 bp
  • A to C, chromosome 8 at 43,521,197 bp
  • G to A, chromosome 8 at 45,315,708 bp
  • A to T, chromosome 8 at 46,599,813 bp
  • G to T, chromosome 8 at 70,333,350 bp
  • G to A, chromosome 8 at 84,212,047 bp
  • C to A, chromosome 9 at 106,020,665 bp
  • A to G, chromosome 9 at 114,902,516 bp
  • G to A, chromosome 10 at 37,140,870 bp
  • A to G, chromosome 11 at 4,939,937 bp
  • A to T, chromosome 13 at 64,063,179 bp
  • G to T, chromosome 13 at 64,921,743 bp
  • G to C, chromosome 13 at 98,355,916 bp
  • G to A, chromosome 14 at 24,165,260 bp
  • G to A, chromosome 15 at 4,952,246 bp
  • A to G, chromosome 15 at 6,427,321 bp
  • A to T, chromosome 17 at 58,973,336 bp
  • A to C, chromosome 19 at 38,777,899 bp
  • T to G, chromosome 19 at 47,619,809 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3750 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040735-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.