Strain Name:
C57BL/6J-MtgxR3758Btlr/Mmmh
Stock Number:
040739-MU
Citation ID:
RRID:MMRRC_040739-MU
Other Names:
R3758 (G1), C57BL/6J-MtgxR3758Btlr
Major Collection:

Strain Information

Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: D11Ertd530e, 2610028O16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52615
Homologene: 32256
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: Bcat-1, BCATc, Eca39
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Magoh
Name: mago homolog, exon junction complex core component
Synonyms: Mago-m, Mos2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17149
HGNC: HGNC:6815
Homologene: 1776
Ror1
Name: receptor tyrosine kinase-like orphan receptor 1
Synonyms: 2810404D04Rik, Ntrkr1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26563
Homologene: 3675
Htt
Name: huntingtin
Synonyms: C430023I11Rik, Hdh, htt, huntingtin, HD, IT15
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Nmd3
Name: NMD3 ribosome export adaptor
Synonyms: C87860
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 97112
Homologene: 6127
Mtcl2
Name: microtubule crosslinking factor 2
Synonyms: D430036N24Rik, Soga1, 9830001H06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320706
Homologene: 52382
Or4a78
Name: olfactory receptor family 4 subfamily A member 78
Synonyms: MOR231-15P, GA_x6K02T2Q125-51109312-51108356, Olfr1251, MOR231-24_p
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259145
Homologene: 74065
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Astn1
Name: astrotactin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: aln, line 158, Thm1, 2410066K11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73668
Homologene: 57006
Ptprt
Name: protein tyrosine phosphatase receptor type T
Synonyms: RPTPrho
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Coq8b
Name: coenzyme Q8B
Synonyms: Adck4, 0610012P18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76889
Homologene: 86731
Fbln2
Name: fibulin 2
Synonyms: 5730577E14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14115
HGNC: HGNC:3601
Homologene: 1514
Tor1aip2
Name: torsin A interacting protein 2
Synonyms: 1110020D10Rik, LULL1, Ifrg15, 15kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240832
Homologene: 17028
Pcdhb7
Name: protocadherin beta 7
Synonyms: Pcdhb4B, PcdhbG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93878
HGNC: HGNC:8689
Homologene: 87123
Ube4a
Name: ubiquitination factor E4A
Synonyms: 9930123J21Rik, 4732444G18Rik, UFD2b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 140630
Homologene: 3517
Serpinb9b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9b
Synonyms: Spi10, ovalbumin, SPI-CI, R86, 1600019A21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20706
HGNC: HGNC:8955
Homologene: 137240
Spsb4
Name: splA/ryanodine receptor domain and SOCS box containing 4
Synonyms: D030068E18Rik, Ssb4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 211949
Homologene: 25315
Sprr1a
Name: small proline-rich protein 1A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20753
Homologene: 105698
Or11h6
Name: olfactory receptor family 11 subfamily H member 6
Synonyms: GA_x6K02T2PMLR-6361495-6362481, Olfr745, MOR106-11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258296
Homologene: 27116
Fkbp10
Name: FK506 binding protein 10
Synonyms: FKBP65, Fkbp1-rs, Fkbp-rs1, Fkbp6, 65kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14230
Homologene: 7718
Cage1
Name: cancer antigen 1
Synonyms: CAGE1, Ctag3, 4933427I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71213
Homologene: 18484
Mill1
Name: MHC I like leukocyte 1
Synonyms: 5530400I18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 266815
HGNC: HGNC:7090
Homologene: 105329
Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Synonyms: GABAA alpha 1, GABAAR alpha1, Gabra-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14394
HGNC: HGNC:4075
Homologene: 629
Or6c207
Name: olfactory receptor family 6 subfamily C member 207
Synonyms: MOR114-9, Olfr777, GA_x6K02T2PULF-10955551-10954616
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258537
Homologene: 27203
Hmgcs2
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Synonyms: mHS
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15360
HGNC: HGNC:5008
Homologene: 38066
Nipa2
Name: non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)
Synonyms: 3830408P04Rik, 2600017P10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 93790
Homologene: 11368
Acat3
Name: acetyl-Coenzyme A acetyltransferase 3
Synonyms: ACTL
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224530
HGNC: HGNC:94
Homologene: 55855
Or52r1b
Name: olfactory receptor family 52 subfamily R member 1B
Synonyms: Olfr582, GA_x6K02T2PBJ9-5752857-5753801, MOR30-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259055
Homologene: 73943
H1f4
Name: H1.4 linker histone, cluster member
Synonyms: H1s-4, H1-4, H1f4, H1e, Hist1h1e, H1var2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 50709
HGNC: HGNC:4718
Homologene: 137314
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 156,065,289 bp
  • A to T, chromosome 1 at 158,597,336 bp
  • G to T, chromosome 2 at 52,201,386 bp
  • G to A, chromosome 2 at 66,191,796 bp
  • A to G, chromosome 2 at 89,667,572 bp
  • T to C, chromosome 2 at 157,020,638 bp
  • A to T, chromosome 2 at 161,812,030 bp
  • T to A, chromosome 3 at 69,724,308 bp
  • A to G, chromosome 3 at 86,776,049 bp
  • T to G, chromosome 3 at 92,484,397 bp
  • A to G, chromosome 3 at 98,291,090 bp
  • T to C, chromosome 3 at 158,163,965 bp
  • A to G, chromosome 4 at 100,412,154 bp
  • A to G, chromosome 4 at 107,885,013 bp
  • A to G, chromosome 5 at 34,895,970 bp
  • T to C, chromosome 6 at 91,256,381 bp
  • T to A, chromosome 6 at 145,032,872 bp
  • G to A, chromosome 7 at 18,262,703 bp
  • C to T, chromosome 7 at 27,242,227 bp
  • T to C, chromosome 7 at 55,935,941 bp
  • A to G, chromosome 7 at 103,041,970 bp
  • G to A, chromosome 9 at 44,949,900 bp
  • A to G, chromosome 9 at 96,995,871 bp
  • T to C, chromosome 10 at 129,269,065 bp
  • G to T, chromosome 11 at 42,175,936 bp
  • A to G, chromosome 11 at 80,024,942 bp
  • G to A, chromosome 11 at 100,422,625 bp
  • T to A, chromosome 13 at 23,622,257 bp
  • A to G, chromosome 13 at 33,035,588 bp
  • A to C, chromosome 13 at 38,025,729 bp
  • A to C, chromosome 14 at 33,023,374 bp
  • A to G, chromosome 14 at 50,643,036 bp
  • A to G, chromosome 17 at 12,927,467 bp
  • A to G, chromosome 18 at 37,343,026 bp
  • G to A, chromosome 18 at 49,935,317 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3758 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040739-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.