Strain Name:
C57BL/6J-MtgxR3766Btlr/Mmmh
Stock Number:
040743-MU
Citation ID:
RRID:MMRRC_040743-MU
Other Names:
R3766 (G1), C57BL/6J-MtgxR3766Btlr
Major Collection:

Strain Information

Sall4
Name: spalt like transcription factor 4
Synonyms: 5730441M18Rik, C330011P20Rik, Tex20
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99377
Homologene: 10716
Trim59
Name: tripartite motif-containing 59
Synonyms: TSBF1, 2700022F13Rik, Mrf1, 2310035M22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66949
Homologene: 32644
Map1b
Name: microtubule-associated protein 1B
Synonyms: Mtap5, MAP5, LC1, Mtap1b, Mtap-5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Tnpo3
Name: transportin 3
Synonyms: 5730544L10Rik, D6Ertd313e, C430013M08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320938
Homologene: 40848
Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: RA-GEF-1, 5830453M24Rik, nRapGEP, CNRasGEF, Pdzgef1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76089
Homologene: 35477
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217342
Homologene: 11113
Plxna1
Name: plexin A1
Synonyms: PlexA1, NOV, Plxn1, 2600013D04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Tubgcp5
Name: tubulin, gamma complex component 5
Synonyms: B130010C12Rik, GCP5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233276
Homologene: 14172
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: rjs, D7H15F32S1, D7H15F37S1, jdf2, D15F32S1h
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Uvrag
Name: UV radiation resistance associated gene
Synonyms: Uvragl, 9530039D02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78610
Homologene: 31150
Cttnbp2nl
Name: CTTNBP2 N-terminal like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80281
Homologene: 36371
Fh1
Name: fumarate hydratase 1
Synonyms: fumarase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14194
HGNC: HGNC:3700
Homologene: 115
Lypla1
Name: lysophospholipase 1
Synonyms: Pla1a, Gm39587
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18777
HGNC: HGNC:6737
Homologene: 100781
Pxk
Name: PX domain containing serine/threonine kinase
Synonyms: D14Ertd813e, MONaKA, C230080L11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218699
VEGA: 14
Homologene: 9828
Brf2
Name: BRF2, RNA polymerase III transcription initiation factor 50kDa subunit
Synonyms: 5730512K07Rik, TFIIIB50, BRFU, 2700059M06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66653
Homologene: 10127
Hspa13
Name: heat shock protein 70 family, member 13
Synonyms: B230217N24Rik, 1600002I10Rik, 60kDa, Stch
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110920
Homologene: 5062
Pcdhb16
Name: protocadherin beta 16
Synonyms: Pcdhb8, PcdhbP
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93887
Homologene: 99843
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG620718, EG667069
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667069
Homologene: 129754
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: GlcT-1, Epcs21, Ugcgl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22234
Homologene: 37763
Slc45a1
Name: solute carrier family 45, member 1
Synonyms: Dnb5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242773
Homologene: 44908
Pus3
Name: pseudouridine synthase 3
Synonyms: 2610020J05Rik, 5730412F04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67049
Homologene: 11339
Dock10
Name: dedicator of cytokinesis 10
Synonyms: Jr5, ZIZ3, 9330153B10Rik, Zizimin3, A630054M16Rik, Jr4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210293
Homologene: 45952
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: Heatr7b1, OTTMUSG00000020804, ENSMUSG00000044873
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Kif6
Name: kinesin family member 6
Synonyms: D130084M03Rik, D130004B10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 319991
Homologene: 35308
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620928
Homologene: 115466
Itgav
Name: integrin alpha V
Synonyms: alphav-integrin, vitronectin receptor alpha polypeptide (VNRA), CD51, D430040G12Rik, 1110004F14Rik, 2610028E01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16410
HGNC: HGNC:6150
Homologene: 20510
Pex5l
Name: peroxisomal biogenesis factor 5-like
Synonyms: 1700016J08Rik, PXR2, TRIP8b, Pex2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 58869
Homologene: 9562
Psg26
Name: pregnancy-specific beta-1-glycoprotein 26
Synonyms: EG574429, cea14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 574429
Homologene: 110989
Or56b1b
Name: olfactory receptor family 56 subfamily B member 1B
Synonyms: MOR40-7P, Olfr504, GA_x6K02T2PBJ9-10895499-10894543, MOR40-15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258163
Homologene: 17189
Frk
Name: fyn-related kinase
Synonyms: BSK/IYK, GTK
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14302
VEGA: 10
HGNC: HGNC:3955
Homologene: 48065
Aacs
Name: acetoacetyl-CoA synthetase
Synonyms: 2210408B16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78894
Homologene: 11322
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68655
Slc18b1
Name: solute carrier family 18, subfamily B, member 1
Synonyms: 1110021L09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76306
Homologene: 33473
Crbn
Name: cereblon
Synonyms: 2900045O07Rik, 2610203G15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58799
Homologene: 9461
Tcim
Name: transcriptional and immune response regulator
Synonyms: 1810011O10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69068
HGNC: HGNC:1357
Homologene: 10590
Sox13
Name: SRY (sex determining region Y)-box 13
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20668
Homologene: 4159
Ston1
Name: stonin 1
Synonyms: 4921524J06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77057
Homologene: 122152
Or52l1
Name: olfactory receptor family 52 subfamily L member 1
Synonyms: Olfr685, MOR37-1, GA_x6K02T2PBJ9-7810071-7809121
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258160
Homologene: 66455
Plac8l1
Name: PLAC8-like 1
Synonyms: 1700015M15Rik, 1700009N18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69401
VEGA: 18
Homologene: 45879
Tada2b
Name: transcriptional adaptor 2B
Synonyms: LOC231151
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231151
Homologene: 51007
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 4,840,978 bp
  • A to G, chromosome 1 at 80,536,926 bp
  • TCTCTCTCTCTCTCTCTCTCTCTCTC to TCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC, chromosome 1 at 88,247,715 bp
  • T to C, chromosome 1 at 133,390,798 bp
  • A to G, chromosome 1 at 175,614,750 bp
  • T to C, chromosome 2 at 83,801,885 bp
  • T to C, chromosome 2 at 168,756,044 bp
  • T to G, chromosome 3 at 33,007,178 bp
  • T to A, chromosome 3 at 64,556,508 bp
  • A to G, chromosome 3 at 69,036,804 bp
  • T to C, chromosome 3 at 79,088,750 bp
  • G to A, chromosome 3 at 105,004,801 bp
  • A to G, chromosome 4 at 11,199,293 bp
  • C to T, chromosome 4 at 59,207,798 bp
  • T to C, chromosome 4 at 150,638,060 bp
  • A to T, chromosome 5 at 36,476,417 bp
  • C to T, chromosome 5 at 125,506,262 bp
  • T to C, chromosome 6 at 29,579,689 bp
  • T to C, chromosome 6 at 89,334,775 bp
  • T to C, chromosome 6 at 106,795,026 bp
  • T to C, chromosome 7 at 18,475,071 bp
  • T to A, chromosome 7 at 55,830,866 bp
  • A to G, chromosome 7 at 56,163,824 bp
  • C to T, chromosome 7 at 85,871,990 bp
  • G to T, chromosome 7 at 98,888,143 bp
  • A to T, chromosome 7 at 105,180,881 bp
  • G to A, chromosome 7 at 108,565,195 bp
  • T to A, chromosome 8 at 24,438,749 bp
  • G to T, chromosome 8 at 27,124,468 bp
  • C to A, chromosome 9 at 35,566,672 bp
  • A to G, chromosome 10 at 23,798,749 bp
  • A to G, chromosome 10 at 34,484,005 bp
  • A to G, chromosome 11 at 116,546,863 bp
  • T to C, chromosome 13 at 99,434,087 bp
  • T to C, chromosome 14 at 8,136,863 bp
  • T to C, chromosome 16 at 75,765,086 bp
  • A to G, chromosome 17 at 7,784,421 bp
  • A to T, chromosome 17 at 49,758,643 bp
  • C to T, chromosome 17 at 88,635,360 bp
  • A to T, chromosome 18 at 37,478,196 bp
  • A to T, chromosome 18 at 42,180,395 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3766 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040743-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.