Beutler Mutagenetix

Strain Name:
C57BL/6J-MtgxR3768Btlr/Mmmh
Stock Number:
040745-MU
Citation ID:
RRID:MMRRC_040745-MU
Other Names:
R3768 (G1), C57BL/6J-MtgxR3768Btlr
Major Collection:

Gene Information

D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330286
Homologene: 19782
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: D230004K18Rik, b2b1625.2Clo, Gp330, Megalin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
B3gnt2
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Synonyms: B3gnt1, B3Galt6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 53625
Homologene: 4797
Dhx35
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 35
Synonyms: 1200009D07Rik, Ddx35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71715
Homologene: 6406
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 114873
VEGA: 9
Homologene: 79549
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: LTRPC7, 5033407O22Rik, CHAK1, CHAK, 2310022G15Rik, Ltpr7, TRP-PLIK, 4833414K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 58800
Homologene: 9774
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: ANCO-2, 2900001A12Rik, GAC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106585
Homologene: 9059
Pabpc4
Name: poly(A) binding protein, cytoplasmic 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230721
HGNC: HGNC:8557
Homologene: 37855
Wdr3
Name: WD repeat domain 3
Synonyms: D030020G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 269470
Homologene: 4937
Pik3c3
Name: phosphatidylinositol 3-kinase catalytic subunit type 3
Synonyms: Vps34, 5330434F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225326
HGNC: HGNC:8974
Homologene: 1986
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRT, SMRTe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Arid4a
Name: AT rich interactive domain 4A (RBP1-like)
Synonyms: A630067N03Rik, Rbbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238247
HGNC: HGNC:9885
Homologene: 11303
Klf3
Name: Kruppel-like factor 3 (basic)
Synonyms: 9930027G08Rik, Tef-2, BKLF, Bklf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 16599
Homologene: 7396
Dock7
Name: dedicator of cytokinesis 7
Synonyms: m, 3110056M06Rik, LOC242555
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67299
Homologene: 23566
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 58996
Homologene: 104145
Gm7964
Name: predicted gene 7964
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 666170
HGNC: null
Homologene: null
C3
Name: complement component 3
Synonyms: Plp, acylation stimulating protein, complement factor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Mgl2
Name: macrophage galactose N-acetyl-galactosamine specific lectin 2
Synonyms: CD301b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216864
Homologene: 7836
Ank1
Name: ankyrin 1, erythroid
Synonyms: pale, Ank-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11733
HGNC: HGNC:492
Homologene: 55427
Fgf10
Name: fibroblast growth factor 10
Synonyms: Gsfaey17, AEY17, FGF-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14165
HGNC: HGNC:3666
Homologene: 3284
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E16Rik, Myospryn, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 76469
VEGA: 13
Homologene: 137367
Sec14l2
Name: SEC14-like lipid binding 2
Synonyms: Spf, tap, 1300013M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67815
Homologene: 8245
Nlgn2
Name: neuroligin 2
Synonyms: NL2, NLG2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216856
Homologene: 69317
Kctd19
Name: potassium channel tetramerisation domain containing 19
Synonyms: 4922504H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 279499
Homologene: 18630
Zfyve9
Name: zinc finger, FYVE domain containing 9
Synonyms: Madhip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230597
HGNC: HGNC:6775
Homologene: 3527
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: Ugcgl, Epcs21, GlcT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 22234
Homologene: 37763
Pfdn6
Name: prefoldin subunit 6
Synonyms: H-2Ke2, Ke-2, H2-Ke2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14976
HGNC: HGNC:4926
Homologene: 40720
Dock10
Name: dedicator of cytokinesis 10
Synonyms: Zizimin3, Jr4, Jr5, A630054M16Rik, 9330153B10Rik, ZIZ3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 210293
Homologene: 45952
Cnga4
Name: cyclic nucleotide gated channel alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233649
HGNC: HGNC:2152
Homologene: 13579
Sclt1
Name: sodium channel and clathrin linker 1
Synonyms: Tg(ACTB-sb10)1Dla, 2610207F23Rik, CAGGS-SB10, 4931421F20Rik, Tg(CAG-sb10)1Dla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 67161
Homologene: 27031
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 435626
Homologene: 52359
Tarm1
Name: T cell-interacting, activating receptor on myeloid cells 1
Synonyms: 9930022N03Rik, Gm9904
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 245126
Homologene: 120241
Abca5
Name: ATP-binding cassette, sub-family A (ABC1), member 5
Synonyms: ABC13, B930033A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Mypn
Name: myopalladin
Synonyms: 1110056A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 68802
VEGA: 10
Homologene: 23778
Ppm1h
Name: protein phosphatase 1H (PP2C domain containing)
Synonyms: C030002B11Rik, ARHCL1, A430075L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 319468
Homologene: 18537
Serpinb11
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
Synonyms: 2310046M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66957
Homologene: 41653
Olfr1384
Name: olfactory receptor 1384
Synonyms: MOR256-23, GA_x6K02T2QP88-5922712-5921756
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258464
HGNC: null
Homologene: 74259
Osbpl3
Name: oxysterol binding protein-like 3
Synonyms: 1200014M06Rik, 6720421I08Rik, ORP3, OSBP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 71720
Homologene: 49422
Zfp229
Name: zinc finger protein 229
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 381067
HGNC: null
Homologene: 136287
Pla2g5
Name: phospholipase A2, group V
Synonyms: sPLA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18784
HGNC: HGNC:9038
Homologene: 716
Ptpru
Name: protein tyrosine phosphatase, receptor type, U
Synonyms: Ptprl, RPTPlambda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: agil, wl, Ib
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50769
Homologene: 4443
Usp36
Name: ubiquitin specific peptidase 36
Synonyms: 2700002L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 72344
Homologene: 11828
Cxcl15
Name: chemokine (C-X-C motif) ligand 15
Synonyms: weche, lungkine, Scyb15, Il8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20309
HGNC: null
Homologene: null
Olfr1378
Name: olfactory receptor 1378
Synonyms: MOR129-2, GA_x6K02T2QP88-4469162-4468215
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258912
HGNC: null
Homologene: 133679
Rhot2
Name: ras homolog family member T2
Synonyms: Arht2, Miro2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 214952
Homologene: 56038
Olfr1426
Name: olfactory receptor 1426
Synonyms: MOR239-1, GA_x6K02T2RE5P-2447610-2446675
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258805
Homologene: 128079
Cplx4
Name: complexin 4
Synonyms: A930004D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225644
VEGA: 18
Homologene: 17150
Btbd7
Name: BTB (POZ) domain containing 7
Synonyms: E130118E17Rik, 5730507E09Rik, FUP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238386
VEGA: 12
Homologene: 34300
Ifna7
Name: interferon alpha 7
Synonyms: Ifa7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 15970
HGNC: HGNC:5425
Homologene: 68536
Sap25
Name: sin3 associated polypeptide
Synonyms: 25 kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 751865
Homologene: 104044
Olfr1420
Name: olfactory receptor 1420
Synonyms: GA_x6K02T2RE5P-2247227-2248156, MOR266-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258405
Homologene: 17234
9130019O22Rik
Name: RIKEN cDNA 9130019O22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 78921
HGNC: null
Homologene: 118005
Krtap12-1
Name: keratin associated protein 12-1
Synonyms: D10Jhu14e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 16694
VEGA: 10
HGNC: null
Homologene: 135687
Pdia6
Name: protein disulfide isomerase associated 6
Synonyms: Txndc7, 1700015E05Rik, P5, CaBP5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 71853
Homologene: 4198
Apol9b
Name: apolipoprotein L 9b
Synonyms: 2310016F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 71898
VEGA: 15
HGNC: null
Homologene: 77567
Ddx3x
Name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
Synonyms: Fin14, Ddx3, D1Pas1-rs2, embryonic RNA helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 13205
HGNC: HGNC:2745
Homologene: 3425
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,147,663 bp
  • T to A, chromosome 1 at 80,532,368 bp
  • T to C, chromosome 1 at 107,377,662 bp
  • C to T, chromosome 2 at 69,505,105 bp
  • TAAAAA to TAAAAAAA, chromosome 2 at 126,825,563 bp
  • A to G, chromosome 2 at 158,827,893 bp
  • A to G, chromosome 3 at 41,730,852 bp
  • A to G, chromosome 3 at 100,144,548 bp
  • C to T, chromosome 4 at 59,207,798 bp
  • T to C, chromosome 4 at 88,816,727 bp
  • T to C, chromosome 4 at 98,970,829 bp
  • T to C, chromosome 4 at 108,682,129 bp
  • T to A, chromosome 4 at 123,294,612 bp
  • C to T, chromosome 4 at 131,808,424 bp
  • C to G, chromosome 4 at 138,801,435 bp
  • A to G, chromosome 5 at 64,827,217 bp
  • A to C, chromosome 5 at 90,801,444 bp
  • A to G, chromosome 5 at 125,028,687 bp
  • T to A, chromosome 5 at 137,642,370 bp
  • A to G, chromosome 6 at 38,142,909 bp
  • G to A, chromosome 6 at 50,348,002 bp
  • A to T, chromosome 7 at 3,497,581 bp
  • T to A, chromosome 7 at 83,756,130 bp
  • A to G, chromosome 7 at 105,407,680 bp
  • A to G, chromosome 7 at 127,384,863 bp
  • A to G, chromosome 8 at 23,116,186 bp
  • T to C, chromosome 8 at 105,396,480 bp
  • T to A, chromosome 9 at 45,732,137 bp
  • C to A, chromosome 10 at 63,125,707 bp
  • G to T, chromosome 10 at 77,720,895 bp
  • G to T, chromosome 10 at 122,904,122 bp
  • A to G, chromosome 11 at 4,103,818 bp
  • T to C, chromosome 11 at 22,836,765 bp
  • T to C, chromosome 11 at 49,513,773 bp
  • A to G, chromosome 11 at 50,969,558 bp
  • C to T, chromosome 11 at 69,828,404 bp
  • T to C, chromosome 11 at 70,135,833 bp
  • A to T, chromosome 11 at 97,476,106 bp
  • T to C, chromosome 11 at 110,313,391 bp
  • T to C, chromosome 11 at 118,263,052 bp
  • T to C, chromosome 12 at 17,270,456 bp
  • A to G, chromosome 12 at 71,067,119 bp
  • G to A, chromosome 12 at 102,795,192 bp
  • A to T, chromosome 13 at 93,096,693 bp
  • G to T, chromosome 13 at 118,781,547 bp
  • T to A, chromosome 14 at 60,044,336 bp
  • G to C, chromosome 15 at 77,404,396 bp
  • A to T, chromosome 17 at 21,745,863 bp
  • T to C, chromosome 17 at 25,840,547 bp
  • G to A, chromosome 17 at 33,939,824 bp
  • C to T, chromosome 17 at 57,205,303 bp
  • T to C, chromosome 17 at 65,985,720 bp
  • T to A, chromosome 18 at 30,333,273 bp
  • T to C, chromosome 18 at 65,969,927 bp
  • G to A, chromosome 19 at 11,896,312 bp
  • A to G, chromosome 19 at 12,087,940 bp
  • T to C, chromosome X at 13,290,569 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3768 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040745-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.