Strain Name:
C57BL/6J-MtgxR3769Btlr/Mmmh
Stock Number:
040746-MU
Citation ID:
RRID:MMRRC_040746-MU
Other Names:
R3769 (G1), C57BL/6J-MtgxR3769Btlr
Major Collection:

Strain Information

Top1
Name: topoisomerase (DNA) I
Synonyms: D130064I21Rik, Top-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21969
Homologene: 2467
Chst5
Name: carbohydrate sulfotransferase 5
Synonyms: I-GlcNAc6ST, GST-4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56773
Homologene: 56927
Ppil2
Name: peptidylprolyl isomerase (cyclophilin)-like 2
Synonyms: C130078A06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66053
HGNC: HGNC:9261
Homologene: 8643
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67958
Homologene: 13964
Celf1
Name: CUGBP, Elav-like family member 1
Synonyms: Brunol2, CUG-BP, D2Wsu101e, Cugbp1, 1600010O03Rik, CUG-BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13046
HGNC: HGNC:2549
Homologene: 134102
Cdkal1
Name: CDK5 regulatory subunit associated protein 1-like 1
Synonyms: 6620401C13Rik, 1190005B03Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68916
Homologene: 9830
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Itgb2
Name: integrin beta 2
Synonyms: Mac-1 beta, Cd18, 2E6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16414
HGNC: HGNC:6155
Homologene: 20092
Klf3
Name: Kruppel-like transcription factor 3 (basic)
Synonyms: Tef-2, Bklf, BKLF, 9930027G08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16599
Homologene: 7396
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67299
Homologene: 23566
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 58996
Homologene: 104145
Chn2
Name: chimerin 2
Synonyms: 1700026N20Rik, 4930557O16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69993
HGNC: HGNC:1944
Homologene: 31213
Gm7964
Name: predicted gene 7964
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 666170
Micu3
Name: mitochondrial calcium uptake family, member 3
Synonyms: Efha2, 2900075B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78506
Homologene: 15058
C3
Name: complement component 3
Synonyms: Plp, complement factor 3, acylation stimulating protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Polr2c
Name: polymerase (RNA) II (DNA directed) polypeptide C
Synonyms: Rpo2-3, RPB3, 33kDa, mRBP31
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20021
HGNC: HGNC:9189
Homologene: 2017
Vps51
Name: VPS51 GARP complex subunit
Synonyms: 3110057M17Rik, 1110014N23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68505
HGNC: HGNC:1172
Homologene: 34675
Ssh2
Name: slingshot protein phosphatase 2
Synonyms: SSH-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237860
Homologene: 14116
Dpy19l4
Name: dpy-19 like 4
Synonyms: LOC381510, Narg3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381510
Homologene: 18773
Mgl2
Name: macrophage galactose N-acetyl-galactosamine specific lectin 2
Synonyms: CD301b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216864
Homologene: 7836
Fgf10
Name: fibroblast growth factor 10
Synonyms: Gsfaey17, AEY17, FGF-10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14165
HGNC: HGNC:3666
Homologene: 3284
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E21Rik, Myospryn, 2310076E16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Slc35e1
Name: solute carrier family 35, member E1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270066
Homologene: 49075
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: Ugcgl, GlcT-1, Epcs21
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22234
Homologene: 37763
Zfp458
Name: zinc finger protein 458
Synonyms: Rslcan-7
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238690
VEGA: 13
Homologene: 128170
Slc27a2
Name: solute carrier family 27 (fatty acid transporter), member 2
Synonyms: Vlacs, FATP2, VLCS, Vlac, ACSVL1, FATP2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26458
Homologene: 37830
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5, mH1, SkM2, Nav1.5c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20271
Homologene: 22738
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 209012
Homologene: 41205
Slco1a4
Name: solute carrier organic anion transporter family, member 1a4
Synonyms: Slc21a5, Oatp1a4, Oatp2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28250
Homologene: 130782
Snx15
Name: sorting nexin 15
Synonyms: 1500032B08Rik, E130013C21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69024
Homologene: 12294
Pex6
Name: peroxisomal biogenesis factor 6
Synonyms: D130055I09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224824
HGNC: HGNC:8859
Homologene: 47914
Hoxb5
Name: homeobox B5
Synonyms: Hox-2.1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15413
HGNC: HGNC:5116
Homologene: 37585
Pla2g5
Name: phospholipase A2, group V
Synonyms: sPLA2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18784
HGNC: HGNC:9038
Homologene: 716
Urgcp
Name: upregulator of cell proliferation
Synonyms: 2010005J08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72046
Homologene: 69243
Ptpru
Name: protein tyrosine phosphatase receptor type U
Synonyms: RPTPlambda, Ptprl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: Sh3md4, 4831416G18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237353
Homologene: 77551
Or1ad6
Name: olfactory receptor family 1 subfamily AD member 6
Synonyms: GA_x6K02T2QP88-4469162-4468215, Olfr1378, MOR129-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258912
HGNC: HGNC:8182
Homologene: 133679
Rhot2
Name: ras homolog family member T2
Synonyms: Arht2, Miro2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214952
Homologene: 56038
Cplx4
Name: complexin 4
Synonyms: A930004D23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225644
VEGA: 18
Homologene: 17150
Ccer1
Name: coiled-coil glutamate-rich protein 1
Synonyms: 4921510H08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66716
VEGA: 10
Homologene: 49839
Ankdd1b
Name: ankyrin repeat and death domain containing 1B
Synonyms: 9330128J19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271144
Homologene: 19566
Zfp747l1
Name: zinc finger protein 747 like 1
Synonyms: 9130019O22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78921
Homologene: 118005
Gm4744
Name: predicted gene 4744
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194360
Pdia6
Name: protein disulfide isomerase associated 6
Synonyms: Txndc7, CaBP5, 1700015E05Rik, P5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71853
Homologene: 4198
Gm826
Name: predicted gene 826
Synonyms: Gm46773, LOC329554
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329554
Apol9b
Name: apolipoprotein L 9b
Synonyms: 2310016F22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71898
VEGA: 15
Homologene: 77567
Ddx3x
Name: DEAD box helicase 3, X-linked
Synonyms: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked, D1Pas1-rs2, embryonic RNA helicase, Fin14, Ddx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 13205
HGNC: HGNC:2745
Homologene: 3425
Gm6356
Name: predicted gene 6356
Type: Gene
Species: Mouse
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 155,953,204 bp
  • A to G, chromosome 2 at 41,408,223 bp
  • T to C, chromosome 2 at 90,998,648 bp
  • A to G, chromosome 2 at 126,567,798 bp
  • A to G, chromosome 2 at 160,327,245 bp
  • A to T, chromosome 2 at 160,721,522 bp
  • T to C, chromosome 4 at 11,276,868 bp
  • C to T, chromosome 4 at 59,207,798 bp
  • T to C, chromosome 4 at 88,816,727 bp
  • T to C, chromosome 4 at 98,970,829 bp
  • C to T, chromosome 4 at 131,808,424 bp
  • C to G, chromosome 4 at 138,801,435 bp
  • A to G, chromosome 5 at 64,827,217 bp
  • C to T, chromosome 6 at 40,949,326 bp
  • A to G, chromosome 6 at 54,290,411 bp
  • A to G, chromosome 6 at 141,839,631 bp
  • T to A, chromosome 7 at 83,756,130 bp
  • A to G, chromosome 7 at 127,384,863 bp
  • T to C, chromosome 8 at 40,335,800 bp
  • A to T, chromosome 8 at 72,491,870 bp
  • G to A, chromosome 8 at 94,860,300 bp
  • T to A, chromosome 8 at 111,889,881 bp
  • A to G, chromosome 9 at 95,493,697 bp
  • G to A, chromosome 9 at 119,552,076 bp
  • A to G, chromosome 9 at 121,263,700 bp
  • A to G, chromosome 10 at 58,984,191 bp
  • T to C, chromosome 10 at 77,549,968 bp
  • G to A, chromosome 10 at 97,694,552 bp
  • T to C, chromosome 11 at 5,717,000 bp
  • A to G, chromosome 11 at 50,969,558 bp
  • T to C, chromosome 11 at 70,135,833 bp
  • T to G, chromosome 11 at 77,327,510 bp
  • A to G, chromosome 11 at 96,303,969 bp
  • A to T, chromosome 11 at 97,476,106 bp
  • T to C, chromosome 12 at 17,270,456 bp
  • T to C, chromosome 13 at 29,552,403 bp
  • T to A, chromosome 13 at 67,257,482 bp
  • A to T, chromosome 13 at 93,096,693 bp
  • G to A, chromosome 13 at 96,441,666 bp
  • G to T, chromosome 13 at 118,781,547 bp
  • C to A, chromosome 14 at 6,971,774 bp
  • G to C, chromosome 15 at 77,404,396 bp
  • T to C, chromosome 16 at 17,109,668 bp
  • T to C, chromosome 17 at 25,840,547 bp
  • G to T, chromosome 17 at 46,724,385 bp
  • C to T, chromosome 17 at 57,205,303 bp
  • T to C, chromosome 18 at 65,969,927 bp
  • T to C, chromosome 19 at 6,076,348 bp
  • T to A, chromosome 19 at 6,123,954 bp
  • T to C, chromosome X at 13,290,569 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3769 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040746-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.