Strain Name:
C57BL/6J-MtgxR3769Btlr/Mmmh
Stock Number:
040746-MU
Citation ID:
RRID:MMRRC_040746-MU
Other Names:
R3769 (G1), C57BL/6J-MtgxR3769Btlr
Major Collection:

Gene Information

Top1
Name: topoisomerase (DNA) I
Synonyms: Top-1, D130064I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21969
Homologene: 2467
Chst5
Name: carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
Synonyms: I-GlcNAc6ST, GST-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56773
Homologene: 56927
Ppil2
Name: peptidylprolyl isomerase (cyclophilin)-like 2
Synonyms: C130078A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66053
HGNC: HGNC:9261
Homologene: 8643
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67958
Homologene: 13964
Celf1
Name: CUGBP, Elav-like family member 1
Synonyms: CUG-BP, Brunol2, D2Wsu101e, 1600010O03Rik, CUG-BP1, Cugbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13046
HGNC: HGNC:2549
Homologene: 134102
Cdkal1
Name: CDK5 regulatory subunit associated protein 1-like 1
Synonyms: 6620401C13Rik, 1190005B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68916
Homologene: 9830
Cep350
Name: centrosomal protein 350
Synonyms: 6430546F08Rik, 4933409L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74081
Homologene: 8879
Itgb2
Name: integrin beta 2
Synonyms: Mac-1 beta, 2E6, Cd18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16414
HGNC: HGNC:6155
Homologene: 20092
Klf3
Name: Kruppel-like factor 3 (basic)
Synonyms: Tef-2, BKLF, Bklf, 9930027G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16599
Homologene: 7396
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67299
Homologene: 23566
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 58996
Homologene: 104145
Chn2
Name: chimerin 2
Synonyms: 1700026N20Rik, 4930557O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69993
HGNC: HGNC:1944
Homologene: 31213
Gm7964
Name: predicted gene 7964
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 666170
Micu3
Name: mitochondrial calcium uptake family, member 3
Synonyms: 2900075B16Rik, Efha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78506
Homologene: 15058
C3
Name: complement component 3
Synonyms: complement factor 3, acylation stimulating protein, Plp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Polr2c
Name: polymerase (RNA) II (DNA directed) polypeptide C
Synonyms: mRBP31, 33kDa, Rpo2-3, RPB3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20021
HGNC: HGNC:9189
Homologene: 2017
Vps51
Name: VPS51 GARP complex subunit
Synonyms: 3110057M17Rik, 1110014N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68505
HGNC: HGNC:1172
Homologene: 34675
Ssh2
Name: slingshot protein phosphatase 2
Synonyms: SSH-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237860
Homologene: 14116
Dpy19l4
Name: dpy-19-like 4 (C. elegans)
Synonyms: LOC381510, Narg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381510
Homologene: 18773
Mgl2
Name: macrophage galactose N-acetyl-galactosamine specific lectin 2
Synonyms: CD301b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216864
Homologene: 7836
Fgf10
Name: fibroblast growth factor 10
Synonyms: FGF-10, AEY17, Gsfaey17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14165
HGNC: HGNC:3666
Homologene: 3284
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Slc35e1
Name: solute carrier family 35, member E1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270066
Homologene: 49075
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: GlcT-1, Epcs21, Ugcgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22234
Homologene: 37763
Zfp458
Name: zinc finger protein 458
Synonyms: Rslcan-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238690
VEGA: 13
Homologene: 128170
Slc27a2
Name: solute carrier family 27 (fatty acid transporter), member 2
Synonyms: FATP2, VLCS, FATP2, Vlacs, Vlac, ACSVL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26458
Homologene: 37830
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5c, Nav1.5, mH1, SkM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20271
Homologene: 22738
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209012
Homologene: 41205
Slco1a4
Name: solute carrier organic anion transporter family, member 1a4
Synonyms: Oatp2, Slc21a5, Oatp1a4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 28250
Homologene: 130782
Snx15
Name: sorting nexin 15
Synonyms: E130013C21Rik, 1500032B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69024
Homologene: 12294
Pex6
Name: peroxisomal biogenesis factor 6
Synonyms: D130055I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224824
HGNC: HGNC:8859
Homologene: 47914
Hoxb5
Name: homeobox B5
Synonyms: Hox-2.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15413
HGNC: HGNC:5116
Homologene: 37585
Pla2g5
Name: phospholipase A2, group V
Synonyms: sPLA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18784
HGNC: HGNC:9038
Homologene: 716
Urgcp
Name: upregulator of cell proliferation
Synonyms: 2010005J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72046
Homologene: 69243
Ptpru
Name: protein tyrosine phosphatase, receptor type, U
Synonyms: Ptprl, RPTPlambda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: 4831416G18Rik, Sh3md4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237353
Homologene: 77551
Olfr1378
Name: olfactory receptor 1378
Synonyms: GA_x6K02T2QP88-4469162-4468215, MOR129-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258912
Homologene: 133679
Rhot2
Name: ras homolog family member T2
Synonyms: Miro2, Arht2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 214952
Homologene: 56038
Cplx4
Name: complexin 4
Synonyms: A930004D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225644
VEGA: 18
Homologene: 17150
Ccer1
Name: coiled-coil glutamate-rich protein 1
Synonyms: 4921510H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66716
VEGA: 10
Homologene: 49839
Ifna7
Name: interferon alpha 7
Synonyms: Ifa7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15970
HGNC: HGNC:5425
Homologene: 68536
Ankdd1b
Name: ankyrin repeat and death domain containing 1B
Synonyms: 9330128J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 271144
Homologene: 19566
9130019O22Rik
Name: RIKEN cDNA 9130019O22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78921
Homologene: 118005
Gm4744
Name: predicted gene 4744
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194360
Pdia6
Name: protein disulfide isomerase associated 6
Synonyms: CaBP5, P5, 1700015E05Rik, Txndc7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71853
Homologene: 4198
Gm826
Name: predicted gene 826
Synonyms: LOC329554
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329554
Apol9b
Name: apolipoprotein L 9b
Synonyms: 2310016F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71898
VEGA: 15
Homologene: 77567
Ddx3x
Name: DEAD box helicase 3, X-linked
Synonyms: D1Pas1-rs2, embryonic RNA helicase, Ddx3, Fin14, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 13205
HGNC: HGNC:2745
Homologene: 3425
Gm6356
Name: predicted gene 6356
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 155,953,204 bp
  • A to G, chromosome 2 at 41,408,223 bp
  • T to C, chromosome 2 at 90,998,648 bp
  • A to G, chromosome 2 at 126,567,798 bp
  • A to G, chromosome 2 at 160,327,245 bp
  • A to T, chromosome 2 at 160,721,522 bp
  • T to C, chromosome 4 at 11,276,868 bp
  • C to T, chromosome 4 at 59,207,798 bp
  • T to C, chromosome 4 at 88,816,727 bp
  • T to C, chromosome 4 at 98,970,829 bp
  • C to T, chromosome 4 at 131,808,424 bp
  • C to G, chromosome 4 at 138,801,435 bp
  • A to G, chromosome 5 at 64,827,217 bp
  • C to T, chromosome 6 at 40,949,326 bp
  • A to G, chromosome 6 at 54,290,411 bp
  • A to G, chromosome 6 at 141,839,631 bp
  • T to A, chromosome 7 at 83,756,130 bp
  • A to G, chromosome 7 at 127,384,863 bp
  • T to C, chromosome 8 at 40,335,800 bp
  • A to T, chromosome 8 at 72,491,870 bp
  • G to A, chromosome 8 at 94,860,300 bp
  • T to A, chromosome 8 at 111,889,881 bp
  • A to G, chromosome 9 at 95,493,697 bp
  • G to A, chromosome 9 at 119,552,076 bp
  • A to G, chromosome 9 at 121,263,700 bp
  • A to G, chromosome 10 at 58,984,191 bp
  • T to C, chromosome 10 at 77,549,968 bp
  • G to A, chromosome 10 at 97,694,552 bp
  • T to C, chromosome 11 at 5,717,000 bp
  • A to G, chromosome 11 at 50,969,558 bp
  • T to C, chromosome 11 at 70,135,833 bp
  • T to G, chromosome 11 at 77,327,510 bp
  • A to G, chromosome 11 at 96,303,969 bp
  • A to T, chromosome 11 at 97,476,106 bp
  • T to C, chromosome 12 at 17,270,456 bp
  • T to C, chromosome 13 at 29,552,403 bp
  • T to A, chromosome 13 at 67,257,482 bp
  • A to T, chromosome 13 at 93,096,693 bp
  • G to A, chromosome 13 at 96,441,666 bp
  • G to T, chromosome 13 at 118,781,547 bp
  • C to A, chromosome 14 at 6,971,774 bp
  • G to C, chromosome 15 at 77,404,396 bp
  • T to C, chromosome 16 at 17,109,668 bp
  • T to C, chromosome 17 at 25,840,547 bp
  • G to T, chromosome 17 at 46,724,385 bp
  • C to T, chromosome 17 at 57,205,303 bp
  • T to C, chromosome 18 at 65,969,927 bp
  • T to C, chromosome 19 at 6,076,348 bp
  • T to A, chromosome 19 at 6,123,954 bp
  • T to C, chromosome X at 13,290,569 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3769 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040746-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.