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Strain Name:
C57BL/6J-MtgxR3778Btlr/Mmmh
Stock Number:
040750-MU
Citation ID:
RRID:MMRRC_040750-MU
Other Names:
R3778 (G1), C57BL/6J-MtgxR3778Btlr
Major Collection:

Strain Information

Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Ncoa7
Name: nuclear receptor coactivator 7
Synonyms: 9030406N13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 211329
VEGA: 10
Homologene: 65245
Ppm1e
Name: protein phosphatase 1E (PP2C domain containing)
Synonyms: PP2CH, POPX1, B930008A12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320472
Homologene: 22848
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Zfhx3
Name: zinc finger homeobox 3
Synonyms: WBP9, A230102L03Rik, Atbf1, Sci
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Ppfibp2
Name: PTPRF interacting protein, binding protein 2 (liprin beta 2)
Synonyms: liprin beta 2, Cclp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19024
HGNC: HGNC:9250
Homologene: 7486
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, D630048A14Rik, Ki67
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Slc12a3
Name: solute carrier family 12, member 3
Synonyms: NCC, TSC
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20497
Homologene: 287
Gls
Name: glutaminase
Synonyms: B230365M23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14660
HGNC: HGNC:4331
Homologene: 22726
Trappc10
Name: trafficking protein particle complex 10
Synonyms: LOC380642, B230307C21Rik, Tmem1, b2b2613Clo, b2b2416Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216131
VEGA: 10
Homologene: 37751
Fhip1b
Name: FHF complex subunit HOOK interacting protein 1B
Synonyms: 4632419K20Rik, 6530415H11Rik, Fam160a2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74349
Homologene: 75329
Mei1
Name: meiotic double-stranded break formation protein 1
Synonyms: mei1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74369
Homologene: 46535
Apc
Name: APC, WNT signaling pathway regulator
Synonyms: Min, CC1, adenomatosis polyposis coli
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11789
HGNC: HGNC:583
Homologene: 30950
Cdc37
Name: cell division cycle 37
Synonyms: p50Cdc37
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12539
VEGA: 9
HGNC: HGNC:1735
Homologene: 38268
Chd1l
Name: chromodomain helicase DNA binding protein 1-like
Synonyms: Snf2p, 4432404A22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68058
HGNC: HGNC:1916
Homologene: 11590
Pard6g
Name: par-6 family cell polarity regulator gamma
Synonyms: 2410049N21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93737
VEGA: 18
Homologene: 36487
Pask
Name: PAS domain containing serine/threonine kinase
Synonyms: Paskin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269224
Homologene: 9038
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: Trrp7, LTRPC2, TRPC7, 9830168K16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28240
Homologene: 20709
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Itpr-3, Ip3r3, tf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Sp8
Name: trans-acting transcription factor 8
Synonyms: mBtd, D930049B17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320145
VEGA: 12
Homologene: 18548
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Pax9
Name: paired box 9
Synonyms: Pax-9
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18511
HGNC: HGNC:8623
Homologene: 31360
Sec24c
Name: SEC24 homolog C, COPII coat complex component
Synonyms: 2610204K03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218811
VEGA: 14
Homologene: 3615
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: PRIP, ASC2, RAP250, AIB3, NRC, ASC-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56406
Homologene: 137337
Gm872
Name: predicted gene 872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Nalcn
Name: sodium leak channel, non-selective
Synonyms: A530023G15Rik, Vgcnl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Slc66a1
Name: solute carrier family 66 member 1
Synonyms: Pqlc2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212555
Homologene: 56784
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-2, Aox-1, Aox2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
H1f8
Name: H1.8 linker histone
Synonyms: H1oo, H1foo, H1-8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171506
Homologene: 51377
Or5p52
Name: olfactory receptor family 5 subfamily P member 52
Synonyms: GA_x6K02T2PBJ9-10231953-10232885, MOR204-5, Olfr472
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258770
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Col22a1
Name: collagen, type XXII, alpha 1
Synonyms: C80743, 2310067L16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69700
Homologene: 43567
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Shcbp1
Name: Shc SH2-domain binding protein 1
Synonyms: mPAL
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20419
Homologene: 32123
Nuggc
Name: nuclear GTPase, germinal center associated
Synonyms: LOC239151, SLIP-GC, Gm600
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100503545
Homologene: 72641
Aldh1a7
Name: aldehyde dehydrogenase family 1, subfamily A7
Synonyms: Aldh-pb, Ahd2-like
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26358
HGNC: HGNC:402
Homologene: 137245
Ankfn1
Name: ankyrin-repeat and fibronectin type III domain containing 1
Synonyms: LOC382543, 4932411E22Rik, nmf9, mWAKE
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 382543
Homologene: 34996
Tmc1
Name: transmembrane channel-like gene family 1
Synonyms: Bth, Beethoven, 4933416G09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13409
VEGA: 19
Homologene: 23670
Zfp229
Name: zinc finger protein 229
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381067
Homologene: 136287
Pgbd5
Name: piggyBac transposable element derived 5
Synonyms: 2900019M05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 209966
Homologene: 11583
Tle6
Name: transducin-like enhancer of split 6
Synonyms: Grg6, 1810057E06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 114606
Homologene: 11701
Hif1an
Name: hypoxia-inducible factor 1, alpha subunit inhibitor
Synonyms: FIH, A830014H24Rik, 2310046M24Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319594
Homologene: 9906
Erp27
Name: endoplasmic reticulum protein 27
Synonyms: 1810047B09Rik, 1810033M07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69187
Homologene: 12303
Gm4871
Name: predicted gene 4871
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231885
Homologene: 86127
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, potassium channel Kv4.3L, Kv4.3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Tmem235
Name: transmembrane protein 235
Synonyms: Tmem235, Gm12581, Cldn27
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 546519
Homologene: 53069
Vat1l
Name: vesicle amine transport protein 1 like
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270097
Homologene: 10855
Man2b2
Name: mannosidase 2, alpha B2
Synonyms: 135 kDa alpha-D-mannosidase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17160
Homologene: 7411
Sirt5
Name: sirtuin 5
Synonyms: 0610012J09Rik, 1500032M05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68346
VEGA: 13
Homologene: 40825
CT485612.2
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Or10c1
Name: olfactory receptor family 10 subfamily C member 1
Synonyms: MOR263-6, GA_x6K02T2PSCP-1651760-1650822, Olfr95
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258506
HGNC: HGNC:8165
Homologene: 71990
AC122511.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Rsph14
Name: radial spoke head homolog 14 (Chlamydomonas)
Synonyms: 4933431K05Rik, Rtdr1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71236
Homologene: 49382
AC122012.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Hadha
Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Synonyms: Mtpa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 97212
HGNC: HGNC:4801
Homologene: 152
Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Synonyms: Cyp2e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13106
HGNC: HGNC:2631
Homologene: 68089
Wnt6
Name: wingless-type MMTV integration site family, member 6
Synonyms: Wnt-6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22420
Homologene: 4756
Fscn3
Name: fascin actin-bundling protein 3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56223
HGNC: HGNC:3961
Homologene: 10475
Hsfy2
Name: heat shock transcription factor, Y-linked 2
Synonyms: 4933413G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71066
Homologene: 134090
Fbxl22
Name: F-box and leucine-rich repeat protein 22
Synonyms: 1110004B15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74165
VEGA: 9
Homologene: 35275
Gm14569
Name: predicted gene 14569
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 101055983
Homologene: 141085
Gp9
Name: glycoprotein 9 platelet
Synonyms: GPIX, Cd42
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54368
HGNC: HGNC:4444
Homologene: 144
Prxl2a
Name: peroxiredoxin like 2A
Synonyms: 5730469M10Rik, Adrx, Adiporedoxin, Fam213a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70564
Homologene: 12356
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 52,168,912 bp
  • A to T, chromosome 1 at 56,636,688 bp
  • A to C, chromosome 1 at 58,053,703 bp
  • A to C, chromosome 1 at 74,782,782 bp
  • T to A, chromosome 1 at 93,327,467 bp
  • A to T, chromosome 1 at 150,802,824 bp
  • A to T, chromosome 2 at 69,509,204 bp
  • C to T, chromosome 2 at 125,317,086 bp
  • A to G, chromosome 2 at 155,421,195 bp
  • A to G, chromosome 3 at 97,566,833 bp
  • T to C, chromosome 3 at 98,146,623 bp
  • A to G, chromosome 3 at 104,457,961 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • T to C, chromosome 4 at 139,298,982 bp
  • A to T, chromosome 5 at 30,120,129 bp
  • T to C, chromosome 5 at 36,815,527 bp
  • A to G, chromosome 5 at 59,054,311 bp
  • A to G, chromosome 5 at 145,030,083 bp
  • A to C, chromosome 6 at 4,524,570 bp
  • A to C, chromosome 6 at 28,430,032 bp
  • A to T, chromosome 6 at 87,779,005 bp
  • T to C, chromosome 6 at 115,949,747 bp
  • A to T, chromosome 6 at 136,919,903 bp
  • A to T, chromosome 6 at 139,622,387 bp
  • T to A, chromosome 7 at 105,388,228 bp
  • A to G, chromosome 7 at 107,729,189 bp
  • C to A, chromosome 7 at 107,902,747 bp
  • A to C, chromosome 7 at 135,696,130 bp
  • T to C, chromosome 7 at 140,763,909 bp
  • A to T, chromosome 8 at 4,736,295 bp
  • T to A, chromosome 8 at 82,041,992 bp
  • C to T, chromosome 8 at 94,339,778 bp
  • C to T, chromosome 8 at 108,914,519 bp
  • T to C, chromosome 8 at 114,236,800 bp
  • T to A, chromosome 8 at 124,374,457 bp
  • C to A, chromosome 9 at 21,149,743 bp
  • T to A, chromosome 9 at 66,514,211 bp
  • A to G, chromosome 10 at 30,689,756 bp
  • G to A, chromosome 10 at 73,947,151 bp
  • C to G, chromosome 10 at 74,957,587 bp
  • T to G, chromosome 10 at 74,957,588 bp
  • A to C, chromosome 10 at 77,935,990 bp
  • A to G, chromosome 10 at 78,200,802 bp
  • G to T, chromosome 10 at 81,596,153 bp
  • C to T, chromosome 10 at 92,904,344 bp
  • T to C, chromosome 11 at 87,248,928 bp
  • G to T, chromosome 11 at 89,441,394 bp
  • A to T, chromosome 11 at 117,862,300 bp
  • A to G, chromosome 12 at 56,696,748 bp
  • A to T, chromosome 12 at 88,285,671 bp
  • G to T, chromosome 12 at 118,849,015 bp
  • A to G, chromosome 13 at 43,383,107 bp
  • G to A, chromosome 14 at 7,915,353 bp
  • A to G, chromosome 14 at 20,683,307 bp
  • T to C, chromosome 14 at 41,002,422 bp
  • T to C, chromosome 14 at 65,610,048 bp
  • T to A, chromosome 14 at 103,197,285 bp
  • G to A, chromosome 14 at 123,464,716 bp
  • A to T, chromosome 15 at 64,746,997 bp
  • A to T, chromosome 15 at 71,973,692 bp
  • T to C, chromosome 15 at 82,082,008 bp
  • C to T, chromosome 16 at 26,371,466 bp
  • A to T, chromosome 17 at 21,745,202 bp
  • A to G, chromosome 17 at 27,095,472 bp
  • T to C, chromosome 17 at 37,211,758 bp
  • T to A, chromosome 18 at 10,469,444 bp
  • A to G, chromosome 18 at 34,313,081 bp
  • A to T, chromosome 18 at 80,079,823 bp
  • A to T, chromosome 19 at 20,719,311 bp
  • A to G, chromosome 19 at 20,913,491 bp
  • A to G, chromosome 19 at 44,569,408 bp
  • T to A, chromosome X at 36,432,432 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3778 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040750-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.