Strain Name:
C57BL/6J-MtgxR3787Btlr/Mmmh
Stock Number:
040754-MU
Citation ID:
RRID:MMRRC_040754-MU
Other Names:
R3787 (G1), C57BL/6J-MtgxR3787Btlr
Major Collection:

Strain Information

Sall4
Name: spalt like transcription factor 4
Synonyms: Tex20, 5730441M18Rik, C330011P20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99377
Homologene: 10716
Neurod1
Name: neurogenic differentiation 1
Synonyms: Neurod, Nd1, bHLHa3, BETA2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18012
HGNC: HGNC:7762
Homologene: 1871
Thbs4
Name: thrombospondin 4
Synonyms: TSP-4, TSP4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21828
Homologene: 20691
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Pmepa1
Name: prostate transmembrane protein, androgen induced 1
Synonyms: N4wbp4, STAG1, PMEPA1, Tmepai, 2210418I02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65112
Homologene: 10608
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 9030227G01Rik, 2510002A14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Inpp5k
Name: inositol polyphosphate 5-phosphatase K
Synonyms: C62, Pps, putative PI-5-phosphatase, PI-5-phosphatase related
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19062
Homologene: 75059
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: Alp145, 140kDa, RFC140, Recc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Exo1
Name: exonuclease 1
Synonyms: 5730442G03Rik, Msa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26909
HGNC: HGNC:3511
Homologene: 31352
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki67, Ki-67, D630048A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Xdh
Name: xanthine dehydrogenase
Synonyms: XO, Xox1, Xor, Xox-1, xanthine oxidase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Wap
Name: whey acidic protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22373
Homologene: 137242
Dnaja2
Name: DnaJ heat shock protein family (Hsp40) member A2
Synonyms: 1500017M13Rik, DNJ3, PRO3015, HIRIP4, 2010206B19Rik, mDj3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56445
Homologene: 21193
Txnl4b
Name: thioredoxin-like 4B
Synonyms: Dim2, D530025J19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234723
Homologene: 9880
Nfs1
Name: nitrogen fixation gene 1 (S. cerevisiae)
Synonyms: m-Nfs1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18041
Homologene: 5463
3110082I17Rik
Name: RIKEN cDNA 3110082I17 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73212
Homologene: 49901
Prdm15
Name: PR domain containing 15
Synonyms: Zfp298, E130018M06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 114604
Homologene: 56941
Ccdc138
Name: coiled-coil domain containing 138
Synonyms: 6230424H07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76138
VEGA: 10
Homologene: 44912
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Aprt
Name: adenine phosphoribosyl transferase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11821
HGNC: HGNC:626
Homologene: 413
Rala
Name: v-ral simian leukemia viral oncogene A (ras related)
Synonyms: 3010001O15Rik, Ral, Rasl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56044
HGNC: HGNC:9839
Homologene: 3942
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: Mcmdc1, 9030408O17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71567
VEGA: 10
Homologene: 13546
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Cul4a
Name: cullin 4A
Synonyms: 2810470J21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 99375
HGNC: HGNC:2554
Homologene: 81724
Ppp1r12c
Name: protein phosphatase 1, regulatory subunit 12C
Synonyms: Mbs85, 2410197A17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232807
Homologene: 75071
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Myo15a
Name: myosin XVA
Synonyms: Myo15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Tns2
Name: tensin 2
Synonyms: nep, nph, Tenc1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 209039
VEGA: 15
Homologene: 37077
Chsy3
Name: chondroitin sulfate synthase 3
Synonyms: 4833446K15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 78923
VEGA: 18
Homologene: 28624
Txndc11
Name: thioredoxin domain containing 11
Synonyms: Txdc11, EFP1, 2810408E11Rik, EF-hand binding protein 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106200
Homologene: 9301
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: S-SCAM, Acvrinp1, Magi-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50791
Homologene: 8189
Stab2
Name: stabilin 2
Synonyms: FEEL-2, STAB-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 192188
Homologene: 23022
Tro
Name: trophinin
Synonyms: Maged3, magphinin-gamma, Maged3l, magphinin-beta 2, magphinin, Trol, necdin and trophinin like, magphinin-alpha, Tnn, trophinin-2
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 56191
Homologene: 75113
Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Synonyms: Care2, mCAR, MB67, ESTM32, CAR, CAR1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12355
HGNC: HGNC:7969
Homologene: 3759
Carmil3
Name: capping protein regulator and myosin 1 linker 3
Synonyms: Lrrc16b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268747
VEGA: 14
Homologene: 74564
Mtpap
Name: mitochondrial poly(A) polymerase
Synonyms: 0610027A18Rik, Papd1, Tent6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67440
VEGA: 18
Homologene: 10008
Auh
Name: AU RNA binding protein/enoyl-coenzyme A hydratase
Synonyms: W91705
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11992
HGNC: HGNC:890
Homologene: 1284
Slc5a3
Name: solute carrier family 5 (inositol transporters), member 3
Synonyms: Smit1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 53881
Homologene: 31412
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D3Bwg1078e, D130016K21Rik, 9430063L05Rik, Usmg4, 4732458A06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: 1600012D06Rik, Abp1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Abcd4
Name: ATP-binding cassette, sub-family D member 4
Synonyms: P69r, Pxmp1l
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19300
VEGA: 12
HGNC: HGNC:68
Homologene: 3703
Vmn1r63
Name: vomeronasal 1 receptor 63
Synonyms: V1rd1, V1R1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81017
Homologene: 41799
Dennd3
Name: DENN domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105841
Homologene: 28254
Or8g32
Name: olfactory receptor family 8 subfamily G member 32
Synonyms: Olfr951, GA_x6K02T2PVTD-33090395-33091330, MOR171-49, MOR171-33P
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258046
VEGA: 9
HGNC: HGNC:8484
Homologene: 71961
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628422
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244668
Homologene: 18956
Fmo1
Name: flavin containing monooxygenase 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14261
HGNC: HGNC:3769
Homologene: 55520
Ttbk2
Name: tau tubulin kinase 2
Synonyms: 2610507N02Rik, B930008N24Rik, TTK
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140810
Homologene: 62795
Tekt1
Name: tektin 1
Synonyms: MT14
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21689
Homologene: 7973
Ccdc112
Name: coiled-coil domain containing 112
Synonyms: 8430438M01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240261
VEGA: 18
Homologene: 17617
Gc
Name: vitamin D binding protein
Synonyms: DBP, vitamin D binding protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14473
HGNC: HGNC:4187
Homologene: 486
Bmp4
Name: bone morphogenetic protein 4
Synonyms: Bmp-4, Bmp2b, Bmp2b1, Bmp2b-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12159
HGNC: HGNC:1071
Homologene: 7247
Gpt2
Name: glutamic pyruvate transaminase (alanine aminotransferase) 2
Synonyms: ALT2, 4631422C05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108682
Homologene: 68832
Or13a28
Name: olfactory receptor family 13 subfamily A member 28
Synonyms: IH7, GA_x6K02T2PBJ9-42783826-42784758, Olfr61, MOR253-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18362
Homologene: 79374
Slc4a1ap
Name: solute carrier family 4 (anion exchanger), member 1, adaptor protein
Synonyms: kanadaptin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20534
Homologene: 7543
Reep1
Name: receptor accessory protein 1
Synonyms: D6Ertd253e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52250
Homologene: 41504
Nsa2
Name: NSA2 ribosome biogenesis homolog
Synonyms: Yr29, LNR42, 5730427N09Rik, Nsa2p
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59050
VEGA: 13
Homologene: 5844
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 162,830,014 bp
  • A to G, chromosome 1 at 171,214,425 bp
  • A to G, chromosome 1 at 175,899,469 bp
  • A to G, chromosome 1 at 194,643,934 bp
  • A to T, chromosome 2 at 66,328,553 bp
  • T to A, chromosome 2 at 79,454,595 bp
  • A to T, chromosome 2 at 120,773,815 bp
  • A to G, chromosome 2 at 156,128,583 bp
  • A to G, chromosome 2 at 168,756,123 bp
  • G to A, chromosome 2 at 173,228,133 bp
  • G to T, chromosome 3 at 97,715,552 bp
  • C to T, chromosome 5 at 20,465,909 bp
  • T to A, chromosome 5 at 31,528,139 bp
  • A to T, chromosome 5 at 65,296,014 bp
  • T to C, chromosome 5 at 73,101,476 bp
  • A to C, chromosome 5 at 89,439,523 bp
  • T to A, chromosome 5 at 95,482,897 bp
  • G to T, chromosome 5 at 139,455,442 bp
  • T to C, chromosome 6 at 48,905,655 bp
  • T to A, chromosome 6 at 71,795,215 bp
  • T to G, chromosome 6 at 113,565,204 bp
  • G to A, chromosome 7 at 4,486,584 bp
  • T to A, chromosome 7 at 5,802,752 bp
  • C to T, chromosome 7 at 41,864,074 bp
  • A to T, chromosome 7 at 135,700,283 bp
  • G to A, chromosome 7 at 140,637,835 bp
  • T to C, chromosome 8 at 13,133,668 bp
  • G to T, chromosome 8 at 85,525,573 bp
  • C to T, chromosome 8 at 85,540,386 bp
  • C to T, chromosome 8 at 109,572,777 bp
  • T to C, chromosome 8 at 122,575,529 bp
  • C to T, chromosome 8 at 125,423,205 bp
  • C to A, chromosome 8 at 125,450,383 bp
  • T to C, chromosome 9 at 39,394,382 bp
  • T to C, chromosome 9 at 54,369,878 bp
  • T to A, chromosome 10 at 39,846,210 bp
  • A to G, chromosome 10 at 53,615,980 bp
  • T to C, chromosome 10 at 58,538,270 bp
  • T to A, chromosome 10 at 86,969,277 bp
  • G to A, chromosome 11 at 6,638,550 bp
  • A to T, chromosome 11 at 60,477,572 bp
  • A to G, chromosome 11 at 72,344,894 bp
  • T to C, chromosome 11 at 75,647,686 bp
  • T to C, chromosome 11 at 84,001,920 bp
  • C to A, chromosome 11 at 107,073,827 bp
  • A to G, chromosome 12 at 84,605,042 bp
  • G to T, chromosome 13 at 12,434,460 bp
  • T to A, chromosome 13 at 17,882,446 bp
  • C to A, chromosome 13 at 52,929,457 bp
  • T to C, chromosome 13 at 92,773,164 bp
  • G to T, chromosome 13 at 97,135,534 bp
  • C to T, chromosome 14 at 46,385,714 bp
  • T to C, chromosome 14 at 55,496,976 bp
  • T to C, chromosome 15 at 73,547,577 bp
  • T to C, chromosome 15 at 102,110,606 bp
  • T to C, chromosome 16 at 11,084,321 bp
  • A to G, chromosome 16 at 92,077,928 bp
  • G to T, chromosome 16 at 97,797,745 bp
  • A to G, chromosome 17 at 30,755,041 bp
  • C to T, chromosome 17 at 73,893,595 bp
  • T to C, chromosome 18 at 4,380,670 bp
  • C to T, chromosome 18 at 46,299,298 bp
  • G to A, chromosome 18 at 49,865,122 bp
  • T to C, chromosome 18 at 59,408,998 bp
  • G to A, chromosome X at 150,655,052 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3787 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040754-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.