Strain Name:
C57BL/6J-MtgxR3815Btlr/Mmmh
Stock Number:
040770-MU
Citation ID:
RRID:MMRRC_040770-MU
Other Names:
R3815 (G1), C57BL/6J-MtgxR3815Btlr
Major Collection:

Strain Information

Apobec3
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
Synonyms: Rfv3, Rfv-3, Gm20117, CEM15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 80287
Homologene: 105420
Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Arl8b
Name: ADP-ribosylation factor-like 8B
Synonyms: Arl10c, 2610313E07Rik, 3100002J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67166
Homologene: 10056
Hmgcr
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: HMG-CoAR, Red, 3-hydroxy-3-methylglutaryl-CoA reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15357
HGNC: HGNC:5006
Homologene: 30994
Luc7l2
Name: LUC7-like 2 (S. cerevisiae)
Synonyms: CGI-59, 4930471C18Rik, CGI-74
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 192196
Homologene: 56737
Smad1
Name: SMAD family member 1
Synonyms: Madr1, Madh1, Smad 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17125
HGNC: HGNC:6767
Homologene: 21196
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: b2b327Clo, A630086P08Rik, opm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Senp1
Name: SUMO1/sentrin specific peptidase 1
Synonyms: E330036L07Rik, 2310046A20Rik, D15Ertd528e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223870
Homologene: 8731
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
Cul5
Name: cullin 5
Synonyms: C330021I08Rik, VACM-1, 4921514I20Rik, 8430423K24Rik, C030032G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Ecel1
Name: endothelin converting enzyme-like 1
Synonyms: DINE, XCE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13599
HGNC: HGNC:3147
Homologene: 3549
Sfrp5
Name: secreted frizzled-related sequence protein 5
Synonyms: SARP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 54612
Homologene: 2268
Coq5
Name: coenzyme Q5 methyltransferase
Synonyms: D5Ertd33e, 1810014G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52064
Homologene: 6559
Aak1
Name: AP2 associated kinase 1
Synonyms: D6Ertd245e, 5530400K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269774
Homologene: 128746
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, 2900010L19Rik, mSorLA, Sorla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
Med6
Name: mediator complex subunit 6
Synonyms: 1500012F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69792
Homologene: 3990
Palld
Name: palladin, cytoskeletal associated protein
Synonyms: 2410003B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72333
Homologene: 75052
AW554918
Name: expressed sequence AW554918
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225289
Homologene: 52652
Nav1
Name: neuron navigator 1
Synonyms: unc53H1, steerin-1, 9930003A20Rik, C230080M11Rik, POMFIL3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215690
Homologene: 10719
Pomgnt1
Name: protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase
Synonyms: 0610016I07Rik, 4930467B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68273
Homologene: 9806
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, skrr, Ryr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Mamstr
Name: MEF2 activating motif and SAP domain containing transcriptional regulator
Synonyms: MASTR, 2810022D01Rik, 5430432N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74490
Homologene: 77700
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Ttn
Name: titin
Synonyms: L56, 1100001C23Rik, D330041I19Rik, 2310057K23Rik, D830007G01Rik, 2310074I15Rik, 2310036G12Rik, mdm, connectin, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pcdhb4
Name: protocadherin beta 4
Synonyms: PcdhbD, Pcdhb5A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93875
HGNC: HGNC:8690
Homologene: 62176
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Gen1
Name: GEN1, Holliday junction 5' flap endonuclease
Synonyms: 5830483C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 209334
VEGA: 12
Homologene: 35313
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Ppp1r9b
Name: protein phosphatase 1, regulatory subunit 9B
Synonyms: neurabin II, spinophilin, Spn, SPL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217124
HGNC: HGNC:9298
Homologene: 32787
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21974
Homologene: 134711
Myo1a
Name: myosin IA
Synonyms: Myhl, brush border myosin 1, BBM-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432516
VEGA: 10
HGNC: HGNC:7595
Homologene: 21113
Mypn
Name: myopalladin
Synonyms: 1110056A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68802
VEGA: 10
Homologene: 23778
Ces1e
Name: carboxylesterase 1E
Synonyms: egasyn, Es-22, Eg, Es22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13897
HGNC: HGNC:1863
Homologene: 115660
Rgma
Name: repulsive guidance molecule family member A
Synonyms: RGM domain family, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244058
Homologene: 10626
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: Pycs, 2810433K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Krt82
Name: keratin 82
Synonyms: Krt2-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 114566
VEGA: 15
HGNC: HGNC:6459
Homologene: 13200
Ankrd6
Name: ankyrin repeat domain 6
Synonyms: diversin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 140577
Homologene: 8967
Cyp4a12b
Name: cytochrome P450, family 4, subfamily a, polypeptide 12B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13118
Homologene: 134044
Or8b40
Name: olfactory receptor family 8 subfamily B member 40
Synonyms: GA_x6K02T2PVTD-31795028-31795957, Olfr889, MOR162-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258475
Homologene: 138311
Ift88
Name: intraflagellar transport 88
Synonyms: polaris, Ttc10, Tg737Rpw, IFT88, Tg737, orpk, Oak Ridge polycystic kidneys, fxo, TgN737Rpw
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21821
Homologene: 4761
Fbxw5
Name: F-box and WD-40 domain protein 5
Synonyms: Fbw5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 30839
Homologene: 8496
Spire1
Name: spire type actin nucleation factor 1
Synonyms: Spir-1, 6030430B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 68166
VEGA: 18
Homologene: 35507
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3L, potassium channel Kv4.3M, Kv4.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Or5b104
Name: olfactory receptor family 5 subfamily B member 104
Synonyms: Olfr1457, GA_x6K02T2RE5P-3423041-3422097, MOR202-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258568
HGNC: HGNC:8324
Homologene: 133676
Cd177
Name: CD177 antigen
Synonyms: Pdp3, 1190003K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68891
Homologene: 49628
Dedd
Name: death effector domain-containing
Synonyms: DEFT, Dedpro1, FLDED1, CASP8IP1, KE05
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21945
HGNC: HGNC:2755
Homologene: 7980
Flacc1
Name: flagellum associated containing coiled-coil domains 1
Synonyms: Als2cr12, 4933425F06Rik, 4933405P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108812
Homologene: 51399
Ly9
Name: lymphocyte antigen 9
Synonyms: T100, Lgp100, CD229, SLAMF3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Kcna1
Name: potassium voltage-gated channel, shaker-related subfamily, member 1
Synonyms: mceph, MBK1, Mk-1, mouse brain potassium channel protein-1, Shak, Kv1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16485
HGNC: HGNC:6218
Homologene: 183
Ptgds
Name: prostaglandin D2 synthase (brain)
Synonyms: Ptgs3, L-PGDS, PGD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19215
HGNC: HGNC:9592
Homologene: 737
Cfap90
Name: cilia and flagella associated protein 90
Synonyms: 1700001L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69315
VEGA: 13
Homologene: 28246
Or8b12c
Name: olfactory receptor family 8 subfamily B member 12C
Synonyms: GA_x6K02T2PVTD-31489645-31490577, Olfr876, MOR161-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258883
Homologene: 74154
Cdca7l
Name: cell division cycle associated 7 like
Synonyms: JPO2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217946
Homologene: 10285
Rhobtb1
Name: Rho-related BTB domain containing 1
Synonyms: 3110048G13Rik, 1700008H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69288
Homologene: 8892
Or8b55
Name: olfactory receptor family 8 subfamily B member 55
Synonyms: GA_x6K02T2PVTD-32518237-32519172, MOR161-3, Olfr922
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258777
VEGA: 9
Homologene: 27262
Gm11077
Name: predicted gene 11077
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Rarres1
Name: retinoic acid receptor responder (tazarotene induced) 1
Synonyms: 5430417P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109222
HGNC: HGNC:9867
Homologene: 2166
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 58,659,005 bp
  • A to G, chromosome 1 at 87,152,900 bp
  • C to A, chromosome 1 at 135,471,124 bp
  • A to G, chromosome 1 at 171,338,901 bp
  • G to T, chromosome 1 at 171,589,085 bp
  • G to T, chromosome 2 at 25,468,820 bp
  • A to T, chromosome 2 at 25,503,564 bp
  • T to A, chromosome 2 at 76,721,733 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • T to A, chromosome 3 at 67,515,321 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • A to C, chromosome 4 at 32,806,206 bp
  • A to G, chromosome 4 at 113,629,122 bp
  • G to A, chromosome 4 at 113,846,299 bp
  • A to T, chromosome 4 at 115,432,470 bp
  • T to A, chromosome 4 at 116,153,942 bp
  • T to C, chromosome 5 at 21,997,875 bp
  • T to G, chromosome 5 at 115,295,898 bp
  • T to C, chromosome 6 at 38,570,591 bp
  • T to C, chromosome 6 at 86,959,042 bp
  • T to A, chromosome 6 at 108,813,697 bp
  • T to C, chromosome 6 at 126,643,046 bp
  • T to G, chromosome 6 at 140,729,315 bp
  • A to G, chromosome 7 at 24,754,392 bp
  • A to T, chromosome 7 at 29,072,902 bp
  • G to T, chromosome 7 at 45,644,532 bp
  • T to C, chromosome 7 at 73,409,758 bp
  • C to T, chromosome 8 at 16,002,522 bp
  • T to A, chromosome 8 at 61,549,837 bp
  • G to A, chromosome 8 at 79,343,730 bp
  • A to G, chromosome 8 at 93,201,839 bp
  • C to T, chromosome 9 at 37,804,169 bp
  • A to T, chromosome 9 at 38,116,626 bp
  • A to G, chromosome 9 at 38,816,426 bp
  • A to G, chromosome 9 at 42,064,049 bp
  • T to A, chromosome 9 at 53,622,943 bp
  • A to G, chromosome 10 at 63,147,868 bp
  • A to G, chromosome 10 at 69,285,693 bp
  • C to T, chromosome 10 at 127,707,428 bp
  • A to T, chromosome 11 at 94,992,533 bp
  • A to T, chromosome 12 at 11,252,033 bp
  • T to C, chromosome 12 at 51,785,969 bp
  • C to T, chromosome 12 at 81,589,085 bp
  • G to A, chromosome 12 at 117,872,213 bp
  • A to G, chromosome 13 at 68,611,225 bp
  • T to C, chromosome 13 at 96,663,017 bp
  • T to G, chromosome 14 at 16,409,189 bp
  • T to C, chromosome 14 at 50,868,315 bp
  • A to T, chromosome 14 at 57,440,981 bp
  • A to C, chromosome 15 at 53,345,089 bp
  • A to G, chromosome 15 at 76,601,149 bp
  • G to T, chromosome 15 at 79,899,100 bp
  • A to C, chromosome 15 at 98,056,832 bp
  • A to G, chromosome 15 at 101,550,600 bp
  • C to T, chromosome 18 at 25,400,047 bp
  • A to T, chromosome 18 at 37,308,012 bp
  • G to T, chromosome 18 at 67,506,663 bp
  • T to C, chromosome 19 at 13,094,913 bp
  • A to G, chromosome 19 at 40,570,500 bp
  • C to T, chromosome 19 at 42,198,791 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3815 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040770-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.