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Strain Name:
C57BL/6J-MtgxR3840Btlr/Mmmh
Stock Number:
040780-MU
Citation ID:
RRID:MMRRC_040780-MU
Other Names:
R3840 (G1), C57BL/6J-MtgxR3840Btlr
Major Collection:

Strain Information

Osbpl1a
Name: oxysterol binding protein-like 1A
Synonyms: LOC328902, G430090F17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 64291
Homologene: 84746
Abcc8
Name: ATP-binding cassette, sub-family C member 8
Synonyms: SUR1, Sur, D930031B21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Tmem87b
Name: transmembrane protein 87B
Synonyms: 2810431I02Rik, 2610301K12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72477
Homologene: 69513
Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108912
Homologene: 18444
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: Wwp4, 1110067P07Rik, A230035H12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225131
Homologene: 41148
Psmd12
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
Synonyms: P55, 1500002F15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66997
HGNC: HGNC:9557
Homologene: 2109
Epc2
Name: enhancer of polycomb homolog 2
Synonyms: D2Ertd694e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227867
Homologene: 32274
Nr2c2
Name: nuclear receptor subfamily 2, group C, member 2
Synonyms: TAK1, Tr4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22026
HGNC: HGNC:7972
Homologene: 2475
Dtna
Name: dystrobrevin alpha
Synonyms: alpha-dystrobrevin, A0, 87K protein, Dtn, adbn, a-DB-1, 2210407P21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13527
VEGA: 18
HGNC: HGNC:3057
Homologene: 20362
Zfp617
Name: zinc finger protein 617
Synonyms: Zfps11-6, Zinc finger protein s11-6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170938
Homologene: 135689
Hsph1
Name: heat shock 105kDa/110kDa protein 1
Synonyms: hsp-E7I, HSP110, Hsp105, hsp110/105
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15505
Homologene: 21322
Snap91
Name: synaptosomal-associated protein 91
Synonyms: F1-20, 91kDa, AP180
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20616
Homologene: 8429
Mastl
Name: microtubule associated serine/threonine kinase-like
Synonyms: THC2, 2700091H24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67121
Homologene: 12086
Fam171b
Name: family with sequence similarity 171, member B
Synonyms: D430039N05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241520
Homologene: 18462
Zap70
Name: zeta-chain (TCR) associated protein kinase
Synonyms: Srk, TZK, ZAP-70
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22637
Homologene: 839
Erbb3
Name: erb-b2 receptor tyrosine kinase 3
Synonyms: Erbb-3, Erbb3r, HER3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13867
HGNC: HGNC:3431
Homologene: 20457
Gask1b
Name: golgi associated kinase 1B
Synonyms: 2210419I08Rik, Ened, 1110032E23Rik, Fam198b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68659
Homologene: 9590
F11r
Name: F11 receptor
Synonyms: BV11 antigen, Ly106, JAM-1, ESTM33, Jcam1, JAM-A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16456
Homologene: 14255
Dennd6a
Name: DENN domain containing 6A
Synonyms: A630054L15Rik, Fam116a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211922
Homologene: 13503
Mideas
Name: mitotic deacetylase associated SANT domain protein
Synonyms: 9430029N19Rik, C130039O16Rik, Elmsan1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238317
Homologene: 19330
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171395
Homologene: 51376
Lrrc4c
Name: leucine rich repeat containing 4C
Synonyms: 6430556C10Rik, netrin g1 ligand, NGL-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241568
Homologene: 18696
Mocos
Name: molybdenum cofactor sulfurase
Synonyms: 1110018O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68591
VEGA: 18
Homologene: 9931
Tnfrsf11b
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Synonyms: osteoclastogenesis inhibitory factor, OCIF, OPG, Opg, TR1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18383
VEGA: 15
Homologene: 1912
Tmprss7
Name: transmembrane serine protease 7
Synonyms: LOC385645, B230219I23Rik, matriptase-3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208171
Homologene: 18178
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Slo3, Kcnma3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16532
Homologene: 7392
Myef2
Name: myelin basic protein expression factor 2, repressor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17876
Homologene: 69079
Tro
Name: trophinin
Synonyms: necdin and trophinin like, Tnn, trophinin-2, magphinin-gamma, magphinin-beta 2, magphinin-alpha, magphinin, Maged3l, Maged3, Trol
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 56191
Homologene: 75113
Slc4a11
Name: solute carrier family 4, sodium bicarbonate transporter-like, member 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269356
Homologene: 12931
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: LOC268884, 5530401I02Rik, 9530025L16Rik, 4632417D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77446
Homologene: 35276
Rap1gap
Name: Rap1 GTPase-activating protein
Synonyms: 2310004O14Rik, 1300019I11Rik, Rap1ga1, Gap
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110351
HGNC: HGNC:9858
Homologene: 2163
Or52s1
Name: olfactory receptor family 52 subfamily S member 1
Synonyms: GA_x6K02T2PBJ9-5927412-5928362, MOR24-2, Olfr593
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258378
Homologene: 27147
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241175
Homologene: 104295
Tbpl1
Name: TATA box binding protein-like 1
Synonyms: TLF, TRP, TRF2, Tlp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237336
Homologene: 3577
Fam83c
Name: family with sequence similarity 83, member C
Synonyms: 5530400B04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71405
Homologene: 18669
Ggt1
Name: gamma-glutamyltransferase 1
Synonyms: GGT, CD224, Ggtp, dwg
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14598
Homologene: 68450
4921524L21Rik
Name: RIKEN cDNA 4921524L21 gene
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70901
VEGA: 18
Homologene: 78009
Btnl7-ps
Name: butyrophilin-like 7, pseudogene
Synonyms: Btnl7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 195349
Slc22a13
Name: solute carrier family 22 (organic cation transporter), member 13
Synonyms: ORCTL3, OCTL3, OCTL1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102570
VEGA: 9
HGNC: HGNC:8494
Homologene: 3140
Or10al7
Name: olfactory receptor family 10 subfamily AL member 7
Synonyms: MOR263-9, GA_x6K02T2PSCP-2503741-2502776, Olfr129
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258324
Homologene: 133641
Cracd
Name: capping protein inhibiting regulator of actin
Synonyms: C530008M17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320827
Homologene: 136278
Jhy
Name: junctional cadherin complex regulator
Synonyms: 4931429I11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70989
Homologene: 11726
Tulp1
Name: TUB like protein 1
Synonyms: Tulp1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22157
Homologene: 2491
Medag
Name: mesenteric estrogen dependent adipogenesis
Synonyms: MEDA-4, 6330406I15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70717
Homologene: 12364
Tnfrsf23
Name: tumor necrosis factor receptor superfamily, member 23
Synonyms: Tnfrh1, mSOB, mDcTrailr1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 79201
Homologene: 84848
BC035947
Name: cDNA sequence BC035947
Type: Gene
Species: Mouse
Chromosome: 1
Podxl
Name: podocalyxin-like
Synonyms: Pclp1, Ly102, PC, podocalyxin, Podxl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27205
HGNC: HGNC:9171
Homologene: 137260
Otud1
Name: OTU domain containing 1
Synonyms: 4933428L19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71198
Homologene: 45953
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 36,778,417 bp
  • G to T, chromosome 1 at 78,497,845 bp
  • C to T, chromosome 1 at 100,383,477 bp
  • G to T, chromosome 1 at 171,460,889 bp
  • GAAGA to GAAGAAAGA, chromosome 1 at 174,582,033 bp
  • G to T, chromosome 2 at 19,658,743 bp
  • T to C, chromosome 2 at 23,140,551 bp
  • A to G, chromosome 2 at 49,488,738 bp
  • C to A, chromosome 2 at 52,207,660 bp
  • C to A, chromosome 2 at 83,880,062 bp
  • A to G, chromosome 2 at 97,630,192 bp
  • A to T, chromosome 2 at 125,095,762 bp
  • T to A, chromosome 2 at 128,826,384 bp
  • A to G, chromosome 2 at 130,688,054 bp
  • C to T, chromosome 2 at 155,834,748 bp
  • T to A, chromosome 3 at 79,908,590 bp
  • T to C, chromosome 4 at 137,717,447 bp
  • A to T, chromosome 5 at 76,859,011 bp
  • T to A, chromosome 5 at 149,427,423 bp
  • T to A, chromosome 5 at 149,620,715 bp
  • C to T, chromosome 6 at 31,523,081 bp
  • C to T, chromosome 6 at 92,163,138 bp
  • A to G, chromosome 7 at 46,108,100 bp
  • G to A, chromosome 7 at 103,212,693 bp
  • A to T, chromosome 7 at 130,516,137 bp
  • A to G, chromosome 7 at 143,681,529 bp
  • G to T, chromosome 8 at 25,885,352 bp
  • G to A, chromosome 8 at 71,932,117 bp
  • T to A, chromosome 9 at 40,944,846 bp
  • C to T, chromosome 9 at 86,839,565 bp
  • T to C, chromosome 9 at 105,928,611 bp
  • T to C, chromosome 9 at 119,208,789 bp
  • A to G, chromosome 10 at 22,711,908 bp
  • T to A, chromosome 10 at 75,581,385 bp
  • A to T, chromosome 10 at 128,570,324 bp
  • T to C, chromosome 11 at 8,889,050 bp
  • T to C, chromosome 11 at 107,485,572 bp
  • T to C, chromosome 12 at 84,171,609 bp
  • A to G, chromosome 13 at 93,094,632 bp
  • T to C, chromosome 14 at 26,626,768 bp
  • A to T, chromosome 14 at 67,680,271 bp
  • T to A, chromosome 15 at 54,252,082 bp
  • T to A, chromosome 16 at 33,719,856 bp
  • T to A, chromosome 16 at 45,660,832 bp
  • A to G, chromosome 17 at 28,353,715 bp
  • A to G, chromosome 17 at 34,542,576 bp
  • A to G, chromosome 17 at 38,055,348 bp
  • A to T, chromosome 18 at 6,620,104 bp
  • C to A, chromosome 18 at 7,918,535 bp
  • A to G, chromosome 18 at 12,756,319 bp
  • A to G, chromosome 18 at 23,595,628 bp
  • C to T, chromosome 18 at 24,676,624 bp
  • A to G, chromosome X at 150,646,202 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3840 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040780-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.