Strain Name:
C57BL/6J-MtgxR3859Btlr/Mmmh
Stock Number:
040787-MU
Citation ID:
RRID:MMRRC_040787-MU
Other Names:
R3859 (G1), C57BL/6J-MtgxR3859Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor poteintial channel interacting
Synonyms: PC-1, PC1, polycystin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Tle4
Name: transducin-like enhancer of split 4
Synonyms: Grg4, ESTM13, Bce1, ESTM14, 5730411M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21888
VEGA: 19
Homologene: 38259
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Cxxc2, Fbxl10, Jhdm1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 30841
Homologene: 13069
Banp
Name: BTG3 associated nuclear protein
Synonyms: SMAR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 53325
Homologene: 9635
Zmym2
Name: zinc finger, MYM-type 2
Synonyms: SCLL, Zfp198, RAMP, FIM, MYM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 76007
VEGA: 14
Homologene: 12631
Fzd3
Name: frizzled class receptor 3
Synonyms: D930050A07Rik, Fz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14365
HGNC: HGNC:4041
Homologene: 23004
Fbl
Name: fibrillarin
Synonyms: RNU3IP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14113
HGNC: HGNC:3599
Homologene: 1099
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: D14Ertd171e, ELKS2alpha, CAST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 238988
Homologene: 69188
Gnao1
Name: guanine nucleotide binding protein, alpha O
Synonyms: alphaO, Galphao, Go alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14681
HGNC: HGNC:4389
Homologene: 39203
Rpgrip1l
Name: Rpgrip1-like
Synonyms: Ftm, Nphp8, fantom, 1700047E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244585
Homologene: 18296
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: D12Ertd777e, syne-2, dice, 6820443O06Rik, Cpfl8, nesprin-2, diminished cone electroretinogram, Nesp2g
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Itga4
Name: integrin alpha 4
Synonyms: VLA-4 receptor, alpha 4 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16401
HGNC: HGNC:6140
Homologene: 37364
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, 9430076A06Rik, D430038H04Rik, LOC382129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 53867
Homologene: 9253
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, 1500037O19Rik, D9Ertd414e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208898
Homologene: 45443
Nfatc1
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Synonyms: NFAT2, NF-ATc, NFATc, 2210017P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18018
VEGA: 18
HGNC: HGNC:7775
Homologene: 32336
Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
Synonyms: p85beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18709
HGNC: HGNC:8980
Homologene: 3687
Slc8a3
Name: solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms: Ncx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110893
Homologene: 62645
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: 2310047C17Rik, DY6, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Tram2
Name: translocating chain-associating membrane protein 2
Synonyms: C330003D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 170829
Homologene: 8183
Tdrd12
Name: tudor domain containing 12
Synonyms: repro23, G1-476-14, 2410070K17Rik, EG434165, 2410004F06Rik, ecat8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71981
Homologene: 87053
Megf8
Name: multiple EGF-like-domains 8
Synonyms: b2b288Clo, b2b1702Clo, Egfl4, m687Ddg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Trim30b
Name: tripartite motif-containing 30B
Synonyms: Trim30-1, A530023O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244183
Olfr1216
Name: olfactory receptor 1216
Synonyms: MOR233-9, GA_x6K02T2Q125-50494588-50493653
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258895
Homologene: 74241
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: 4732433M03Rik, CPSase I, CPS, D1Ucla3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Prl8a9
Name: prolactin family8, subfamily a, member 9
Synonyms: 1600019F10Rik, Prlpc2, PLP-Cbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67310
Homologene: 11344
Ctla2b
Name: cytotoxic T lymphocyte-associated protein 2 beta
Synonyms: Ctla-2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13025
VEGA: 13
Homologene: 130627
Pth2r
Name: parathyroid hormone 2 receptor
Synonyms: Pthr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213527
HGNC: HGNC:9609
Homologene: 3701
Itih4
Name: inter alpha-trypsin inhibitor, heavy chain 4
Synonyms: Itih-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16427
HGNC: HGNC:6169
Homologene: 1670
Krt12
Name: keratin 12
Synonyms: Krt1-12, K12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268482
HGNC: HGNC:6414
Homologene: 188
Olfr1475
Name: olfactory receptor 1475
Synonyms: MOR202-36, GA_x6K02T2RE5P-3812807-3811863
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258298
Homologene: 77370
H2-Q6
Name: histocompatibility 2, Q region locus 6
Synonyms: Qa6, H-2Q6, Qa-6, 0610037M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 110557
HGNC: HGNC:4931
Homologene: 128352
Hspa14
Name: heat shock protein 14
Synonyms: HSP70L1, Hsp70-4, NST-1, 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 50497
Homologene: 74307
Papss1
Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Synonyms: SK1, Asapk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23971
HGNC: HGNC:8603
Homologene: 81740
Zfp2
Name: zinc finger protein 2
Synonyms: mkr-2, Fnp-2, Zfp-2, 9930007F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22678
Homologene: 121779
AU022751
Name: expressed sequence AU022751
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 102991
Purg
Name: purine-rich element binding protein G
Synonyms: 4930486B15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75029
Homologene: 22747
Dnajc5b
Name: DnaJ heat shock protein family (Hsp40) member C5 beta
Synonyms: 1700008A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66326
Homologene: 32634
Cav2
Name: caveolin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12390
HGNC: HGNC:1528
Homologene: 942
Olfr922
Name: olfactory receptor 922
Synonyms: MOR161-3, GA_x6K02T2PVTD-32518237-32519172
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258777
VEGA: 9
Homologene: 27262
Acot4
Name: acyl-CoA thioesterase 4
Synonyms: Pte2b, B430212I04Rik, PTE-Ib
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 171282
Homologene: 44237
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 21,003,980 bp
  • A to T, chromosome 1 at 65,322,047 bp
  • A to G, chromosome 1 at 67,168,278 bp
  • A to T, chromosome 2 at 3,494,579 bp
  • T to A, chromosome 2 at 79,288,878 bp
  • A to G, chromosome 2 at 89,014,061 bp
  • G to T, chromosome 3 at 19,574,802 bp
  • G to A, chromosome 3 at 114,167,470 bp
  • T to A, chromosome 3 at 131,607,335 bp
  • A to G, chromosome 5 at 122,880,227 bp
  • G to T, chromosome 6 at 17,281,463 bp
  • T to A, chromosome 7 at 25,346,664 bp
  • G to A, chromosome 7 at 28,174,510 bp
  • A to G, chromosome 7 at 35,493,820 bp
  • T to C, chromosome 7 at 104,357,280 bp
  • T to C, chromosome 8 at 33,386,559 bp
  • T to C, chromosome 8 at 70,769,986 bp
  • T to C, chromosome 8 at 91,263,658 bp
  • C to T, chromosome 8 at 93,811,645 bp
  • T to C, chromosome 8 at 121,991,513 bp
  • G to A, chromosome 9 at 15,997,228 bp
  • A to G, chromosome 9 at 20,793,630 bp
  • G to A, chromosome 9 at 38,816,147 bp
  • G to T, chromosome 9 at 73,699,108 bp
  • T to C, chromosome 11 at 50,900,096 bp
  • G to A, chromosome 11 at 99,418,493 bp
  • T to C, chromosome 12 at 75,929,784 bp
  • G to A, chromosome 12 at 81,314,872 bp
  • A to G, chromosome 12 at 84,043,444 bp
  • C to T, chromosome 13 at 27,558,164 bp
  • T to A, chromosome 13 at 60,896,043 bp
  • A to G, chromosome 14 at 28,475,642 bp
  • T to C, chromosome 14 at 30,892,329 bp
  • A to G, chromosome 14 at 56,944,250 bp
  • A to T, chromosome 14 at 65,239,839 bp
  • A to G, chromosome 17 at 24,578,092 bp
  • C to T, chromosome 17 at 35,425,566 bp
  • T to C, chromosome 18 at 80,665,275 bp
  • A to G, chromosome 19 at 9,010,859 bp
  • T to A, chromosome 19 at 13,480,130 bp
  • G to A, chromosome 19 at 14,468,213 bp
  • A to G, chromosome 19 at 21,852,234 bp
  • A to G, chromosome X at 6,082,656 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3859 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040787-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.