Strain Name:
C57BL/6J-MtgxR3883Btlr/Mmmh
Stock Number:
040796-MU
Citation ID:
RRID:MMRRC_040796-MU
Other Names:
R3883 (G1), C57BL/6J-MtgxR3883Btlr
Major Collection:

Strain Information

Cdk17
Name: cyclin dependent kinase 17
Synonyms: 6430598J10Rik, Pctk2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237459
VEGA: 10
HGNC: HGNC:8750
Homologene: 55666
Mrtfb
Name: myocardin related transcription factor B
Synonyms: Mrtfb, Mkl2, MRTF-B, Gt4-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239719
Homologene: 40917
Kat2b
Name: K(lysine) acetyltransferase 2B
Synonyms: A930006P13Rik, Pcaf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18519
HGNC: HGNC:8638
Homologene: 20834
Fbxo22
Name: F-box protein 22
Synonyms: 0610033L19Rik, 1600016C16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71999
Homologene: 12433
Rabggtb
Name: Rab geranylgeranyl transferase, b subunit
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19352
HGNC: HGNC:9796
Homologene: 3371
Zbtb32
Name: zinc finger and BTB domain containing 32
Synonyms: 4930524C15Rik, PLZP, Rog, Tzfp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 58206
Homologene: 8661
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Epc1
Name: enhancer of polycomb homolog 1
Synonyms: 2400007E14Rik, A930032N02Rik, 5730566F07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13831
Homologene: 32627
Ddx42
Name: DEAD box helicase 42
Synonyms: B430002H05Rik, 1810047H21Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 42, SF3b125
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72047
Homologene: 49137
Epb41l3
Name: erythrocyte membrane protein band 4.1 like 3
Synonyms: NBL3, DAL1P, 4.1B, Epb4.1l3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13823
HGNC: HGNC:3380
Homologene: 49308
Cntn2
Name: contactin 2
Synonyms: D130012K04Rik, TAG-1, Tax, TAG1, axonin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21367
HGNC: HGNC:2172
Homologene: 3720
Hipk2
Name: homeodomain interacting protein kinase 2
Synonyms: 1110014O20Rik, Stank, B230339E18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15258
Homologene: 68766
Trpm4
Name: transient receptor potential cation channel, subfamily M, member 4
Synonyms: TRPM4B, 1110030C19Rik, LTRPC4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68667
Homologene: 23033
Tap1
Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: Ham1, Ham-1, Tap-1, RING4, Abcb2, PSF-1, MTP1, TAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21354
HGNC: HGNC:43
Homologene: 495
C3
Name: complement component 3
Synonyms: Plp, complement factor 3, acylation stimulating protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Neto2
Name: neuropilin (NRP) and tolloid (TLL)-like 2
Synonyms: 5530601C23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74513
Homologene: 32387
Pigk
Name: phosphatidylinositol glycan anchor biosynthesis, class K
Synonyms: 3000001O05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329777
HGNC: HGNC:8965
Homologene: 4002
Peak1
Name: pseudopodium-enriched atypical kinase 1
Synonyms: 1110049L02Rik, C230081A13Rik, NKF3 kinase family member
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244895
Homologene: 18259
Mavs
Name: mitochondrial antiviral signaling protein
Synonyms: IPS-1, D430028G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228607
Homologene: 17004
F2
Name: coagulation factor II
Synonyms: Cf2, FII, Cf-2, thrombin, prothrombin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14061
HGNC: HGNC:3535
Homologene: 426
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1203Clo, Dnahc11, avc4, b2b1289Clo, b2b1279Clo, lrd, b2b598Clo, b2b1727Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Arsi
Name: arylsulfatase i
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 545260
Homologene: 44428
Slc5a8
Name: solute carrier family 5 (iodide transporter), member 8
Synonyms: SMCT
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216225
VEGA: 10
Homologene: 64832
Gls2
Name: glutaminase 2 (liver, mitochondrial)
Synonyms: Lga, A330074B06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216456
Homologene: 40861
Acsl1
Name: acyl-CoA synthetase long-chain family member 1
Synonyms: Acas1, Facl2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14081
HGNC: HGNC:3569
Homologene: 37561
Lgsn
Name: lengsin, lens protein with glutamine synthetase domain
Synonyms: Gluld1, lengsin, Lgs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 266744
Homologene: 9569
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D3Bwg1078e, D130016K21Rik, 9430063L05Rik, Usmg4, 4732458A06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Fmnl1
Name: formin-like 1
Synonyms: 8030453N10Rik, formin-related gene in leukocytes
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57778
HGNC: HGNC:1212
Homologene: 135620
Folh1
Name: folate hydrolase 1
Synonyms: glutamate carboxypeptidase II, mopsm, GCP2, prostate-specific membrane antigen
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53320
Homologene: 55826
Edn1
Name: endothelin 1
Synonyms: ET-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13614
VEGA: 13
HGNC: HGNC:3176
Homologene: 1476
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628422
Enthd1
Name: ENTH domain containing 1
Synonyms: LOC383075
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 383075
VEGA: 15
Homologene: 45131
Mtrf1
Name: mitochondrial translational release factor 1
Synonyms: A830062K05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211253
VEGA: 14
HGNC: HGNC:7469
Homologene: 20903
Ano5
Name: anoctamin 5
Synonyms: Tmem16e, Gdd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233246
Homologene: 100071
Gm15446
Name: predicted gene 15446
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100642166
Ankmy1
Name: ankyrin repeat and MYND domain containing 1
Synonyms: 4930483I10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241158
Homologene: 9561
Sprr1a
Name: small proline-rich protein 1A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20753
Homologene: 105698
Kif4-ps
Name: kinesin family member 4, pseudogene
Synonyms: Kif4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74947
Or10d4c
Name: olfactory receptor family 10 subfamily D member 4C
Synonyms: GA_x6K02T2PVTD-33343617-33344561, MOR224-5, Olfr961
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258497
VEGA: 9
Homologene: 74020
Ngly1
Name: N-glycanase 1
Synonyms: 1110002C09Rik, PNGase, Png1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 59007
Homologene: 10117
Or13p5
Name: olfactory receptor family 13 subfamily P member 5
Synonyms: MOR258-2, GA_x6K02T2QD9B-18815145-18814198, Olfr1339
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258851
Homologene: 27280
Zbtb7a
Name: zinc finger and BTB domain containing 7a
Synonyms: Pokemon, 9130006G12Rik, 9030619K07Rik, FBI-1, Leukemia/lymphoma Related Factor, Lrf, Zbtb7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16969
Homologene: 7820
Serpinb13
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
Synonyms: HURPIN, PI13, headpin, HUR7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241196
HGNC: HGNC:8944
Homologene: 22718
Cracd
Name: capping protein inhibiting regulator of actin
Synonyms: C530008M17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320827
Homologene: 136278
Reep6
Name: receptor accessory protein 6
Synonyms: Dp1l1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70335
Homologene: 133833
Klk1b16
Name: kallikrein 1-related peptidase b16
Synonyms: Klk16, mGk-16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16615
Homologene: 68141
Bhlhe41
Name: basic helix-loop-helix family, member e41
Synonyms: 6430520M22Rik, Sharp1, DEC2, Bhlhb3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 79362
Homologene: 137371
CAAA01083517.2
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Batf2
Name: basic leucine zipper transcription factor, ATF-like 2
Synonyms: 4933430F08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74481
Homologene: 12569
Gm10220
Name: predicted gene 10220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 434689
Homologene: 69402
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 31,176,459 bp
  • T to G, chromosome 1 at 92,886,152 bp
  • T to C, chromosome 1 at 106,998,572 bp
  • A to G, chromosome 1 at 132,528,939 bp
  • A to T, chromosome 1 at 183,390,948 bp
  • T to C, chromosome 1 at 188,263,382 bp
  • A to T, chromosome 2 at 91,630,138 bp
  • T to C, chromosome 2 at 131,245,298 bp
  • G to A, chromosome 3 at 92,484,520 bp
  • T to C, chromosome 3 at 97,713,188 bp
  • T to C, chromosome 3 at 152,714,195 bp
  • A to G, chromosome 3 at 153,910,780 bp
  • T to C, chromosome 4 at 118,734,685 bp
  • A to C, chromosome 5 at 26,116,910 bp
  • T to A, chromosome 5 at 76,856,574 bp
  • G to T, chromosome 5 at 109,940,447 bp
  • A to G, chromosome 6 at 38,699,265 bp
  • A to G, chromosome 6 at 145,864,563 bp
  • A to G, chromosome 7 at 30,591,144 bp
  • A to T, chromosome 7 at 41,864,490 bp
  • T to C, chromosome 7 at 44,139,463 bp
  • C to T, chromosome 7 at 45,321,998 bp
  • T to A, chromosome 7 at 51,566,304 bp
  • A to G, chromosome 7 at 86,775,656 bp
  • A to G, chromosome 7 at 105,762,563 bp
  • C to T, chromosome 8 at 46,527,191 bp
  • A to G, chromosome 8 at 85,663,265 bp
  • A to G, chromosome 9 at 39,647,124 bp
  • A to T, chromosome 9 at 55,223,262 bp
  • A to T, chromosome 9 at 56,241,354 bp
  • G to A, chromosome 10 at 80,335,535 bp
  • T to C, chromosome 10 at 81,148,025 bp
  • T to A, chromosome 10 at 88,902,463 bp
  • T to C, chromosome 10 at 93,212,077 bp
  • C to T, chromosome 10 at 128,207,017 bp
  • A to G, chromosome 11 at 103,182,114 bp
  • T to A, chromosome 11 at 106,247,692 bp
  • G to T, chromosome 12 at 101,146,214 bp
  • T to C, chromosome 12 at 117,978,453 bp
  • T to A, chromosome 13 at 42,301,906 bp
  • A to G, chromosome 14 at 16,270,574 bp
  • A to G, chromosome 14 at 79,419,267 bp
  • A to C, chromosome 14 at 103,295,250 bp
  • T to C, chromosome 15 at 80,509,170 bp
  • T to A, chromosome 16 at 13,401,458 bp
  • T to A, chromosome 17 at 34,193,258 bp
  • T to A, chromosome 17 at 53,654,428 bp
  • T to C, chromosome 17 at 57,217,173 bp
  • C to T, chromosome 17 at 69,274,116 bp
  • T to C, chromosome 18 at 6,452,258 bp
  • G to A, chromosome 18 at 60,916,651 bp
  • T to C, chromosome 19 at 6,171,295 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3883 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040796-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.