Strain Name:
C57BL/6J-MtgxR3886Btlr/Mmmh
Stock Number:
040798-MU
Citation ID:
RRID:MMRRC_040798-MU
Other Names:
R3886 (G1), C57BL/6J-MtgxR3886Btlr
Major Collection:

Gene Information

Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330286
Homologene: 19782
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 1810033J14Rik, D230038D11Rik, 9530077A04Rik, Mll5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69188
Homologene: 18822
Lcor
Name: ligand dependent nuclear receptor corepressor
Synonyms: 3110023F06Rik, Mlr2, A630025C20Rik, LOC381224, Gm340
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 212391
VEGA: 19
Homologene: 18153
Tti1
Name: TELO2 interacting protein 1
Synonyms: 2610036D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75425
Homologene: 40969
Usp1
Name: ubiquitin specific peptidase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230484
Homologene: 2528
Lrch2
Name: leucine-rich repeats and calponin homology (CH) domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 210297
Homologene: 32491
Chchd6
Name: coiled-coil-helix-coiled-coil-helix domain containing 6
Synonyms: 1700021B03Rik, 0710001P09Rik, Micos25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66098
Homologene: 11920
Pcnt
Name: pericentrin (kendrin)
Synonyms: Pcnt2, m239Asp, m275Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18541
VEGA: 10
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227446
Homologene: 10834
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Mdh1
Name: malate dehydrogenase 1, NAD (soluble)
Synonyms: Mor-2, MDH-s, Mor2, B230377B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17449
HGNC: HGNC:6970
Homologene: 4324
Slitrk5
Name: SLIT and NTRK-like family, member 5
Synonyms: 2610019D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75409
VEGA: 14
Homologene: 9193
Robo3
Name: roundabout guidance receptor 3
Synonyms: Rig-1, Rbig1, Robo3b, Robo3a, Rig1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19649
Homologene: 32119
Adss
Name: adenylosuccinate synthetase, non muscle
Synonyms: AS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11566
HGNC: HGNC:292
Homologene: 875
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68750
Homologene: 2218
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: Tace, CD156b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Tent4b
Name: terminal nucleotidyltransferase 4B
Synonyms: 5730445M16Rik, Papd5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 214627
Homologene: 64245
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Rbm45
Name: RNA binding motif protein 45
Synonyms: Drb1, G430095G15Rik, Drbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241490
Homologene: 15560
Dennd1a
Name: DENN/MADD domain containing 1A
Synonyms: 6030446I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227801
Homologene: 17141
Lct
Name: lactase
Synonyms: LOC226413, Lphl, LPH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Cd22
Name: CD22 antigen
Synonyms: Lyb-8, Lyb8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12483
HGNC: HGNC:1643
Homologene: 31052
Sohlh1
Name: spermatogenesis and oogenesis specific basic helix-loop-helix 1
Synonyms: LOC227631, NOHLH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227631
Homologene: 45955
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Abca4
Name: ATP-binding cassette, sub-family A (ABC1), member 4
Synonyms: Rim protein, RmP, Abc10, D430003I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Ccdc73
Name: coiled-coil domain containing 73
Synonyms: 2210415I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 211936
Homologene: 52235
Snapc4
Name: small nuclear RNA activating complex, polypeptide 4
Synonyms: 5730436L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227644
Homologene: 2321
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: b2b012Clo, Jbts17, Hug, 2410089E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73692
Homologene: 11315
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: D28, PTPROt, PTP-phi, PTP-BK, PTP-U2, GLEPP1, PTP-oc, Ptpn15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Kcng4
Name: potassium voltage-gated channel, subfamily G, member 4
Synonyms: KV6.4, KV6.3, 4921535I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66733
Homologene: 23553
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: Gm10331, C330021H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100045792
Homologene: 46005
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81877
Homologene: 49589
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 665033
Homologene: 122792
Olfr1243
Name: olfactory receptor 1243
Synonyms: GA_x6K02T2Q125-50972538-50971621, MOR231-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258971
Homologene: 27317
Lrrk1
Name: leucine-rich repeat kinase 1
Synonyms: D130026O16Rik, C230002E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233328
Homologene: 23464
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, CPSase I, 4732433M03Rik, D1Ucla3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Jade2
Name: jade family PHD finger 2
Synonyms: 1200017K05Rik, Phf15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76901
Homologene: 9082
Pramel17
Name: PRAME like 17
Synonyms: B020004J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 545662
Homologene: 128627
Olfr978
Name: olfactory receptor 978
Synonyms: GA_x6K02T2PVTD-33692287-33693222, MOR223-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 259109
VEGA: 9
Homologene: 88420
Kcnb2
Name: potassium voltage gated channel, Shab-related subfamily, member 2
Synonyms: Kv2.2, 9630047L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98741
HGNC: HGNC:6232
Homologene: 31263
Vill
Name: villin-like
Synonyms: Villp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22351
Homologene: 22650
4933407L21Rik
Name: RIKEN cDNA 4933407L21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71141
Cobll1
Name: Cobl-like 1
Synonyms: Coblr1, D430044D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319876
Homologene: 8933
AC091683.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Tmem40
Name: transmembrane protein 40
Synonyms: 9030407H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 94346
Homologene: 10124
Slc35f2
Name: solute carrier family 35, member F2
Synonyms: 1500009K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72022
VEGA: 9
Homologene: 36363
Foxd2
Name: forkhead box D2
Synonyms: Mf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17301
HGNC: HGNC:3803
Homologene: 3292
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 15,710,415 bp
  • C to A, chromosome 1 at 67,165,500 bp
  • T to C, chromosome 1 at 71,640,306 bp
  • T to A, chromosome 1 at 85,940,551 bp
  • A to G, chromosome 1 at 105,692,213 bp
  • T to C, chromosome 1 at 128,304,226 bp
  • A to G, chromosome 1 at 177,767,769 bp
  • A to G, chromosome 2 at 25,843,371 bp
  • G to A, chromosome 2 at 26,365,498 bp
  • T to C, chromosome 2 at 37,858,077 bp
  • A to G, chromosome 2 at 65,107,000 bp
  • A to G, chromosome 2 at 76,375,424 bp
  • T to A, chromosome 2 at 89,527,732 bp
  • A to T, chromosome 2 at 104,991,343 bp
  • A to G, chromosome 2 at 158,008,950 bp
  • T to C, chromosome 3 at 19,989,111 bp
  • T to C, chromosome 3 at 122,171,031 bp
  • T to C, chromosome 4 at 98,929,736 bp
  • T to C, chromosome 4 at 101,835,723 bp
  • T to C, chromosome 4 at 114,908,286 bp
  • T to C, chromosome 5 at 23,496,397 bp
  • A to C, chromosome 6 at 14,719,912 bp
  • A to G, chromosome 6 at 38,142,698 bp
  • T to C, chromosome 6 at 89,467,451 bp
  • T to C, chromosome 6 at 115,733,986 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • T to C, chromosome 7 at 30,870,107 bp
  • C to T, chromosome 7 at 66,292,364 bp
  • C to A, chromosome 8 at 88,200,415 bp
  • T to C, chromosome 8 at 119,633,247 bp
  • G to A, chromosome 9 at 37,422,181 bp
  • A to G, chromosome 9 at 39,994,539 bp
  • T to A, chromosome 9 at 53,816,957 bp
  • A to G, chromosome 9 at 105,930,930 bp
  • A to G, chromosome 9 at 119,066,714 bp
  • C to T, chromosome 10 at 18,168,458 bp
  • C to T, chromosome 10 at 76,354,161 bp
  • A to G, chromosome 11 at 21,559,832 bp
  • C to T, chromosome 11 at 51,830,499 bp
  • G to A, chromosome 12 at 21,325,587 bp
  • G to A, chromosome 13 at 37,898,506 bp
  • T to C, chromosome 13 at 49,902,163 bp
  • T to C, chromosome 13 at 70,605,370 bp
  • T to A, chromosome 14 at 111,679,797 bp
  • T to A, chromosome 15 at 8,171,805 bp
  • A to G, chromosome 17 at 34,718,911 bp
  • T to A, chromosome 18 at 49,878,259 bp
  • T to A, chromosome 19 at 41,558,356 bp
  • C to G, chromosome X at 147,473,007 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3886 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040798-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.