Strain Name:
C57BL/6J-MtgxR3887Btlr/Mmmh
Stock Number:
040799-MU
Citation ID:
RRID:MMRRC_040799-MU
Other Names:
R3887 (G1), C57BL/6J-MtgxR3887Btlr
Major Collection:

Gene Information

Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Syngr1
Name: synaptogyrin 1
Synonyms: Syngr1b, p29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20972
Homologene: 3456
Strn4
Name: striatin, calmodulin binding protein 4
Synonyms: ZIN, zinedin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 97387
Homologene: 8378
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LRP7, LR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16973
HGNC: HGNC:6697
Homologene: 1746
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Ano6
Name: anoctamin 6
Synonyms: 2900059G15Rik, F730003B03Rik, Tmem16f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Pcnt
Name: pericentrin (kendrin)
Synonyms: Pcnt2, m239Asp, m275Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18541
VEGA: 10
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Stxbp3
Name: syntaxin binding protein 3
Synonyms: Munc-18c, Stxbp3, Stxbp3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20912
Homologene: 5260
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
Scube2
Name: signal peptide, CUB domain, EGF-like 2
Synonyms: ICRFP703N2430Q5.1, ICRFP703B1614Q5.1, 4932442O19Rik, Cegf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56788
Homologene: 36383
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68750
Homologene: 2218
Slc17a8
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
Synonyms: Vglut3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216227
Homologene: 13584
Tbc1d10b
Name: TBC1 domain family, member 10b
Synonyms: 1110003P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68449
Homologene: 9177
Ncapg
Name: non-SMC condensin I complex, subunit G
Synonyms: MFT.M05.13, Hcapg, 5730507H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54392
Homologene: 44071
Rbm45
Name: RNA binding motif protein 45
Synonyms: Drb1, G430095G15Rik, Drbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241490
Homologene: 15560
Pla2g15
Name: phospholipase A2, group XV
Synonyms: LLPL, C87498, Lpla2, Lypla3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 192654
Homologene: 8200
Lct
Name: lactase
Synonyms: LOC226413, Lphl, LPH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Stag3
Name: stromal antigen 3
Synonyms: stromalin 3, SA-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50878
Homologene: 40844
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Mylk3
Name: myosin light chain kinase 3
Synonyms: D830007F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 213435
Homologene: 35278
Ccdc175
Name: coiled-coil domain containing 175
Synonyms: 4930403N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73936
VEGA: 12
Homologene: 79144
Snapc4
Name: small nuclear RNA activating complex, polypeptide 4
Synonyms: 5730436L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227644
Homologene: 2321
Add2
Name: adducin 2 (beta)
Synonyms: 2900072M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11519
HGNC: HGNC:244
Homologene: 1221
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: D28, PTPROt, PTP-phi, PTP-BK, PTP-U2, GLEPP1, PTP-oc, Ptpn15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: Pept2, 8430408C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 57738
Homologene: 56912
Olfr1243
Name: olfactory receptor 1243
Synonyms: GA_x6K02T2Q125-50972538-50971621, MOR231-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258971
Homologene: 27317
Mapk12
Name: mitogen-activated protein kinase 12
Synonyms: Sapk3, Erk6, P38gamma, Prkm12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 29857
VEGA: 15
HGNC: HGNC:6874
Homologene: 55705
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, CPSase I, 4732433M03Rik, D1Ucla3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Speg
Name: SPEG complex locus
Synonyms: BPEG, SPEGbeta, SPEGalpha, D1Bwg1450e, SPEG, Apeg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11790
Homologene: 55619
Efcab14
Name: EF-hand calcium binding domain 14
Synonyms: 4732418C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230648
Homologene: 8858
Ankdd1a
Name: ankyrin repeat and death domain containing 1A
Synonyms: LOC384945, EG330963
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330963
VEGA: 9
Homologene: 65619
Arhgap26
Name: Rho GTPase activating protein 26
Synonyms: 1810044B20Rik, 2610010G17Rik, 4933432P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 71302
Homologene: 36349
4933407L21Rik
Name: RIKEN cDNA 4933407L21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71141
Cobll1
Name: Cobl-like 1
Synonyms: Coblr1, D430044D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319876
Homologene: 8933
Cerk
Name: ceramide kinase
Synonyms: D330016D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223753
Homologene: 11247
Steap4
Name: STEAP family member 4
Synonyms: Tiarp, Tnfaip9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 117167
Homologene: 36422
Tmem40
Name: transmembrane protein 40
Synonyms: 9030407H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 94346
Homologene: 10124
Ceacam14
Name: carcinoembryonic antigen-related cell adhesion molecule 14
Synonyms: 1600025E09Rik, 1600021E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67084
Homologene: 135962
Mdfic
Name: MyoD family inhibitor domain containing
Synonyms: clone 1.5, Kdt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16543
Homologene: 18404
Foxd2
Name: forkhead box D2
Synonyms: Mf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17301
HGNC: HGNC:3803
Homologene: 3292
Fmc1
Name: formation of mitochondrial complex V assembly factor 1
Synonyms: 1110001J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66117
Homologene: 41627
Scgb2b12
Name: secretoglobin, family 2B, member 12
Synonyms: Gm9138, Abpbg12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668379
Homologene: 83171
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 67,165,500 bp
  • T to C, chromosome 1 at 71,640,306 bp
  • C to T, chromosome 1 at 75,417,816 bp
  • T to A, chromosome 1 at 85,940,551 bp
  • T to C, chromosome 1 at 128,304,226 bp
  • C to T, chromosome 2 at 20,529,961 bp
  • G to A, chromosome 2 at 26,365,498 bp
  • A to G, chromosome 2 at 65,107,000 bp
  • A to G, chromosome 2 at 76,375,424 bp
  • T to A, chromosome 2 at 89,527,732 bp
  • C to T, chromosome 3 at 108,805,233 bp
  • T to C, chromosome 4 at 114,908,286 bp
  • T to A, chromosome 4 at 115,738,660 bp
  • G to T, chromosome 5 at 7,980,494 bp
  • T to C, chromosome 5 at 21,910,849 bp
  • G to A, chromosome 5 at 45,674,363 bp
  • A to G, chromosome 5 at 138,298,839 bp
  • C to T, chromosome 6 at 15,799,711 bp
  • T to C, chromosome 6 at 38,539,288 bp
  • C to T, chromosome 6 at 82,734,961 bp
  • T to A, chromosome 6 at 86,118,466 bp
  • T to C, chromosome 6 at 115,733,986 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • T to C, chromosome 7 at 16,822,998 bp
  • T to A, chromosome 7 at 17,814,138 bp
  • A to T, chromosome 7 at 32,325,545 bp
  • A to T, chromosome 7 at 109,843,176 bp
  • A to T, chromosome 7 at 127,199,795 bp
  • A to G, chromosome 8 at 85,352,047 bp
  • A to G, chromosome 8 at 106,161,135 bp
  • C to A, chromosome 9 at 65,502,248 bp
  • C to T, chromosome 10 at 76,354,161 bp
  • G to T, chromosome 10 at 89,591,138 bp
  • A to G, chromosome 12 at 72,136,048 bp
  • G to T, chromosome 13 at 37,893,965 bp
  • A to G, chromosome 14 at 103,174,797 bp
  • A to G, chromosome 15 at 80,116,039 bp
  • A to T, chromosome 15 at 86,149,331 bp
  • A to T, chromosome 15 at 89,135,637 bp
  • A to C, chromosome 15 at 95,894,449 bp
  • A to G, chromosome 16 at 36,782,304 bp
  • G to A, chromosome 18 at 39,229,966 bp
  • T to A, chromosome 18 at 49,878,259 bp
  • G to A, chromosome 19 at 3,612,330 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3887 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040799-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.