Strain Name:
C57BL/6J-MtgxR3893Btlr/Mmmh
Stock Number:
040805-MU
Citation ID:
RRID:MMRRC_040805-MU
Other Names:
R3893 (G1), C57BL/6J-MtgxR3893Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: PC1, polycystin-1, PC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, trabeculin alpha, Aclp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LR3, LRP7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16973
HGNC: HGNC:6697
Homologene: 1746
Sart3
Name: squamous cell carcinoma antigen recognized by T cells 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 53890
Homologene: 40977
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: Prp8, DBF3/PRP8, D11Bwg0410e, Sfprp8l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192159
Homologene: 4706
Plekhg5
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269608
Homologene: 10768
Atoh1
Name: atonal bHLH transcription factor 1
Synonyms: Math1, bHLHa14, Hath1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11921
HGNC: HGNC:797
Homologene: 31297
Gprin3
Name: GPRIN family member 3
Synonyms: C030038J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243385
Homologene: 52334
Prkcq
Name: protein kinase C, theta
Synonyms: PKCtheta, PKC-theta, PKC theta, A130035A12Rik, PKC-0, Pkcq
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18761
HGNC: HGNC:9410
Homologene: 21263
Rsbn1l
Name: round spermatid basic protein 1-like
Synonyms: C330002G24Rik, 8430412F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242860
Homologene: 19435
Micu3
Name: mitochondrial calcium uptake family, member 3
Synonyms: 2900075B16Rik, Efha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78506
Homologene: 15058
Adam19
Name: a disintegrin and metallopeptidase domain 19 (meltrin beta)
Synonyms: Mltnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11492
HGNC: HGNC:197
Homologene: 74925
Gcnt2
Name: glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
Synonyms: IGnT, IGnTB, 5330430K10Rik, IGnTA, IGnTC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14538
VEGA: 13
HGNC: HGNC:4204
Homologene: 41535
Gca
Name: grancalcin
Synonyms: 5133401E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227960
Homologene: 22702
Dnajc18
Name: DnaJ heat shock protein family (Hsp40) member C18
Synonyms: 2700075B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 76594
VEGA: 18
Homologene: 23692
Wdr19
Name: WD repeat domain 19
Synonyms: C330027H04Rik, Ift144, D330023L08Rik, DYF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 213081
Homologene: 11842
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: FPC, tigmin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Tnfsf8
Name: tumor necrosis factor (ligand) superfamily, member 8
Synonyms: Cd30L, CD30LG, CD153
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21949
Homologene: 950
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: GLEPP1, PTPROt, PTP-oc, PTP-phi, D28, PTP-BK, PTP-U2, Ptpn15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Cracdl
Name: capping protein inhibiting regulator of actin like
Synonyms: 2010300C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72097
Homologene: 19208
Rin2
Name: Ras and Rab interactor 2
Synonyms: 2010003K16Rik, RASSF4, 4632403N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74030
Homologene: 32430
Skint3
Name: selection and upkeep of intraepithelial T cells 3
Synonyms: A430090E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 195564
Cfap69
Name: cilia and flagella associated protein 69
Synonyms: A330021E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 207686
Homologene: 11718
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74424
Homologene: 11713
Fmnl1
Name: formin-like 1
Synonyms: formin-related gene in leukocytes, 8030453N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57778
HGNC: HGNC:1212
Homologene: 135620
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: 4930532L22Rik, B230399N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269610
Homologene: 56712
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Krt20
Name: keratin 20
Synonyms: cytokeratin 20, CK20, 9030623C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66809
Homologene: 56837
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225638
Homologene: 50475
Lrrk1
Name: leucine-rich repeat kinase 1
Synonyms: C230002E15Rik, D130026O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233328
Homologene: 23464
Vmn1r214
Name: vomeronasal 1 receptor 214
Synonyms: V1rh5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171248
Homologene: 110880
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: TJ6s, Tj6, ATP6a2, V-ATPase a2, Atp6n2, 8430408C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21871
Homologene: 56523
Cyria
Name: CYFIP related Rac1 interactor A
Synonyms: Fam49a, 2410157M17Rik, D12Ertd553e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76820
VEGA: 12
Homologene: 12657
Pnliprp2
Name: pancreatic lipase-related protein 2
Synonyms: PLRP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18947
VEGA: 19
HGNC: HGNC:9157
Homologene: 3936
Trim5
Name: tripartite motif-containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 667823
Homologene: 75345
Ggps1
Name: geranylgeranyl diphosphate synthase 1
Synonyms: 1810026C22Rik, GGPP synthase, 9530089B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14593
VEGA: 13
HGNC: HGNC:4249
Homologene: 31267
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: TRANCE-R, Rank
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21934
Homologene: 2848
Gpc5
Name: glypican 5
Synonyms: A230034F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 103978
HGNC: HGNC:4453
Homologene: 3285
Zc3h6
Name: zinc finger CCCH type containing 6
Synonyms: 4631426G04Rik, 4833425H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78751
Homologene: 35328
Zfp955b
Name: zinc finger protein 955B
Synonyms: A430003O12Rik, C430039G02Rik, Gm4455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100043468
VEGA: 17
Homologene: 104925
H2-M11
Name: histocompatibility 2, M region locus 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224754
Homologene: 52241
Akr1c19
Name: aldo-keto reductase family 1, member C19
Synonyms: 1810010N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 432720
Homologene: 134145
Spesp1
Name: sperm equatorial segment protein 1
Synonyms: 4921508E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66712
VEGA: 9
Homologene: 49838
Gtf2a1l
Name: general transcription factor IIA, 1-like
Synonyms: Gtf2a1lf, Alf, 1700011N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71828
Homologene: 86732
2610303G11Rik
Name: RIKEN cDNA 2610303G11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Tmem181a
Name: transmembrane protein 181A
Synonyms: Gpr178, C76977, Tmem181, 5930418K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77106
Homologene: 44787
Slc11a1
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms: Lsh, Ity, Bcg, Nramp, host resistance locus Bcg/Ity/Lsh, Ity1, Nramp1, ity
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18173
Homologene: 73884
B930094E09Rik
Name: RIKEN cDNA B930094E09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 20,312,138 bp
  • T to A, chromosome 1 at 37,631,458 bp
  • G to A, chromosome 1 at 74,384,706 bp
  • T to C, chromosome 1 at 105,817,658 bp
  • A to C, chromosome 2 at 11,226,971 bp
  • A to G, chromosome 2 at 62,679,220 bp
  • A to G, chromosome 2 at 129,016,140 bp
  • C to T, chromosome 2 at 145,860,446 bp
  • G to T, chromosome 4 at 63,860,959 bp
  • A to G, chromosome 4 at 112,253,918 bp
  • A to G, chromosome 4 at 123,486,406 bp
  • C to T, chromosome 4 at 152,114,823 bp
  • A to G, chromosome 4 at 152,360,656 bp
  • A to T, chromosome 5 at 5,581,245 bp
  • C to T, chromosome 5 at 20,905,840 bp
  • A to G, chromosome 5 at 65,228,292 bp
  • C to T, chromosome 5 at 113,746,636 bp
  • G to A, chromosome 5 at 124,639,265 bp
  • G to T, chromosome 6 at 48,476,571 bp
  • T to C, chromosome 6 at 59,354,479 bp
  • A to G, chromosome 6 at 64,730,133 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • T to C, chromosome 7 at 66,278,520 bp
  • T to A, chromosome 7 at 104,276,835 bp
  • A to C, chromosome 7 at 118,645,369 bp
  • C to T, chromosome 8 at 40,366,224 bp
  • T to C, chromosome 9 at 62,281,994 bp
  • A to T, chromosome 9 at 98,186,811 bp
  • C to T, chromosome 11 at 46,128,838 bp
  • C to A, chromosome 11 at 75,500,257 bp
  • T to C, chromosome 11 at 99,429,086 bp
  • T to A, chromosome 11 at 103,196,757 bp
  • T to C, chromosome 12 at 12,362,525 bp
  • G to A, chromosome 13 at 4,238,442 bp
  • T to C, chromosome 13 at 14,053,699 bp
  • A to G, chromosome 13 at 23,034,641 bp
  • A to G, chromosome 13 at 40,860,446 bp
  • A to G, chromosome 14 at 12,488,883 bp
  • T to C, chromosome 14 at 115,370,060 bp
  • T to A, chromosome 17 at 6,295,786 bp
  • G to A, chromosome 17 at 24,572,110 bp
  • T to C, chromosome 17 at 33,302,994 bp
  • A to G, chromosome 17 at 36,547,090 bp
  • C to T, chromosome 17 at 88,690,051 bp
  • G to A, chromosome 18 at 31,609,689 bp
  • A to T, chromosome 18 at 35,700,995 bp
  • G to T, chromosome 18 at 65,274,997 bp
  • G to A, chromosome 19 at 3,612,330 bp
  • A to G, chromosome 19 at 58,766,273 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3893 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040805-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.