Strain Name:
C57BL/6J-MtgxR3897Btlr/Mmmh
Stock Number:
040808-MU
Citation ID:
RRID:MMRRC_040808-MU
Other Names:
R3897 (G1), C57BL/6J-MtgxR3897Btlr
Major Collection:

Gene Information

Nrxn2
Name: neurexin II
Synonyms: 6430591O13Rik, neurexin II beta, neurexin II alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Gluralpha4, Glur4, spkw1, Glur-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Nisch
Name: nischarin
Synonyms: 1200007D05Rik, 3202002H23Rik, edsn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 64652
Homologene: 136161
Fzd8
Name: frizzled class receptor 8
Synonyms: Fz8, mFZ8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 14370
VEGA: 18
HGNC: HGNC:4046
Homologene: 40606
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: Jmjd2b, 4732474L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 193796
Homologene: 27773
Dlgap4
Name: DLG associated protein 4
Synonyms: SAP90/PSD-95-associated protein 4, DAP4, PSD-95/SAP90 binding protein 4, Sapap4, WBP16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228836
Homologene: 8935
Psat1
Name: phosphoserine aminotransferase 1
Synonyms: EPIP, PSA, D8Ertd814e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107272
Homologene: 6973
Ap1g1
Name: adaptor protein complex AP-1, gamma 1 subunit
Synonyms: gamma-adaptin, D8Ertd374e, Adtg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11765
HGNC: HGNC:555
Homologene: 47995
Gosr2
Name: golgi SNAP receptor complex member 2
Synonyms: GS27, 2310032N09Rik, SNARE, membrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 56494
HGNC: HGNC:4431
Homologene: 37907
Tra2a
Name: transformer 2 alpha
Synonyms: 1500010G04Rik, G430041M01Rik, mAWMS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 101214
Homologene: 40866
Rfwd3
Name: ring finger and WD repeat domain 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234736
Homologene: 41230
Adam15
Name: a disintegrin and metallopeptidase domain 15 (metargidin)
Synonyms: metargidin, MDC15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 11490
HGNC: HGNC:193
Homologene: 2829
Arhgef28
Name: Rho guanine nucleotide exchange factor (GEF) 28
Synonyms: RhoGEF, p190RhoGEF, Rgnef, 9230110L08Rik, D13Bwg1089e, RIP2, Rho specific exchange factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110596
VEGA: 13
Homologene: 8078
4933406M09Rik
Name: RIKEN cDNA 4933406M09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240755
Homologene: 128441
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E16Rik, Myospryn, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 76469
VEGA: 13
Homologene: 137367
Psd
Name: pleckstrin and Sec7 domain containing
Synonyms: Psdl, 1110007H17Rik, Efa6, Efa6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 73728
VEGA: 19
HGNC: HGNC:9507
Homologene: 31115
Colgalt1
Name: collagen beta(1-O)galactosyltransferase 1
Synonyms: 2810024B22Rik, Glt25d1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234407
Homologene: 23465
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: MIBP1, Gm20114, Shn-2, Schnurri-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: 9430031G15Rik, b2b1000Clo, LTBP-1, Ltbp1L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 70882
Homologene: 31589
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Pabpc6
Name: poly(A) binding protein, cytoplasmic 6
Synonyms: 4932702K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 67543
VEGA: 17
Homologene: 129776
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: aln, Thm1, line 158, 2410066K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 73668
Homologene: 57006
Iqcm
Name: IQ motif containing M
Synonyms: 1700007B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 71831
Homologene: 53050
Olfr1283
Name: olfactory receptor 1283
Synonyms: MOR248-19, GA_x6K02T2Q125-72420217-72421134
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228443
Homologene: 133657
Tmc4
Name: transmembrane channel-like gene family 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 353499
Homologene: 16971
Ecm1
Name: extracellular matrix protein 1
Synonyms: p85
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 13601
HGNC: HGNC:3153
Homologene: 3260
Olfr1259
Name: olfactory receptor 1259
Synonyms: GA_x6K02T2Q125-51376062-51375133, MOR232-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258338
Homologene: 128115
Rnf144a
Name: ring finger protein 144A
Synonyms: Rnf144, UIP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 108089
VEGA: 12
Homologene: 40982
Cts3
Name: cathepsin 3
Synonyms: 1600000I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 117066
VEGA: 13
Slc35b3
Name: solute carrier family 35, member B3
Synonyms: PAPST2, 4921526O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 108652
VEGA: 13
Homologene: 9313
Commd7
Name: COMM domain containing 7
Synonyms: 2310010I22Rik, mU3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99311
Homologene: 24933
Tmem203
Name: transmembrane protein 203
Synonyms: C730025P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227615
Homologene: 107047
F630040L22Rik
Name: RIKEN cDNA F630040L22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 134,390,438 bp
  • T to C, chromosome 2 at 19,269,177 bp
  • T to C, chromosome 2 at 25,255,923 bp
  • C to T, chromosome 2 at 66,235,069 bp
  • T to C, chromosome 2 at 89,943,809 bp
  • T to C, chromosome 2 at 111,368,761 bp
  • T to C, chromosome 2 at 153,622,790 bp
  • C to A, chromosome 2 at 156,746,069 bp
  • T to C, chromosome 3 at 89,346,938 bp
  • A to G, chromosome 3 at 95,735,986 bp
  • T to C, chromosome 6 at 49,245,542 bp
  • A to G, chromosome 7 at 3,671,088 bp
  • G to A, chromosome 8 at 71,619,662 bp
  • C to T, chromosome 8 at 75,753,400 bp
  • G to T, chromosome 8 at 85,096,948 bp
  • A to G, chromosome 8 at 109,854,999 bp
  • C to T, chromosome 8 at 111,288,242 bp
  • T to A, chromosome 9 at 4,513,260 bp
  • A to G, chromosome 9 at 108,115,042 bp
  • C to A, chromosome 10 at 14,128,969 bp
  • A to G, chromosome 11 at 103,697,646 bp
  • A to G, chromosome 12 at 26,310,713 bp
  • A to G, chromosome 13 at 38,934,763 bp
  • A to G, chromosome 13 at 61,564,986 bp
  • T to C, chromosome 13 at 93,096,681 bp
  • C to T, chromosome 13 at 97,956,576 bp
  • A to G, chromosome 14 at 31,191,000 bp
  • T to C, chromosome 17 at 9,669,127 bp
  • T to C, chromosome 17 at 56,396,955 bp
  • T to C, chromosome 17 at 75,274,016 bp
  • G to A, chromosome 18 at 9,214,939 bp
  • T to G, chromosome 19 at 6,519,257 bp
  • A to G, chromosome 19 at 15,919,453 bp
  • A to C, chromosome 19 at 46,324,585 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3897 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040808-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.