Strain Name:
C57BL/6J-MtgxR3967Btlr/Mmmh
Stock Number:
040838-MU
Citation ID:
RRID:MMRRC_040838-MU
Other Names:
R3967 (G1), C57BL/6J-MtgxR3967Btlr
Major Collection:

Gene Information

Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluR-B, GluR2, Glur-2, Glur2, GluA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Uri1
Name: URI1, prefoldin-like chaperone
Synonyms: NNX3, Rmp, C80913
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19777
Homologene: 2813
Arhgef12
Name: Rho guanine nucleotide exchange factor (GEF) 12
Synonyms: LARG, 2310014B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69632
VEGA: 9
Homologene: 9088
Slc16a3
Name: solute carrier family 16 (monocarboxylic acid transporters), member 3
Synonyms: MCT3, monocarboxylate transporter 4, MCT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 80879
Homologene: 37900
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 277854
Homologene: 34718
Pkn2
Name: protein kinase N2
Synonyms: PRK2, 6030436C20Rik, Stk7, Prkcl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109333
HGNC: HGNC:9406
Homologene: 2054
Wwox
Name: WW domain-containing oxidoreductase
Synonyms: WOX1, 9030416C10Rik, 5330426P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 80707
Homologene: 56334
Thoc1
Name: THO complex 1
Synonyms: 3110002N20Rik, NMP-84
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225160
VEGA: 18
Homologene: 38012
Uhrf2
Name: ubiquitin-like, containing PHD and RING finger domains 2
Synonyms: 2310065A22Rik, Nirf, D130071B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 109113
Homologene: 17001
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: MLTKbeta, MLTKalpha, B230120H23Rik, Zak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65964
Homologene: 32331
Rnf39
Name: ring finger protein 39
Synonyms: LIRF, LOC240094, LOC386465, LOC386454
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 386454
Homologene: 11891
Smc6
Name: structural maintenance of chromosomes 6
Synonyms: 2810489L22Rik, 3830418C19Rik, Smc6l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67241
VEGA: 12
Homologene: 41575
Adam18
Name: a disintegrin and metallopeptidase domain 18
Synonyms: Adam27, Dtgn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13524
HGNC: HGNC:196
Homologene: 74941
Enpp7
Name: ectonucleotide pyrophosphatase/phosphodiesterase 7
Synonyms: Alk-SMase, LOC238011
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 238011
Homologene: 110852
Ctnnd2
Name: catenin (cadherin associated protein), delta 2
Synonyms: Nprap, Catnd2, neurojugin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18163
VEGA: 15
HGNC: HGNC:2516
Homologene: 55574
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Psd
Name: pleckstrin and Sec7 domain containing
Synonyms: Efa6, 1110007H17Rik, Psdl, Efa6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73728
VEGA: 19
HGNC: HGNC:9507
Homologene: 31115
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: LaXp180, 2900055E04Rik, Cc1, 5930404L04Rik, Fip200
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12421
Homologene: 7659
Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
Synonyms: p85beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18709
HGNC: HGNC:8980
Homologene: 3687
Olfr921
Name: olfactory receptor 921
Synonyms: GA_x6K02T2PVTD-32478047-32478988, MOR165-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258778
VEGA: 9
Homologene: 128138
Ly75
Name: lymphocyte antigen 75
Synonyms: DEC-205, CD205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17076
HGNC: HGNC:6729
Homologene: 31085
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 669149
Homologene: 129606
Olfr512
Name: olfactory receptor 512
Synonyms: GA_x6K02T2PBJ9-11043421-11044365, MOR268-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258719
Homologene: 138316
Vmn2r83
Name: vomeronasal 2, receptor 83
Synonyms: EG625029
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625029
Homologene: 83669
Narf
Name: nuclear prelamin A recognition factor
Synonyms: 4430402O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67608
Homologene: 57048
Tmc6
Name: transmembrane channel-like gene family 6
Synonyms: EVER1, D11Ertd204e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217353
Homologene: 5258
Slc26a4
Name: solute carrier family 26, member 4
Synonyms: Pds, pendrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 23985
VEGA: 12
HGNC: HGNC:8818
Homologene: 20132
Slc27a1
Name: solute carrier family 27 (fatty acid transporter), member 1
Synonyms: FATP1, Fatp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26457
Homologene: 8063
Rab39
Name: RAB39, member RAS oncogene family
Synonyms: C230094F14Rik, Rab39a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270160
Homologene: 56773
Pidd1
Name: p53 induced death domain protein 1
Synonyms: 1200011D09Rik, Pidd, Lrdd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57913
Homologene: 11220
Kbtbd12
Name: kelch repeat and BTB (POZ) domain containing 12
Synonyms: 4833415F11Rik, 4933428M03Rik, Klhdc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74589
Homologene: 52613
Ctnna2
Name: catenin (cadherin associated protein), alpha 2
Synonyms: alpha(N)-catenin, alpha N-catenin, Catna, chp, Catna2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12386
HGNC: HGNC:2510
Homologene: 68394
Nlrx1
Name: NLR family member X1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270151
VEGA: 9
Homologene: 11623
Gm6871
Name: predicted gene 6871
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102642386
Grtp1
Name: GH regulated TBC protein 1
Synonyms: 5430401C05Rik, Tbc1d6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66790
Homologene: 84592
Gm14401
Name: predicted gene 14401
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100534275
1700018B08Rik
Name: RIKEN cDNA 1700018B08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76405
Homologene: 81929
Armcx6
Name: armadillo repeat containing, X-linked 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 278097
Homologene: 10373
Gm5069
Name: predicted pseudogene 5069
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 277333
Gm9964
Name: predicted gene 9964
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Pabpc5
Name: poly(A) binding protein, cytoplasmic 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 93728
Homologene: 5857
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,248,270 bp
  • A to T, chromosome 1 at 180,327,798 bp
  • T to C, chromosome 2 at 60,327,873 bp
  • T to A, chromosome 2 at 72,438,193 bp
  • T to C, chromosome 2 at 177,086,996 bp
  • T to A, chromosome 3 at 80,710,777 bp
  • A to G, chromosome 3 at 142,809,677 bp
  • T to A, chromosome 5 at 32,944,115 bp
  • A to G, chromosome 6 at 77,605,167 bp
  • A to G, chromosome 6 at 88,618,506 bp
  • A to G, chromosome 7 at 37,965,502 bp
  • A to T, chromosome 7 at 41,546,724 bp
  • A to G, chromosome 7 at 108,713,853 bp
  • A to G, chromosome 7 at 141,439,082 bp
  • G to A, chromosome 8 at 13,189,705 bp
  • C to A, chromosome 8 at 24,629,710 bp
  • G to A, chromosome 8 at 70,770,421 bp
  • A to G, chromosome 8 at 71,579,787 bp
  • G to A, chromosome 8 at 114,488,933 bp
  • G to T, chromosome 8 at 121,539,980 bp
  • A to G, chromosome 9 at 38,775,368 bp
  • C to A, chromosome 9 at 43,005,551 bp
  • A to T, chromosome 9 at 44,255,425 bp
  • G to A, chromosome 9 at 53,686,632 bp
  • T to A, chromosome 10 at 79,491,320 bp
  • T to C, chromosome 11 at 79,296,376 bp
  • T to C, chromosome 11 at 117,769,292 bp
  • T to C, chromosome 11 at 118,991,001 bp
  • C to T, chromosome 11 at 120,955,425 bp
  • A to T, chromosome 11 at 121,238,421 bp
  • T to C, chromosome 12 at 11,298,326 bp
  • G to T, chromosome 12 at 31,528,687 bp
  • A to T, chromosome 12 at 53,141,453 bp
  • A to T, chromosome 14 at 51,413,190 bp
  • C to A, chromosome 15 at 30,646,929 bp
  • C to A, chromosome 17 at 36,943,143 bp
  • T to A, chromosome 18 at 9,968,787 bp
  • A to T, chromosome 18 at 12,580,341 bp
  • T to C, chromosome 19 at 30,079,915 bp
  • C to T, chromosome 19 at 37,901,263 bp
  • T to G, chromosome 19 at 38,022,610 bp
  • C to T, chromosome 19 at 46,324,406 bp
  • A to G, chromosome X at 119,928,624 bp
  • G to T, chromosome X at 134,749,756 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3967 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040838-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.