Strain Name:
C57BL/6J-MtgxR4006Btlr/Mmmh
Stock Number:
040845-MU
Citation ID:
RRID:MMRRC_040845-MU
Other Names:
R4006 (G1), C57BL/6J-MtgxR4006Btlr
Major Collection:

Gene Information

Mc1r
Name: melanocortin 1 receptor
Synonyms: Mcr1, e, Mshra, extension recessive yellow
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17199
HGNC: HGNC:6929
Homologene: 1789
Gsn
Name: gelsolin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227753
HGNC: HGNC:4620
Homologene: 147
Htr2a
Name: 5-hydroxytryptamine (serotonin) receptor 2A
Synonyms: Htr-2, Htr2, 5-HT2A receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15558
VEGA: 14
HGNC: HGNC:5293
Homologene: 68073
Nup188
Name: nucleoporin 188
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227699
Homologene: 45683
Ppp1r37
Name: protein phosphatase 1, regulatory subunit 37
Synonyms: Lrrc68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232947
Homologene: 17851
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: A330063D19Rik, 1810014J18Rik, AD013, 9030205D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109151
Homologene: 11844
Zfp292
Name: zinc finger protein 292
Synonyms: 9430062L07Rik, Krox-10, Zfp-15, 5730450D02Rik, Zn-15, Zn-16, Zfp15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30046
Homologene: 8493
Lpin2
Name: lipin 2
Synonyms: 2610511G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 64898
Homologene: 8769
Trim23
Name: tripartite motif-containing 23
Synonyms: Arfd1, 6330516O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 81003
HGNC: HGNC:660
Homologene: 1251
Fntb
Name: farnesyltransferase, CAAX box, beta
Synonyms: 2010013E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110606
HGNC: HGNC:3785
Homologene: 1535
Zbtb20
Name: zinc finger and BTB domain containing 20
Synonyms: D16Wsu73e, Zfp288, 1300017A20Rik, HOF, 7330412A13Rik, A930017C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 56490
Homologene: 9226
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: synarfGEF, BRAG3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243621
Homologene: 46091
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 2310058O09Rik, 1810059M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100072
Homologene: 18942
Dsg4
Name: desmoglein 4
Synonyms: CDHF13, lah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16769
Homologene: 65341
Zfp317
Name: zinc finger protein 317
Synonyms: Zfp67, D230022C05Rik, Zfp75, KRAB9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244713
Homologene: 36389
Camkv
Name: CaM kinase-like vesicle-associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235604
Homologene: 56983
Tap1
Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: Abcb2, MTP1, RING4, Ham-1, TAP, Ham1, Tap-1, PSF-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21354
HGNC: HGNC:43
Homologene: 495
Lrrn2
Name: leucine rich repeat protein 2, neuronal
Synonyms: 5730406J09Rik, NLRR-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16980
Homologene: 21274
Nfatc3
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Synonyms: D8Ertd281e, NFAT4, NFATx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18021
HGNC: HGNC:7777
Homologene: 27827
Cul4a
Name: cullin 4A
Synonyms: 2810470J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 99375
HGNC: HGNC:2554
Homologene: 81724
Ano4
Name: anoctamin 4
Synonyms: Tmem16d, A330096O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320091
Homologene: 66599
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Xylt1
Name: xylosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233781
Homologene: 32534
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Farp1
Name: FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
Synonyms: Cdep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 223254
HGNC: HGNC:3591
Homologene: 38098
Prkcg
Name: protein kinase C, gamma
Synonyms: Prkcc, Pkcc, PKCgamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18752
HGNC: HGNC:9402
Homologene: 20602
Shoc1
Name: shortage in chiasmata 1
Synonyms: Gm426, Mzip2, LOC242489, AI481877
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100155
Homologene: 79783
Fbln2
Name: fibulin 2
Synonyms: 5730577E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14115
HGNC: HGNC:3601
Homologene: 1514
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: M-type receptor, Pla2g1br, PLA2-I receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Pate3
Name: prostate and testis expressed 3
Synonyms: Gm17365
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100312956
Homologene: 129908
Grm8
Name: glutamate receptor, metabotropic 8
Synonyms: Gprc1h, mGluR8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14823
HGNC: HGNC:4600
Homologene: 654
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226438
Homologene: 130054
Xkr4
Name: X-linked Kx blood group related 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 497097
Homologene: 45848
Olfr513
Name: olfactory receptor 513
Synonyms: GA_x6K02T2PBJ9-11084889-11085818, MOR195-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258718
Homologene: 64908
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: D9H3F15S2, DNF15S2h, D3F15S2h, Hgfl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15235
HGNC: HGNC:7380
Homologene: 7360
Zfp974
Name: zinc finger protein 974
Synonyms: 1700049G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73430
1700021F07Rik
Name: RIKEN cDNA 1700021F07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72221
Homologene: 82371
Gm2128
Name: predicted gene 2128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100039269
Homologene: 45597
Olfr1082
Name: olfactory receptor 1082
Synonyms: MOR192-4_p, GA_x6K02T2Q125-48079993-48079157
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404473
Homologene: 104285
Adamts14
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
Synonyms: Adamts-14, TS14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237360
Homologene: 16383
Reg1
Name: regenerating islet-derived 1
Synonyms: pancreatic stone protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19692
Homologene: 68282
Syce1
Name: synaptonemal complex central element protein 1
Synonyms: 4933406J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74075
Homologene: 77044
Psmb11
Name: proteasome (prosome, macropain) subunit, beta type, 11
Synonyms: 5830406J20Rik, beta5t
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 73902
VEGA: 14
Homologene: 13729
Prame
Name: preferentially expressed antigen in melanoma
Synonyms: 4930534P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 75829
Homologene: 87352
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 3,421,775 bp
  • A to T, chromosome 1 at 132,937,740 bp
  • C to T, chromosome 1 at 135,982,362 bp
  • G to A, chromosome 2 at 30,309,878 bp
  • G to A, chromosome 2 at 35,307,621 bp
  • A to T, chromosome 2 at 60,522,873 bp
  • T to C, chromosome 2 at 86,594,564 bp
  • T to C, chromosome 2 at 173,526,087 bp
  • T to C, chromosome 4 at 34,807,744 bp
  • G to T, chromosome 4 at 34,809,611 bp
  • A to T, chromosome 4 at 59,076,500 bp
  • A to G, chromosome 4 at 151,586,488 bp
  • T to C, chromosome 5 at 137,463,939 bp
  • T to C, chromosome 6 at 27,981,230 bp
  • A to G, chromosome 6 at 78,427,030 bp
  • C to A, chromosome 6 at 91,269,961 bp
  • A to G, chromosome 6 at 121,376,228 bp
  • G to A, chromosome 7 at 3,327,467 bp
  • A to G, chromosome 7 at 19,535,069 bp
  • G to A, chromosome 7 at 27,912,252 bp
  • G to A, chromosome 7 at 41,155,875 bp
  • C to T, chromosome 7 at 108,755,261 bp
  • A to G, chromosome 7 at 117,475,513 bp
  • C to A, chromosome 7 at 140,779,896 bp
  • A to G, chromosome 8 at 13,122,859 bp
  • T to C, chromosome 8 at 90,933,560 bp
  • T to A, chromosome 8 at 106,108,839 bp
  • T to C, chromosome 8 at 123,407,637 bp
  • T to G, chromosome 9 at 19,648,037 bp
  • T to A, chromosome 9 at 35,646,102 bp
  • C to T, chromosome 9 at 107,946,641 bp
  • A to G, chromosome 9 at 108,082,948 bp
  • A to G, chromosome 10 at 61,202,821 bp
  • C to A, chromosome 10 at 89,088,263 bp
  • C to A, chromosome 12 at 76,887,888 bp
  • A to G, chromosome 13 at 104,187,623 bp
  • T to A, chromosome 14 at 54,625,646 bp
  • A to T, chromosome 14 at 74,642,141 bp
  • T to C, chromosome 14 at 121,275,577 bp
  • T to C, chromosome 16 at 43,609,399 bp
  • T to A, chromosome 17 at 34,192,834 bp
  • C to T, chromosome 17 at 71,246,501 bp
  • G to T, chromosome 18 at 12,557,805 bp
  • G to A, chromosome 18 at 20,470,965 bp
  • A to T, chromosome X at 135,613,625 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4006 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040845-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.