Strain Name:
C57BL/6J-MtgxR4084Btlr/Mmmh
Stock Number:
040857-MU
Citation ID:
RRID:MMRRC_040857-MU
Other Names:
R4084 (G1), C57BL/6J-MtgxR4084Btlr
Major Collection:

Strain Information

Prkaca
Name: protein kinase, cAMP dependent, catalytic, alpha
Synonyms: C alpha, Pkaca, PKA, Cs
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18747
HGNC: HGNC:9380
Homologene: 121574
Hgf
Name: hepatocyte growth factor
Synonyms: NK2, SF/HGF, HGF/SF, C230052L06Rik, scatter factor, NK1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Ptch1
Name: patched 1
Synonyms: Ptc, wig, Patched 1, A230106A15Rik, Ptc1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Nap1l1
Name: nucleosome assembly protein 1-like 1
Synonyms: D10Ertd68e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 53605
VEGA: 10
HGNC: HGNC:7637
Homologene: 129218
Arhgdig
Name: Rho GDP dissociation inhibitor gamma
Synonyms: Gdi5, Rho-GDI-3, Rho-GDI2, RIP2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14570
HGNC: HGNC:680
Homologene: 7337
Herc4
Name: hect domain and RLD 4
Synonyms: 4921531D01Rik, 1700056O17Rik, 9530080M15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67345
VEGA: 10
Homologene: 56715
Lgals9
Name: lectin, galactose binding, soluble 9
Synonyms: galectin-9, Lgals5, gal-9, LGALS35
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16859
Homologene: 134662
Triobp
Name: TRIO and F-actin binding protein
Synonyms: EST478828, Mus EST 478828, Tara
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110253
Homologene: 5104
Lig3
Name: ligase III, DNA, ATP-dependent
Synonyms: D11Wsu78e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16882
HGNC: HGNC:6600
Homologene: 32109
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, A130082H20Rik, D430004I05Rik, TIF1alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21848
Homologene: 20830
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Lamb2
Name: laminin, beta 2
Synonyms: Lams, npht, Lamb-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Slu7
Name: SLU7 splicing factor homolog (S. cerevisiae)
Synonyms: D11Ertd730e, D3Bwg0878e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193116
Homologene: 4690
Seh1l
Name: SEH1-like (S. cerevisiae
Synonyms: 2610007A16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72124
VEGA: 18
Homologene: 68701
Ypel3
Name: yippee like 3
Synonyms: Suap, 1190001G19Rik, 0610043B10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66090
Homologene: 116010
Flna
Name: filamin, alpha
Synonyms: Fln1, Dilp2, GENA 379, actin-binding protein 280, filamin-1, ABP-280, F730004A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 192176
HGNC: HGNC:3754
Homologene: 1119
Fmnl2
Name: formin-like 2
Synonyms: man, 5430425K04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Fbxw11
Name: F-box and WD-40 domain protein 11
Synonyms: HOS, 2310065A07Rik, Fbxw1b, BTRC2, BTRCP2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103583
Homologene: 76444
Slc44a4
Name: solute carrier family 44, member 4
Synonyms: NG22, 2210409B01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70129
Homologene: 11359
Camkk1
Name: calcium/calmodulin-dependent protein kinase kinase 1, alpha
Synonyms: CaMKKalpha
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 55984
HGNC: HGNC:1469
Homologene: 10327
Gja1
Name: gap junction protein, alpha 1
Synonyms: connexin 43, Cx43, Cx43alpha1, Cnx43, Gja-1, alpha 1 connexin, connexin43
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14609
VEGA: 10
HGNC: HGNC:4274
Homologene: 136
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Col28a1
Name: collagen, type XXVIII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213945
Homologene: 66345
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Chia1
Name: chitinase, acidic 1
Synonyms: Chia, 2200003E03Rik, YNL, AMCase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 81600
Homologene: 75168
Slc6a18
Name: solute carrier family 6 (neurotransmitter transporter), member 18
Synonyms: XT2, Xtrp2, D630001K16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22598
VEGA: 13
Homologene: 40785
Btnl1
Name: butyrophilin-like 1
Synonyms: NG10, LOC240074, Btnl3, LOC240074
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100038862
Homologene: 103816
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Pcdh10
Name: protocadherin 10
Synonyms: OL-pc, Olpc, 6430521D13Rik, 6430703F07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18526
Homologene: 74967
Htra1
Name: HtrA serine peptidase 1
Synonyms: RSPP11, Prss11, L56, HtrA1, insulin-like growth factor binding protein 5 protease
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56213
HGNC: HGNC:9476
Homologene: 31114
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: nmf247, A930002K18Rik, 4930505G06Rik, 4930401L23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 77945
Homologene: 10679
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: LOC381522, E230008N13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381522
Homologene: 117988
Ripor3
Name: RIPOR family member 3
Synonyms: 2310033K02Rik, Fam65c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69553
Homologene: 15438
Lipn
Name: lipase, family member N
Synonyms: Lipl4, 2210418G03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70166
Homologene: 66969
Ppp1r15b
Name: protein phosphatase 1, regulatory subunit 15B
Synonyms: CReP, C530022L24Rik, 1810033K10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108954
Homologene: 13134
Capn13
Name: calpain 13
Synonyms: LOC381122
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381122
VEGA: 17
Homologene: 27026
Vmn2r37
Name: vomeronasal 2, receptor 37
Synonyms: V2r14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22305
Homologene: 113703
Ugt1a6a
Name: UDP glucuronosyltransferase 1 family, polypeptide A6A
Synonyms: Ugt1a6, UGT1.6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 94284
Homologene: 85959
Vstm2a
Name: V-set and transmembrane domain containing 2A
Synonyms: Vstm2, 9330184N17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 211739
Homologene: 17123
Lnpk
Name: lunapark, ER junction formation factor
Synonyms: 4921514L11Rik, Lnp, 2310011O18Rik, lunapark, 9530051D01Rik, Lnpk1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69605
Homologene: 12319
Zfp27
Name: zinc finger protein 27
Synonyms: Zfp-27, mkr-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22689
Homologene: 81823
Vmn2r7
Name: vomeronasal 2, receptor 7
Synonyms: 4933425M15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319217
Homologene: 129754
Ifi44
Name: interferon-induced protein 44
Synonyms: MTAP44, p44, A430056A10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99899
Homologene: 4683
Tmem45a2
Name: transmembrane protein 45A2
Synonyms: 2310005G13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69457
VEGA: 16
Homologene: 131266
Noxred1
Name: NADP+ dependent oxidoreductase domain containing 1
Synonyms: 4933437F05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71275
VEGA: 12
Homologene: 51388
Gtpbp3
Name: GTP binding protein 3
Synonyms: Gtpbp3, 2410009F13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70359
Homologene: 6600
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: nmf192, 4930564O18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 260305
Homologene: 9024
Slc23a2
Name: solute carrier family 23 (nucleobase transporters), member 2
Synonyms: SVCT2, YSPL3, Slc23a1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54338
Homologene: 68440
Ecm1
Name: extracellular matrix protein 1
Synonyms: p85
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13601
HGNC: HGNC:3153
Homologene: 3260
Elp5
Name: elongator acetyltransferase complex subunit 5
Synonyms: Rai12, Clone 13u
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54351
Homologene: 10291
Catsperd
Name: cation channel sperm associated auxiliary subunit delta
Synonyms: 4921529N20Rik, 4933402B14Rik, Tmem146, Gm6095
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106757
VEGA: 17
Homologene: 51896
Or11h6
Name: olfactory receptor family 11 subfamily H member 6
Synonyms: MOR106-11, GA_x6K02T2PMLR-6361495-6362481, Olfr745
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258296
Homologene: 27116
Tlr5
Name: toll-like receptor 5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53791
Homologene: 20698
Lmtk3
Name: lemur tyrosine kinase 3
Synonyms: AATYK3, Aatyk3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381983
Homologene: 79449
Stx5a
Name: syntaxin 5A
Synonyms: D19Ertd627e, 0610031F24Rik, syntaxin 5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56389
Homologene: 2381
Slc10a2
Name: solute carrier family 10, member 2
Synonyms: 9130221J18Rik, ASBT
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20494
Homologene: 390
Or52ab4
Name: olfactory receptor family 52 subfamily AB member 4
Synonyms: GA_x6K02T2PBJ9-6047402-6048349, MOR23-1, Olfr599
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258726
Homologene: 27244
Pla2g4f
Name: phospholipase A2, group IVF
Synonyms: 4732472I07Rik, Pla2zeta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271844
Homologene: 77933
H2-Eb1
Name: histocompatibility 2, class II antigen E beta
Synonyms: Ia-4, Ia4, H-2Eb
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14969
Homologene: 101524
Lonrf2
Name: LON peptidase N-terminal domain and ring finger 2
Synonyms: 2900060P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381338
Homologene: 18871
Or2b2
Name: olfactory receptor family 2 subfamily B member 2
Synonyms: GA_x6K02T2QHY8-11534186-11533245, MOR256-60, MOR256-35, Olfr1359
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258067
Homologene: 11056
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 38,821,151 bp
  • A to T, chromosome 1 at 88,139,177 bp
  • T to C, chromosome 1 at 133,133,067 bp
  • A to T, chromosome 1 at 182,974,848 bp
  • A to T, chromosome 2 at 53,107,495 bp
  • T to A, chromosome 2 at 74,537,461 bp
  • A to G, chromosome 2 at 112,900,908 bp
  • C to G, chromosome 2 at 120,312,325 bp
  • A to T, chromosome 2 at 132,091,217 bp
  • T to A, chromosome 2 at 150,266,202 bp
  • A to G, chromosome 2 at 167,984,466 bp
  • A to C, chromosome 3 at 45,392,707 bp
  • C to T, chromosome 3 at 64,692,993 bp
  • A to T, chromosome 3 at 95,734,363 bp
  • A to G, chromosome 3 at 106,128,442 bp
  • A to G, chromosome 3 at 151,745,489 bp
  • A to G, chromosome 4 at 45,950,632 bp
  • T to C, chromosome 4 at 123,450,072 bp
  • T to C, chromosome 4 at 152,488,791 bp
  • G to T, chromosome 5 at 16,615,858 bp
  • G to A, chromosome 6 at 8,013,131 bp
  • C to G, chromosome 6 at 8,013,132 bp
  • A to G, chromosome 6 at 37,915,257 bp
  • C to T, chromosome 7 at 9,215,985 bp
  • C to T, chromosome 7 at 29,895,367 bp
  • T to A, chromosome 7 at 45,793,292 bp
  • GCGGCGGCGGCGGCGGC to GCGGCGGCGGCGGCGGCGGCGGCGGC, chromosome 7 at 97,579,919 bp
  • T to G, chromosome 7 at 103,338,320 bp
  • T to C, chromosome 7 at 105,709,588 bp
  • T to C, chromosome 7 at 126,778,365 bp
  • T to C, chromosome 7 at 130,936,344 bp
  • C to T, chromosome 7 at 141,648,655 bp
  • T to G, chromosome 8 at 5,089,126 bp
  • A to G, chromosome 8 at 71,490,512 bp
  • C to A, chromosome 8 at 83,995,310 bp
  • A to G, chromosome 9 at 108,488,018 bp
  • A to C, chromosome 10 at 56,388,511 bp
  • G to T, chromosome 10 at 63,283,237 bp
  • G to A, chromosome 10 at 111,490,077 bp
  • A to G, chromosome 11 at 16,263,098 bp
  • T to C, chromosome 11 at 32,739,248 bp
  • G to A, chromosome 11 at 43,443,391 bp
  • T to C, chromosome 11 at 69,980,206 bp
  • C to T, chromosome 11 at 73,037,865 bp
  • A to T, chromosome 11 at 78,969,763 bp
  • T to A, chromosome 11 at 82,795,424 bp
  • A to G, chromosome 12 at 87,233,484 bp
  • G to A, chromosome 13 at 21,703,068 bp
  • C to A, chromosome 13 at 21,703,069 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • C to T, chromosome 13 at 73,667,029 bp
  • T to A, chromosome 14 at 50,642,848 bp
  • A to G, chromosome 14 at 52,149,351 bp
  • T to A, chromosome 15 at 78,973,671 bp
  • C to T, chromosome 16 at 57,071,024 bp
  • T to C, chromosome 17 at 26,199,825 bp
  • T to C, chromosome 17 at 34,314,443 bp
  • C to T, chromosome 17 at 34,381,159 bp
  • T to C, chromosome 17 at 34,917,347 bp
  • A to G, chromosome 17 at 56,654,453 bp
  • C to T, chromosome 17 at 73,337,449 bp
  • T to C, chromosome 18 at 67,788,790 bp
  • G to T, chromosome 19 at 8,743,431 bp
  • T to C, chromosome 19 at 34,078,940 bp
  • C to T, chromosome X at 74,236,925 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4084 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040857-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.