Strain Name:
C57BL/6J-MtgxR4095Btlr/Mmmh
Stock Number:
040858-MU
Citation ID:
RRID:MMRRC_040858-MU
Other Names:
R4095 (G1), C57BL/6J-MtgxR4095Btlr
Major Collection:

Strain Information

Hps5
Name: HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
Synonyms: ru-2, ruby eye 2, ru2, Hermansky-Pudlak syndrome 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246694
Homologene: 35333
Htr2a
Name: 5-hydroxytryptamine (serotonin) receptor 2A
Synonyms: 5-HT2A receptor, Htr-2, Htr2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15558
VEGA: 14
HGNC: HGNC:5293
Homologene: 68073
Spns1
Name: SPNS lysolipid transporter 1, lysophospholipid
Synonyms: 2210013K02Rik, spinster homolog
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73658
Homologene: 41530
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20562
Homologene: 2302
Mapt
Name: microtubule-associated protein tau
Synonyms: Tau, Mtapt
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: 6430573H23Rik, Prkwnk1, EG406236, Hsn2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Gtf2a1
Name: general transcription factor II A, 1
Synonyms: TfIIAa/b, 19kDa, 37kDa, 6330549H03Rik, Tfiia1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 83602
HGNC: HGNC:4646
Homologene: 56331
Sfswap
Name: splicing factor SWAP
Synonyms: 6330437E22Rik, 1190005N23Rik, Sfrs8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231769
Homologene: 134548
Tmem104
Name: transmembrane protein 104
Synonyms: C630005D06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320534
Homologene: 9802
Tnpo2
Name: transportin 2 (importin 3, karyopherin beta 2b)
Synonyms: 1110034O24Rik, Kpnb2b, TRN2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212999
Homologene: 8381
Casp3
Name: caspase 3
Synonyms: CPP32, Apopain, Yama, Caspase-3, A830040C14Rik, CC3, mldy, AC-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12367
HGNC: HGNC:1504
Homologene: 37912
Rell1
Name: RELT-like 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100532
Homologene: 27084
Ctr9
Name: CTR9 homolog, Paf1/RNA polymerase II complex component
Synonyms: Tsp, Tsbp, Sh2bp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22083
Homologene: 40668
Lrig1
Name: leucine-rich repeats and immunoglobulin-like domains 1
Synonyms: LIG-1, Img
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16206
Homologene: 7380
Alas1
Name: aminolevulinic acid synthase 1
Synonyms: 5-aminolevulinate synthase, succinyl-CoA: glycine C-succinyl transferase, Alas-1, ALAS-N
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11655
HGNC: HGNC:396
Homologene: 55478
Ube2b
Name: ubiquitin-conjugating enzyme E2B
Synonyms: E2-14k, HR6B, Rad6b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22210
Homologene: 101298
Coq7
Name: demethyl-Q 7
Synonyms: clk-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12850
HGNC: HGNC:2244
Homologene: 6953
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Dda1
Name: DET1 and DDB1 associated 1
Synonyms: 1700095J19Rik, 1500034J01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66498
Homologene: 11436
Fmnl2
Name: formin-like 2
Synonyms: 5430425K04Rik, man
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Dcaf6
Name: DDB1 and CUL4 associated factor 6
Synonyms: PC326, 1200006M05Rik, Iqwd1, NRIP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74106
Homologene: 10199
Ppp1r12c
Name: protein phosphatase 1, regulatory subunit 12C
Synonyms: 2410197A17Rik, Mbs85
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232807
Homologene: 75071
Brd9
Name: bromodomain containing 9
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105246
VEGA: 13
Homologene: 82462
Parm1
Name: prostate androgen-regulated mucin-like protein 1
Synonyms: 2210012L08Rik, 9130213B05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231440
Homologene: 41036
Foxn3
Name: forkhead box N3
Synonyms: HTLFL1, 5430426H20Rik, Ches1l, Ches1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71375
HGNC: HGNC:1928
Homologene: 135955
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: 4930556H18Rik, 2310009M18Rik, 1700048H13Rik, D630041K24Rik, STAMP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320244
Homologene: 9013
Dach1
Name: dachshund family transcription factor 1
Synonyms: Dac, E130112M23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Akap6
Name: A kinase anchor protein 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Zfp605
Name: zinc finger protein 605
Synonyms: A830023I12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 675812
Homologene: 52335
Ccser1
Name: coiled-coil serine rich 1
Synonyms: 6230405M12Rik, C130092O11Rik, Fam190a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232035
Homologene: 28086
Brinp3
Name: bone morphogenetic protein/retinoic acid inducible neural specific 3
Synonyms: B830045N13Rik, Fam5c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215378
Homologene: 17786
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Arvcf
Name: armadillo repeat gene deleted in velocardiofacial syndrome
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11877
HGNC: HGNC:728
Homologene: 31046
Apba1
Name: amyloid beta precursor protein binding family A member 1
Synonyms: X11alpha, Lin-10, X11, Mint1, Mint, 6430513E09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319924
VEGA: 19
HGNC: HGNC:578
Homologene: 897
Bcl11b
Name: B cell leukemia/lymphoma 11B
Synonyms: COUP-TF interacting protein 2, CTIP2, B630002E05Rik, Rit1, 9130430L19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 58208
Homologene: 10974
Entpd7
Name: ectonucleoside triphosphate diphosphohydrolase 7
Synonyms: LALP1, 2810003F23Rik, 1810020C02Rik, 1810012B13Rik, Lysal2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 93685
Homologene: 122202
Zc3h7a
Name: zinc finger CCCH type containing 7 A
Synonyms: A430104C18Rik, Zc3h7
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106205
Homologene: 8563
Ccdc106
Name: coiled-coil domain containing 106
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232821
Homologene: 81845
Vmn1r185
Name: vomeronasal 1 receptor 185
Synonyms: V1re12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171265
Homologene: 74353
St3gal6
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 6
Synonyms: ST3Gal VI, 1700023B24Rik, Siat10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 54613
Homologene: 4448
Slc22a23
Name: solute carrier family 22, member 23
Synonyms: 3110004L20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73102
Homologene: 41457
Gbp2
Name: guanylate binding protein 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14469
Homologene: 10289
Gm15446
Name: predicted gene 15446
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100642166
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: VKIND, very-kind, 2410012C07Rik, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Sema6c
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
Synonyms: Sema Y, Semay
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20360
Homologene: 7931
Or10am5
Name: olfactory receptor family 10 subfamily AM member 5
Synonyms: GA_x6K02T2QGBW-3245761-3244808, MOR232-8, Olfr1349
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269862
Homologene: 133589
Or8s10
Name: olfactory receptor family 8 subfamily S member 1
Synonyms: GA_x6K02T2NBG7-5293798-5292872, MOR160-2, Olfr282
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 258449
Homologene: 133621
Krt27
Name: keratin 27
Synonyms: Krt1-c29, mIRSa3.1, stpm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16675
Homologene: 7805
Zfp61
Name: zinc finger protein 61
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22719
Homologene: 74923
Kcnf1
Name: potassium voltage-gated channel, subfamily F, member 1
Synonyms: LOC382571
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 382571
HGNC: HGNC:6246
Homologene: 124236
Tmem74
Name: transmembrane protein 74
Synonyms: B230382K22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239408
VEGA: 15
Homologene: 17684
C1qc
Name: complement component 1, q subcomponent, C chain
Synonyms: C1qg
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12262
HGNC: HGNC:1245
Homologene: 32020
Pdxk
Name: pyridoxal (pyridoxine, vitamin B6) kinase
Synonyms: 2310036D04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216134
HGNC: HGNC:8819
Homologene: 2731
Ighv2-6-8
Name: immunoglobulin heavy variable 2-6-8
Synonyms: Gm16887
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 791090
Trav6-2
Name: T cell receptor alpha variable 6-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 436539
Or6e1
Name: olfactory receptor family 6 subfamily E member 1
Synonyms: IC6, MOR118-1, GA_x6K02T2QVSB-39745261-39746202, Olfr49
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18348
Homologene: 106373
Pcdhgb2
Name: protocadherin gamma subfamily B, 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93700
HGNC: HGNC:8709
Homologene: 49571
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 146,901,692 bp
  • T to C, chromosome 1 at 165,429,305 bp
  • G to A, chromosome 2 at 41,449,191 bp
  • A to G, chromosome 2 at 53,101,523 bp
  • T to A, chromosome 3 at 95,173,194 bp
  • A to G, chromosome 3 at 142,637,449 bp
  • A to T, chromosome 4 at 81,383,823 bp
  • T to C, chromosome 4 at 136,890,326 bp
  • C to A, chromosome 5 at 63,968,670 bp
  • T to C, chromosome 5 at 91,594,180 bp
  • T to A, chromosome 5 at 109,940,724 bp
  • A to G, chromosome 5 at 110,127,736 bp
  • A to G, chromosome 5 at 129,560,741 bp
  • A to T, chromosome 6 at 61,311,538 bp
  • T to C, chromosome 6 at 94,613,578 bp
  • G to A, chromosome 6 at 119,948,126 bp
  • T to C, chromosome 7 at 4,483,367 bp
  • C to A, chromosome 7 at 5,059,525 bp
  • T to A, chromosome 7 at 6,515,253 bp
  • A to G, chromosome 7 at 24,291,275 bp
  • A to T, chromosome 7 at 26,611,783 bp
  • A to G, chromosome 7 at 27,325,216 bp
  • T to C, chromosome 7 at 46,775,794 bp
  • T to A, chromosome 7 at 111,051,587 bp
  • T to G, chromosome 7 at 118,527,478 bp
  • T to C, chromosome 7 at 126,370,786 bp
  • A to G, chromosome 7 at 139,937,025 bp
  • G to A, chromosome 8 at 46,634,216 bp
  • A to G, chromosome 8 at 71,473,792 bp
  • T to A, chromosome 8 at 85,038,419 bp
  • A to G, chromosome 8 at 110,541,547 bp
  • G to T, chromosome 9 at 106,241,801 bp
  • A to T, chromosome 10 at 39,097,122 bp
  • T to C, chromosome 10 at 78,464,810 bp
  • A to C, chromosome 11 at 51,997,827 bp
  • T to C, chromosome 11 at 99,345,793 bp
  • T to C, chromosome 11 at 104,310,536 bp
  • T to A, chromosome 11 at 115,243,923 bp
  • A to T, chromosome 12 at 17,175,479 bp
  • A to T, chromosome 12 at 53,139,462 bp
  • A to T, chromosome 12 at 85,956,602 bp
  • G to T, chromosome 12 at 91,575,637 bp
  • G to T, chromosome 12 at 99,196,441 bp
  • G to T, chromosome 12 at 107,916,835 bp
  • T to C, chromosome 12 at 113,796,153 bp
  • A to G, chromosome 13 at 34,305,206 bp
  • G to A, chromosome 13 at 73,944,799 bp
  • G to T, chromosome 14 at 52,667,815 bp
  • T to C, chromosome 14 at 54,282,731 bp
  • G to A, chromosome 14 at 74,706,349 bp
  • C to T, chromosome 14 at 97,901,379 bp
  • G to A, chromosome 15 at 43,867,282 bp
  • T to C, chromosome 15 at 98,437,682 bp
  • T to C, chromosome 16 at 11,145,235 bp
  • T to A, chromosome 16 at 18,401,577 bp
  • G to A, chromosome 16 at 58,484,765 bp
  • T to A, chromosome 18 at 37,690,950 bp
  • A to T, chromosome 19 at 23,944,024 bp
  • A to T, chromosome 19 at 41,608,486 bp
  • A to G, chromosome 19 at 43,704,201 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4095 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040858-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.