Strain Name:
C57BL/6J-MtgxR1508Btlr/Mmmh
Stock Number:
040869-MU
Citation ID:
RRID:MMRRC_040869-MU
Other Names:
R1508 (G1), C57BL/6J-MtgxR1508Btlr
Major Collection:

Strain Information

Angpt2
Name: angiopoietin 2
Synonyms: Ang2, Ang-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11601
HGNC: HGNC:485
Homologene: 22401
H2-D1
Name: histocompatibility 2, D region locus 1
Synonyms: H-2D
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14964
Homologene: 128352
Slit3
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Dcaf1
Name: DDB1 and CUL4 associated factor 1
Synonyms: B930007L02Rik, Vprbp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 321006
Homologene: 8805
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Dsk9, Mhdadsk9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Specc1l
Name: sperm antigen with calponin homology and coiled-coil domains 1-like
Synonyms: 4930470P14Rik, 9530057A13Rik, 4932439K10Rik, Specc1l, Cytsa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74392
VEGA: 10
Homologene: 15610
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: LOC380993, Zfp406, Zfat1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380993
Homologene: 16829
Pex14
Name: peroxisomal biogenesis factor 14
Synonyms: Pex14p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56273
HGNC: HGNC:8856
Homologene: 37936
Slc8a2
Name: solute carrier family 8 (sodium/calcium exchanger), member 2
Synonyms: Ncx2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110891
Homologene: 27358
Golga1
Name: golgin A1
Synonyms: golgin-97, 0710001G09Rik, 2210418B03Rik, Golgi97, awag
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76899
HGNC: HGNC:4424
Homologene: 68223
Wbp1l
Name: WW domain binding protein 1 like
Synonyms: D19Wsu162e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226178
Homologene: 9839
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: RPA2, RPA116, 128kDa, D630020H17Rik, Rpo1-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20017
Homologene: 7133
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: H-FABP, Fabph-4, Fabph-1, Fabph4, Fabph1, Mdgi, Fabp3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, Drad-1, E130320P19Rik, E030015M03Rik, b2b1200.1Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20563
Homologene: 3516
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Klhl12
Name: kelch-like 12
Synonyms: C3ip1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240756
Homologene: 23317
Supt6
Name: SPT6, histone chaperone and transcription elongation factor
Synonyms: SPT6, 5131400N11Rik, Supt6h
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20926
Homologene: 40661
Zbtb14
Name: zinc finger and BTB domain containing 14
Synonyms: ZF5, Zfp161, b2b1982Clo
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22666
Homologene: 2560
Ppp3cb
Name: protein phosphatase 3, catalytic subunit, beta isoform
Synonyms: PP2BA beta, Calnb, CnAbeta, 1110063J16Rik, Cnab
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19056
HGNC: HGNC:9315
Homologene: 56429
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Ccdc47
Name: coiled-coil domain containing 47
Synonyms: asp4, 2610204L23Rik, calumin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67163
Homologene: 41351
2610008E11Rik
Name: RIKEN cDNA 2610008E11 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72128
Homologene: 86705
Cep76
Name: centrosomal protein 76
Synonyms: 6230425F05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225659
VEGA: 18
Homologene: 11774
Papln
Name: papilin, proteoglycan-like sulfated glycoprotein
Synonyms: E030033C16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 170721
Homologene: 71541
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Prf1
Name: perforin 1 (pore forming protein)
Synonyms: perforin, Prf-1, Pfp, Pfn
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18646
VEGA: 10
HGNC: HGNC:9360
Homologene: 3698
Cubn
Name: cubilin
Synonyms: D2Wsu88e, intrinsic factor-cobalamin receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Tex15
Name: testis expressed gene 15 meiosis and synapsis associated
Synonyms: 2210014E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104271
Homologene: 12837
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Clec4a3
Name: C-type lectin domain family 4, member a3
Synonyms: 3110037K17Rik, mDcir3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73149
Homologene: 9413
Ptprn2
Name: protein tyrosine phosphatase receptor type N polypeptide 2
Synonyms: PTP-NP, IA-2 beta, phogrin, IA-2beta, 4930425H11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19276
HGNC: HGNC:9677
Homologene: 2134
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D3Bwg1078e, 4732458A06Rik, D130016K21Rik, 9430063L05Rik, Usmg4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Myocd
Name: myocardin
Synonyms: Srfcp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 214384
Homologene: 17043
Tdrd1
Name: tudor domain containing 1
Synonyms: MTR-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83561
Homologene: 12850
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Albfm1
Name: albumin superfamily member 1
Synonyms: ARG, Gm17754, 5830473C10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622307
Homologene: 129803
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
Vstm4
Name: V-set and transmembrane domain containing 4
Synonyms: E130203B14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 320736
Homologene: 18707
Usp4
Name: ubiquitin specific peptidase 4 (proto-oncogene)
Synonyms: Unp, F730026I20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22258
Homologene: 20716
Slfn1
Name: schlafen 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20555
Homologene: 86967
Col20a1
Name: collagen, type XX, alpha 1
Synonyms: 1700051I12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73368
Homologene: 75138
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: 4930578N11Rik, 4931433A01Rik, Ccp6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78933
Homologene: 84880
Tmem67
Name: transmembrane protein 67
Synonyms: 5330408M12Rik, b2b1291.1Clo, b2b1163.1Clo
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329795
Homologene: 71886
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100009609
Cyp4a31
Name: cytochrome P450, family 4, subfamily a, polypeptide 31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666168
HGNC: HGNC:2642
Homologene: 128044
Clec2j
Name: C-type lectin domain family 2, member J
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 677440
Skint11
Name: selection and upkeep of intraepithelial T cells 11
Synonyms: A630098G03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230623
Homologene: 136292
Jazf1
Name: JAZF zinc finger 1
Synonyms: Tip27, Jaz1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 231986
Homologene: 18291
Or6k2
Name: olfactory receptor family 6 subfamily K member 2
Synonyms: GA_x6K02T2P20D-20995211-20994246, MOR105-10, Olfr420
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258302
Homologene: 17185
Trim56
Name: tripartite motif-containing 56
Synonyms: LOC384309, RNF109, A130009K11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384309
Homologene: 12812
Lpcat2b
Name: lysophosphatidylcholine acyltransferase 2B
Synonyms: 4921521K07Rik, Aytl1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70902
Homologene: 86793
Plppr3
Name: phospholipid phosphatase related 3
Synonyms: BC005764, Lppr3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216152
Homologene: 11769
Or52z15
Name: olfactory receptor family 52 subfamily Z member 15
Synonyms: GA_x6K02T2PBJ9-6416276-6417237, MOR31-15P, Olfr625
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258169
Echdc3
Name: enoyl Coenzyme A hydratase domain containing 3
Synonyms: 2310005D12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67856
Homologene: 11484
AC164627.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Trim21
Name: tripartite motif-containing 21
Synonyms: Ro52, Ssa1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20821
Homologene: 2365
Glrx
Name: glutaredoxin
Synonyms: D13Wsu156e, Grx1, TTase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 93692
HGNC: HGNC:4330
Homologene: 37566
Ceacam13
Name: CEA cell adhesion molecule 13
Synonyms: Ceacam13-C2, Ceacam13-C1, 1600025J19Rik, 1600012K03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69785
HGNC: HGNC:1819
Homologene: 135962
Gm17364
Name: predicted gene, 17364
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 82,455,836 bp
  • T to C, chromosome 1 at 134,488,974 bp
  • T to A, chromosome 1 at 174,159,364 bp
  • A to T, chromosome 2 at 6,206,420 bp
  • A to G, chromosome 2 at 13,427,105 bp
  • A to G, chromosome 2 at 39,023,249 bp
  • A to G, chromosome 2 at 129,113,734 bp
  • A to G, chromosome 2 at 180,992,577 bp
  • T to C, chromosome 3 at 97,888,483 bp
  • A to G, chromosome 4 at 12,057,428 bp
  • T to C, chromosome 4 at 111,656,398 bp
  • T to C, chromosome 4 at 114,231,766 bp
  • T to A, chromosome 4 at 115,565,053 bp
  • C to T, chromosome 4 at 130,312,387 bp
  • T to C, chromosome 4 at 148,967,572 bp
  • A to G, chromosome 5 at 48,192,249 bp
  • A to G, chromosome 5 at 90,581,921 bp
  • A to T, chromosome 5 at 107,433,464 bp
  • C to T, chromosome 5 at 137,113,937 bp
  • G to A, chromosome 6 at 52,812,181 bp
  • A to T, chromosome 6 at 122,967,508 bp
  • A to T, chromosome 6 at 128,655,989 bp
  • T to C, chromosome 7 at 16,140,597 bp
  • T to A, chromosome 7 at 18,011,071 bp
  • T to A, chromosome 7 at 84,940,678 bp
  • T to A, chromosome 7 at 102,559,576 bp
  • T to C, chromosome 7 at 103,683,471 bp
  • T to C, chromosome 8 at 18,703,472 bp
  • C to G, chromosome 8 at 33,576,852 bp
  • T to C, chromosome 8 at 45,026,862 bp
  • A to T, chromosome 9 at 106,854,177 bp
  • T to C, chromosome 9 at 108,372,674 bp
  • A to G, chromosome 10 at 61,303,550 bp
  • A to G, chromosome 10 at 75,307,238 bp
  • A to T, chromosome 10 at 79,068,056 bp
  • A to T, chromosome 10 at 79,867,540 bp
  • A to T, chromosome 10 at 100,306,838 bp
  • A to T, chromosome 11 at 35,570,621 bp
  • C to T, chromosome 11 at 65,184,516 bp
  • A to G, chromosome 11 at 78,216,203 bp
  • A to G, chromosome 11 at 79,440,909 bp
  • T to A, chromosome 11 at 83,121,355 bp
  • T to C, chromosome 11 at 104,710,677 bp
  • C to T, chromosome 11 at 106,202,416 bp
  • T to C, chromosome 12 at 8,011,481 bp
  • T to A, chromosome 12 at 82,440,893 bp
  • A to G, chromosome 12 at 83,782,916 bp
  • A to G, chromosome 12 at 83,786,693 bp
  • T to C, chromosome 12 at 117,184,722 bp
  • A to G, chromosome 13 at 41,273,823 bp
  • T to C, chromosome 13 at 75,847,162 bp
  • T to C, chromosome 14 at 20,524,424 bp
  • T to C, chromosome 14 at 32,863,554 bp
  • C to T, chromosome 14 at 64,030,892 bp
  • T to A, chromosome 15 at 68,178,751 bp
  • T to A, chromosome 17 at 35,263,868 bp
  • C to G, chromosome 17 at 69,387,764 bp
  • C to A, chromosome 18 at 65,349,305 bp
  • A to G, chromosome 18 at 67,623,288 bp
  • T to A, chromosome 19 at 46,606,768 bp
  • G to A, chromosome 19 at 56,851,358 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1508 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040869-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.