Strain Name:
C57BL/6J-MtgxR1525Btlr/Mmmh
Stock Number:
040872-MU
Citation ID:
RRID:MMRRC_040872-MU
Other Names:
R1525 (G1), C57BL/6J-MtgxR1525Btlr
Major Collection:

Gene Information

Txndc2
Name: thioredoxin domain containing 2 (spermatozoa)
Synonyms: Sptrx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213272
VEGA: 17
Homologene: 41856
Dgat1
Name: diacylglycerol O-acyltransferase 1
Synonyms: D15Ertd23e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13350
HGNC: HGNC:2843
Homologene: 7688
Fam110b
Name: family with sequence similarity 110, member B
Synonyms: 1700012H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242297
Homologene: 17518
Tfr2
Name: transferrin receptor 2
Synonyms: Tfr2, Trfr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50765
Homologene: 2428
Mob2
Name: MOB kinase activator 2
Synonyms: 1110017M21Rik, 2700078K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101513
Homologene: 12477
Zfp729a
Name: zinc finger protein 729a
Synonyms: A530054K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 212281
Homologene: 133713
Pitpnb
Name: phosphatidylinositol transfer protein, beta
Synonyms: Pitp beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56305
HGNC: HGNC:9002
Homologene: 4533
Larp4b
Name: La ribonucleoprotein domain family, member 4B
Synonyms: D13Wsu64e, Larp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 217980
Homologene: 18195
Rere
Name: arginine glutamic acid dipeptide (RE) repeats
Synonyms: 1110033A15Rik, atrophin-2, Atr2, eyem03Jus, eyes3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68703
HGNC: HGNC:9965
Homologene: 8101
Ints9
Name: integrator complex subunit 9
Synonyms: D14Ertd231e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 210925
VEGA: 14
Homologene: 10096
Ranbp3
Name: RAN binding protein 3
Synonyms: 2610024N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71810
VEGA: 17
HGNC: HGNC:9850
Homologene: 136516
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Brpf1
Name: bromodomain and PHD finger containing, 1
Synonyms: 4930540D11Rik, 4833438B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78783
Homologene: 31251
Pvr
Name: poliovirus receptor
Synonyms: mE4, 3830421F03Rik, Taa1, CD155, Tage4, necl-5, D7Ertd458e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52118
Homologene: 79541
Pias1
Name: protein inhibitor of activated STAT 1
Synonyms: GBP, 2900068C24Rik, Ddxbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56469
VEGA: 9
HGNC: HGNC:2752
Homologene: 22953
Prss16
Name: protease, serine 16 (thymus)
Synonyms: TSSP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 54373
HGNC: HGNC:9480
Homologene: 38106
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: MEKK1, Mekk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Zc3h18
Name: zinc finger CCCH-type containing 18
Synonyms: 1190001B23Rik, 5830416A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76014
Homologene: 44894
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12294
Homologene: 74929
Zfp410
Name: zinc finger protein 410
Synonyms: D12Ertd748e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 52708
VEGA: 12
Homologene: 10918
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Amotl2
Name: angiomotin-like 2
Synonyms: Lccp, MASCOT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56332
Homologene: 9420
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Zbtb1
Name: zinc finger and BTB domain containing 1
Synonyms: C430003J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268564
Homologene: 8974
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20265
Homologene: 21375
Frmd4b
Name: FERM domain containing 4B
Synonyms: 6030440G05Rik, GRSP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232288
Homologene: 14916
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233651
Homologene: 2771
Fcsk
Name: fucose kinase
Synonyms: L-fucose kinase, 1110046B12Rik, Fuk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234730
Homologene: 15452
Olfr720
Name: olfactory receptor 720
Synonyms: GA_x6K02T2PLTE-6544896-6543946, MOR274-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258387
Homologene: 74036
Dock10
Name: dedicator of cytokinesis 10
Synonyms: Jr5, Jr4, ZIZ3, 9330153B10Rik, A630054M16Rik, Zizimin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210293
Homologene: 45952
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Krt6a
Name: keratin 6A
Synonyms: mK6[a], MK6a, Krt2-6c, Krt2-6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16687
VEGA: 15
Homologene: 136794
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Stard9
Name: START domain containing 9
Synonyms: N-3 kinesin, Kif16a, 4831403C07Rik, E230025N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668880
Homologene: 130712
Myoc
Name: myocilin
Synonyms: TIGR, GLC1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17926
HGNC: HGNC:7610
Homologene: 220
Il17ra
Name: interleukin 17 receptor A
Synonyms: VDw217, Il17r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16172
HGNC: HGNC:5985
Homologene: 7378
Sh3pxd2a
Name: SH3 and PX domains 2A
Synonyms: Fish, Sh3md1, Tks5, 2310014D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14218
VEGA: 19
Homologene: 7317
Cfap69
Name: cilia and flagella associated protein 69
Synonyms: A330021E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 207686
Homologene: 11718
Syna
Name: syncytin a
Synonyms: syncytin-A, Gm52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 214292
Homologene: 86751
Cyp2d11
Name: cytochrome P450, family 2, subfamily d, polypeptide 11
Synonyms: P450-2D, Cyp2d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 545123
VEGA: 15
Homologene: 86099
Mei4
Name: meiotic double-stranded break formation protein 4
Synonyms: 4930486G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75033
Homologene: 87251
Tmem97
Name: transmembrane protein 97
Synonyms: D11Bhm182e, 1810014L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69071
Homologene: 6443
Cdh24
Name: cadherin-like 24
Synonyms: cadherin 14-like, EY-cadherin, 1700040A22Rik, ENSMUSG00000022188
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239096
VEGA: 14
Homologene: 56951
Olfr50
Name: olfactory receptor 50
Synonyms: ID3, MOR136-6, GA_x6K02T2NLDC-33487752-33488690
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18350
Homologene: 74212
Slc34a2
Name: solute carrier family 34 (sodium phosphate), member 2
Synonyms: type IIb Na/Picotransporter, Npt2b, NaPi-2b, D5Ertd227e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20531
Homologene: 2297
Dennd4b
Name: DENN/MADD domain containing 4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229541
Homologene: 28281
Mep1a
Name: meprin 1 alpha
Synonyms: meprin A alpha-subunit, meprin alpha, Mep-1a, Mep-1, Mep1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17287
HGNC: HGNC:7015
Homologene: 31323
Dmc1
Name: DNA meiotic recombinase 1
Synonyms: Dmc1, Dmc1h, Mei11, sgdp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13404
VEGA: 15
HGNC: HGNC:2927
Homologene: 5135
Rhoj
Name: ras homolog family member J
Synonyms: TCL, 1110005O19Rik, TC10L, Arhj
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 80837
HGNC: HGNC:688
Homologene: 56894
Abcc3
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Synonyms: 1700019L09Rik, MRP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Lamc2
Name: laminin, gamma 2
Synonyms: nicein, 100kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16782
HGNC: HGNC:6493
Homologene: 4062
Cdk9
Name: cyclin-dependent kinase 9 (CDC2-related kinase)
Synonyms: PITALRE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107951
HGNC: HGNC:1780
Homologene: 55566
Orm2
Name: orosomucoid 2
Synonyms: Orm-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18406
HGNC: HGNC:8499
Homologene: 130632
Fem1al
Name: fem-1 homolog A like
Synonyms: 4931440F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216622
Pdilt
Name: protein disulfide isomerase-like, testis expressed
Synonyms: PDILT, 1700007B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71830
Homologene: 18382
Pttg1ip2
Name: PTTG1IP family member 2
Synonyms: LOC381716, 1700015F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381716
Homologene: 136447
Zfp382
Name: zinc finger protein 382
Synonyms: 5930415A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233060
Homologene: 32798
Olfr1188
Name: olfactory receptor 1188
Synonyms: GA_x6K02T2Q125-50046879-50047784, MOR238-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258921
Ndn
Name: necdin, MAGE family member
Synonyms: Peg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17984
HGNC: HGNC:7675
Homologene: 20559
Kctd14
Name: potassium channel tetramerisation domain containing 14
Synonyms: D7Ertd760e, AI449310
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233529
Homologene: 11396
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 80,606,164 bp
  • T to C, chromosome 1 at 153,130,756 bp
  • T to G, chromosome 1 at 162,648,651 bp
  • A to G, chromosome 2 at 32,710,509 bp
  • A to T, chromosome 2 at 36,794,143 bp
  • C to T, chromosome 2 at 66,319,462 bp
  • C to G, chromosome 2 at 88,559,641 bp
  • A to G, chromosome 2 at 91,167,928 bp
  • G to T, chromosome 2 at 112,678,090 bp
  • T to A, chromosome 2 at 118,609,992 bp
  • T to A, chromosome 2 at 120,702,052 bp
  • G to T, chromosome 3 at 90,270,870 bp
  • A to G, chromosome 4 at 5,799,578 bp
  • C to T, chromosome 4 at 63,364,038 bp
  • T to A, chromosome 4 at 150,439,330 bp
  • C to A, chromosome 5 at 5,452,019 bp
  • G to T, chromosome 5 at 5,640,230 bp
  • A to G, chromosome 5 at 53,069,506 bp
  • G to T, chromosome 5 at 111,347,116 bp
  • T to C, chromosome 5 at 134,559,258 bp
  • T to C, chromosome 5 at 137,579,030 bp
  • G to A, chromosome 6 at 97,296,386 bp
  • A to G, chromosome 6 at 113,317,154 bp
  • T to C, chromosome 6 at 120,473,790 bp
  • G to A, chromosome 7 at 19,910,626 bp
  • G to A, chromosome 7 at 30,133,719 bp
  • C to T, chromosome 7 at 62,348,508 bp
  • A to T, chromosome 7 at 97,457,867 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,908 bp
  • T to C, chromosome 7 at 105,758,931 bp
  • T to A, chromosome 7 at 119,487,994 bp
  • A to T, chromosome 7 at 142,010,390 bp
  • T to C, chromosome 8 at 110,889,673 bp
  • T to C, chromosome 8 at 122,413,938 bp
  • T to C, chromosome 9 at 62,920,487 bp
  • T to C, chromosome 9 at 81,890,199 bp
  • C to T, chromosome 9 at 102,728,568 bp
  • A to G, chromosome 10 at 127,539,529 bp
  • A to C, chromosome 11 at 29,823,994 bp
  • T to A, chromosome 11 at 78,542,760 bp
  • A to T, chromosome 11 at 78,542,761 bp
  • A to T, chromosome 11 at 94,361,236 bp
  • T to C, chromosome 12 at 75,309,013 bp
  • T to G, chromosome 12 at 76,386,432 bp
  • T to C, chromosome 12 at 84,322,966 bp
  • C to T, chromosome 13 at 9,145,450 bp
  • A to C, chromosome 13 at 22,009,443 bp
  • G to T, chromosome 13 at 67,619,321 bp
  • A to T, chromosome 13 at 70,605,410 bp
  • A to T, chromosome 13 at 111,776,027 bp
  • T to A, chromosome 14 at 14,175,725 bp
  • T to C, chromosome 14 at 28,972,242 bp
  • A to T, chromosome 14 at 54,638,589 bp
  • T to C, chromosome 14 at 64,995,011 bp
  • C to A, chromosome 15 at 4,951,130 bp
  • T to C, chromosome 15 at 76,511,586 bp
  • G to A, chromosome 15 at 79,585,768 bp
  • G to T, chromosome 15 at 82,389,297 bp
  • T to G, chromosome 15 at 101,694,202 bp
  • T to C, chromosome 17 at 43,491,636 bp
  • A to G, chromosome 17 at 56,710,865 bp
  • T to A, chromosome 17 at 65,638,315 bp
  • T to C, chromosome 19 at 47,278,425 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1525 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040872-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.