Strain Name:
C57BL/6J-MtgxR3822Btlr/Mmmh
Stock Number:
040884-MU
Citation ID:
RRID:MMRRC_040884-MU
Other Names:
R3822 (G1), C57BL/6J-MtgxR3822Btlr
Major Collection:

Strain Information

Hlcs
Name: holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
Synonyms: 410I21.SP6, D16Jhu34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 110948
VEGA: 16
HGNC: HGNC:4976
Homologene: 37302
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 170750
Homologene: 6424
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: Bmn, 2410030O07Rik, B930014J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Cnot6
Name: CCR4-NOT transcription complex, subunit 6
Synonyms: A230103N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104625
Homologene: 69187
Anp32e
Name: acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
Synonyms: CPD1, 2810018A15Rik, LANP-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66471
Homologene: 41519
Ccnf
Name: cyclin F
Synonyms: CycF, Fbxo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12449
VEGA: 17
HGNC: HGNC:1591
Homologene: 1335
Psmb7
Name: proteasome (prosome, macropain) subunit, beta type 7
Synonyms: MC14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19177
HGNC: HGNC:9544
Homologene: 2093
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: Ten-m2, D3Bwg1534e, 9330187F13Rik, 2610040L17Rik, Odz2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23964
Homologene: 22672
Aarsd1
Name: alanyl-tRNA synthetase domain containing 1
Synonyms: 2310044P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69684
Homologene: 6821
Gpr89
Name: G protein-coupled receptor 89
Synonyms: SH120, 4933412D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67549
Homologene: 9475
Neto2
Name: neuropilin (NRP) and tolloid (TLL)-like 2
Synonyms: 5530601C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74513
Homologene: 32387
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Wdr4
Name: WD repeat domain 4
Synonyms: D530049K22Rik, Wh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57773
Homologene: 32422
Herpud2
Name: HERPUD family member 2
Synonyms: 5031400M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 80517
VEGA: 9
Homologene: 10756
Nup160
Name: nucleoporin 160
Synonyms: 2810011M03Rik, Gtl1-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 59015
Homologene: 32509
Man1a2
Name: mannosidase, alpha, class 1A, member 2
Synonyms: Man1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17156
HGNC: HGNC:6822
Homologene: 55982
Mns1
Name: meiosis-specific nuclear structural protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17427
Homologene: 40628
Itgam
Name: integrin alpha M
Synonyms: complement component receptor 3 alpha, CD11B (p170), Mac-1 alpha, Mac-1, complement receptor type 3, CR3, CD11b/CD18, Mac-1a, F730045J24Rik, Ly-40, Cd11b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16409
HGNC: HGNC:6149
Homologene: 526
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: PRIP, ASC2, RAP250, AIB3, NRC, ASC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56406
Homologene: 137337
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, LOC235639, C030048J01Rik, Lba1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320429
Homologene: 45845
Flad1
Name: flavin adenine dinucleotide synthetase 1
Synonyms: Pp591, A930017E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 319945
Homologene: 115598
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: Cryabp1, alphaA-CRYBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Acpp
Name: acid phosphatase, prostate
Synonyms: PAP, A030005E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56318
HGNC: HGNC:125
Homologene: 55552
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 671232
VEGA: 9
Homologene: 19835
Ccdc13
Name: coiled-coil domain containing 13
Synonyms: 2900041A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100502861
Homologene: 87213
Ugt1a6a
Name: UDP glucuronosyltransferase 1 family, polypeptide A6A
Synonyms: UGT1.6, Ugt1a6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 94284
Homologene: 85959
Lrrc4b
Name: leucine rich repeat containing 4B
Synonyms: Lrig4, NGL-3, Ngl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 272381
Homologene: 45681
Slc28a3
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
Synonyms: Cnt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 114304
Homologene: 32533
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Casr-rs3, EG637898, Gprc2a-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637898
Homologene: 129683
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Gm6041, Fam196b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 574403
VEGA: 11
Homologene: 107175
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218441
Homologene: 8826
Ido2
Name: indoleamine 2,3-dioxygenase 2
Synonyms: C230043N17Rik, Ido2, Indol1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 209176
Homologene: 48830
Cth
Name: cystathionase (cystathionine gamma-lyase)
Synonyms: 0610010I13Rik, CSE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 107869
HGNC: HGNC:2501
Homologene: 1432
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 88,138,529 bp
  • A to T, chromosome 2 at 38,613,428 bp
  • T to C, chromosome 2 at 90,707,067 bp
  • T to A, chromosome 2 at 155,406,938 bp
  • T to A, chromosome 3 at 89,411,187 bp
  • A to T, chromosome 3 at 95,934,869 bp
  • A to G, chromosome 3 at 96,892,944 bp
  • A to G, chromosome 3 at 100,632,597 bp
  • T to A, chromosome 3 at 135,511,984 bp
  • A to G, chromosome 3 at 157,918,499 bp
  • T to C, chromosome 6 at 84,207,088 bp
  • A to T, chromosome 7 at 42,135,701 bp
  • T to A, chromosome 7 at 44,462,558 bp
  • A to G, chromosome 7 at 128,112,286 bp
  • T to C, chromosome 8 at 24,533,755 bp
  • C to A, chromosome 8 at 85,663,295 bp
  • G to A, chromosome 9 at 25,124,924 bp
  • A to G, chromosome 9 at 72,439,448 bp
  • G to T, chromosome 9 at 104,324,717 bp
  • G to A, chromosome 9 at 111,378,819 bp
  • C to A, chromosome 9 at 121,831,019 bp
  • A to G, chromosome 9 at 122,797,783 bp
  • T to C, chromosome 11 at 34,403,007 bp
  • A to T, chromosome 11 at 36,024,320 bp
  • A to T, chromosome 11 at 49,689,172 bp
  • C to A, chromosome 11 at 65,851,003 bp
  • T to A, chromosome 11 at 101,411,145 bp
  • A to T, chromosome 13 at 42,184,311 bp
  • A to G, chromosome 13 at 58,558,278 bp
  • A to T, chromosome 13 at 92,521,261 bp
  • T to C, chromosome 16 at 94,267,981 bp
  • A to G, chromosome 17 at 24,226,460 bp
  • T to G, chromosome 17 at 31,512,221 bp
  • C to A, chromosome 17 at 67,779,046 bp
  • G to A, chromosome 19 at 53,003,819 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3822 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040884-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.