Strain Name:
C57BL/6J-MtgxR3856Btlr/Mmmh
Stock Number:
040902-MU
Citation ID:
RRID:MMRRC_040902-MU
Other Names:
R3856 (G1), C57BL/6J-MtgxR3856Btlr
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: Ankyrin-2, ankyrin B, Ank-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: Cav3.2, alpha13.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Gpr82
Name: G protein-coupled receptor 82
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 319200
HGNC: HGNC:4533
Homologene: 36824
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Cnst
Name: consortin, connexin sorting protein
Synonyms: 9630058J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226744
Homologene: 17139
Cep131
Name: centrosomal protein 131
Synonyms: Azi1, AZ1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12009
Homologene: 7638
Ppp1r12a
Name: protein phosphatase 1, regulatory subunit 12A
Synonyms: D10Ertd625e, 1200015F06Rik, Mypt1, 5730577I22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17931
VEGA: 10
HGNC: HGNC:7618
Homologene: 1855
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
Ap3d1
Name: adaptor-related protein complex 3, delta 1 subunit
Synonyms: mBLVR1, Bolvr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11776
VEGA: 10
HGNC: HGNC:568
Homologene: 2926
Ccdc60
Name: coiled-coil domain containing 60
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269693
Homologene: 18624
Dffa
Name: DNA fragmentation factor, alpha subunit
Synonyms: ICAD-L, DFF35, A330085O09Rik, ICAD-S, Dff45
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13347
HGNC: HGNC:2772
Homologene: 3240
Arhgef1
Name: Rho guanine nucleotide exchange factor 1
Synonyms: Lbcl2, Lsc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16801
HGNC: HGNC:681
Homologene: 3454
Apex1
Name: apurinic/apyrimidinic endonuclease 1
Synonyms: Ref-1, HAP1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11792
HGNC: HGNC:587
Homologene: 1241
Pcnx3
Name: pecanex homolog 3
Synonyms: Pcnxl3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104401
Homologene: 17000
Nhlrc2
Name: NHL repeat containing 2
Synonyms: 1200003G01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66866
VEGA: 19
Homologene: 12048
Crtc2
Name: CREB regulated transcription coactivator 2
Synonyms: 4632407F12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74343
Homologene: 18765
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: C030002J06Rik, 4930429G18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 78787
Homologene: 90902
Prmt9
Name: protein arginine methyltransferase 9
Synonyms: Prmt10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102182
Homologene: 16298
Dnajc16
Name: DnaJ heat shock protein family (Hsp40) member C16
Synonyms: 2900037O03Rik, 4732437J24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214063
Homologene: 45414
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Kdm4a
Name: lysine (K)-specific demethylase 4A
Synonyms: JHDM3A, Jmjd2a, D4Ertd222e, Jmjd2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230674
Homologene: 27780
Scn2b
Name: sodium channel, voltage-gated, type II, beta
Synonyms: LOC214238, 2810451E09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72821
VEGA: 9
Homologene: 3373
Trim55
Name: tripartite motif-containing 55
Synonyms: D830041C10Rik, Murf2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381485
Homologene: 13205
Sall3
Name: spalt like transcription factor 3
Synonyms: Salt, Msal, B130022O04Rik, Spalt, Msal-1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20689
VEGA: 18
Homologene: 18142
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: Gpr116, 8430401C09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: MyHC-eo, EO Myosin, extraocular myosin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Ush2a
Name: usherin
Synonyms: MUSH2A, A930037M10Rik, LOC381317, LOC269160, Ushrn, A930011D15Rik, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Atp1a3
Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide
Synonyms: Atpa-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232975
HGNC: HGNC:801
Homologene: 113729
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Slc13a4
Name: solute carrier family 13 (sodium/sulfate symporters), member 4
Synonyms: 9630060C05Rik, SUT-1, SUT1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243755
Homologene: 69125
F12
Name: coagulation factor XII (Hageman factor)
Synonyms: FXII
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 58992
HGNC: HGNC:3530
Homologene: 425
Acod1
Name: aconitate decarboxylase 1
Synonyms: Irg1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16365
Homologene: 35405
Slc8a1
Name: solute carrier family 8 (sodium/calcium exchanger), member 1
Synonyms: Ncx1, D930008O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20541
VEGA: 17
Homologene: 69090
Frmpd1
Name: FERM and PDZ domain containing 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666060
Homologene: 8939
Spag17
Name: sperm associated antigen 17
Synonyms: PF6, 4931427F14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74362
Homologene: 52601
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76390
Homologene: 88945
Kctd1
Name: potassium channel tetramerisation domain containing 1
Synonyms: 4933402K10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106931
VEGA: 18
Homologene: 65999
Aox4
Name: aldehyde oxidase 4
Synonyms: 2310003G12Rik, AOH2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71872
Homologene: 70273
Atxn7l1
Name: ataxin 7-like 1
Synonyms: Atxn7l4, 2810423G08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380753
Homologene: 53366
Hspa4l
Name: heat shock protein 4 like
Synonyms: APG-1, Osp94, 94kDa
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18415
Homologene: 22610
Idi1
Name: isopentenyl-diphosphate delta isomerase
Synonyms: 4832416K17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319554
HGNC: HGNC:5387
Homologene: 3315
Atxn7l3
Name: ataxin 7-like 3
Synonyms: E030022H21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217218
Homologene: 35401
Galnt7
Name: polypeptide N-acetylgalactosaminyltransferase 7
Synonyms: ppGaNTase-T7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108150
HGNC: HGNC:4129
Homologene: 9685
Vmn1r189
Name: vomeronasal 1 receptor 189
Synonyms: V1rh2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 252906
Homologene: 110880
Eef2k
Name: eukaryotic elongation factor-2 kinase
Synonyms: eEF-2K
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13631
Homologene: 7299
Gm2128
Name: predicted gene 2128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100039269
Homologene: 45597
Fbxo40
Name: F-box protein 40
Synonyms: 9830003A13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207215
Homologene: 9459
Or52ae7
Name: olfactory receptor family 52 subfamily AE member 7
Synonyms: GA_x6K02T2PBJ9-6191595-6192545, Olfr608, MOR26-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258751
Nt5c2
Name: 5'-nucleotidase, cytosolic II
Synonyms: cN-II, PNT5, NT5B
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76952
HGNC: HGNC:8022
Homologene: 8158
Gadd45a
Name: growth arrest and DNA-damage-inducible 45 alpha
Synonyms: Ddit1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13197
HGNC: HGNC:4095
Homologene: 1449
Gpr171
Name: G protein-coupled receptor 171
Synonyms: H963, F730001G15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229323
Homologene: 36330
Fxyd1
Name: FXYD domain-containing ion transport regulator 1
Synonyms: 0610012C17Rik, PLM, PML, phospholemman, 1110006M24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56188
HGNC: HGNC:4025
Homologene: 3691
Pudp
Name: pseudouridine 5'-phosphatase
Synonyms: 1700121L12Rik, Hdhd1a, GS1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67365
VEGA: 18
Homologene: 8093
Ctsr
Name: cathepsin R
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56835
VEGA: 13
Homologene: 75127
Fam43b
Name: family with sequence similarity 43, member B
Synonyms: OTTMUSG00000009974
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 625638
Homologene: 45810
Pbp2
Name: phosphatidylethanolamine binding protein 2
Synonyms: 1700023A18Rik, Pebp2, Pebp-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76400
HGNC: HGNC:8630
Homologene: 135930
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 58,253,934 bp
  • C to T, chromosome 1 at 179,579,714 bp
  • C to A, chromosome 1 at 188,626,567 bp
  • T to C, chromosome 3 at 19,672,956 bp
  • C to A, chromosome 3 at 40,785,389 bp
  • T to C, chromosome 3 at 59,098,085 bp
  • G to T, chromosome 3 at 90,262,570 bp
  • A to T, chromosome 3 at 100,106,759 bp
  • T to C, chromosome 3 at 126,929,844 bp
  • T to C, chromosome 4 at 45,283,698 bp
  • C to T, chromosome 4 at 118,153,231 bp
  • G to C, chromosome 4 at 138,395,098 bp
  • G to A, chromosome 4 at 141,763,653 bp
  • A to T, chromosome 4 at 149,104,251 bp
  • A to G, chromosome 5 at 113,263,259 bp
  • A to C, chromosome 5 at 116,172,455 bp
  • C to A, chromosome 6 at 35,271,604 bp
  • C to T, chromosome 6 at 67,037,005 bp
  • T to C, chromosome 6 at 82,736,676 bp
  • A to G, chromosome 6 at 135,310,145 bp
  • G to A, chromosome 7 at 24,919,272 bp
  • A to G, chromosome 7 at 24,989,979 bp
  • G to A, chromosome 7 at 31,053,878 bp
  • G to A, chromosome 7 at 41,157,835 bp
  • T to A, chromosome 7 at 103,470,660 bp
  • T to A, chromosome 7 at 120,899,371 bp
  • T to C, chromosome 8 at 57,532,624 bp
  • G to A, chromosome 8 at 77,568,265 bp
  • A to G, chromosome 9 at 45,125,461 bp
  • A to G, chromosome 10 at 80,712,185 bp
  • T to C, chromosome 10 at 108,253,501 bp
  • T to C, chromosome 11 at 67,353,759 bp
  • T to C, chromosome 11 at 73,711,456 bp
  • T to C, chromosome 11 at 102,293,903 bp
  • T to C, chromosome 11 at 119,480,939 bp
  • G to A, chromosome 11 at 120,067,185 bp
  • A to G, chromosome 12 at 33,367,600 bp
  • T to C, chromosome 12 at 98,816,024 bp
  • G to T, chromosome 13 at 8,885,932 bp
  • A to T, chromosome 13 at 22,102,269 bp
  • G to A, chromosome 13 at 55,421,222 bp
  • A to T, chromosome 13 at 61,161,936 bp
  • C to A, chromosome 14 at 20,588,420 bp
  • A to G, chromosome 14 at 50,926,257 bp
  • T to C, chromosome 14 at 103,055,446 bp
  • A to T, chromosome 16 at 36,969,083 bp
  • T to C, chromosome 17 at 25,392,453 bp
  • T to A, chromosome 17 at 36,812,504 bp
  • A to T, chromosome 17 at 43,447,036 bp
  • T to C, chromosome 17 at 81,648,374 bp
  • A to G, chromosome 18 at 15,007,883 bp
  • T to C, chromosome 18 at 50,568,053 bp
  • G to A, chromosome 18 at 80,972,502 bp
  • G to T, chromosome 19 at 5,678,967 bp
  • A to G, chromosome 19 at 46,896,518 bp
  • T to C, chromosome 19 at 56,588,271 bp
  • A to T, chromosome X at 13,665,338 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3856 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040902-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.