Strain Name:
C57BL/6J-MtgxR3937Btlr/Mmmh
Stock Number:
040921-MU
Citation ID:
RRID:MMRRC_040921-MU
Other Names:
R3937 (G1), C57BL/6J-MtgxR3937Btlr
Major Collection:

Gene Information

Utrn
Name: utrophin
Synonyms: DRP, G-utrophin, Dmdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Plekhj1
Name: pleckstrin homology domain containing, family J member 1
Synonyms: 9530063M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 78670
VEGA: 10
Homologene: 11389
Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: Sema6D-6, Sema6D-1, 1110067B02Rik, Sema6D-4, Sema6D-2, Sema6D-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214968
Homologene: 16195
Elavl3
Name: ELAV like RNA binding protein 3
Synonyms: Huc, 2600009P04Rik, mHuC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15571
VEGA: 9
HGNC: HGNC:3314
Homologene: 31035
Nes
Name: nestin
Synonyms: Marc2, ESTM46, Ifaprc2, RC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Smarcad1
Name: SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Synonyms: D6Pas1, Etl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13990
Homologene: 5301
Hspa4
Name: heat shock protein 4
Synonyms: Hsp110, Hsp70RY, 70kDa, APG-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15525
HGNC: HGNC:5237
Homologene: 1624
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Bwf1, Alfy, D5Ertd66e, Ggtb3, 2610509D04Rik, Bchs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72145
Homologene: 22855
Ints3
Name: integrator complex subunit 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229543
Homologene: 11309
Faf1
Name: Fas-associated factor 1
Synonyms: Dffrx, Fam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14084
HGNC: HGNC:3578
Homologene: 5120
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: RIM2, 2810036I15Rik, Syt3-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 116838
VEGA: 15
Homologene: 81639
Garem1
Name: GRB2 associated regulator of MAPK1 subtype 1
Synonyms: Garem, Fam59a, LOC381126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381126
VEGA: 18
Homologene: 11237
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, D630001M17Rik, 4921513O20Rik, 9330188B09Rik, LOC381026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Sun2
Name: Sad1 and UNC84 domain containing 2
Synonyms: Unc84b, B230369L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223697
Homologene: 9113
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329559
Homologene: 11129
Chpf
Name: chondroitin polymerizing factor
Synonyms: D1Bwg1363e, 1700028N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74241
Homologene: 11574
Tcea3
Name: transcription elongation factor A (SII), 3
Synonyms: SII-K1, S-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21401
Homologene: 20684
Jmjd6
Name: jumonji domain containing 6
Synonyms: 5730436I23Rik, Ptdsr, PSR, PtdSerR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 107817
Homologene: 9046
Hectd3
Name: HECT domain E3 ubiquitin protein ligase 3
Synonyms: 1700064K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76608
Homologene: 18426
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217351
Homologene: 23137
Gemin4
Name: gem nuclear organelle associated protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276919
Homologene: 69193
Esyt3
Name: extended synaptotagmin-like protein 3
Synonyms: D9Ertd280e, Fam62c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 272636
Homologene: 18626
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Hps6
Name: HPS6, biogenesis of lysosomal organelles complex 2 subunit 3
Synonyms: 5330434M19Rik, Hermansky-Pudlak syndrome 6, BLOC-2, ruby eye, ru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20170
VEGA: 19
Homologene: 11691
Fastkd2
Name: FAST kinase domains 2
Synonyms: 2810421I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75619
Homologene: 8957
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alphaMHC, Myhca, cardiomyopathy, hypertrophic 1, alpha-MHC, Myhc-a, A830009F23Rik, alpha myosin, alpha cardiac MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Vmn2r57
Name: vomeronasal 2, receptor 57
Synonyms: EG269902
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269902
Homologene: 104832
Nalcn
Name: sodium leak channel, non-selective
Synonyms: A530023G15Rik, Vgcnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: OTTMUSG00000020804, ENSMUSG00000044873, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Olfr118
Name: olfactory receptor 118
Synonyms: GA_x6K02T2PSCP-2131124-2132089, MOR263-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 404308
Homologene: 110622
Abca8b
Name: ATP-binding cassette, sub-family A (ABC1), member 8b
Synonyms: Abca8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Fam227b
Name: family with sequence similarity 227, member B
Synonyms: 4930525F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75823
Homologene: 27384
F13a1
Name: coagulation factor XIII, A1 subunit
Synonyms: Factor XIIIA, 1200014I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74145
VEGA: 13
HGNC: HGNC:3531
Homologene: 20077
Myo5b
Name: myosin VB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Tg(Prnp-PFN1*G118V)838Kiaei, 6720489L24Rik, Mdga2, Mamdc1, 9330209L04Rik, Adp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320772
Homologene: 45659
D630003M21Rik
Name: RIKEN cDNA D630003M21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228846
Homologene: 18598
Adamts1
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
Synonyms: ADAM-TS1, METH1, ADAMTS-1, METH-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Pip5kl1
Name: phosphatidylinositol-4-phosphate 5-kinase-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227733
Homologene: 45457
Pdhx
Name: pyruvate dehydrogenase complex, component X
Synonyms: Pdx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27402
Homologene: 55757
Olfr1328
Name: olfactory receptor 1328
Synonyms: MOR259-1, MOR259-13, Olfr1519, MOR259-1, GA_x6K02T2QD9B-18602750-18603691
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258394
Homologene: 121524
Fbxl6
Name: F-box and leucine-rich repeat protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 30840
VEGA: 15
Homologene: 8130
Ptpru
Name: protein tyrosine phosphatase, receptor type, U
Synonyms: Ptprl, RPTPlambda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Tbpl2
Name: TATA box binding protein like 2
Synonyms: Trf3, LOC227606
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227606
Homologene: 133152
Fhod3
Name: formin homology 2 domain containing 3
Synonyms: A930009H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225288
VEGA: 18
Homologene: 45323
BC049715
Name: cDNA sequence BC049715
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320135
Homologene: 52193
Vmn1r35
Name: vomeronasal 1 receptor 35
Synonyms: V1rc12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171185
Homologene: 110800
Dip2a
Name: disco interacting protein 2 homolog A
Synonyms: Kiaa0184-hp, Dip2, 4931420H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64451
Homologene: 41012
Olfr1052
Name: olfactory receptor 1052
Synonyms: MOR172-1, GA_x6K02T2Q125-47777498-47778436
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259012
Homologene: 79679
Gnal
Name: guanine nucleotide binding protein, alpha stimulating, olfactory type
Synonyms: Galphaolf, 2610011C15Rik, G alpha 10, Gna10, Golf, 9630020G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14680
VEGA: 18
HGNC: HGNC:4388
Homologene: 68222
Cth
Name: cystathionase (cystathionine gamma-lyase)
Synonyms: CSE, 0610010I13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 107869
HGNC: HGNC:2501
Homologene: 1432
Hacl1
Name: 2-hydroxyacyl-CoA lyase 1
Synonyms: Hpcl, Phyh2, 1600020H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56794
Homologene: 5794
Ccdc183
Name: coiled-coil domain containing 183
Synonyms: 4921530D09Rik, Cccd183
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77058
Homologene: 50023
Ctrc
Name: chymotrypsin C (caldecrin)
Synonyms: 1810044E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76701
HGNC: HGNC:2523
Homologene: 21422
Vmn1r212
Name: vomeronasal 1 receptor 212
Synonyms: V1rh18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171275
Homologene: 110880
Gm572
Name: predicted gene 572
Synonyms: LOC230909, b2b1167Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230909
Homologene: 52134
Fcamr
Name: Fc receptor, IgA, IgM, high affinity
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 64435
Homologene: 12929
2510039O18Rik
Name: RIKEN cDNA 2510039O18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77034
Homologene: 12668
Olfr453
Name: olfactory receptor 453
Synonyms: MOR257-8P, GA_x6K02T2P3E9-4815856-4814903
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258016
HGNC: HGNC:8246
Homologene: 128151
Abhd15
Name: abhydrolase domain containing 15
Synonyms: 1300007F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67477
Homologene: 12142
AC161872.7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Tmem185a
Name: transmembrane protein 185A
Synonyms: BC023829
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 236848
Homologene: 66313
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 63,737,836 bp
  • A to T, chromosome 1 at 75,477,540 bp
  • A to G, chromosome 1 at 88,258,664 bp
  • A to T, chromosome 1 at 130,804,576 bp
  • C to T, chromosome 2 at 24,087,139 bp
  • A to G, chromosome 2 at 25,610,639 bp
  • A to G, chromosome 2 at 32,579,112 bp
  • T to A, chromosome 2 at 86,298,016 bp
  • T to C, chromosome 2 at 103,022,219 bp
  • A to T, chromosome 2 at 124,656,850 bp
  • A to T, chromosome 2 at 126,127,060 bp
  • A to G, chromosome 2 at 158,200,360 bp
  • G to T, chromosome 2 at 164,910,700 bp
  • C to T, chromosome 3 at 19,971,034 bp
  • A to T, chromosome 3 at 87,971,236 bp
  • G to A, chromosome 3 at 90,403,987 bp
  • A to G, chromosome 3 at 157,920,040 bp
  • T to C, chromosome 4 at 109,757,692 bp
  • T to C, chromosome 4 at 116,998,530 bp
  • T to C, chromosome 4 at 118,934,683 bp
  • T to C, chromosome 4 at 131,774,304 bp
  • T to A, chromosome 4 at 136,255,143 bp
  • T to C, chromosome 4 at 141,840,321 bp
  • T to G, chromosome 4 at 147,942,053 bp
  • T to C, chromosome 4 at 148,654,956 bp
  • A to T, chromosome 5 at 101,944,239 bp
  • A to T, chromosome 6 at 14,719,074 bp
  • T to A, chromosome 6 at 42,744,076 bp
  • T to G, chromosome 6 at 65,114,336 bp
  • T to A, chromosome 6 at 66,679,073 bp
  • T to C, chromosome 6 at 136,840,455 bp
  • A to G, chromosome 7 at 41,428,130 bp
  • A to G, chromosome 9 at 22,018,744 bp
  • A to T, chromosome 9 at 99,336,192 bp
  • T to C, chromosome 10 at 12,709,955 bp
  • T to C, chromosome 10 at 58,476,472 bp
  • A to T, chromosome 10 at 76,286,500 bp
  • A to G, chromosome 10 at 80,797,775 bp
  • T to A, chromosome 11 at 53,270,949 bp
  • C to T, chromosome 11 at 76,212,888 bp
  • T to C, chromosome 11 at 77,515,938 bp
  • G to T, chromosome 11 at 109,974,567 bp
  • T to C, chromosome 11 at 116,841,165 bp
  • C to T, chromosome 11 at 117,723,529 bp
  • C to A, chromosome 12 at 67,221,206 bp
  • A to T, chromosome 13 at 22,883,188 bp
  • A to T, chromosome 13 at 36,916,901 bp
  • T to C, chromosome 14 at 31,634,191 bp
  • T to A, chromosome 14 at 53,538,323 bp
  • T to C, chromosome 14 at 54,963,055 bp
  • T to A, chromosome 14 at 123,369,945 bp
  • A to G, chromosome 15 at 39,437,845 bp
  • G to A, chromosome 15 at 76,536,624 bp
  • T to C, chromosome 15 at 79,734,155 bp
  • C to A, chromosome 15 at 91,778,504 bp
  • C to T, chromosome 16 at 85,795,619 bp
  • A to G, chromosome 17 at 37,672,967 bp
  • A to T, chromosome 18 at 21,148,806 bp
  • A to G, chromosome 18 at 25,090,761 bp
  • A to G, chromosome 18 at 67,135,370 bp
  • T to C, chromosome 18 at 74,716,037 bp
  • A to G, chromosome 19 at 46,004,053 bp
  • C to T, chromosome X at 70,462,186 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3937 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040921-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.