Strain Name:
C57BL/6J-MtgxR3943Btlr/Mmmh
Stock Number:
040924-MU
Citation ID:
RRID:MMRRC_040924-MU
Other Names:
R3943 (G1), C57BL/6J-MtgxR3943Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: Mll3, E330008K23Rik, HALR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Tmem59l
Name: transmembrane protein 59-like
Synonyms: 5330410G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67937
Homologene: 8104
Usp28
Name: ubiquitin specific peptidase 28
Synonyms: 9830148O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235323
VEGA: 9
Homologene: 10840
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm3, Shrm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27428
Homologene: 9263
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 4833414K03Rik, CHAK, TRP-PLIK, 5033407O22Rik, CHAK1, LTRPC7, 2310022G15Rik, Ltpr7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58800
Homologene: 9774
Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms: b2b449Clo, Map3k7ip1, Tak1-binding protein 1, 2310012M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66513
VEGA: 15
Homologene: 4461
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Gpat4
Name: glycerol-3-phosphate acyltransferase 4
Synonyms: Agpat6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102247
Homologene: 32425
Smg6
Name: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103677
Homologene: 23024
Sspn
Name: sarcospan
Synonyms: Krag
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16651
Homologene: 3727
Adnp
Name: activity-dependent neuroprotective protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11538
Homologene: 7617
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209018
Homologene: 44592
Trf
Name: transferrin
Synonyms: Tfn, HP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22041
Homologene: 68153
Dock7
Name: dedicator of cytokinesis 7
Synonyms: m, 3110056M06Rik, LOC242555
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67299
Homologene: 23566
Camkv
Name: CaM kinase-like vesicle-associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235604
Homologene: 56983
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Tcerg1
Name: transcription elongation regulator 1 (CA150)
Synonyms: 2900090C16Rik, Fbp28, ca150, p144, 2410022J09Rik, Taf2s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 56070
Homologene: 4879
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217351
Homologene: 23137
H2-T23
Name: histocompatibility 2, T region locus 23
Synonyms: 37b, T18c(37), T18c, 37c, T23d, Qa-1, Qa1, T23b, Qed-1, H-2T23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15040
HGNC: HGNC:4962
Homologene: 134018
Il16
Name: interleukin 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16170
HGNC: HGNC:5980
Homologene: 18157
Atf3
Name: activating transcription factor 3
Synonyms: LRG-21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11910
HGNC: HGNC:785
Homologene: 1265
Kcnq1
Name: potassium voltage-gated channel, subfamily Q, member 1
Synonyms: KVLQT1, Kcna9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16535
HGNC: HGNC:6294
Homologene: 85014
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, 1110021D17Rik, Polydom, D430029O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
2610507B11Rik
Name: RIKEN cDNA 2610507B11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72503
Homologene: 34730
Fbp2
Name: fructose bisphosphatase 2
Synonyms: FBPase muscle, Fbp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14120
VEGA: 13
HGNC: HGNC:3607
Homologene: 55784
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Stard9
Name: START domain containing 9
Synonyms: 4831403C07Rik, E230025N21Rik, Kif16a, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668880
Homologene: 130712
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4A, Birc1f, Naip-rs4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Krt4
Name: keratin 4
Synonyms: Krt-2.4, K4, Krt2-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16682
VEGA: 15
HGNC: HGNC:6441
Homologene: 20523
Rhpn1
Name: rhophilin, Rho GTPase binding protein 1
Synonyms: Grbp, Rhophilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14787
Homologene: 7346
Hltf
Name: helicase-like transcription factor
Synonyms: Smarca3, P113, Snf2l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20585
Homologene: 30136
Zfp947
Name: zinc finger protein 947
Synonyms: Gm4769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210853
Homologene: 133253
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241263
Homologene: 19381
Zfp712
Name: zinc finger protein 712
Synonyms: 4921504N20Rik, mszf31, mszf89
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78251
VEGA: 13
Homologene: 136296
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432486
Homologene: 32576
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75729
Homologene: 123434
Atp6v0a1
Name: ATPase, H+ transporting, lysosomal V0 subunit A1
Synonyms: Vpp1, Vpp-1, Atp6n1a, V-ATPase a1, Atp6n1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11975
HGNC: HGNC:865
Homologene: 3795
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231591
Homologene: 129606
Olfr845
Name: olfactory receptor 845
Synonyms: MOR150-1, MOR150-1P, GA_x6K02T2PVTD-13076685-13077623, MOR150-1P, MOR150-2, Olfr1522-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258249
Homologene: 133689
Vwa2
Name: von Willebrand factor A domain containing 2
Synonyms: Amaco
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240675
Homologene: 18238
Zpld2
Name: zona pellucida like domain containing 2
Synonyms: Gm7534
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 665186
Homologene: 104039
Ribc2
Name: RIB43A domain with coiled-coils 2
Synonyms: 4930579A10Rik, Trib
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67747
VEGA: 15
Homologene: 9230
CAAA01083517.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Tmem102
Name: transmembrane protein 102
Synonyms: Cbap, Tmem102-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380705
Homologene: 86820
Insyn1
Name: inhibitory synaptic factor 1
Synonyms: 6030419C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319477
VEGA: 9
Homologene: 18538
Vmn2r42
Name: vomeronasal 2, receptor 42
Synonyms: V2r4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22310
Homologene: 113703
Rassf6
Name: Ras association (RalGDS/AF-6) domain family member 6
Synonyms: 1600016B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 73246
Homologene: 37125
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 183,358,783 bp
  • A to G, chromosome 1 at 191,171,516 bp
  • C to A, chromosome 2 at 21,368,559 bp
  • A to G, chromosome 2 at 120,698,229 bp
  • A to T, chromosome 2 at 126,831,218 bp
  • A to G, chromosome 2 at 168,185,060 bp
  • A to T, chromosome 3 at 20,092,744 bp
  • T to A, chromosome 4 at 58,084,807 bp
  • A to G, chromosome 4 at 98,992,431 bp
  • T to A, chromosome 4 at 113,942,753 bp
  • T to C, chromosome 4 at 134,200,345 bp
  • A to G, chromosome 5 at 25,287,693 bp
  • T to A, chromosome 5 at 31,072,385 bp
  • G to T, chromosome 5 at 90,604,326 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • A to T, chromosome 5 at 109,216,064 bp
  • T to A, chromosome 6 at 145,934,357 bp
  • A to T, chromosome 7 at 8,194,780 bp
  • G to A, chromosome 7 at 83,652,015 bp
  • T to C, chromosome 7 at 143,426,088 bp
  • G to A, chromosome 8 at 23,180,155 bp
  • A to G, chromosome 8 at 70,487,301 bp
  • T to A, chromosome 9 at 19,339,075 bp
  • T to A, chromosome 9 at 49,000,366 bp
  • AGAGGAGGAGGAGGAGG to AGAGGAGGAGGAGG, chromosome 9 at 58,499,432 bp
  • T to A, chromosome 9 at 103,222,952 bp
  • T to A, chromosome 9 at 107,947,983 bp
  • G to T, chromosome 10 at 88,433,894 bp
  • A to G, chromosome 11 at 69,804,937 bp
  • G to A, chromosome 11 at 74,929,541 bp
  • T to A, chromosome 11 at 78,269,524 bp
  • A to G, chromosome 11 at 101,055,517 bp
  • C to T, chromosome 11 at 117,723,529 bp
  • A to G, chromosome 13 at 62,841,793 bp
  • T to C, chromosome 13 at 67,041,332 bp
  • T to C, chromosome 13 at 100,294,739 bp
  • T to C, chromosome 15 at 75,711,806 bp
  • C to T, chromosome 15 at 79,620,859 bp
  • T to C, chromosome 15 at 80,153,740 bp
  • A to G, chromosome 15 at 85,135,250 bp
  • G to A, chromosome 15 at 101,921,250 bp
  • A to T, chromosome 16 at 21,470,123 bp
  • C to A, chromosome 17 at 22,145,820 bp
  • T to A, chromosome 17 at 30,694,065 bp
  • A to G, chromosome 17 at 36,030,643 bp
  • T to C, chromosome 18 at 42,571,921 bp
  • T to A, chromosome 19 at 6,473,335 bp
  • T to G, chromosome 19 at 56,909,315 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3943 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040924-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.