Strain Name:
C57BL/6J-MtgxR3963Btlr/Mmmh
Stock Number:
040932-MU
Citation ID:
RRID:MMRRC_040932-MU
Other Names:
R3963 (G1), C57BL/6J-MtgxR3963Btlr
Major Collection:

Gene Information

Qk
Name: quaking
Synonyms: QkI, 1110003F05Rik, l(17)-1Wis, l17Wis1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19317
VEGA: 17
Homologene: 11059
Ank2
Name: ankyrin 2, brain
Synonyms: Ank-2, ankyrin B, Gm4392, Ankyrin-B, Ankyrin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108096
Homologene: 56603
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: RPTPkappa, PTPk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Jade1
Name: jade family PHD finger 1
Synonyms: D530048A03Rik, Phf17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269424
Homologene: 18162
Gdf3
Name: growth differentiation factor 3
Synonyms: ecat9, Gdf-3, Vgr-2, Vgr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14562
HGNC: HGNC:4218
Homologene: 7336
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109294
Homologene: 23523
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: D330022K21Rik, Usp31, 2810449C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 170707
Homologene: 12988
Srsf3
Name: serine and arginine-rich splicing factor 3
Synonyms: Sfrs3, X16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20383
Homologene: 55708
Gtf3c1
Name: general transcription factor III C 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233863
HGNC: HGNC:4664
Homologene: 31040
Clptm1
Name: cleft lip and palate associated transmembrane protein 1
Synonyms: HS9, N14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56457
HGNC: HGNC:2087
Homologene: 37464
Leo1
Name: Leo1, Paf1/RNA polymerase II complex component
Synonyms: LOC235497
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235497
VEGA: 9
Homologene: 133895
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 338355
Homologene: 28743
Dyrk1a
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
Synonyms: 2310043O08Rik, Dyrk, D16Ertd272e, Mnbh, D16Ertd493e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13548
HGNC: HGNC:3091
Homologene: 55576
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Snap91
Name: synaptosomal-associated protein 91
Synonyms: AP180, 91kDa, F1-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20616
Homologene: 8429
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: Tg(SMN2)89Ahmb, mGlu7a receptor, Gpr1g, SMN2, mGluR7, 6330570A01Rik, E130018M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Minar1
Name: membrane integral NOTCH2 associated receptor 1
Synonyms: AF529169, DD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209743
Homologene: 17782
Cd200r1
Name: CD200 receptor 1
Synonyms: OX2R, CD200R, Mox2r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 57781
Homologene: 10957
Ntng1
Name: netrin G1
Synonyms: A930010C08Rik, Lmnt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80883
Homologene: 8949
Cdc23
Name: CDC23 cell division cycle 23
Synonyms: D18Ertd243e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 52563
HGNC: HGNC:1724
Homologene: 3426
Ttf2
Name: transcription termination factor, RNA polymerase II
Synonyms: 4632434F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74044
Homologene: 37826
Zfp979
Name: zinc finger protein 979
Synonyms: 2610305D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 112422
Homologene: 133076
Itpkc
Name: inositol 1,4,5-trisphosphate 3-kinase C
Synonyms: 9130023N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233011
Homologene: 11868
Frmd6
Name: FERM domain containing 6
Synonyms: 2610019M19Rik, 4930488L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319710
VEGA: 12
Homologene: 12449
B3gnt5
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 108105
Homologene: 24989
Rtn3
Name: reticulon 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20168
VEGA: 19
Homologene: 24934
A830010M20Rik
Name: RIKEN cDNA A830010M20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231570
VEGA: 5
Homologene: 128318
Plcxd2
Name: phosphatidylinositol-specific phospholipase C, X domain containing 2
Synonyms: EG433022
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 433022
Homologene: 44374
Fam160b1
Name: family with sequence similarity 160, member B1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226252
VEGA: 19
Homologene: 28133
Dennd4a
Name: DENN/MADD domain containing 4A
Synonyms: F730015K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102442
VEGA: 9
Homologene: 55933
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242274
Homologene: 10817
Ttf1
Name: transcription termination factor, RNA polymerase I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22130
Homologene: 137223
Tmem63a
Name: transmembrane protein 63a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208795
Homologene: 101673
Hrg
Name: histidine-rich glycoprotein
Synonyms: D18020, D16JH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 94175
HGNC: HGNC:5181
Homologene: 137650
Oas1e
Name: 2'-5' oligoadenylate synthetase 1E
Synonyms: 2'-5' oligoadenylate synthetase-like 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231699
HGNC: HGNC:8086
Homologene: 110815
Krt72
Name: keratin 72
Synonyms: Krt72-ps, K6irs2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105866
Homologene: 25876
Arfgef3
Name: ARFGEF family member 3
Synonyms: D10Bwg1379e, B930094H20Rik, BIG3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Adamts18
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
Synonyms: E130314N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 208936
Homologene: 65241
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
Vmn1r222
Name: vomeronasal 1 receptor 222
Synonyms: V1rh16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171274
Homologene: 110880
Fpr-rs6
Name: formyl peptide receptor, related sequence 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 321020
Homologene: 104303
Rpusd2
Name: RNA pseudouridylate synthase domain containing 2
Synonyms: 4921503C21Rik, BB231107
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 271842
Homologene: 5588
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Vmn2r4
Name: vomeronasal 2, receptor 4
Synonyms: EG637053
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 637053
Homologene: 129754
Ccdc85a
Name: coiled-coil domain containing 85A
Synonyms: E030025D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216613
Homologene: 65605
Cr2
Name: complement receptor 2
Synonyms: Cr1, Cr-1, CD35, CD21, C3DR, Cr-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Cyp4a31
Name: cytochrome P450, family 4, subfamily a, polypeptide 31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 666168
HGNC: HGNC:2642
Homologene: 128044
Cers3
Name: ceramide synthase 3
Synonyms: Lass3, LOC233330, CerS3, T3L, related to TRH3, 4930550L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545975
Homologene: 18719
Olfr67
Name: olfactory receptor 67
Synonyms: GA_x6K02T2PBJ9-6515150-6514170, MOR31-1, 3'[b]1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18368
Homologene: 85930
G6pd2
Name: glucose-6-phosphate dehydrogenase 2
Synonyms: G6pdx-ps1, Gpd2, Gpd-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14380
Tmem267
Name: transmembrane protein 267
Synonyms: Gm7120
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 633640
Homologene: 49708
Anks6
Name: ankyrin repeat and sterile alpha motif domain containing 6
Synonyms: LOC269533, b2b1801.1Clo, 2210417J20Rik, SamCystin, Samd6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75691
Homologene: 19545
Trim35
Name: tripartite motif-containing 35
Synonyms: Hls5, A430106H13Rik, Mair, 0710005M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66854
Homologene: 134331
Exoc3l2
Name: exocyst complex component 3-like 2
Synonyms: Gm19857, 4933417E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74463
Homologene: 16328
Ccdc82
Name: coiled-coil domain containing 82
Synonyms: 2310043N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66396
VEGA: 9
Homologene: 11678
Tubg2
Name: tubulin, gamma 2
Synonyms: Tubgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103768
Homologene: 69216
Ubap1l
Name: ubiquitin-associated protein 1-like
Synonyms: LOC208080, Gm514
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208080
VEGA: 9
Homologene: 19477
Tnfaip8
Name: tumor necrosis factor, alpha-induced protein 8
Synonyms: Tipe, Gm10539, E130304C20Rik, Nded, Ssc-2, Gg2-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 106869
Homologene: 8649
Psg29
Name: pregnancy-specific glycoprotein 29
Synonyms: cea17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114872
Homologene: 83380
Mmaa
Name: methylmalonic aciduria (cobalamin deficiency) type A
Synonyms: 2810018E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109136
Homologene: 14586
Gm7251
Name: predicted pseudogene 7251
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 638833
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 11,110,357 bp
  • G to A, chromosome 1 at 180,963,114 bp
  • A to G, chromosome 1 at 195,159,739 bp
  • A to G, chromosome 2 at 29,064,804 bp
  • A to G, chromosome 2 at 119,038,604 bp
  • T to C, chromosome 3 at 41,601,410 bp
  • T to A, chromosome 3 at 64,415,151 bp
  • T to C, chromosome 3 at 100,941,820 bp
  • T to A, chromosome 3 at 109,934,868 bp
  • A to T, chromosome 3 at 126,934,596 bp
  • A to T, chromosome 3 at 158,160,405 bp
  • A to G, chromosome 4 at 47,023,735 bp
  • A to T, chromosome 4 at 62,340,677 bp
  • A to G, chromosome 4 at 115,574,772 bp
  • A to T, chromosome 4 at 137,633,439 bp
  • A to T, chromosome 4 at 147,613,131 bp
  • T to A, chromosome 5 at 61,808,885 bp
  • G to A, chromosome 5 at 107,507,356 bp
  • A to G, chromosome 5 at 120,794,140 bp
  • G to T, chromosome 6 at 110,646,348 bp
  • C to T, chromosome 6 at 122,606,758 bp
  • C to T, chromosome 6 at 142,248,644 bp
  • T to A, chromosome 7 at 17,208,585 bp
  • G to A, chromosome 7 at 19,495,256 bp
  • C to T, chromosome 7 at 19,638,196 bp
  • T to C, chromosome 7 at 27,227,509 bp
  • G to A, chromosome 7 at 28,898,266 bp
  • G to T, chromosome 7 at 66,786,075 bp
  • G to T, chromosome 7 at 103,788,034 bp
  • T to C, chromosome 7 at 125,693,225 bp
  • A to T, chromosome 8 at 79,268,214 bp
  • T to C, chromosome 8 at 113,777,811 bp
  • C to A, chromosome 9 at 13,252,386 bp
  • T to A, chromosome 9 at 64,862,331 bp
  • C to T, chromosome 9 at 65,369,195 bp
  • C to A, chromosome 9 at 75,450,480 bp
  • A to T, chromosome 9 at 86,775,612 bp
  • G to A, chromosome 9 at 89,601,910 bp
  • T to C, chromosome 10 at 18,592,277 bp
  • A to G, chromosome 10 at 28,551,665 bp
  • A to C, chromosome 11 at 28,576,396 bp
  • T to C, chromosome 11 at 101,160,398 bp
  • A to G, chromosome 12 at 70,893,864 bp
  • T to C, chromosome 12 at 85,268,680 bp
  • A to G, chromosome 13 at 23,232,932 bp
  • T to C, chromosome 13 at 49,805,699 bp
  • A to T, chromosome 13 at 119,492,639 bp
  • T to C, chromosome 14 at 66,304,054 bp
  • C to A, chromosome 15 at 34,388,791 bp
  • A to T, chromosome 15 at 101,785,994 bp
  • A to G, chromosome 16 at 19,769,048 bp
  • G to A, chromosome 16 at 22,956,075 bp
  • T to A, chromosome 16 at 44,792,795 bp
  • T to C, chromosome 16 at 45,980,501 bp
  • T to A, chromosome 16 at 94,663,746 bp
  • G to A, chromosome 17 at 10,216,465 bp
  • G to A, chromosome 17 at 20,182,217 bp
  • C to T, chromosome 17 at 29,036,456 bp
  • C to T, chromosome 18 at 20,051,227 bp
  • T to C, chromosome 18 at 34,646,919 bp
  • C to A, chromosome 18 at 50,090,586 bp
  • G to A, chromosome 19 at 5,754,022 bp
  • T to C, chromosome 19 at 7,458,145 bp
  • T to C, chromosome 19 at 57,373,010 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3963 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040932-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.