Strain Name:
C57BL/6J-MtgxR3969Btlr/Mmmh
Stock Number:
040937-MU
Citation ID:
RRID:MMRRC_040937-MU
Other Names:
R3969 (G1), C57BL/6J-MtgxR3969Btlr
Major Collection:

Strain Information

Arhgef12
Name: Rho guanine nucleotide exchange factor (GEF) 12
Synonyms: LARG, 2310014B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69632
VEGA: 9
Homologene: 9088
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72313
Homologene: 103956
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm, Shrm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27428
Homologene: 9263
Zfp462
Name: zinc finger protein 462
Synonyms: Gt4-2, 9430078C22Rik, Zfpip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242466
Homologene: 41430
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52357
Homologene: 32618
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76501
Homologene: 8584
Ahi1
Name: Abelson helper integration site 1
Synonyms: Ahi-1, 1700015F03Rik, D10Bwg0629e, Jouberin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Flna
Name: filamin, alpha
Synonyms: actin-binding protein 280, ABP-280, Fln1, GENA 379, F730004A14Rik, Dilp2, filamin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 192176
HGNC: HGNC:3754
Homologene: 1119
Ncstn
Name: nicastrin
Synonyms: nicastrin, 9430068N19Rik, Nct, D1Dau13e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 59287
Homologene: 41029
Nol8
Name: nucleolar protein 8
Synonyms: 4921532D18Rik, D13Ertd548e, 5730412B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 70930
VEGA: 13
Homologene: 41210
Lins1
Name: lines homolog 1
Synonyms: 2700083B01Rik, Wins2, Lins
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72635
Homologene: 10034
E2f1
Name: E2F transcription factor 1
Synonyms: E2F-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13555
HGNC: HGNC:3113
Homologene: 3828
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: 9430028L06Rik, 9030411M15Rik, Fam38b2, Piezo2, Fam38b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 667742
Homologene: 49695
Chia1
Name: chitinase, acidic 1
Synonyms: AMCase, YNL, 2200003E03Rik, Chia
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 81600
Homologene: 75168
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: LaXp180, 2900055E04Rik, Cc1, 5930404L04Rik, Fip200
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12421
Homologene: 7659
Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
Synonyms: p85beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18709
HGNC: HGNC:8980
Homologene: 3687
Camk2d
Name: calcium/calmodulin-dependent protein kinase II, delta
Synonyms: CaMK II, 2810011D23Rik, 8030469K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 108058
HGNC: HGNC:1462
Homologene: 55561
Or8b54
Name: olfactory receptor family 8 subfamily B member 54
Synonyms: GA_x6K02T2PVTD-32478047-32478988, MOR165-8, Olfr921
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258778
VEGA: 9
Homologene: 128138
Faap100
Name: Fanconi anemia core complex associated protein 100
Synonyms: 2310003H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71885
Homologene: 69394
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 621430
Homologene: 115466
Irf5
Name: interferon regulatory factor 5
Synonyms: mirf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27056
HGNC: HGNC:6120
Homologene: 8088
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665227
Homologene: 129751
Ybx2
Name: Y box protein 2
Synonyms: MSY2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53422
Homologene: 22942
Cers5
Name: ceramide synthase 5
Synonyms: Trh4, 2310081H14Rik, CerS5, Lass5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71949
Homologene: 23634
Rab39
Name: RAB39, member RAS oncogene family
Synonyms: C230094F14Rik, Rab39a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270160
Homologene: 56773
Camk4
Name: calcium/calmodulin-dependent protein kinase IV
Synonyms: Ca2+/calmodulin-dependent protein kinase type IV/Gr, CaMKIV/Gr, CaMKIV, A430110E23Rik, D18Bwg0362e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12326
VEGA: 18
HGNC: HGNC:1464
Homologene: 100780
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Gm6041, Fam196b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 574403
VEGA: 11
Homologene: 107175
Gm12185
Name: predicted gene 12185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 620913
Homologene: 83188
Tspoap1
Name: TSPO associated protein 1
Synonyms: peripheral, Bzrap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207777
Homologene: 37961
Habp2
Name: hyaluronic acid binding protein 2
Synonyms: FSAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226243
HGNC: HGNC:4798
Homologene: 3050
Nlrx1
Name: NLR family member X1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270151
VEGA: 9
Homologene: 11623
Slc26a1
Name: solute carrier family 26 (sulfate transporter), member 1
Synonyms: Sat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231583
Homologene: 32539
Cpeb4
Name: cytoplasmic polyadenylation element binding protein 4
Synonyms: 4930447D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67579
Homologene: 12736
Or7g21
Name: olfactory receptor family 7 subfamily G member 21
Synonyms: GA_x6K02T2PVTD-12857805-12858749, MOR152-3, Olfr836
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258557
HGNC: HGNC:8466
Homologene: 115507
Pecr
Name: peroxisomal trans-2-enoyl-CoA reductase
Synonyms: 2400003B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 111175
Homologene: 69255
Usp17lc
Name: ubiquitin specific peptidase 17-like C
Synonyms: Dub2b, Dub2, Dub-2, Usp17l5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13532
Homologene: 131315
Prl2a1
Name: prolactin family 2, subfamily a, member 1
Synonyms: PLP-M, Prlpm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56635
HGNC: HGNC:9445
Homologene: 10556
Pole3
Name: polymerase (DNA directed), epsilon 3 (p17 subunit)
Synonyms: YBL1, 1810034K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 59001
Homologene: 9694
Armcx6
Name: armadillo repeat containing, X-linked 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 278097
Homologene: 10373
Pabpc5
Name: poly(A) binding protein, cytoplasmic 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 93728
Homologene: 5857
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,248,270 bp
  • G to A, chromosome 1 at 72,276,309 bp
  • A to C, chromosome 1 at 172,070,009 bp
  • C to A, chromosome 2 at 101,897,141 bp
  • C to G, chromosome 2 at 154,564,022 bp
  • T to G, chromosome 3 at 106,121,635 bp
  • G to T, chromosome 3 at 126,796,959 bp
  • C to T, chromosome 4 at 55,012,402 bp
  • G to T, chromosome 4 at 62,524,961 bp
  • A to T, chromosome 5 at 73,112,423 bp
  • T to C, chromosome 5 at 92,940,879 bp
  • A to G, chromosome 5 at 108,673,952 bp
  • A to T, chromosome 6 at 29,536,782 bp
  • C to T, chromosome 7 at 66,708,198 bp
  • T to C, chromosome 7 at 87,003,593 bp
  • A to T, chromosome 7 at 103,418,419 bp
  • T to C, chromosome 8 at 47,856,323 bp
  • G to A, chromosome 8 at 70,770,421 bp
  • A to G, chromosome 9 at 19,121,660 bp
  • A to G, chromosome 9 at 38,775,368 bp
  • C to A, chromosome 9 at 43,005,551 bp
  • A to T, chromosome 9 at 44,255,425 bp
  • G to A, chromosome 9 at 53,686,632 bp
  • A to G, chromosome 10 at 20,959,947 bp
  • T to C, chromosome 11 at 31,872,811 bp
  • A to T, chromosome 11 at 34,419,739 bp
  • A to T, chromosome 11 at 48,907,345 bp
  • G to A, chromosome 11 at 69,940,416 bp
  • A to T, chromosome 11 at 87,762,446 bp
  • G to A, chromosome 11 at 118,041,158 bp
  • A to T, chromosome 11 at 120,378,705 bp
  • A to G, chromosome 13 at 27,806,280 bp
  • A to T, chromosome 13 at 49,660,016 bp
  • A to G, chromosome 15 at 99,736,451 bp
  • C to A, chromosome 17 at 18,258,385 bp
  • A to T, chromosome 18 at 12,580,341 bp
  • T to A, chromosome 18 at 33,179,581 bp
  • A to T, chromosome 18 at 63,011,696 bp
  • A to G, chromosome 19 at 56,311,701 bp
  • A to T, chromosome X at 74,235,667 bp
  • A to G, chromosome X at 119,928,624 bp
  • G to T, chromosome X at 134,749,756 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3969 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040937-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.