Strain Name:
C57BL/6J-MtgxR3970Btlr/Mmmh
Stock Number:
040938-MU
Citation ID:
RRID:MMRRC_040938-MU
Other Names:
R3970 (G1), C57BL/6J-MtgxR3970Btlr
Major Collection:

Gene Information

Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
Synonyms: TRPC2b, TRPC2a, mTrp2, trp2, Trrp2, 3010009O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22064
Homologene: 135989
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101772
Homologene: 75079
Sf3b1
Name: splicing factor 3b, subunit 1
Synonyms: SAP155, Prp10, SF3b155, 2810001M05Rik, Targ4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 81898
Homologene: 6696
Fcho2
Name: FCH domain only 2
Synonyms: 5832424M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218503
VEGA: 13
Homologene: 9030
Akap13
Name: A kinase (PRKA) anchor protein 13
Synonyms: AKAP-Lbc, PROTO-LBC, PROTO-LB, Ht31, 5730522G15Rik, 1700026G02Rik, 5830460E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Nampt
Name: nicotinamide phosphoribosyltransferase
Synonyms: 1110035O14Rik, Visfatin, Pbef1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 59027
VEGA: 12
Homologene: 4201
Tlk1
Name: tousled-like kinase 1
Synonyms: 4930545J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228012
Homologene: 130657
Uhrf2
Name: ubiquitin-like, containing PHD and RING finger domains 2
Synonyms: 2310065A22Rik, Nirf, D130071B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 109113
Homologene: 17001
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76501
Homologene: 8584
Zfp219
Name: zinc finger protein 219
Synonyms: 2010302A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 69890
VEGA: 14
Homologene: 9504
Flna
Name: filamin, alpha
Synonyms: actin-binding protein 280, ABP-280, Fln1, GENA 379, F730004A14Rik, Dilp2, filamin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 192176
HGNC: HGNC:3754
Homologene: 1119
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 171395
Homologene: 51376
E2f1
Name: E2F transcription factor 1
Synonyms: E2F-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13555
HGNC: HGNC:3113
Homologene: 3828
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: 9430028L06Rik, 9030411M15Rik, Fam38b2, Piezo2, Fam38b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 667742
Homologene: 49695
Psd
Name: pleckstrin and Sec7 domain containing
Synonyms: Efa6, 1110007H17Rik, Psdl, Efa6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73728
VEGA: 19
HGNC: HGNC:9507
Homologene: 31115
Chia1
Name: chitinase, acidic 1
Synonyms: AMCase, YNL, 2200003E03Rik, Chia
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 81600
Homologene: 75168
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Vwa7
Name: von Willebrand factor A domain containing 7
Synonyms: G7c, D17H6S56E-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 27762
Homologene: 11895
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 192188
Homologene: 23022
Kif5c
Name: kinesin family member 5C
Synonyms: Khc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16574
HGNC: HGNC:6325
Homologene: 56234
Pramel4
Name: PRAME like 4
Synonyms: D4Ertd792e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 347710
Homologene: 133722
Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
Synonyms: p85beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18709
HGNC: HGNC:8980
Homologene: 3687
Plcb2
Name: phospholipase C, beta 2
Synonyms: B230205M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18796
HGNC: HGNC:9055
Homologene: 20957
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Cdhr2
Name: cadherin-related family member 2
Synonyms: LOC268663, Pcdh24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 268663
Homologene: 134510
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Pcdh8
Name: protocadherin 8
Synonyms: Papc, 1700080P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18530
HGNC: HGNC:8660
Homologene: 1943
Slc6a7
Name: solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
Synonyms: Prot
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240332
VEGA: 18
Homologene: 8592
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Adamts15
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235130
VEGA: 9
Homologene: 8610
Narf
Name: nuclear prelamin A recognition factor
Synonyms: 4430402O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67608
Homologene: 57048
Tmc6
Name: transmembrane channel-like gene family 6
Synonyms: EVER1, D11Ertd204e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217353
Homologene: 5258
Slc26a4
Name: solute carrier family 26, member 4
Synonyms: Pds, pendrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 23985
VEGA: 12
HGNC: HGNC:8818
Homologene: 20132
Camk4
Name: calcium/calmodulin-dependent protein kinase IV
Synonyms: Ca2+/calmodulin-dependent protein kinase type IV/Gr, CaMKIV/Gr, CaMKIV, A430110E23Rik, D18Bwg0362e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12326
VEGA: 18
HGNC: HGNC:1464
Homologene: 100780
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Olfr251
Name: olfactory receptor 251
Synonyms: GA_x6K02T2MYUG-9124-8183, MOR170-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 404313
VEGA: 9
Homologene: 133654
Myrf
Name: myelin regulatory factor
Synonyms: LOC225908, LOC386531, Gm98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225908
HGNC: HGNC:1181
Homologene: 32167
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Gm6041, Fam196b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 574403
VEGA: 11
Homologene: 107175
Gm12185
Name: predicted gene 12185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 620913
Homologene: 83188
Cherp
Name: calcium homeostasis endoplasmic reticulum protein
Synonyms: 5730408I11Rik, SCAF6, DAN16, D8Wsu96e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 27967
Homologene: 4656
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101613
Homologene: 15881
Ppl
Name: periplakin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Sema3g
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218877
Homologene: 10602
2510039O18Rik
Name: RIKEN cDNA 2510039O18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77034
Homologene: 12668
Gm14401
Name: predicted gene 14401
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100534275
Pecr
Name: peroxisomal trans-2-enoyl-CoA reductase
Synonyms: 2400003B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 111175
Homologene: 69255
Armcx6
Name: armadillo repeat containing, X-linked 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 278097
Homologene: 10373
Pabpc5
Name: poly(A) binding protein, cytoplasmic 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 93728
Homologene: 5857
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 55,012,182 bp
  • G to A, chromosome 1 at 72,276,309 bp
  • A to C, chromosome 1 at 105,656,003 bp
  • A to G, chromosome 2 at 49,688,744 bp
  • A to G, chromosome 2 at 70,716,652 bp
  • C to A, chromosome 2 at 101,897,141 bp
  • A to G, chromosome 2 at 118,715,690 bp
  • C to G, chromosome 2 at 154,564,022 bp
  • T to C, chromosome 2 at 177,086,996 bp
  • T to G, chromosome 3 at 106,121,635 bp
  • A to T, chromosome 3 at 114,097,189 bp
  • A to T, chromosome 4 at 144,068,474 bp
  • T to C, chromosome 4 at 147,945,322 bp
  • T to C, chromosome 7 at 28,962,032 bp
  • T to A, chromosome 7 at 75,569,951 bp
  • A to G, chromosome 7 at 102,084,324 bp
  • C to A, chromosome 7 at 140,921,655 bp
  • T to C, chromosome 7 at 144,607,963 bp
  • G to A, chromosome 8 at 70,770,421 bp
  • T to C, chromosome 8 at 72,469,951 bp
  • T to C, chromosome 9 at 30,910,602 bp
  • T to C, chromosome 9 at 38,377,926 bp
  • T to C, chromosome 10 at 86,878,886 bp
  • C to T, chromosome 11 at 8,874,218 bp
  • A to T, chromosome 11 at 34,419,739 bp
  • A to T, chromosome 11 at 48,907,345 bp
  • G to A, chromosome 11 at 59,051,662 bp
  • T to C, chromosome 11 at 117,769,292 bp
  • G to A, chromosome 11 at 118,041,158 bp
  • A to T, chromosome 11 at 121,238,421 bp
  • G to T, chromosome 12 at 31,528,687 bp
  • T to A, chromosome 12 at 32,833,096 bp
  • A to T, chromosome 12 at 53,141,453 bp
  • A to T, chromosome 13 at 54,726,458 bp
  • A to T, chromosome 13 at 98,735,056 bp
  • T to C, chromosome 14 at 31,226,521 bp
  • T to A, chromosome 14 at 52,006,964 bp
  • C to T, chromosome 14 at 79,770,266 bp
  • T to C, chromosome 16 at 5,100,332 bp
  • T to A, chromosome 17 at 3,428,831 bp
  • G to A, chromosome 17 at 35,017,708 bp
  • A to T, chromosome 18 at 12,580,341 bp
  • T to A, chromosome 18 at 33,179,581 bp
  • A to C, chromosome 18 at 61,003,345 bp
  • A to T, chromosome 18 at 63,011,696 bp
  • A to G, chromosome 19 at 10,223,237 bp
  • T to C, chromosome 19 at 30,079,915 bp
  • C to T, chromosome 19 at 37,901,263 bp
  • T to G, chromosome 19 at 38,022,610 bp
  • C to T, chromosome 19 at 46,324,406 bp
  • A to T, chromosome X at 74,235,667 bp
  • A to G, chromosome X at 119,928,624 bp
  • G to T, chromosome X at 134,749,756 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3970 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040938-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.