Strain Name:
C57BL/6J-MtgxR3981Btlr/Mmmh
Stock Number:
040943-MU
Citation ID:
RRID:MMRRC_040943-MU
Other Names:
R3981 (G1), C57BL/6J-MtgxR3981Btlr
Major Collection:

Gene Information

Mfap2
Name: microfibrillar-associated protein 2
Synonyms: Magp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17150
HGNC: HGNC:7033
Homologene: 1801
Chrnb3
Name: cholinergic receptor, nicotinic, beta polypeptide 3
Synonyms: Acrb3, 5730417K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 108043
HGNC: HGNC:1963
Homologene: 36035
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Mras
Name: muscle and microspikes RAS
Synonyms: 2900078C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17532
HGNC: HGNC:7227
Homologene: 7424
Cct2
Name: chaperonin containing Tcp1, subunit 2 (beta)
Synonyms: Cctb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12461
VEGA: 10
HGNC: HGNC:1615
Homologene: 4696
Cry1
Name: cryptochrome 1 (photolyase-like)
Synonyms: Phll1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12952
VEGA: 10
HGNC: HGNC:2384
Homologene: 7042
Esf1
Name: ESF1 nucleolar pre-rRNA processing protein homolog
Synonyms: 2610101J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66580
Homologene: 5717
Tiam1
Name: T cell lymphoma invasion and metastasis 1
Synonyms: D16Ium10, D16Ium10e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 21844
Homologene: 2443
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: MLTKbeta, MLTKalpha, Zak, B230120H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 65964
Homologene: 32331
Mbnl1
Name: muscleblind like splicing factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56758
HGNC: HGNC:6923
Homologene: 23186
Ift122
Name: intraflagellar transport 122
Synonyms: Wdr10, sopb, C86139
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 81896
Homologene: 12819
Mme
Name: membrane metallo endopeptidase
Synonyms: neprilysin, NEP, neutral endopeptidase, CD10, 6030454K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Tmem183a
Name: transmembrane protein 183A
Synonyms: 1300007B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 57439
Homologene: 10757
Samd8
Name: sterile alpha motif domain containing 8
Synonyms: Smsr, 1700010P07Rik, 1110053F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 67630
Homologene: 41670
Cep295
Name: centrosomal protein 295
Synonyms: LOC382128, 5830418K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319675
Homologene: 27936
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268379
Homologene: 27991
Grb7
Name: growth factor receptor bound protein 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14786
HGNC: HGNC:4567
Homologene: 3881
Maml2
Name: mastermind like transcriptional coactivator 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270118
Homologene: 134147
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Spata31d1c
Name: spermatogenesis associated 31 subfamily D, member 1C
Synonyms: 4932441B19Rik, Fam75d1c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 238683
VEGA: 13
Zfp605
Name: zinc finger protein 605
Synonyms: A830023I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 675812
Homologene: 52335
Rdh19
Name: retinol dehydrogenase 19
Synonyms: RDH-S, Rdhs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216453
Homologene: 129514
Zfp839
Name: zinc finger protein 839
Synonyms: 2810455K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 72805
VEGA: 12
Homologene: 49541
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241516
Homologene: 110349
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: LGL3, 0710001E20Rik, 4930565N16Rik, tomosyn 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 78808
Homologene: 16402
1700022I11Rik
Name: RIKEN cDNA 1700022I11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67317
Homologene: 52406
Bhlhe22
Name: basic helix-loop-helix family, member e22
Synonyms: Beta3, Bhlhb5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 59058
Homologene: 10994
Ros1
Name: Ros1 proto-oncogene
Synonyms: c-ros, Ros-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19886
Homologene: 2207
Erich6
Name: glutamate rich 6
Synonyms: 4932431H17Rik, Fam194a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 545527
Homologene: 65043
Cacnb2
Name: calcium channel, voltage-dependent, beta 2 subunit
Synonyms: Cchb2, Cavbeta2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12296
HGNC: HGNC:1402
Homologene: 75191
Palmd
Name: palmdelphin
Synonyms: PALML, 4631423C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 114301
Homologene: 9804
Cep89
Name: centrosomal protein 89
Synonyms: Ccdc123, 2610507L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72140
Homologene: 12444
Olfr1062
Name: olfactory receptor 1062
Synonyms: MOR185-1, GA_x6K02T2Q125-47892992-47892045
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 259082
Homologene: 83135
Tec
Name: tec protein tyrosine kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21682
Homologene: 1302
Xirp1
Name: xin actin-binding repeat containing 1
Synonyms: mXin alpha, Cmya1, Xin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22437
VEGA: 9
Homologene: 7998
Alkbh2
Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Synonyms: Abh2, mABH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231642
Homologene: 18393
Prb1
Name: proline-rich protein BstNI subfamily 1
Synonyms: proline-rich proteoglycan 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 381833
HGNC: HGNC:9338
Fkbp7
Name: FK506 binding protein 7
Synonyms: FKBP23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14231
HGNC: HGNC:3723
Homologene: 22568
Vps16
Name: VSP16 CORVET/HOPS core subunit
Synonyms: 1810074M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 80743
Homologene: 7116
Dlgap1
Name: DLG associated protein 1
Synonyms: SAPAP1, Sapap1, D17Bwg0511e, Gkap, 4933422O14Rik, GKAP/SAPAP, DAP-1 beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224997
HGNC: HGNC:2905
Homologene: 31258
Slc7a11
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Synonyms: System xc, 9930009M05Rik, xc, xCT, sut
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 26570
Homologene: 22684
Clca1
Name: chloride channel accessory 1
Synonyms: Clca3, gob-5, gob5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: 1700042J16Rik, A730034A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 209462
Homologene: 10807
Mmd2
Name: monocyte to macrophage differentiation-associated 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75104
Homologene: 18425
H2-M3
Name: histocompatibility 2, M region locus 3
Synonyms: R4B2, Hmt, H-2M3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14991
HGNC: HGNC:4964
Homologene: 133255
Gm15056
Name: predicted gene 15056
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 100504014
Homologene: 134600
Tex37
Name: testis expressed 37
Synonyms: 1700011F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 74221
Homologene: 17643
Defb38
Name: defensin beta 38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 360212
Hcar1
Name: hydrocarboxylic acid receptor 1
Synonyms: Gpr81
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 243270
HGNC: HGNC:4532
Homologene: 13060
Bckdk
Name: branched chain ketoacid dehydrogenase kinase
Synonyms: BCKD-kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12041
Homologene: 37642
Gbx1
Name: gastrulation brain homeobox 1
Synonyms: Gbx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231044
HGNC: HGNC:4185
Homologene: 41063
AI747448
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
Zak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 134,355,649 bp
  • A to G, chromosome 2 at 14,604,503 bp
  • C to T, chromosome 2 at 72,438,227 bp
  • A to C, chromosome 2 at 76,663,257 bp
  • T to A, chromosome 2 at 82,958,662 bp
  • T to A, chromosome 2 at 86,422,842 bp
  • T to C, chromosome 2 at 130,442,594 bp
  • G to A, chromosome 2 at 140,158,556 bp
  • G to T, chromosome 3 at 18,054,894 bp
  • C to A, chromosome 3 at 50,427,774 bp
  • T to C, chromosome 3 at 58,636,704 bp
  • A to T, chromosome 3 at 60,603,696 bp
  • T to A, chromosome 3 at 63,328,064 bp
  • T to C, chromosome 3 at 116,923,823 bp
  • T to A, chromosome 3 at 144,755,309 bp
  • T to C, chromosome 3 at 144,926,036 bp
  • C to T, chromosome 4 at 42,971,534 bp
  • A to G, chromosome 4 at 141,014,243 bp
  • T to C, chromosome 5 at 24,526,215 bp
  • T to A, chromosome 5 at 72,823,599 bp
  • T to C, chromosome 5 at 110,127,738 bp
  • C to T, chromosome 5 at 114,124,226 bp
  • T to C, chromosome 5 at 123,878,620 bp
  • T to C, chromosome 5 at 142,564,799 bp
  • T to C, chromosome 6 at 70,913,299 bp
  • T to C, chromosome 6 at 115,913,921 bp
  • G to A, chromosome 6 at 132,312,694 bp
  • A to G, chromosome 7 at 35,438,383 bp
  • C to A, chromosome 7 at 127,905,418 bp
  • T to C, chromosome 7 at 141,813,775 bp
  • A to G, chromosome 8 at 19,026,467 bp
  • T to A, chromosome 8 at 20,900,941 bp
  • C to T, chromosome 8 at 27,394,006 bp
  • T to C, chromosome 9 at 13,621,068 bp
  • G to T, chromosome 9 at 15,317,067 bp
  • T to C, chromosome 9 at 99,411,416 bp
  • T to C, chromosome 9 at 120,017,744 bp
  • T to C, chromosome 10 at 9,789,316 bp
  • T to G, chromosome 10 at 45,590,364 bp
  • G to A, chromosome 10 at 52,120,878 bp
  • C to A, chromosome 10 at 77,088,887 bp
  • A to T, chromosome 10 at 85,146,592 bp
  • G to A, chromosome 10 at 117,054,135 bp
  • A to G, chromosome 10 at 127,850,148 bp
  • T to G, chromosome 11 at 9,532,407 bp
  • T to G, chromosome 11 at 98,454,565 bp
  • G to A, chromosome 12 at 110,866,331 bp
  • A to G, chromosome 13 at 65,035,111 bp
  • A to G, chromosome 14 at 21,780,180 bp
  • G to A, chromosome 16 at 89,804,753 bp
  • C to T, chromosome 17 at 37,271,130 bp
  • A to G, chromosome 17 at 70,516,785 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3981 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040943-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.