Strain Name:
C57BL/6J-MtgxR4011Btlr/Mmmh
Stock Number:
040948-MU
Citation ID:
RRID:MMRRC_040948-MU
Other Names:
R4011 (G1), C57BL/6J-MtgxR4011Btlr
Major Collection:

Gene Information

Kat2b
Name: K(lysine) acetyltransferase 2B
Synonyms: Pcaf, A930006P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18519
HGNC: HGNC:8638
Homologene: 20834
Mga
Name: MAX gene associated
Synonyms: D030062C11Rik, C130042M01Rik, Mga, Mad5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 29808
Homologene: 49351
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: Dhm2, mXrn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 24127
Homologene: 5894
Adsl
Name: adenylosuccinate lyase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11564
HGNC: HGNC:291
Homologene: 12
Xpo6
Name: exportin 6
Synonyms: C230091E20Rik, Ranbp20, 2610005L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74204
Homologene: 12544
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: 2900041G10Rik, KPI-2, A330101P12Rik, BREK, AATYK2, cprk, KPI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231876
Homologene: 8948
Prom1
Name: prominin 1
Synonyms: 4932416E19Rik, Prom, CD133, AC133, Prom-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: MLTKalpha, B230120H23Rik, Zak, MLTKbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 65964
Homologene: 32331
Gfm2
Name: G elongation factor, mitochondrial 2
Synonyms: 6530419G12Rik, EFG2, MST027, A930009M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 320806
Homologene: 6238
Ddx18
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
Synonyms: 2310005B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66942
HGNC: HGNC:2741
Homologene: 6697
Gas1
Name: growth arrest specific 1
Synonyms: Gas-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14451
HGNC: HGNC:4165
Homologene: 1548
C1qtnf1
Name: C1q and tumor necrosis factor related protein 1
Synonyms: CTRP1, 1600017K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 56745
Homologene: 10548
Chd1l
Name: chromodomain helicase DNA binding protein 1-like
Synonyms: 4432404A22Rik, Snf2p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 68058
HGNC: HGNC:1916
Homologene: 11590
Tox4
Name: TOX high mobility group box family member 4
Synonyms: 5730589K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 268741
Homologene: 8889
Tubgcp3
Name: tubulin, gamma complex associated protein 3
Synonyms: Spc98p, GCP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 259279
Homologene: 4609
Vit
Name: vitrin
Synonyms: 1700110E08Rik, akhirin, AKH, 1700052E02Rik, 2810429K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 74199
VEGA: 17
Homologene: 24942
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268379
Homologene: 27991
Epha3
Name: Eph receptor A3
Synonyms: Cek4, Mek4, Tyro4, Hek, Hek4, End3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 545030
Homologene: 83473
Ifit2
Name: interferon-induced protein with tetratricopeptide repeats 2
Synonyms: Ifi54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 15958
HGNC: HGNC:5409
Homologene: 1187
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
F830045P16Rik
Name: RIKEN cDNA F830045P16 gene
Synonyms: Sirpb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228592
Homologene: 136180
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: NG2, AN2, 4732461B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 329421
Homologene: 51393
Impdh1
Name: inosine monophosphate dehydrogenase 1
Synonyms: B930086D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 23917
HGNC: HGNC:6052
Homologene: 68096
Olfr512
Name: olfactory receptor 512
Synonyms: GA_x6K02T2PBJ9-11043421-11044365, MOR268-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258719
Homologene: 138316
Map1a
Name: microtubule-associated protein 1 A
Synonyms: 6330416M19Rik, Mtap1a, Mtap1, Mtap-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Psd2
Name: pleckstrin and Sec7 domain containing 2
Synonyms: 6330404E20Rik, EFA6C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 74002
Homologene: 12522
Trim65
Name: tripartite motif-containing 65
Synonyms: 4732463G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 338364
Homologene: 27844
Osmr
Name: oncostatin M receptor
Synonyms: OSMRB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 18414
HGNC: HGNC:8507
Homologene: 2972
Pcolce
Name: procollagen C-endopeptidase enhancer protein
Synonyms: Astt-2, Astt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 18542
HGNC: HGNC:8738
Homologene: 1946
Hbb-bh2
Name: hemoglobin beta, bh2
Synonyms: Gm5736
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 436003
Gm1110
Name: predicted gene 1110
Synonyms: LOC382064
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 382064
VEGA: 9
Homologene: 78608
Slc28a3
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
Synonyms: Cnt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 114304
Homologene: 32533
Tdpoz3
Name: TD and POZ domain containing 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 399674
Homologene: 128308
Sgce
Name: sarcoglycan, epsilon
Synonyms: e-SG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20392
Homologene: 31205
Olfr1118
Name: olfactory receptor 1118
Synonyms: GA_x6K02T2Q125-48795705-48796673, MOR264-22, Olfr1118-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 404328
Homologene: 134077
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: Nope, WI-16786, 9330155G14Rik, WI-18508
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 56741
VEGA: 9
Homologene: 10570
Olfr1122
Name: olfactory receptor 1122
Synonyms: GA_x6K02T2Q125-48880078-48881058, MOR264-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 259033
Homologene: 73977
Slc30a3
Name: solute carrier family 30 (zinc transporter), member 3
Synonyms: Znt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22784
Homologene: 74470
Prdm11
Name: PR domain containing 11
Synonyms: 8030443D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 100042784
Homologene: 82511
Gm5592
Name: predicted gene 5592
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434172
Homologene: 45597
Gm11487
Name: predicted gene 11487
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 433719
Homologene: 128423
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: Acs1, AceCS1, Acas2, acetyl-CoA synthetase 1, Acas1, ACAS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 60525
Homologene: 6469
Serpina3a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3A
Synonyms: alpha-1 antiproteinase,, 4933406L18Rik, antitrypsin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 74069
HGNC: HGNC:16
Olfr110
Name: olfactory receptor 110
Synonyms: GA_x6K02T2PSCP-1956307-1957260, MOR249-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258325
Homologene: 73968
Olfr657
Name: olfactory receptor 657
Synonyms: GA_x6K02T2PBJ9-7263864-7264823, MOR40-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258309
Homologene: 17189
Reg3a
Name: regenerating islet-derived 3 alpha
Synonyms: RegIII (alpha)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 19694
HGNC: HGNC:8601
Homologene: 136247
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 121,562,081 bp
  • A to G, chromosome 2 at 70,096,376 bp
  • G to A, chromosome 2 at 72,384,124 bp
  • A to G, chromosome 2 at 87,309,211 bp
  • A to T, chromosome 2 at 87,388,580 bp
  • A to G, chromosome 2 at 93,012,830 bp
  • T to C, chromosome 2 at 119,931,780 bp
  • G to A, chromosome 2 at 121,300,127 bp
  • A to T, chromosome 2 at 129,463,547 bp
  • T to A, chromosome 2 at 155,557,628 bp
  • A to T, chromosome 3 at 93,826,243 bp
  • A to T, chromosome 3 at 97,570,402 bp
  • T to C, chromosome 4 at 73,401,810 bp
  • A to G, chromosome 5 at 31,086,859 bp
  • A to G, chromosome 5 at 44,018,406 bp
  • G to T, chromosome 5 at 137,605,774 bp
  • A to G, chromosome 5 at 144,175,879 bp
  • G to T, chromosome 6 at 4,691,563 bp
  • A to G, chromosome 6 at 29,206,054 bp
  • G to A, chromosome 6 at 78,383,570 bp
  • G to T, chromosome 7 at 41,289,510 bp
  • T to A, chromosome 7 at 103,840,209 bp
  • A to G, chromosome 7 at 104,636,348 bp
  • A to T, chromosome 7 at 108,714,159 bp
  • T to C, chromosome 7 at 126,140,608 bp
  • A to T, chromosome 8 at 12,639,634 bp
  • A to G, chromosome 9 at 26,879,971 bp
  • A to G, chromosome 9 at 56,887,317 bp
  • T to C, chromosome 9 at 65,135,479 bp
  • T to A, chromosome 9 at 95,985,225 bp
  • G to A, chromosome 11 at 9,622,013 bp
  • T to A, chromosome 11 at 65,834,464 bp
  • A to G, chromosome 11 at 116,127,703 bp
  • G to A, chromosome 11 at 118,446,539 bp
  • A to T, chromosome 12 at 104,118,643 bp
  • T to C, chromosome 13 at 58,566,250 bp
  • T to G, chromosome 13 at 60,175,977 bp
  • T to A, chromosome 13 at 97,143,100 bp
  • C to A, chromosome 14 at 33,102,680 bp
  • T to C, chromosome 14 at 52,285,651 bp
  • G to T, chromosome 15 at 6,824,533 bp
  • T to C, chromosome 15 at 80,966,156 bp
  • G to A, chromosome 16 at 63,566,564 bp
  • T to C, chromosome 17 at 37,499,491 bp
  • G to A, chromosome 17 at 53,644,741 bp
  • C to T, chromosome 17 at 78,534,692 bp
  • C to T, chromosome 18 at 35,987,247 bp
  • G to T, chromosome 19 at 34,574,045 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4011 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040948-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.