Strain Name:
C57BL/6J-MtgxR4013Btlr/Mmmh
Stock Number:
040950-MU
Citation ID:
RRID:MMRRC_040950-MU
Other Names:
R4013 (G1), C57BL/6J-MtgxR4013Btlr
Major Collection:

Gene Information

Tyr
Name: tyrosinase
Synonyms: skc35, Oca1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22173
Homologene: 30969
Ptch1
Name: patched 1
Synonyms: Ptc, Patched 1, Ptc1, A230106A15Rik, wig
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Kdm5b
Name: lysine (K)-specific demethylase 5B
Synonyms: PLU-1, 2010009J12Rik, Plu1, Rb-Bp2, 2210016I17Rik, D1Ertd202e, Jarid1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75605
Homologene: 48448
Taok1
Name: TAO kinase 1
Synonyms: D130018F14Rik, 2810468K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216965
Homologene: 27041
Ptpn12
Name: protein tyrosine phosphatase, non-receptor type 12
Synonyms: P19-PTP, PTP-PEST, PTP-P19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19248
HGNC: HGNC:9645
Homologene: 37691
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 545085
VEGA: 15
Homologene: 9972
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Kdm5a
Name: lysine (K)-specific demethylase 5A
Synonyms: RBP2, Rbbp2, Jarid1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, AD013, A330063D19Rik, 9030205D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109151
Homologene: 11844
Nr2c1
Name: nuclear receptor subfamily 2, group C, member 1
Synonyms: TR2, Tr2-11, 4831444H07Rik, Eenr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22025
HGNC: HGNC:7971
Homologene: 55731
Ppp2r1a
Name: protein phosphatase 2, regulatory subunit A, alpha
Synonyms: PR65, protein phosphatase PP2A, 6330556D22Rik, PP2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 51792
HGNC: HGNC:9302
Homologene: 68559
Cbln4
Name: cerebellin 4 precursor protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228942
Homologene: 15419
Trim9
Name: tripartite motif-containing 9
Synonyms: C030048G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94090
VEGA: 12
Homologene: 9045
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 64580
Homologene: 11208
Wdr93
Name: WD repeat domain 93
Synonyms: EG626359
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 626359
Homologene: 56878
Kcns1
Name: K+ voltage-gated channel, subfamily S, 1
Synonyms: Kv9.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16538
HGNC: HGNC:6300
Homologene: 20517
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Kif1a
Name: kinesin family member 1A
Synonyms: Kns1, ATSV, N-3 kinesin, LOC381283, C630002N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Pik3r6
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: p87PIKAP, p84 Pikap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104709
Homologene: 46215
Abcc6
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Synonyms: DCC, Mrp6, Dyscalc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Myo15b
Name: myosin XVB
Synonyms: LOC217328, LOC380737, E330039G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217328
Adgrg3
Name: adhesion G protein-coupled receptor G3
Synonyms: Pb99, A030001G24Rik, Gpr97
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54672
Homologene: 18129
Vmn1r214
Name: vomeronasal 1 receptor 214
Synonyms: V1rh5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171248
Homologene: 110880
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: TJ6s, Tj6, ATP6a2, Atp6n2, 8430408C20Rik, V-ATPase a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21871
Homologene: 56523
Ndor1
Name: NADPH dependent diflavin oxidoreductase 1
Synonyms: NR1, 4930447P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78797
Homologene: 7144
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68625
Homologene: 51350
Vmn2r52
Name: vomeronasal 2, receptor 52
Synonyms: EG384534
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384534
Homologene: 129605
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: brm, Snf2l2, 2610209L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67155
Homologene: 2308
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100041449
Homologene: 135775
Ano3
Name: anoctamin 3
Synonyms: B230324K02Rik, Tmem16c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228432
Homologene: 57147
Gabrg2
Name: gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
Synonyms: Gabrg-2, gamma2, GABAA-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14406
HGNC: HGNC:4087
Homologene: 22443
Lrrc63
Name: leucine rich repeat containing 63
Synonyms: 4921509B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70859
Homologene: 52823
Olfr1019
Name: olfactory receptor 1019
Synonyms: GA_x6K02T2Q125-47320309-47319377, MOR180-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259017
Homologene: 17464
Ube2i
Name: ubiquitin-conjugating enzyme E2I
Synonyms: Mmubc9, UBC9, Ubce9, 5830467E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22196
Homologene: 5574
Tas2r116
Name: taste receptor, type 2, member 116
Synonyms: TRB4, TRB1, Tas2r7, mt2r56, T2R16, mGR16, Tas2r16, Tas2r14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 112408
Homologene: 130070
Gm4846
Name: predicted gene 4846
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226601
Homologene: 136281
Slc39a13
Name: solute carrier family 39 (metal ion transporter), member 13
Synonyms: 1100001L14Rik, ZIP13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68427
Homologene: 62681
Clip4
Name: CAP-GLY domain containing linker protein family, member 4
Synonyms: 1700074B05Rik, 5830409B12Rik, 4833417L20Rik, 1700024K14Rik, Rsnl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78785
VEGA: 17
Homologene: 11662
Igsf21
Name: immunoglobulin superfamily, member 21
Synonyms: LOC230868
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230868
Homologene: 13153
Apold1
Name: apolipoprotein L domain containing 1
Synonyms: LOC381823
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381823
Homologene: 12781
Olfr609
Name: olfactory receptor 609
Synonyms: GA_x6K02T2PBJ9-6207735-6206776, MOR9-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259086
Homologene: 64952
Kcnf1
Name: potassium voltage-gated channel, subfamily F, member 1
Synonyms: LOC382571
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 382571
HGNC: HGNC:6246
Homologene: 124236
Cyp4f14
Name: cytochrome P450, family 4, subfamily f, polypeptide 14
Synonyms: 1300014O15Rik, leukotriene B4 omega hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 64385
VEGA: 17
Homologene: 81872
Cysltr2
Name: cysteinyl leukotriene receptor 2
Synonyms: CYSLT2R, Cyslt2, CysLT2, 2300001H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70086
VEGA: 14
Homologene: 10688
Esp34
Name: exocrine gland secreted peptide 34
Synonyms: Gm20410
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100126773
Col8a2
Name: collagen, type VIII, alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329941
HGNC: HGNC:2216
Homologene: 55879
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 93,076,292 bp
  • A to G, chromosome 1 at 134,627,329 bp
  • A to C, chromosome 1 at 166,494,680 bp
  • A to T, chromosome 2 at 25,250,150 bp
  • GTGGCT to GT, chromosome 2 at 29,154,061 bp
  • A to G, chromosome 2 at 40,802,984 bp
  • A to G, chromosome 2 at 85,841,381 bp
  • T to C, chromosome 2 at 91,064,902 bp
  • A to G, chromosome 2 at 110,774,976 bp
  • A to G, chromosome 2 at 164,168,257 bp
  • A to T, chromosome 2 at 172,037,557 bp
  • T to A, chromosome 3 at 125,683,170 bp
  • A to G, chromosome 4 at 118,593,143 bp
  • T to A, chromosome 4 at 126,311,115 bp
  • T to C, chromosome 4 at 140,037,469 bp
  • G to A, chromosome 5 at 20,992,743 bp
  • G to A, chromosome 5 at 124,712,796 bp
  • A to G, chromosome 5 at 146,079,383 bp
  • T to A, chromosome 6 at 120,394,106 bp
  • A to G, chromosome 6 at 132,856,267 bp
  • A to G, chromosome 6 at 134,983,906 bp
  • G to A, chromosome 7 at 10,170,676 bp
  • T to C, chromosome 7 at 46,018,680 bp
  • T to A, chromosome 7 at 79,768,411 bp
  • A to G, chromosome 7 at 87,437,940 bp
  • T to C, chromosome 7 at 103,492,633 bp
  • A to G, chromosome 8 at 90,973,169 bp
  • A to G, chromosome 8 at 95,035,099 bp
  • G to A, chromosome 10 at 94,156,986 bp
  • T to C, chromosome 11 at 41,971,880 bp
  • T to A, chromosome 11 at 68,533,521 bp
  • A to T, chromosome 11 at 77,559,833 bp
  • G to T, chromosome 11 at 115,871,456 bp
  • A to G, chromosome 12 at 17,175,993 bp
  • G to A, chromosome 12 at 70,346,352 bp
  • G to A, chromosome 13 at 23,035,350 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • A to G, chromosome 14 at 73,029,565 bp
  • A to G, chromosome 14 at 75,098,291 bp
  • A to T, chromosome 15 at 8,079,214 bp
  • G to A, chromosome 17 at 20,951,347 bp
  • C to A, chromosome 17 at 25,269,388 bp
  • G to A, chromosome 17 at 32,916,879 bp
  • C to A, chromosome 17 at 38,559,555 bp
  • T to A, chromosome 17 at 71,856,546 bp
  • G to A, chromosome 19 at 26,683,927 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4013 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040950-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.