Strain Name:
C57BL/6J-MtgxR4021Btlr/Mmmh
Stock Number:
040955-MU
Citation ID:
RRID:MMRRC_040955-MU
Other Names:
R4021 (G1), C57BL/6J-MtgxR4021Btlr
Major Collection:

Gene Information

Zic4
Name: zinc finger protein of the cerebellum 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22774
Homologene: 32075
Ppp1r1b
Name: protein phosphatase 1, regulatory inhibitor subunit 1B
Synonyms: DARPP-32, Darpp32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19049
HGNC: HGNC:9287
Homologene: 12972
Slc32a1
Name: solute carrier family 32 (GABA vesicular transporter), member 1
Synonyms: R75019, VGAT, Viaat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22348
Homologene: 56451
Ranbp17
Name: RAN binding protein 17
Synonyms: 4932704E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66011
Homologene: 36409
Mtif3
Name: mitochondrial translational initiation factor 3
Synonyms: 2810012L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76366
Homologene: 49927
Csnk2a1
Name: casein kinase 2, alpha 1 polypeptide
Synonyms: Csnk2a1-rs4, CK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12995
HGNC: HGNC:2457
Homologene: 90874
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Dock9
Name: dedicator of cytokinesis 9
Synonyms: B230309H04Rik, D14Wsu89e, Zizimin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105445
Homologene: 41026
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 328329
Homologene: 42094
Tbck
Name: TBC1 domain containing kinase
Synonyms: A630047E20Rik, C030007I09Rik, 1700120J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 271981
Homologene: 13221
Ddias
Name: DNA damage-induced apoptosis suppressor
Synonyms: noxin, 4632434I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74041
Homologene: 51655
Krit1
Name: KRIT1, ankyrin repeat containing
Synonyms: Krit1, 2010007K12Rik, Krit1B, Krit1A, A630036P20Rik, Ccm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 79264
HGNC: HGNC:1573
Homologene: 12746
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76501
Homologene: 8584
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Iars2
Name: isoleucine-tRNA synthetase 2, mitochondrial
Synonyms: 2010002H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381314
Homologene: 7118
Foxi2
Name: forkhead box I2
Synonyms: B130055A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 270004
Homologene: 18838
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67299
Homologene: 23566
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230895
Homologene: 15583
Got2
Name: glutamatic-oxaloacetic transaminase 2, mitochondrial
Synonyms: mAspAT, mitochondrial aspartate aminotransferase, FABP-pm, plasma membrane fatty acid binding protein, Kyat4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14719
HGNC: HGNC:4433
Homologene: 1572
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: Mpr300, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Haus2
Name: HAUS augmin-like complex, subunit 2
Synonyms: 1700101G24Rik, 2410007P03Rik, Cep27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66296
Homologene: 10001
Farsa
Name: phenylalanyl-tRNA synthetase, alpha subunit
Synonyms: 0610012A19Rik, Farsla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66590
HGNC: HGNC:3592
Homologene: 3280
Dnajb11
Name: DnaJ heat shock protein family (Hsp40) member B11
Synonyms: Dj9, 1810031F23Rik, ABBP-2, ERdj3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67838
Homologene: 9464
Wdr6
Name: WD repeat domain 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83669
Homologene: 117682
Znrf3
Name: zinc and ring finger 3
Synonyms: LOC382477
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 407821
Homologene: 46592
Sag
Name: S-antigen, retina and pineal gland (arrestin)
Synonyms: A930001K18Rik, rod arrestin, Arr1, arrestin 1, visual arrestin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20215
Homologene: 455
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 546144
Homologene: 52326
Chmp3
Name: charged multivesicular body protein 3
Synonyms: 25.1, CGI-49, 4921505F14Rik, 9130011K15Rik, D6Ertd286e, Vps24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66700
Homologene: 6368
Flywch2
Name: FLYWCH family member 2
Synonyms: 3010014L17Rik, 2810417J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76917
Homologene: 12664
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: 8430401C09Rik, Gpr116
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213262
Homologene: 10584
Gpr63
Name: G protein-coupled receptor 63
Synonyms: PSP24beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 81006
Homologene: 12759
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Mrgprb1
Name: MAS-related GPR, member B1
Synonyms: MrgB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233231
Homologene: 24986
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: PYPAF2, E330007A02Rik, Nalp2, Pan1, Nbs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232827
Homologene: 56789
Tril
Name: TLR4 interactor with leucine-rich repeats
Synonyms: 1200009O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66873
Homologene: 69404
Pear1
Name: platelet endothelial aggregation receptor 1
Synonyms: 3110045G13Rik, Jedi-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 73182
Homologene: 12492
Olfr703
Name: olfactory receptor 703
Synonyms: GA_x6K02T2PBJ9-9222217-9223176, MOR283-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258589
Gm11492
Name: predicted gene 11492
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Entpd7
Name: ectonucleoside triphosphate diphosphohydrolase 7
Synonyms: LALP1, 2810003F23Rik, 1810020C02Rik, Lysal2, 1810012B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 93685
Homologene: 122202
Tshz2
Name: teashirt zinc finger family member 2
Synonyms: Mtsh2, Sdccag33l, 2900073F20Rik, Zfp218, teashirt2, Tsh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228911
Homologene: 35258
Myo15b
Name: myosin XVB
Synonyms: LOC217328, LOC380737, E330039G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217328
Spag17
Name: sperm associated antigen 17
Synonyms: 4931427F14Rik, PF6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74362
Homologene: 52601
Gtf2h4
Name: general transcription factor II H, polypeptide 4
Synonyms: p52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14885
HGNC: HGNC:4658
Homologene: 7090
Hexdc
Name: hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 238023
Homologene: 68120
Atp11a
Name: ATPase, class VI, type 11A
Synonyms: Ih, 4930558F19Rik, 9130422H11Rik, LOC100045280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50770
Homologene: 75050
Gbp4
Name: guanylate binding protein 4
Synonyms: Mag-2, Mpa-2, Mpa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17472
Homologene: 128731
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72277
Bank1
Name: B cell scaffold protein with ankyrin repeats 1
Synonyms: A530094C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242248
Homologene: 9926
Gabbr2
Name: gamma-aminobutyric acid (GABA) B receptor, 2
Synonyms: Gababr2, LOC242425, Gpr51, GB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Lilra6
Name: leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
Synonyms: 7M1, Pira3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18726
HGNC: HGNC:6607
Homologene: 134028
Cyp2c55
Name: cytochrome P450, family 2, subfamily c, polypeptide 55
Synonyms: 2010318C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72082
HGNC: HGNC:2620
Homologene: 133567
Itgax
Name: integrin alpha X
Synonyms: CD11C (p150) alpha polypeptide, Cd11c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Lair1
Name: leukocyte-associated Ig-like receptor 1
Synonyms: 5133400O11Rik, mLair-1, Lair-1, D7Bwg0421e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52855
HGNC: HGNC:6477
Homologene: 48097
Habp2
Name: hyaluronic acid binding protein 2
Synonyms: FSAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226243
HGNC: HGNC:4798
Homologene: 3050
Taar7a
Name: trace amine-associated receptor 7A
Synonyms: LOC215856, Taar7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215856
Homologene: 110833
Slc22a2
Name: solute carrier family 22 (organic cation transporter), member 2
Synonyms: Oct2, Orct2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20518
VEGA: 17
Homologene: 68293
Zfp488
Name: zinc finger protein 488
Synonyms: LOC382867
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 382867
Homologene: 17688
Fibp
Name: fibroblast growth factor (acidic) intracellular binding protein
Synonyms: 2010004G08Rik, 3010027N18Rik, 2010005N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 58249
VEGA: 19
HGNC: HGNC:3705
Homologene: 3106
Cdh22
Name: cadherin 22
Synonyms: PB-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 104010
Homologene: 23148
Olfr1157
Name: olfactory receptor 1157
Synonyms: GA_x6K02T2Q125-49446395-49445457, MOR174-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258846
HGNC: HGNC:8350
Homologene: 17402
1700008P02Rik
Name: RIKEN cDNA 1700008P02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69347
Fam107b
Name: family with sequence similarity 107, member B
Synonyms: 3110001A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66540
Homologene: 75316
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 87,821,305 bp
  • C to T, chromosome 1 at 185,325,677 bp
  • G to A, chromosome 2 at 3,778,474 bp
  • T to A, chromosome 2 at 87,962,722 bp
  • G to A, chromosome 2 at 101,886,331 bp
  • A to T, chromosome 2 at 120,615,930 bp
  • C to T, chromosome 2 at 152,258,689 bp
  • C to T, chromosome 2 at 158,611,232 bp
  • T to C, chromosome 2 at 165,143,673 bp
  • G to A, chromosome 2 at 169,885,862 bp
  • A to G, chromosome 3 at 6,620,088 bp
  • A to G, chromosome 3 at 76,628,975 bp
  • T to C, chromosome 3 at 87,756,222 bp
  • A to T, chromosome 3 at 100,049,230 bp
  • C to A, chromosome 3 at 132,727,134 bp
  • G to A, chromosome 3 at 136,100,601 bp
  • T to C, chromosome 4 at 25,008,470 bp
  • G to A, chromosome 4 at 46,846,435 bp
  • T to C, chromosome 4 at 99,003,920 bp
  • A to G, chromosome 4 at 145,075,061 bp
  • T to A, chromosome 5 at 3,832,132 bp
  • T to A, chromosome 5 at 105,120,923 bp
  • T to A, chromosome 5 at 146,955,678 bp
  • T to G, chromosome 6 at 53,819,019 bp
  • T to C, chromosome 6 at 71,574,238 bp
  • G to T, chromosome 7 at 3,911,418 bp
  • A to G, chromosome 7 at 4,055,916 bp
  • A to G, chromosome 7 at 5,325,012 bp
  • A to T, chromosome 7 at 48,447,123 bp
  • G to T, chromosome 7 at 92,861,478 bp
  • T to A, chromosome 7 at 106,845,019 bp
  • T to A, chromosome 7 at 128,133,139 bp
  • A to T, chromosome 7 at 135,410,530 bp
  • A to G, chromosome 8 at 12,842,938 bp
  • A to G, chromosome 8 at 84,868,870 bp
  • T to G, chromosome 8 at 95,877,753 bp
  • G to A, chromosome 9 at 74,151,593 bp
  • A to G, chromosome 9 at 91,379,036 bp
  • C to T, chromosome 9 at 107,514,058 bp
  • A to G, chromosome 9 at 108,575,206 bp
  • G to T, chromosome 10 at 23,993,386 bp
  • T to C, chromosome 11 at 5,281,278 bp
  • G to A, chromosome 11 at 33,479,189 bp
  • A to G, chromosome 11 at 87,567,280 bp
  • G to GCCC, chromosome 11 at 98,355,313 bp
  • A to G, chromosome 11 at 115,873,505 bp
  • T to C, chromosome 11 at 121,218,161 bp
  • G to A, chromosome 13 at 102,739,321 bp
  • T to A, chromosome 14 at 33,971,153 bp
  • C to T, chromosome 14 at 55,775,178 bp
  • C to T, chromosome 14 at 56,460,001 bp
  • C to T, chromosome 14 at 103,152,157 bp
  • T to C, chromosome 14 at 121,626,912 bp
  • T to A, chromosome 15 at 4,925,100 bp
  • G to C, chromosome 15 at 99,941,799 bp
  • A to G, chromosome 16 at 22,869,446 bp
  • T to C, chromosome 17 at 12,584,489 bp
  • T to A, chromosome 17 at 12,748,751 bp
  • G to A, chromosome 17 at 23,777,039 bp
  • T to C, chromosome 17 at 35,670,664 bp
  • A to T, chromosome 17 at 43,430,714 bp
  • T to C, chromosome 19 at 5,460,734 bp
  • T to A, chromosome 19 at 39,035,434 bp
  • G to A, chromosome 19 at 43,691,158 bp
  • G to T, chromosome 19 at 56,311,855 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4021 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040955-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.