Strain Name:
C57BL/6J-MtgxR4023Btlr/Mmmh
Stock Number:
040957-MU
Citation ID:
RRID:MMRRC_040957-MU
Other Names:
R4023 (G1), C57BL/6J-MtgxR4023Btlr
Major Collection:

Gene Information

Fezf2
Name: Fez family zinc finger 2
Synonyms: forebrain embryonic zinc finger, Fez, Fezl, Zfp312
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54713
VEGA: 14
Homologene: 9957
Myo1e
Name: myosin IE
Synonyms: 2310020N23Rik, 9130023P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Usp46
Name: ubiquitin specific peptidase 46
Synonyms: 2410018I08Rik, 1190009E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69727
Homologene: 56957
Wdr20
Name: WD repeat domain 20
Synonyms: 2310040A13Rik, Wdr20a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69641
Homologene: 32684
Zfp462
Name: zinc finger protein 462
Synonyms: Gt4-2, 9430078C22Rik, Zfpip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242466
Homologene: 41430
Akap9
Name: A kinase (PRKA) anchor protein (yotiao) 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Ppp3r1
Name: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
Synonyms: PP2B beta 1, Cnb1, CaNB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19058
HGNC: HGNC:9317
Homologene: 68099
Rif1
Name: replication timing regulatory factor 1
Synonyms: 5730435J01Rik, 6530403D07Rik, D2Ertd145e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 51869
Homologene: 41231
Zfyve1
Name: zinc finger, FYVE domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217695
VEGA: 12
Homologene: 10945
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: BC016423, Fam208b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Mctp2
Name: multiple C2 domains, transmembrane 2
Synonyms: LOC244049
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244049
Homologene: 69254
Siglecf
Name: sialic acid binding Ig-like lectin F
Synonyms: mSiglec-F, Siglec5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233186
Homologene: 50482
Stat5a
Name: signal transducer and activator of transcription 5A
Synonyms: STAT5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20850
Homologene: 20680
Depdc1a
Name: DEP domain containing 1a
Synonyms: 5830484J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76131
Homologene: 9834
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77480
VEGA: 12
Homologene: 14254
Olfr1102
Name: olfactory receptor 1102
Synonyms: GA_x6K02T2Q125-48487992-48488966, MOR179-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228228
Homologene: 88426
Colec10
Name: collectin sub-family member 10
Synonyms: CL-L1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239447
VEGA: 15
HGNC: HGNC:2220
Homologene: 31381
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: GlcT-1, Epcs21, Ugcgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22234
Homologene: 37763
Akna
Name: AT-hook transcription factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100182
Homologene: 49947
Cap2
Name: CAP, adenylate cyclase-associated protein, 2 (yeast)
Synonyms: 2810452G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67252
Homologene: 101397
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21974
Homologene: 134711
Ccdc105
Name: coiled-coil domain containing 105
Synonyms: 4931413A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70976
VEGA: 10
Homologene: 18299
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Flnc
Name: filamin C, gamma
Synonyms: Fln2, 1110055E19Rik, actin binding protein 280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Tmem150cos
Name: transmembrane protein 150C, opposite strand
Synonyms: 5830403M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76003
Clcn4
Name: chloride channel, voltage-sensitive 4
Synonyms: Clc4-2, Clcn4-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12727
HGNC: HGNC:2022
Homologene: 68207
Gm5581
Name: predicted gene 5581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224916
Sidt1
Name: SID1 transmembrane family, member 1
Synonyms: B830021E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 320007
Homologene: 41189
Ctnna2
Name: catenin (cadherin associated protein), alpha 2
Synonyms: alpha(N)-catenin, alpha N-catenin, Catna, chp, Catna2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12386
HGNC: HGNC:2510
Homologene: 68394
Bivm
Name: basic, immunoglobulin-like variable motif containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 246229
Homologene: 9783
Vmn1r34
Name: vomeronasal 1 receptor 34
Synonyms: Gm5991
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 546901
Homologene: 110800
Catsperb
Name: cation channel sperm associated auxiliary subunit beta
Synonyms: 4932415G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 271036
VEGA: 12
Homologene: 81904
Olfr895
Name: olfactory receptor 895
Synonyms: GA_x6K02T2PVTD-31962461-31963411, MOR170-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258875
Homologene: 74253
Adgrg7
Name: adhesion G protein-coupled receptor G7
Synonyms: 9130020O16Rik, Gpr128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239853
Homologene: 13115
Tas2r105
Name: taste receptor, type 2, member 105
Synonyms: Tas2r5, T2R05, T2R9, mGR05, mt2r5, T2r5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 57252
Homologene: 69307
Acad8
Name: acyl-Coenzyme A dehydrogenase family, member 8
Synonyms: 2310016C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66948
HGNC: HGNC:87
Homologene: 8662
1110038F14Rik
Name: RIKEN cDNA 1110038F14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 117171
VEGA: 15
Homologene: 11320
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 44,137,128 bp
  • T to A, chromosome 2 at 52,121,087 bp
  • A to T, chromosome 2 at 87,002,922 bp
  • G to A, chromosome 3 at 159,516,149 bp
  • T to C, chromosome 4 at 55,007,790 bp
  • C to T, chromosome 4 at 59,207,798 bp
  • C to G, chromosome 4 at 63,374,390 bp
  • T to A, chromosome 4 at 148,014,283 bp
  • C to T, chromosome 5 at 3,992,077 bp
  • A to G, chromosome 5 at 74,032,475 bp
  • G to A, chromosome 5 at 100,093,012 bp
  • T to C, chromosome 6 at 29,451,635 bp
  • T to A, chromosome 6 at 66,637,704 bp
  • A to T, chromosome 6 at 77,636,844 bp
  • G to A, chromosome 6 at 131,167,068 bp
  • A to G, chromosome 6 at 131,686,826 bp
  • T to G, chromosome 7 at 7,290,428 bp
  • T to A, chromosome 7 at 43,355,571 bp
  • C to A, chromosome 7 at 72,090,239 bp
  • T to C, chromosome 9 at 26,979,185 bp
  • G to A, chromosome 9 at 38,269,461 bp
  • A to G, chromosome 9 at 70,324,875 bp
  • T to C, chromosome 9 at 119,137,340 bp
  • T to C, chromosome 10 at 78,752,893 bp
  • T to C, chromosome 11 at 17,194,786 bp
  • T to A, chromosome 11 at 100,874,926 bp
  • A to G, chromosome 12 at 25,057,144 bp
  • A to G, chromosome 12 at 83,594,522 bp
  • C to A, chromosome 12 at 101,602,683 bp
  • A to G, chromosome 12 at 110,793,516 bp
  • T to C, chromosome 13 at 3,584,554 bp
  • C to T, chromosome 13 at 46,637,841 bp
  • A to T, chromosome 14 at 12,343,986 bp
  • T to G, chromosome 14 at 16,409,189 bp
  • A to G, chromosome 15 at 54,462,551 bp
  • CGGG to CGGGGGG, chromosome 15 at 76,949,663 bp
  • A to G, chromosome 16 at 44,281,886 bp
  • A to T, chromosome 16 at 56,730,298 bp
  • T to A, chromosome 17 at 57,536,718 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4023 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040957-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.