Strain Name:
C57BL/6J-MtgxR4034Btlr/Mmmh
Stock Number:
040962-MU
Citation ID:
RRID:MMRRC_040962-MU
Other Names:
R4034 (G1), C57BL/6J-MtgxR4034Btlr
Major Collection:

Gene Information

Zfa-ps
Name: zinc finger protein, autosomal, pseudogene
Synonyms: Zfa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22639
Zfp423
Name: zinc finger protein 423
Synonyms: ataxia1, Roaz, Ebfaz, Zfp104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 94187
Homologene: 9010
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: Daple, 0610010D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 68339
VEGA: 12
Homologene: 18903
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 70683
VEGA: 10
Homologene: 38373
Cwf19l2
Name: CWF19-like 2, cell cycle control (S. pombe)
Synonyms: 3230401L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244672
Homologene: 12366
Hmgcr
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: 3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoAR, Red
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 15357
HGNC: HGNC:5006
Homologene: 30994
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 3010027A04Rik, Yod, 9530048I21Rik, 2410104C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 77087
Homologene: 69134
Wapl
Name: WAPL cohesin release factor
Synonyms: Wapal, A530089A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218914
Homologene: 41002
Srsf4
Name: serine/arginine-rich splicing factor 4
Synonyms: SRp75, 5730499P16Rik, Sfrs4, MNCb-2616
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 57317
Homologene: 25624
Aarsd1
Name: alanyl-tRNA synthetase domain containing 1
Synonyms: 2310044P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69684
Homologene: 6821
Zfp37
Name: zinc finger protein 37
Synonyms: Zfp-37, Tzn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 22696
Homologene: 40682
Arap1
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms: Centd2, 2410002L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 69710
Homologene: 12326
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: 2410140K03Rik, D5Ertd591e, 3110031A07Rik, A630018G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 76800
Homologene: 35425
Tcerg1
Name: transcription elongation regulator 1 (CA150)
Synonyms: 2410022J09Rik, 2900090C16Rik, p144, Taf2s, Fbp28, ca150
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 56070
Homologene: 4879
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: Cngb1, Cngb1b, BC016201
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Pgm5
Name: phosphoglucomutase 5
Synonyms: aciculin, 9530034F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226041
HGNC: HGNC:8908
Homologene: 74881
Taf5l
Name: TATA-box binding protein associated factor 5 like
Synonyms: 1110005N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 102162
Homologene: 8676
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223825
VEGA: 15
Homologene: 128807
Gm8251
Name: predicted gene 8251
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 102636082
VEGA: 1
Homologene: 141149
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: SZP, MSF, DOL54, lubricin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
4921528O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Fbll1
Name: fibrillarin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237730
Homologene: 28185
St18
Name: suppression of tumorigenicity 18
Synonyms: Nzf3, Myt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240690
Homologene: 8792
Tmco4
Name: transmembrane and coiled-coil domains 4
Synonyms: 4632413C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 77056
Homologene: 57112
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237711
Homologene: 104282
Csn1s2a
Name: casein alpha s2-like A
Synonyms: Csng, Csn1s2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12993
Homologene: 7284
Lrrc71
Name: leucine rich repeat containing 71
Synonyms: 4933430H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74485
Homologene: 83646
Olfr1385
Name: olfactory receptor 1385
Synonyms: MOR256-42P, MOR256-42P, GA_x6K02T2QP88-5941817-5940888, Olfr1549-ps1, MOR256-41P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258027
Homologene: 86692
Cyp2c68
Name: cytochrome P450, family 2, subfamily c, polypeptide 68
Synonyms: 9030012A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 433247
Homologene: 74936
Sgpp1
Name: sphingosine-1-phosphate phosphatase 1
Synonyms: SPP, mSPP1, SPP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 81535
VEGA: 12
Homologene: 101696
Ppl
Name: periplakin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Vmn1r14
Name: vomeronasal 1 receptor 14
Synonyms: V1rc7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 113864
Homologene: 74373
Aspa
Name: aspartoacylase
Synonyms: nur7, aspartoacylase, Acy-2, small lethargic, Acy2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11484
HGNC: HGNC:756
Homologene: 33
9930111J21Rik2
Name: RIKEN cDNA 9930111J21 gene 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 245240
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 6,855,473 bp
  • A to G, chromosome 1 at 44,058,866 bp
  • T to A, chromosome 1 at 150,452,213 bp
  • A to G, chromosome 1 at 163,080,553 bp
  • A to G, chromosome 3 at 87,745,533 bp
  • G to A, chromosome 4 at 62,191,696 bp
  • C to T, chromosome 4 at 131,900,102 bp
  • T to C, chromosome 4 at 139,020,861 bp
  • A to G, chromosome 5 at 87,781,887 bp
  • C to T, chromosome 5 at 143,715,439 bp
  • G to A, chromosome 6 at 57,234,325 bp
  • A to T, chromosome 7 at 101,400,277 bp
  • G to A, chromosome 7 at 141,799,844 bp
  • A to G, chromosome 8 at 87,781,344 bp
  • C to A, chromosome 8 at 95,264,450 bp
  • A to G, chromosome 8 at 122,896,715 bp
  • T to C, chromosome 8 at 124,009,675 bp
  • A to T, chromosome 9 at 3,456,803 bp
  • T to A, chromosome 10 at 52,544,540 bp
  • C to T, chromosome 10 at 88,762,806 bp
  • C to A, chromosome 11 at 29,803,137 bp
  • G to A, chromosome 11 at 35,797,678 bp
  • A to T, chromosome 11 at 49,019,281 bp
  • A to G, chromosome 11 at 49,495,460 bp
  • T to C, chromosome 11 at 73,308,771 bp
  • C to T, chromosome 11 at 101,411,332 bp
  • A to G, chromosome 12 at 75,716,190 bp
  • A to T, chromosome 12 at 84,804,474 bp
  • G to A, chromosome 12 at 100,930,524 bp
  • C to G, chromosome 13 at 96,651,063 bp
  • T to C, chromosome 14 at 34,737,914 bp
  • T to C, chromosome 15 at 4,945,148 bp
  • T to C, chromosome 16 at 5,106,857 bp
  • T to A, chromosome 18 at 42,519,533 bp
  • T to A, chromosome 19 at 24,861,657 bp
  • G to A, chromosome 19 at 39,740,864 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4034 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040962-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.