Strain Name:
C57BL/6J-MtgxR4038Btlr/Mmmh
Stock Number:
040965-MU
Citation ID:
RRID:MMRRC_040965-MU
Other Names:
R4038 (G1), C57BL/6J-MtgxR4038Btlr
Major Collection:

Gene Information

Elp2
Name: elongator acetyltransferase complex subunit 2
Synonyms: Statip1, StIP1, Stat3-interacting protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 58523
VEGA: 18
Homologene: 6019
Gpr83
Name: G protein-coupled receptor 83
Synonyms: RP39, glucocorticoid-induced receptor, RP82, GIR, Gpr72, RP105, Gir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14608
HGNC: HGNC:4523
Homologene: 7732
Nfia
Name: nuclear factor I/A
Synonyms: 1110047K16Rik, 9430022M17Rik, NF1-A, NF1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18027
HGNC: HGNC:7784
Homologene: 4086
Ptprf
Name: protein tyrosine phosphatase, receptor type, F
Synonyms: RPTP-LAR, LAR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Ssc4d
Name: scavenger receptor cysteine rich family, 4 domains
Synonyms: Srcrb4d, C330016E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 109267
Homologene: 34137
Dhcr24
Name: 24-dehydrocholesterol reductase
Synonyms: 5830417J06Rik, seladin-1, 2310076D10Rik, 3-beta-hydroxysterol delta-24 reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74754
HGNC: HGNC:2859
Homologene: 8850
Mmachc
Name: methylmalonic aciduria cblC type, with homocystinuria
Synonyms: 1810037K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67096
Homologene: 12082
Ate1
Name: arginyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11907
HGNC: HGNC:782
Homologene: 31420
Tfap2c
Name: transcription factor AP-2, gamma
Synonyms: Tcfap2c, Stra2, Ap-2.2, AP2gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21420
Homologene: 2423
Zfp931
Name: zinc finger protein 931
Synonyms: 2810021G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 353208
Homologene: 136272
Iqcd
Name: IQ motif containing D
Synonyms: 4933433C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75732
Homologene: 49921
Syngap1
Name: synaptic Ras GTPase activating protein 1 homolog (rat)
Synonyms: Syngap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240057
Homologene: 84739
Crnkl1
Name: crooked neck pre-mRNA splicing factor 1
Synonyms: crn, 5730590A01Rik, 1200013P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66877
Homologene: 6462
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: 1110031M08Rik, Hnrpul2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68693
VEGA: 19
Homologene: 28583
Usp37
Name: ubiquitin specific peptidase 37
Synonyms: 4932415L06Rik, C330008N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319651
Homologene: 10858
Dennd1c
Name: DENN/MADD domain containing 1C
Synonyms: 4432409M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70785
VEGA: 17
Homologene: 11773
Prkaa2
Name: protein kinase, AMP-activated, alpha 2 catalytic subunit
Synonyms: 2310008I11Rik, AMPKalpha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 108079
HGNC: HGNC:9377
Homologene: 4551
Metrn
Name: meteorin, glial cell differentiation regulator
Synonyms: 1810034B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70083
VEGA: 17
Homologene: 11432
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: 8430418G19Rik, C79217, Cchl1a, D-LTCC, Cav1.3alpha1, Cacnl1a2, Cchl1a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208898
Homologene: 45443
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Slc16a10
Name: solute carrier family 16 (monocarboxylic acid transporters), member 10
Synonyms: Mct10, TAT1, 2610103N14Rik, PRO0813
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72472
VEGA: 10
Homologene: 75089
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 3830402K23Rik, 4930518F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320558
Homologene: 8604
Sfmbt1
Name: Scm-like with four mbt domains 1
Synonyms: 4930442N21Rik, 9330180L21Rik, Smr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54650
Homologene: 9472
Vmn1r218
Name: vomeronasal 1 receptor 218
Synonyms: V1ri5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171256
Homologene: 110880
Gm4787
Name: predicted gene 4787
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 214321
Homologene: 86950
Lmod3
Name: leiomodin 3 (fetal)
Synonyms: 5430424A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320502
HGNC: HGNC:6649
Homologene: 28097
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: AK220484, mKIAA4095
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381157
Homologene: 73393
Wiz
Name: widely-interspaced zinc finger motifs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22404
Homologene: 7997
Wipf3
Name: WAS/WASL interacting protein family, member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330319
Homologene: 113391
Slc28a2
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
Synonyms: 2010208B10Rik, CNT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269346
Homologene: 20891
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12722
Homologene: 77224
Zer1
Name: zyg-11 related, cell cycle regulator
Synonyms: C230075L19Rik, Zyg11bl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227693
Homologene: 4621
Glb1l3
Name: galactosidase, beta 1 like 3
Synonyms: 4921509F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70893
Homologene: 72240
Creb3l3
Name: cAMP responsive element binding protein 3-like 3
Synonyms: D10Bur1e, CREB-H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 208677
Homologene: 13080
Hspa2
Name: heat shock protein 2
Synonyms: Hsp70-2, 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15512
VEGA: 12
HGNC: HGNC:5235
Homologene: 68564
Carmil2
Name: capping protein regulator and myosin 1 linker 2
Synonyms: D130029J02Rik, Rltpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234695
Homologene: 128439
Olfr1158
Name: olfactory receptor 1158
Synonyms: MOR173-3, GA_x6K02T2Q125-49480812-49481753
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258639
Gpr137c
Name: G protein-coupled receptor 137C
Synonyms: LOC380893, TM7SF1L2, 6330416L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70713
Homologene: 28613
Eef2kmt
Name: eukaryotic elongation factor 2 lysine methyltransferase
Synonyms: 5730409G15Rik, Fam86
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70511
Homologene: 45719
AC151712.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Scrt1
Name: scratch family zinc finger 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170729
VEGA: 15
Homologene: 113534
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 74,471,543 bp
  • T to C, chromosome 2 at 30,107,523 bp
  • T to A, chromosome 2 at 87,990,918 bp
  • C to A, chromosome 2 at 122,454,515 bp
  • T to A, chromosome 2 at 145,932,327 bp
  • A to T, chromosome 2 at 172,556,190 bp
  • T to A, chromosome 2 at 178,067,984 bp
  • C to A, chromosome 2 at 178,380,927 bp
  • T to A, chromosome 3 at 144,755,233 bp
  • C to A, chromosome 4 at 98,020,837 bp
  • T to C, chromosome 4 at 105,051,247 bp
  • T to C, chromosome 4 at 106,573,878 bp
  • G to T, chromosome 4 at 113,885,814 bp
  • T to A, chromosome 4 at 116,706,018 bp
  • C to T, chromosome 4 at 118,257,608 bp
  • T to C, chromosome 5 at 120,602,522 bp
  • C to A, chromosome 5 at 135,970,316 bp
  • G to A, chromosome 6 at 54,481,828 bp
  • T to C, chromosome 6 at 97,248,314 bp
  • A to G, chromosome 7 at 130,504,765 bp
  • C to A, chromosome 8 at 105,695,407 bp
  • A to G, chromosome 9 at 14,860,777 bp
  • A to C, chromosome 9 at 26,829,047 bp
  • A to G, chromosome 9 at 73,533,906 bp
  • G to C, chromosome 10 at 40,056,624 bp
  • A to G, chromosome 10 at 81,089,338 bp
  • T to C, chromosome 12 at 76,405,768 bp
  • A to T, chromosome 12 at 81,378,358 bp
  • T to C, chromosome 13 at 23,136,801 bp
  • T to A, chromosome 14 at 30,066,083 bp
  • T to G, chromosome 14 at 30,787,492 bp
  • C to A, chromosome 14 at 45,220,230 bp
  • A to T, chromosome 15 at 76,521,582 bp
  • A to T, chromosome 16 at 5,245,271 bp
  • T to C, chromosome 17 at 25,795,010 bp
  • T to C, chromosome 17 at 26,957,720 bp
  • T to C, chromosome 17 at 32,359,224 bp
  • A to C, chromosome 17 at 57,070,638 bp
  • C to T, chromosome 18 at 10,515,209 bp
  • T to A, chromosome 18 at 24,634,348 bp
  • T to A, chromosome 19 at 8,823,227 bp
  • G to A, chromosome Y at 90,762,294 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4038 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040965-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.