Strain Name:
C57BL/6J-MtgxR4044Btlr/Mmmh
Stock Number:
040967-MU
Citation ID:
RRID:MMRRC_040967-MU
Other Names:
R4044 (G1), C57BL/6J-MtgxR4044Btlr
Major Collection:

Gene Information

Atg7
Name: autophagy related 7
Synonyms: 1810013K23Rik, Apg7l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74244
Homologene: 4662
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Cep70
Name: centrosomal protein 70
Synonyms: 6720484E09Rik, C030018L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68121
Homologene: 11387
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: CD221, IGF-1R, line 186, hyft, A330103N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Armh3
Name: armadillo-like helical domain containing 3
Synonyms: 9130011E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 71617
VEGA: 19
Homologene: 15843
Gtf2a1
Name: general transcription factor II A, 1
Synonyms: TfIIAa/b, 19kDa, 37kDa, 6330549H03Rik, Tfiia1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 83602
HGNC: HGNC:4646
Homologene: 56331
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Jam3
Name: junction adhesion molecule 3
Synonyms: JAM-3, 1110002N23Rik, Jcam3, JAM-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83964
Homologene: 11338
Orc3
Name: origin recognition complex, subunit 3
Synonyms: Orc3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50793
HGNC: HGNC:8489
Homologene: 8225
Galnt5
Name: polypeptide N-acetylgalactosaminyltransferase 5
Synonyms: ppGaNTase-T5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241391
HGNC: HGNC:4127
Homologene: 8733
D16Ertd472e
Name: DNA segment, Chr 16, ERATO Doi 472, expressed
Synonyms: 2310009O17Rik, E330003K22Rik, 1700010I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67102
Homologene: 9696
Znrd2
Name: zinc ribbon domain containing 2
Synonyms: 1500016H19Rik, Sjogren's syndrome/scleroderma autoantigen 1 homolog (human), Sssca1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56390
Homologene: 4663
Katnip
Name: katanin interacting protein
Synonyms: D430042O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233865
Homologene: 45841
Wnt9b
Name: wingless-type MMTV integration site family, member 9B
Synonyms: clf, Wnt14b, Wnt15, clf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22412
Homologene: 2551
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Ksr2
Name: kinase suppressor of ras 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 333050
Homologene: 45469
Nell1
Name: NEL-like 1
Synonyms: B230343H07Rik, l7R6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Scaf1
Name: SR-related CTD-associated factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233208
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Ccl1
Name: chemokine (C-C motif) ligand 1
Synonyms: I-309, CCR8 ligand, Tca-3, Scya1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20290
Homologene: 55541
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Map6
Name: microtubule-associated protein 6
Synonyms: F-STOP, STOP, 2810411E12Rik, Mtap6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17760
HGNC: HGNC:6868
Homologene: 7850
Vrtn
Name: vertebrae development associated
Synonyms: 7420416P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 432677
VEGA: 12
Homologene: 41236
Ada
Name: adenosine deaminase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11486
HGNC: HGNC:186
Homologene: 37249
L3mbtl4
Name: L3MBTL4 histone methyl-lysine binding protein
Synonyms: D930040M24Rik, A730037L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320858
Homologene: 114383
Otol1
Name: otolin 1
Synonyms: LOC229389, Gm414
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229389
Homologene: 19018
Rpp40
Name: ribonuclease P 40 subunit
Synonyms: D8Bwg1265e, Rnasep1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 208366
Homologene: 4836
Or4k35
Name: olfactory receptor family 4 subfamily K member 35
Synonyms: GA_x6K02T2Q125-72321818-72320907, MOR248-11, Olfr1277
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258391
Homologene: 105176
Dsg1a
Name: desmoglein 1 alpha
Synonyms: Dsg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13510
HGNC: HGNC:3048
Homologene: 1463
Sncaip
Name: synuclein, alpha interacting protein (synphilin)
Synonyms: SYPH1, 4933427B05Rik, synphilin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67847
Homologene: 3987
Tsnaxip1
Name: translin-associated factor X (Tsnax) interacting protein 1
Synonyms: 1700016K08Rik, TXI1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72236
Homologene: 10194
Klk1b4
Name: kallikrein 1-related pepidase b4
Synonyms: mGk-4, Ngfa, Ngfa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18048
Homologene: 68141
Prss40
Name: protease, serine 40
Synonyms: Tesp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21756
Homologene: 69043
Itih4
Name: inter alpha-trypsin inhibitor, heavy chain 4
Synonyms: Itih-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16427
HGNC: HGNC:6169
Homologene: 1670
Zswim5
Name: zinc finger SWIM-type containing 5
Synonyms: 4933426E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74464
Homologene: 18958
Npm3
Name: nucleoplasmin 3
Synonyms: Nub1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18150
HGNC: HGNC:7931
Homologene: 5083
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: VKIND, very-kind, 2410012C07Rik, B830014K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76484
Homologene: 45138
4930579C12Rik
Name: RIKEN cDNA 4930579C12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319213
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
Spata6l
Name: spermatogenesis associated 6 like
Synonyms: 4430402I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381218
Homologene: 128454
Pals1
Name: protein associated with LIN7 1, MAGUK family member
Synonyms: Pals1, 3830420B02Rik, Mpp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56217
VEGA: 12
Homologene: 9512
Radx
Name: RPA1 related single stranded DNA binding protein, X-linked
Synonyms: D330045A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 102871
Homologene: 9962
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 34,560,879 bp
  • A to G, chromosome 2 at 22,577,700 bp
  • T to A, chromosome 2 at 57,998,460 bp
  • C to T, chromosome 2 at 111,269,582 bp
  • A to T, chromosome 2 at 163,735,460 bp
  • A to G, chromosome 3 at 70,027,779 bp
  • G to A, chromosome 4 at 34,587,055 bp
  • A to G, chromosome 4 at 116,986,702 bp
  • T to A, chromosome 4 at 143,811,600 bp
  • A to T, chromosome 5 at 22,128,632 bp
  • C to T, chromosome 5 at 117,555,062 bp
  • T to C, chromosome 6 at 114,701,978 bp
  • A to G, chromosome 7 at 44,210,755 bp
  • G to A, chromosome 7 at 45,006,374 bp
  • A to G, chromosome 7 at 50,219,619 bp
  • A to G, chromosome 7 at 68,190,062 bp
  • T to C, chromosome 7 at 99,268,049 bp
  • A to G, chromosome 7 at 125,868,741 bp
  • A to G, chromosome 7 at 139,924,129 bp
  • G to A, chromosome 8 at 105,833,545 bp
  • C to A, chromosome 9 at 27,101,863 bp
  • T to A, chromosome 9 at 89,162,294 bp
  • T to A, chromosome 9 at 99,262,609 bp
  • T to C, chromosome 11 at 66,133,635 bp
  • T to A, chromosome 11 at 82,179,693 bp
  • T to C, chromosome 11 at 103,731,998 bp
  • G to A, chromosome 12 at 78,824,839 bp
  • T to C, chromosome 12 at 84,649,070 bp
  • T to C, chromosome 12 at 91,575,667 bp
  • A to G, chromosome 13 at 35,898,566 bp
  • T to A, chromosome 13 at 89,692,543 bp
  • A to T, chromosome 14 at 30,895,038 bp
  • A to T, chromosome 14 at 35,450,401 bp
  • A to T, chromosome 16 at 78,576,006 bp
  • T to C, chromosome 17 at 68,777,914 bp
  • A to G, chromosome 17 at 84,441,707 bp
  • C to A, chromosome 18 at 20,324,030 bp
  • A to G, chromosome 18 at 52,907,403 bp
  • T to C, chromosome 19 at 5,730,403 bp
  • A to T, chromosome 19 at 28,945,783 bp
  • T to C, chromosome 19 at 45,748,253 bp
  • A to T, chromosome 19 at 45,820,324 bp
  • C to T, chromosome X at 139,507,003 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4044 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040967-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.