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Strain Name:
C57BL/6J-MtgxR4050Btlr/Mmmh
Stock Number:
040968-MU
Citation ID:
RRID:MMRRC_040968-MU
Other Names:
R4050 (G1), C57BL/6J-MtgxR4050Btlr
Major Collection:

Strain Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Mad1l1
Name: MAD1 mitotic arrest deficient 1-like 1
Synonyms: Mad1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17120
HGNC: HGNC:6762
Homologene: 74500
Prune1
Name: prune exopolyphosphatase
Synonyms: 9230112O05Rik, Prune-M1, Prune
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229589
Homologene: 41429
Scrib
Name: scribbled planar cell polarity
Synonyms: Scrb1, Crc
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Ppp1r1a
Name: protein phosphatase 1, regulatory inhibitor subunit 1A
Synonyms: I-1, protein phosphatase inhibitor-1, inhibitor-1, 0610038N18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58200
VEGA: 15
HGNC: HGNC:9286
Homologene: 4905
Cyp39a1
Name: cytochrome P450, family 39, subfamily a, polypeptide 1
Synonyms: oxysterol 7-alpha-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56050
VEGA: 17
Homologene: 9580
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: med, seal, motor end-plate disease, nmf2, ataxia 3, mnd2, mnd-2, C630029C19Rik, nmf58, NaCh6, Nav1.6, nmf335, NMF335, nur14
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20273
Homologene: 7927
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Rab3gap2
Name: RAB3 GTPase activating protein subunit 2
Synonyms: 1110059F07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98732
Homologene: 40842
Nup35
Name: nucleoporin 35
Synonyms: 5330402E05Rik, 2310006I24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69482
Homologene: 44517
Taf4
Name: TATA-box binding protein associated factor 4
Synonyms: Taf2c1, TAFII135, TAFII130, Taf4a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228980
Homologene: 55723
Ncbp1
Name: nuclear cap binding protein subunit 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433702
HGNC: HGNC:7658
Homologene: 1859
Ddb1
Name: damage specific DNA binding protein 1
Synonyms: p127-Ddb1, damage-specific DNA-binding protein, DNA repair, DNA repair protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13194
VEGA: 19
HGNC: HGNC:2717
Homologene: 1448
Zfp26
Name: zinc finger protein 26
Synonyms: mkr-3, Zfp-26, 5033428C05Rik, Zfp70, KRAB15, Zfp81-rs1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22688
Homologene: 52318
Abca1
Name: ATP-binding cassette, sub-family A member 1
Synonyms: ABC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Hnf1a
Name: HNF1 homeobox A
Synonyms: hepatocyte nuclear factor 1, HNF1-alpha, HNF1[a], HNF1, Hnf-1, Hnf1alpha, LFB1, Tcf1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21405
Homologene: 459
Gga1
Name: golgi associated, gamma adaptin ear containing, ARF binding protein 1
Synonyms: 4930406E12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 106039
VEGA: 15
Homologene: 39250
Ddx39a
Name: DEAD box helicase 39a
Synonyms: 2610307C23Rik, BAT1, Ddx39
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68278
Homologene: 68487
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: BC016423, Fam208b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Galnt5
Name: polypeptide N-acetylgalactosaminyltransferase 5
Synonyms: ppGaNTase-T5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241391
HGNC: HGNC:4127
Homologene: 8733
Kif26a
Name: kinesin family member 26A
Synonyms: N-11 kinesin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668303
Homologene: 18970
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Plk2
Name: polo like kinase 2
Synonyms: Snk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20620
VEGA: 13
Homologene: 21317
Lmo7
Name: LIM domain only 7
Synonyms: LOC380928, FBXO20
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Vav2
Name: vav 2 oncogene
Synonyms: 2810040F13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22325
Homologene: 2530
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Gtl5, Wcrf180, Acf1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Slx9
Name: SLX9 ribosome biogenesis factor
Synonyms: 1810008A18Rik, Fam207a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108707
VEGA: 10
Homologene: 14384
Heatr6
Name: HEAT repeat containing 6
Synonyms: 2700008B19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217026
Homologene: 11116
Actr3
Name: ARP3 actin-related protein 3
Synonyms: 1200003A09Rik, Arp3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74117
HGNC: HGNC:170
Homologene: 68483
Cep57l1
Name: centrosomal protein 57-like 1
Synonyms: 4930484D11Rik, 2410017P07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103268
Homologene: 12254
Sall3
Name: spalt like transcription factor 3
Synonyms: Msal, Msal-1, Spalt, Salt, B130022O04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20689
VEGA: 18
Homologene: 18142
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70885
Homologene: 10029
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: MSF, DOL54, lubricin, SZP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 5930426O13Rik, 9030605H24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319767
Homologene: 70969
Synpo2
Name: synaptopodin 2
Synonyms: myopodin, Myo, 9530006G20Rik, 1110069I04Rik, 2310068J10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 118449
Homologene: 15400
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 435626
Homologene: 52359
Edar
Name: ectodysplasin-A receptor
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13608
HGNC: HGNC:2895
Homologene: 7699
Dennd3
Name: DENN domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105841
Homologene: 28254
Zbtb26
Name: zinc finger and BTB domain containing 26
Synonyms: A630026F21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320633
Homologene: 10853
Tpte
Name: transmembrane phosphatase with tensin homology
Synonyms: Pten2, Vsp
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234129
Homologene: 50411
Cdc20b
Name: cell division cycle 20B
Synonyms: EG238896, EG622422
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238896
Homologene: 65056
Otulin
Name: OTU deubiquitinase with linear linkage specificity
Synonyms: m7-1Sapc, gumby, Fam105b, m3Sapc
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 432940
VEGA: 15
Homologene: 106591
Ovgp1
Name: oviductal glycoprotein 1
Synonyms: MOGP, muc9, mucin 9, oviductin, Chit5, OGP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12659
HGNC: HGNC:8524
Homologene: 74442
Pcgf5
Name: polycomb group ring finger 5
Synonyms: 5830443C21Rik, 9530023M17Rik, 1110054A01Rik, 0610009F02Rik, 5830406C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76073
VEGA: 19
Homologene: 12632
Ggps1
Name: geranylgeranyl diphosphate synthase 1
Synonyms: GGPP synthase, 9530089B04Rik, 1810026C22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14593
VEGA: 13
HGNC: HGNC:4249
Homologene: 31267
Dip2a
Name: disco interacting protein 2 homolog A
Synonyms: Kiaa0184-hp, 4931420H10Rik, Dip2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64451
Homologene: 41012
Mpp4
Name: membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
Synonyms: DLG6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227157
Homologene: 23296
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625109
Homologene: 129606
Spire1
Name: spire type actin nucleation factor 1
Synonyms: Spir-1, 6030430B19Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68166
VEGA: 18
Homologene: 35507
Skint4
Name: selection and upkeep of intraepithelial T cells 4
Synonyms: 9530098N22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320640
Or2y8
Name: olfactory receptor family 2 subfamily Y member 8
Synonyms: GA_x6K02T2QP88-3283154-3284089, MOR256-69_p, Olfr1373
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 211472
Homologene: 72463
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76074
H2-Eb1
Name: histocompatibility 2, class II antigen E beta
Synonyms: H-2Eb, Ia-4, Ia4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14969
Homologene: 101524
Zfp324
Name: zinc finger protein 324
Synonyms: D430030K24Rik, ZF5128
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243834
Homologene: 8648
Slc29a2
Name: solute carrier family 29 (nucleoside transporters), member 2
Synonyms: ENT2, Der12, HNP36
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13340
VEGA: 19
Homologene: 37493
2510039O18Rik
Name: RIKEN cDNA 2510039O18 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77034
Homologene: 12668
Mycl
Name: v-myc avian myelocytomatosis viral oncogene lung carcinoma derived
Synonyms: Lmyc-1, Lmyc1, L-myc, bHLHe38, Mycl1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16918
Homologene: 3921
Gm10518
Name: predicted gene 10518
Type: Gene
Species: Mouse
Chromosome: 1
Or4p20
Name: olfactory receptor family 4 subfamily P member 20
Synonyms: GA_x6K02T2Q125-49911636-49910701, MOR225-9P, Olfr1181
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258060
Homologene: 86666
Gm8074
Name: predicted gene 8074
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 59,146,744 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • A to T, chromosome 1 at 125,411,388 bp
  • G to T, chromosome 1 at 132,610,305 bp
  • G to C, chromosome 1 at 150,454,759 bp
  • C to A, chromosome 1 at 179,803,813 bp
  • G to A, chromosome 1 at 185,272,643 bp
  • T to C, chromosome 2 at 27,288,679 bp
  • A to G, chromosome 2 at 27,291,403 bp
  • A to C, chromosome 2 at 37,436,988 bp
  • A to G, chromosome 2 at 58,024,735 bp
  • A to G, chromosome 2 at 76,821,166 bp
  • A to G, chromosome 2 at 80,655,976 bp
  • A to G, chromosome 2 at 88,423,623 bp
  • C to A, chromosome 2 at 179,932,012 bp
  • T to C, chromosome 3 at 95,262,231 bp
  • T to C, chromosome 3 at 105,986,567 bp
  • A to G, chromosome 3 at 105,986,596 bp
  • T to C, chromosome 3 at 123,114,278 bp
  • G to A, chromosome 4 at 46,147,483 bp
  • T to A, chromosome 4 at 53,044,144 bp
  • C to T, chromosome 4 at 112,124,614 bp
  • A to T, chromosome 4 at 122,996,839 bp
  • T to C, chromosome 4 at 143,727,122 bp
  • A to G, chromosome 4 at 147,944,992 bp
  • T to A, chromosome 5 at 105,031,238 bp
  • T to A, chromosome 5 at 114,970,574 bp
  • A to G, chromosome 5 at 140,132,816 bp
  • A to G, chromosome 6 at 17,533,984 bp
  • T to C, chromosome 7 at 12,970,867 bp
  • T to C, chromosome 7 at 28,152,985 bp
  • T to A, chromosome 8 at 22,365,984 bp
  • C to T, chromosome 8 at 68,827,351 bp
  • T to A, chromosome 8 at 83,722,234 bp
  • G to A, chromosome 9 at 20,442,229 bp
  • T to G, chromosome 9 at 67,860,896 bp
  • G to A, chromosome 9 at 78,322,336 bp
  • G to T, chromosome 10 at 41,729,360 bp
  • G to T, chromosome 10 at 58,609,947 bp
  • G to A, chromosome 10 at 76,278,607 bp
  • T to C, chromosome 10 at 77,514,330 bp
  • T to A, chromosome 10 at 130,448,566 bp
  • G to A, chromosome 11 at 43,259,536 bp
  • T to G, chromosome 11 at 52,145,134 bp
  • A to G, chromosome 11 at 83,755,773 bp
  • G to A, chromosome 12 at 8,015,390 bp
  • A to G, chromosome 12 at 54,929,619 bp
  • T to A, chromosome 12 at 112,179,916 bp
  • A to G, chromosome 13 at 3,573,507 bp
  • T to C, chromosome 13 at 14,053,699 bp
  • C to T, chromosome 13 at 110,399,866 bp
  • G to A, chromosome 13 at 113,064,285 bp
  • A to T, chromosome 14 at 101,902,277 bp
  • A to G, chromosome 15 at 27,616,476 bp
  • T to C, chromosome 15 at 73,522,215 bp
  • G to A, chromosome 15 at 76,051,473 bp
  • A to G, chromosome 15 at 78,891,491 bp
  • A to T, chromosome 15 at 101,013,413 bp
  • A to G, chromosome 15 at 103,532,454 bp
  • A to T, chromosome 16 at 37,092,820 bp
  • T to A, chromosome 17 at 34,314,368 bp
  • T to A, chromosome 17 at 43,676,981 bp
  • G to T, chromosome 18 at 67,529,031 bp
  • G to A, chromosome 18 at 80,971,482 bp
  • A to T, chromosome 19 at 5,029,453 bp
  • A to G, chromosome 19 at 10,627,807 bp
  • G to A, chromosome 19 at 36,442,911 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4050 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040968-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.