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Strain Name:
C57BL/6J-MtgxR4085Btlr/Mmmh
Stock Number:
040979-MU
Citation ID:
RRID:MMRRC_040979-MU
Other Names:
R4085 (G1), C57BL/6J-MtgxR4085Btlr
Major Collection:

Strain Information

Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Rbm47
Name: RNA binding motif protein 47
Synonyms: 9530077J19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 245945
Homologene: 36932
Adgrl3
Name: adhesion G protein-coupled receptor L3
Synonyms: D130075K09Rik, lectomedin 3, LEC3, 5430402I23Rik, Lphn3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319387
Homologene: 22878
Kdm1a
Name: lysine (K)-specific demethylase 1A
Synonyms: 1810043O07Rik, LSD1, Aof2, Kdm1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 99982
Homologene: 32240
Mef2c
Name: myocyte enhancer factor 2C
Synonyms: 9930028G15Rik, 5430401D19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17260
HGNC: HGNC:6996
Homologene: 31087
Ddx4
Name: DEAD box helicase 4
Synonyms: mvh / m'vasa, VASA, Mvh, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13206
VEGA: 13
Homologene: 49227
Dynlrb1
Name: dynein light chain roadblock-type 1
Synonyms: DNLC2A, 2010320M17Rik, 2010012N15Rik, Dncl2a, km23-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67068
Homologene: 69161
Urb2
Name: URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382038
Homologene: 8859
Sall1
Name: spalt like transcription factor 1
Synonyms: Msal-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 58198
Homologene: 2230
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Kank2
Name: KN motif and ankyrin repeat domains 2
Synonyms: Ankrd25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235041
VEGA: 9
Homologene: 9163
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox-1, Xox1, Xor, xanthine oxidase, XO
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Bicd2
Name: BICD cargo adaptor 2
Synonyms: 0610027D24Rik, 1110005D12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76895
VEGA: 13
Homologene: 9070
Dcc
Name: DCC netrin 1 receptor
Synonyms: C030036D22Rik, Igdcc1, deleted in colorectal carcinoma
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Atraid
Name: all-trans retinoic acid induced differentiation factor
Synonyms: HSPC013, p18, 0610007C21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381629
Homologene: 15412
Gad1
Name: glutamate decarboxylase 1
Synonyms: GAD67, Gad-1, Z49976, EP10, GAD44, GAD25
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14415
HGNC: HGNC:4092
Homologene: 635
Ppp3cb
Name: protein phosphatase 3, catalytic subunit, beta isoform
Synonyms: PP2BA beta, Calnb, CnAbeta, 1110063J16Rik, Cnab
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19056
HGNC: HGNC:9315
Homologene: 56429
Ehbp1
Name: EH domain binding protein 1
Synonyms: Flj21950, KIAA0903-like
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216565
Homologene: 22880
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Fbxo33
Name: F-box protein 33
Synonyms: 5730501N20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70611
Homologene: 16501
Ccr1
Name: C-C motif chemokine receptor 1
Synonyms: Cmkbr1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12768
VEGA: 9
HGNC: HGNC:1602
Homologene: 20344
Sall3
Name: spalt like transcription factor 3
Synonyms: Msal, Msal-1, Spalt, Salt, B130022O04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20689
VEGA: 18
Homologene: 18142
Sim2
Name: single-minded family bHLH transcription factor 2
Synonyms: bHLHe15
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20465
VEGA: 16
Homologene: 3716
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 637515
Homologene: 19080
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64580
Homologene: 11208
Rbm15b
Name: RNA binding motif protein 15B
Synonyms: 1810017N16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109095
Homologene: 8325
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: F77, 1700016D22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56523
Homologene: 23182
Abca15
Name: ATP-binding cassette, sub-family A member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320631
Homologene: 87255
Trim14
Name: tripartite motif-containing 14
Synonyms: 5830400N10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74735
Homologene: 13241
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Taok2
Name: TAO kinase 2
Synonyms: TAO1, PSK1, 1110033K02Rik, MAP3K17, TAO2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381921
Homologene: 74531
Ucp1
Name: uncoupling protein 1 (mitochondrial, proton carrier)
Synonyms: Slc25a7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22227
Homologene: 22524
Sik2
Name: salt inducible kinase 2
Synonyms: G630080D20Rik, Snf1lk2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235344
Homologene: 22875
Or2y13
Name: olfactory receptor family 2 subfamily Y member 14
Synonyms: GA_x6K02T2QP88-5912627-5911692, MOR256-56, Olfr1383
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 404337
Homologene: 105344
Fam20b
Name: FAM20B, glycosaminoglycan xylosylkinase
Synonyms: C530043G21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215015
Homologene: 8909
Traf3ip3
Name: TRAF3 interacting protein 3
Synonyms: 6030423D04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215243
Homologene: 11885
Sypl2
Name: synaptophysin like 2
Synonyms: Mg29
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17306
Homologene: 7421
Coro1b
Name: coronin, actin binding protein 1B
Synonyms: coronin 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 23789
HGNC: HGNC:2253
Homologene: 40790
Wbp2nl
Name: WBP2 N-terminal like
Synonyms: 4930521I23Rik, PAWP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74716
VEGA: 15
Homologene: 17633
Inhca
Name: inhibitor of carbonic anhydrase
Synonyms: mICA, 1300017J02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71775
Homologene: 826
Herc6
Name: hect domain and RLD 6
Synonyms: 4930427L17Rik, 1700121D12Rik, CEB1, 2510038N07Rik, Herc5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67138
Homologene: 70768
Nlrp5
Name: NLR family, pyrin domain containing 5
Synonyms: Op1, Mater, Nalp5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23968
Homologene: 65105
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Tle6
Name: transducin-like enhancer of split 6
Synonyms: Grg6, 1810057E06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 114606
Homologene: 11701
Opn1sw
Name: opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
Synonyms: Blue/UV Opsin, Blue Opsin, SWS opsin, Short Wavelength Sensitive opsin, S Opsin, Blue Cone Opsin, Bcp, UV cone pigment
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12057
HGNC: HGNC:1012
Homologene: 1291
Rassf2
Name: Ras association (RalGDS/AF-6) domain family member 2
Synonyms: 3830431H01Rik, 9030412M04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215653
HGNC: HGNC:9883
Homologene: 22840
Tedc2
Name: tubulin epsilon and delta complex 2
Synonyms: 1600002H07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72016
Homologene: 45943
Styxl1
Name: serine/threonine/tyrosine interacting-like 1
Synonyms: 1700011C14Rik, Dusp24
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76571
Homologene: 9378
Fndc4
Name: fibronectin type III domain containing 4
Synonyms: 6330410H20Rik, FRCP1, 2810430J06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 64339
Homologene: 49716
Gkn3
Name: gastrokine 3
Synonyms: 1190003M12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68888
Homologene: 87422
3110039M20Rik
Name: RIKEN cDNA 3110039M20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67293
Ccdc107
Name: coiled-coil domain containing 107
Synonyms: 1110032O22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 622404
Homologene: 52163
Cldn34c4
Name: claudin 34C4
Synonyms: 4930412D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 73934
Homologene: 132184
Aurkaip1
Name: aurora kinase A interacting protein 1
Synonyms: AIP, Aurora-A kinase interacting protein, 0610033H09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66077
Homologene: 11916
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,135,227 bp
  • C to A, chromosome 1 at 82,471,188 bp
  • T to C, chromosome 1 at 156,705,875 bp
  • A to G, chromosome 1 at 193,181,320 bp
  • G to T, chromosome 2 at 70,589,848 bp
  • C to A, chromosome 2 at 132,004,379 bp
  • G to T, chromosome 2 at 155,249,976 bp
  • G to A, chromosome 2 at 155,992,632 bp
  • A to G, chromosome 3 at 108,217,676 bp
  • A to G, chromosome 3 at 125,609,482 bp
  • A to T, chromosome 4 at 43,493,693 bp
  • T to A, chromosome 4 at 46,523,709 bp
  • A to C, chromosome 4 at 136,551,962 bp
  • A to T, chromosome 4 at 155,832,905 bp
  • A to T, chromosome 5 at 31,052,306 bp
  • A to G, chromosome 5 at 31,293,777 bp
  • A to G, chromosome 5 at 66,022,737 bp
  • A to G, chromosome 5 at 81,512,544 bp
  • G to A, chromosome 5 at 135,759,165 bp
  • A to G, chromosome 6 at 29,380,144 bp
  • G to A, chromosome 6 at 57,647,069 bp
  • C to T, chromosome 6 at 87,383,525 bp
  • T to A, chromosome 6 at 146,144,248 bp
  • C to A, chromosome 7 at 23,430,098 bp
  • T to C, chromosome 7 at 120,382,726 bp
  • T to C, chromosome 7 at 126,874,725 bp
  • T to C, chromosome 8 at 83,293,951 bp
  • C to T, chromosome 8 at 89,028,509 bp
  • A to G, chromosome 8 at 109,494,947 bp
  • A to G, chromosome 8 at 124,030,941 bp
  • A to G, chromosome 9 at 21,795,119 bp
  • A to T, chromosome 9 at 50,935,385 bp
  • T to C, chromosome 9 at 103,250,661 bp
  • T to C, chromosome 9 at 106,885,737 bp
  • C to T, chromosome 9 at 123,963,950 bp
  • A to G, chromosome 10 at 81,594,515 bp
  • A to T, chromosome 11 at 22,095,898 bp
  • T to C, chromosome 11 at 49,524,128 bp
  • T to C, chromosome 11 at 71,161,762 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • A to G, chromosome 12 at 49,391,114 bp
  • A to T, chromosome 12 at 51,774,750 bp
  • A to G, chromosome 12 at 59,200,805 bp
  • T to A, chromosome 13 at 49,384,962 bp
  • C to T, chromosome 13 at 83,575,702 bp
  • A to G, chromosome 13 at 112,613,761 bp
  • A to G, chromosome 14 at 20,508,543 bp
  • A to G, chromosome 15 at 82,308,561 bp
  • A to G, chromosome 16 at 94,109,354 bp
  • C to T, chromosome 17 at 22,559,115 bp
  • A to T, chromosome 17 at 24,219,839 bp
  • A to T, chromosome 17 at 73,916,879 bp
  • T to A, chromosome 18 at 71,826,169 bp
  • A to T, chromosome 18 at 80,972,133 bp
  • T to C, chromosome 19 at 4,153,619 bp
  • A to T, chromosome X at 127,721,388 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4085 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040979-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.