Strain Name:
C57BL/6J-MtgxR4097Btlr/Mmmh
Stock Number:
040984-MU
Citation ID:
RRID:MMRRC_040984-MU
Other Names:
R4097 (G1), C57BL/6J-MtgxR4097Btlr
Major Collection:

Gene Information

Becn1
Name: beclin 1, autophagy related
Synonyms: Atg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56208
HGNC: HGNC:1034
Homologene: 2794
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 108829
Homologene: 3129
Sgpl1
Name: sphingosine phosphate lyase 1
Synonyms: D10Xrf456
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20397
Homologene: 2897
Wdr43
Name: WD repeat domain 43
Synonyms: 2610318G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72515
VEGA: 17
Homologene: 38810
Thrap3
Name: thyroid hormone receptor associated protein 3
Synonyms: 9330151F09Rik, Trap150, B230333E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230753
Homologene: 31289
Taf3
Name: TATA-box binding protein associated factor 3
Synonyms: mTAFII140, 4933439M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209361
Homologene: 35415
Ranbp9
Name: RAN binding protein 9
Synonyms: IBAP-1, RanBPM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56705
VEGA: 13
Homologene: 38057
Zfp516
Name: zinc finger protein 516
Synonyms: C330029B10Rik, Zfp26l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Nrf1
Name: nuclear respiratory factor 1
Synonyms: D6Ertd415e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18181
HGNC: HGNC:7996
Homologene: 3674
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
Wdr26
Name: WD repeat domain 26
Synonyms: 1600024A01Rik, Gid7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226757
Homologene: 11857
Ice2
Name: interactor of little elongation complex ELL subunit 2
Synonyms: B230343B06Rik, Narg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 93697
Homologene: 11618
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 6430549P11Rik, 2310047C04Rik, 2A-HUB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224170
Homologene: 8771
Dctn2
Name: dynactin 2
Synonyms: RBP50, DCTN-50, p50, 2310042E05Rik, C130077D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69654
VEGA: 10
HGNC: HGNC:2712
Homologene: 4667
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Snapc5
Name: small nuclear RNA activating complex, polypeptide 5
Synonyms: 2010103A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330959
VEGA: 9
Homologene: 4414
Bbs1
Name: Bardet-Biedl syndrome 1 (human)
Synonyms: D19Ertd609e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 52028
VEGA: 19
HGNC: HGNC:966
Homologene: 11641
Wdr17
Name: WD repeat domain 17
Synonyms: 3010002I12Rik, B230207L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244484
Homologene: 12460
Cyp4a10
Name: cytochrome P450, family 4, subfamily a, polypeptide 10
Synonyms: RP1, Cyp4a, D4Rp1, Msp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13117
HGNC: HGNC:2642
Homologene: 128044
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Cntnap4
Name: contactin associated protein-like 4
Synonyms: Caspr4, E130114F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170571
Homologene: 24912
Sh3pxd2a
Name: SH3 and PX domains 2A
Synonyms: Fish, Sh3md1, Tks5, 2310014D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14218
VEGA: 19
Homologene: 7317
Stil
Name: Scl/Tal1 interrupting locus
Synonyms: Sil
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20460
Homologene: 2283
Ankrd36
Name: ankyrin repeat domain 36
Synonyms: 1700012M14Rik, GC3, 1700008J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76389
Homologene: 137366
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Mgarp
Name: mitochondria localized glutamic acid rich protein
Synonyms: Osap, 4930583H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67749
Homologene: 49858
Lrrc66
Name: leucine rich repeat containing 66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231296
Homologene: 51944
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: EG381742, Zfp469
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231861
Homologene: 45603
Olfr829
Name: olfactory receptor 829
Synonyms: GA_x6K02T2PVTD-12599710-12600648, MOR147-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 259070
Homologene: 138324
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: Great, LGR8, Gpr106
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 140498
Homologene: 15402
Cttnbp2
Name: cortactin binding protein 2
Synonyms: ORF4, Cortbp2, 9130022E09Rik, 4732477G22Rik, 3010022N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 30785
Homologene: 14125
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216188
Homologene: 51942
Scg2
Name: secretogranin II
Synonyms: SgII, Chgc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20254
Homologene: 2591
Oprk1
Name: opioid receptor, kappa 1
Synonyms: KOR-1, R21, Oprk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18387
HGNC: HGNC:8154
Homologene: 20253
Nt5dc3
Name: 5'-nucleotidase domain containing 3
Synonyms: Gnn, C630002B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103466
VEGA: 10
Homologene: 9571
Ralb
Name: v-ral simian leukemia viral oncogene B
Synonyms: 5730472O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 64143
HGNC: HGNC:9840
Homologene: 20632
Olfr1012
Name: olfactory receptor 1012
Synonyms: GA_x6K02T2Q125-47239120-47238185, MOR213-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258561
Homologene: 64889
Slc6a20b
Name: solute carrier family 6 (neurotransmitter transporter), member 20B
Synonyms: XT3, Xtrp3, Sit1, Slc6a20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22599
Homologene: 130652
Tgoln1
Name: trans-golgi network protein
Synonyms: TGN38A, TGN38, Ttgn1, D6Ertd384e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22134
Homologene: 137224
Ubxn6
Name: UBX domain protein 6
Synonyms: 2210415J11Rik, 1200008L11Rik, Ubxdc2, Ubxd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66530
Homologene: 11538
Spopl
Name: speckle-type BTB/POZ protein-like
Synonyms: E430033K04Rik, 4921517N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76857
Homologene: 78016
Clec4n
Name: C-type lectin domain family 4, member n
Synonyms: dectin-2, Clecsf10, Nkcl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56620
Homologene: 84615
Tmem269
Name: transmembrane protein 269
Synonyms: 4930538K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75180
Homologene: 28290
Pramel6
Name: PRAME like 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 347711
Homologene: 77635
Serpine3
Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
Synonyms: E130113E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 319433
VEGA: 14
Homologene: 53117
Tes3-ps
Name: testis derived transcript 3, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 54339
VEGA: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 5,602,811 bp
  • T to A, chromosome 1 at 79,435,821 bp
  • T to C, chromosome 1 at 119,483,498 bp
  • T to C, chromosome 1 at 181,182,787 bp
  • C to A, chromosome 2 at 9,952,367 bp
  • T to C, chromosome 2 at 23,511,401 bp
  • T to C, chromosome 2 at 85,759,696 bp
  • T to G, chromosome 2 at 87,509,353 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • A to T, chromosome 3 at 51,391,852 bp
  • T to A, chromosome 4 at 81,335,700 bp
  • T to A, chromosome 4 at 115,023,600 bp
  • T to A, chromosome 4 at 115,529,283 bp
  • A to T, chromosome 4 at 119,205,780 bp
  • A to G, chromosome 4 at 126,171,802 bp
  • T to A, chromosome 5 at 73,607,704 bp
  • ATCTTCC to A, chromosome 5 at 142,773,806 bp
  • A to T, chromosome 5 at 150,052,880 bp
  • T to C, chromosome 6 at 18,420,872 bp
  • C to T, chromosome 6 at 30,151,672 bp
  • T to C, chromosome 6 at 72,615,801 bp
  • A to T, chromosome 6 at 123,230,741 bp
  • C to A, chromosome 8 at 54,635,469 bp
  • A to G, chromosome 8 at 112,752,307 bp
  • T to C, chromosome 9 at 18,856,637 bp
  • T to C, chromosome 9 at 64,180,527 bp
  • T to C, chromosome 9 at 69,421,671 bp
  • A to G, chromosome 9 at 123,612,757 bp
  • C to T, chromosome 10 at 61,103,238 bp
  • A to G, chromosome 10 at 67,219,008 bp
  • A to G, chromosome 10 at 83,512,364 bp
  • G to A, chromosome 10 at 86,833,956 bp
  • C to T, chromosome 10 at 127,277,493 bp
  • A to G, chromosome 11 at 5,628,703 bp
  • T to C, chromosome 11 at 65,990,459 bp
  • C to T, chromosome 11 at 101,294,266 bp
  • T to C, chromosome 11 at 116,223,177 bp
  • A to T, chromosome 13 at 43,421,257 bp
  • A to T, chromosome 13 at 49,493,789 bp
  • T to A, chromosome 14 at 62,670,946 bp
  • A to T, chromosome 16 at 48,958,489 bp
  • T to C, chromosome 17 at 56,069,712 bp
  • A to G, chromosome 17 at 71,657,537 bp
  • A to G, chromosome 18 at 82,987,256 bp
  • T to A, chromosome 19 at 4,897,317 bp
  • T to C, chromosome 19 at 47,424,512 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4097 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040984-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.